Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. Branchereau P, Cattaert D, Delpy A, Allain AE, Martin E, Meyrand P. Sci Rep. 2016 Feb 25;6:21753. doi: 10.1038/srep21753. By acting on their ionotropic chloride channel receptor, GABA and glycine represent the major inhibitory amino acid transmitters of the central nervous system. These…
Mise en ligne : 22 March 2018
Inhibiting Microglia Expansion Prevents Diet-induced Hypothalamic and Peripheral Inflammation. André C, Guzman-Quevedo O, Rey C, Rémus-Borel J, Clark S, Castellanos-Jankiewicz A, Ladeveze E, Leste-Lasserre T, Nadjar A, Abrous DN, Laye S, Cota D. Diabetes. 2016 Nov 30. pii: db160586. [Epub ahead of print] PMID: 27903745 This work was carried out in collaboration with the laboratories of…
Mise en ligne : 21 March 2018
NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, Yonehara K, Roska B, Xu C, Lüthi A, Caille S, Georges F. Nat Commun. 2017 Feb 20;8:14456. doi: 10.1038/ncomms14456. Une publication soutenu par le LabEx BRAIN Abstract NMDA-receptor-dependent plasticity in the…
Mise en ligne : 20 March 2018
March 23rd, 2017 The CB1 Receptor as the Cornerstone of Exostasis. Pier Vincenzo Piazza, Daniela Cota, and Giovanni Marsicano. Neuron (2017),Neuron 93, March 22, 2017 ª 2017 Elsevier Inc. 1/j.neuron.2017.02.002/ Volume 93, Issue 6, p1252–1274, 22 March 2017 Giovanni Marsicano DVM, PhD Group Leader Group “Endocannabinoids and Neuroadaptation », Daniela Cota, MD,Group Leader, Group “Energy Balance and…
Mise en ligne : 20 March 2018
Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons, Karine Guillem, Serge H. Ahmed. Cereb Cortex 1-14.DOI: https://doi.org/10.1093/cercor/bhw398a Serge Ahmed, team leader: Pathological decison-making in addiction / IMN https://doi.org/10.1093/cercor/bhw398a Information in french: La cocaïne est la deuxième drogue illicite la plus utilisée en Europe. Heureusement, tous les usagers de cocaïne…
Mise en ligne : 20 March 2018
Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects. Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G. Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects. Mol Psychiatry. 2017 May 9. Information in french: L’un des principaux défis de la…
Mise en ligne : 20 March 2018
June 6th, 2017 Thalamic alterations remote to infarct appear as focal iron accumulation and impact clinical outcome. Kuchcinski G, Munsch F, Lopes R, Bigourdan A, Su J, Sagnier S, Renou P, Pruvo JP, Rutt BK, Dousset V, Sibon I, Tourdias T. Brain. 2017 May 25. doi: 10.1093/brain/awx114. [Epub ahead of print] Post-stroke outcome includes not only…
Mise en ligne : 20 March 2018
June 29th, 2017 Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents. Parkes SL, Ravassard PM, Cerpa JC, Wolff M, Ferreira G, Coutureau E. Cereb Cortex. 2017 May 25:1-13. doi: 10.1093/cercor/bhx132. [Epub ahead of print] PMID: 28541407 CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, Université de Bordeaux. / INRA, Nutrition…
Mise en ligne : 20 March 2018
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Penn A.C., Zhang C.L., Georges F., Royer L., Breillat C., Hosy E., Petersen J.D., Humeau Y. and Choquet D. Nature, le 13 septembre 2017. DOI : 10.1038/nature23658 Institute for Interdisciplinary Neuroscience (IINS) / Bordeaux Neurocampus / Campus Carreire / Université de Bordeaux …
Mise en ligne : 20 March 2018
Laurent Groc et al. in Nature communications Single receptor imaging in the intact brain : finally there !! The March 17, 2016 Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices Juan A. Varela, Julien P. Dupuis, Laetitia Etchepare, Agnès Espana, Laurent Cognet & Laurent Groc. Nature Communications 7, Article number: 10947…
Mise en ligne : 20 March 2018
The July 20, 2016 Israel JM, Oliet SH, Ciofi P. Electrophysiology of Hypothalamic Magnocellular Neurons In vitro: A Rhythmic Drive in Organotypic Cultures and Acute Slices. Front Neurosci. 2016 Mar 31;10:109. 2016 This is a follow-up paper of our recent study concerning the pulsatile activity of hypothalamic neuroendocrine oxytocin neurons (Israel et al., 2014; see previous presentationand movie). A…
Mise en ligne : 20 March 2018
Janaury 23rd, 2017 STED imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity by Ronan Chereau, Ezequiel Saraceno, Julie Angibaud, Daniel Cattaert and U. Valentin Nägerl Publication date: January 23, 2017 in Proceedings of the National Academy of Sciences (PNAS) Valentin Nagerl : Group leader Synaptic Plasticity and Super-Resolution…
Mise en ligne : 20 March 2018
Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System. Naneix F, Tantot F, Glangetas C, Kaufling J, Janthakhin Y, Boitard C, De Smedt-Peyrusse V, Pape JR, Vancassel S, Trifilieff P, Georges F, Coutureau E, Ferreira G. eNeuro. 2017 Jun 1;4(3). pii: ENEURO.0120-17.2017. doi: 10.1523/ENEURO.0120-17.2017. eCollection 2017 May Une Publication NutriNeuro (Guillaume Ferreira /…
Mise en ligne : 20 March 2018
Amplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits in a mouse model of adolescent and adult dietary polyunsaturated fatty acids imbalance. Antonia Manduca, Anissa Bara, Thomas Larrieu, Olivier Lassalle, Corinne Joffre, Sophie Layé and Olivier J. Manzoni / Journal of Neuroscience 19 June 2017, 3516-16; DOI Poor Adolescent Diet May Influence Brain and Behavior…
Mise en ligne : 12 March 2018
Spatial Rule Learning and Corresponding CA1 Place Cell Reorientation Depend on Local Dopamine Release. Aude Retailleau and Genela Morris. Current Biology 28 , 1–11, March 19, 2018
Mise en ligne : 12 March 2018
Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior.
