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Cell stretching is amplified by active actin remodeling to deform and recruit proteins in mechano-sensitive structures.

Mise en ligne : 27 July 2020

Vincent David et al in Journal of Neuroscience

β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement.

Mise en ligne : 23 July 2020

Emily Johansson and Laurent Groc in Science Advances

Retrovirus, inflammation and psychosis: a missing link identified!

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E.Bezard, L. Cognet et al in Nature Communications

Brain extracellular microenvironment and Parkinson’s disease

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Giovanni Marsicano et al. in Nature

Star-Shaped Brain Cells Shed Light on the Link Between Cannabis Use and Sociability

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Anes Ju, Anna Beyeler et al in Mol Brain

Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex

Mise en ligne : 6 July 2020

G. Barthet and C. Mulle in Progress in Neurobiology

Presynaptic failure in Alzheimer’s disease

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Receptor mobility under the spotlight

A review in Science by Laurent Groc and Daniel Choquet and other publications…

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M. Bourdenx et al in Science Advances

Parkinson’s disease signatures discovered using machine learning

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ML Arotcarena et al in Brain

Bidirectional propagation of alpha-synuclein pathology in nonhuman primates: new insights into the gut-brain axis in Parkinson’s disease

Mise en ligne : 11 May 2020

Figure 1 : CA1 neurons in a mouse organotypic hippocampal slice, that were single cell electroporated with TdTomato as a volume marker and observed by confocal microscopy at the Bordeaux Imaging Center.

Mathieu Letellier and Olivier Thoumine in eLife

Controlling synapse differentiation with light

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Misa Arizono et al in Nature Communications

Structural basis of astrocytic Ca2+ signals at tripartite synapses

Mise en ligne : 20 April 2020

Fabien Ducrocq, Pierre Trifilieff et al in Cell Metabolism

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

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Aude Panatier in Cell Metabolism

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease.

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Pascal Branchereau et al. in eLife

Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks.

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Pierre Philip et al in NPJ Digital Medicine

Trust and acceptance of a virtual psychiatric interview between embodied conversational agents and outpatients

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Steve Dos-Santos Carvalho et al in eLife

Vangl2 and the tale of the missing commissure

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Eric Boué Grabot et al. in Molecular Psychiatry

An innovative mouse model to understand the role of ATP receptor P2X4 in Brain diseases as well as in peripheral disorders.

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Eric Hosy et al. in Neuron

A discrete presynaptic vesicle cycle for neuromodulator receptors

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Etienne Herzog in eLife

A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency.

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V. Nägerl, J.B. Sibarita et al in Nature Methods

A super-resolution platform for correlative live single-molecule imaging and STED microscopy

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Wilfrid Mazier & al. in Molecular Metabolism

mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability

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M. Thiebaut de Schotten in Communications Biology

An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

Mise en ligne : 14 October 2019

David Perrais and Matthieu Sainlos in Nature Communications

Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis.

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Amine Mehidi et al. in Current Biology

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion

Mise en ligne : 26 September 2019

Marion Rincel and Muriel Darnaudéry in Proceedings of the Nutrition Society

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives.

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Maria Florencia Angelo and Etienne Herzog in Acta Neuropathol

Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy.

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Marie-Laure Arotcarena, Benjamin Dehay et al. in JCI Insight

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies

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Giovanni Marsicano, Guillaume Ferreira et al. in Current Biology

CB1 receptors in the anterior piriform cortex control odor preference memory

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Laurent Groc, Thomas Tourdias et al in Cell Reports

Aquaporin-4 surface trafficking regulates astrocytic process motility and synaptic activity in health and autoimmune disease

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Mathieu Letellier et al in Plos Biology

Differential role of pre and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites

Mise en ligne : 12 June 2019

Etienne Herzog in Science

Local transcriptome and translation in presynaptic terminals

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Schematics of the task. Left: Choices by the rat are rewarded with different probabilities in easy trials (7/8; 1/16; 1/16) and difficult trials (5/8; 3/16; 3/16). Learning measurement is the proportion of choices on the best lever during 24-trial blocks of learning where best lever and probabilities do not change. Exploration measurement is the proportion of choice shifts after a reward. Difficult trials as well as dopamine blockade decrease performance and increase exploration. Right: A simple Q-learning model with forgetting accurately reproduces the rat’s behavior. Random exploration parameters of the model significantly increase when dopamine is blocked. Learning parameters are not affected.

Virginie Fresno, Alain Marchand et al in Scientific Reports

Neurobiological control of exploration during learning

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M. Wolff et al in Elife

A thalamocortical circuit for updating action-outcome associations

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B. Mazoyer et al in Genes Brain Behav.

Genome sequencing for rightward hemispheric language dominance.

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© Pierrick Coupé, LABRI (CNRS/Bordeaux INP/Université de Bordeaux). Silhouettes : © rashadashurov/Stock.adobe.com

P. Coupé, E. Lanuza, J.V. Manjón, G. Catheline in Scientific Reports

Lifespan changes of the human brain in Alzheimer’s disease

Mise en ligne : 10 March 2019

Arne Battefeld et al. in Cell Reports

High frequency microdomain Ca2+ transients and waves during early myelin internode remodeling

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Mathieu Wolff & Seralynne Vann in JNeurosci

The Cognitive Thalamus as a gateway to mental representations. 

Mise en ligne : 16 January 2019

Florent Laferrière et al. in Nature Neuroscience

Maladie de Charcot et maladie de Pick: portrait-robot des suspects

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G.Barthet, C.Mulle et al. in Nature comm.

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity.

Mise en ligne : 5 December 2018