Mise en ligne : 12 March 2018
Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat.
Mise en ligne : 7 March 2018
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model. Mathieu Bourdenx, Sandra Dovero, Marie-Laure Thiolat, Erwan Bezard & Benjamin Dehay.
Mise en ligne : 5 March 2018
Maria Isabel Carreno-Munoz, Fabienne Martins, Maria Carmen Medrano, Elisabetta Aloisi, Susanna Pietropaolo, Corentin Dechaud, Enejda Subashi, Guillaume Bony, Melanie Ginger, Abdelmalik Moujahid, Andreas Frick & Xavier Leinekugel (2017). Potential involvement of impaired BKCa channel function in sensory defensiveness and some behavioral disturbances induced by unfamiliar environment in a mouse model of FXS. Neuropsychopharmacology, Jul 19 (in…
Mise en ligne : 5 March 2018
Super-resolution imaging of the extracellular space in living brain tissue. Tonnesen J, VVGK Inavalli and Nägerl UV. Cell. 2018 Feb 22;172(5):1108-1121.e15. doi: 10.1016/j.cell.2018.02.007. Prof. U. Valentin Nägerl, PhD Institut Interdisciplinaire de Neurosciences (IINS) CNRS UMR 5297 / Université de Bordeaux / Centre Broca Nouvelle-Aquitaine / Bordeaux Neurocampus / Email : The extracellular space (ECS) of the brain provides the physical…
Mise en ligne : 2 March 2018
Localization-based super-resolution imaging meets high-content screening.
Mise en ligne : 9 January 2018
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, Spatuzza M, Georg Haberl M, Costa L, Shigemoto R, Tappe-Theodor A, Drago F, Vincenzo Piazza P, Mulle C, Groc L, Ciranna L, Catania MV, Frick A. Nat…
Mise en ligne : 9 January 2018
Localization-based super-resolution imaging meets high-content screening. Beghin A, Kechkar A, Butler C, Levet F, Cabillic M, Rossier O, Giannone G, Galland R, Choquet D, Sibarita JB. Nat Methods. 2017 Oct 30. doi: 10.1038/nmeth.4486. [Epub ahead of print] Jean-Baptiste Sibarita team leader et Anne Beghin: Quantitative Imaging of the Cell Institut Interdisciplinaire de Neurosciences / Bordeaux Neurocampus…
Mise en ligne : 9 January 2018
Le 21 novembre 2017 Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, Spatuzza M, Georg Haberl M, Costa L, Shigemoto R, Tappe-Theodor A, Drago F, Vincenzo Piazza P, Mulle C, Groc L, Ciranna L, Catania MV,…
Mise en ligne : 21 November 2017
The challenge of mapping the human connectome based on diffusion tractography. Nature Communications, doi:10.1038/s41467-017-01285-x. Maier-Hein, K. H., Neher, P. F., Houde, J.-C., Côté, M.-A., Garyfallidis, E., Zhong, J., et al. (2017). The challenge of mapping the human connectome based on diffusion tractography. Nature Communications, 1–13. http://doi.org/10.1038/s41467-017-01285-x > Sorry, in french! Cartographier le « connectome » humain requiert d’identifier les…
Mise en ligne : 20 November 2017
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses. Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, Oliet SHR, Groc L. Elife. 2017 Jun 9;6. pii: e25492. doi: 10.7554/eLife.25492. Laurent Groc: Interdisciplinary Institute for NeuroSciences, CNRS , Bordeaux, France Stéphane Oliet: Neurocentre Magendie, Inserm,…
Mise en ligne : 9 June 2017
Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding/ Rebola N, Carta M, Mulle C. Nat Rev Neurosci. 2017 Apr;18(4):208-220. Review. The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the dentate gyrus to CA3…
Mise en ligne : 29 May 2017
Altena E, Chen IY, Daviaux Y, Ivers H, Philip P, Morin CM. How Hyperarousal and Sleep Reactivity Are Represented in Different Adult Age Groups: Results from a Large Cohort Study on Insomnia. Brain Sci. 2017 Apr 14;7(4). pii: E41. Abstract Hyperarousal is a 24-h state of elevated cognitive and physiological activation, and is a core…
Mise en ligne : 14 April 2017
Chamma I, Rossier O, Giannone G, Thoumine O, Sainlos M. Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin. Nat Protoc. 2017 Apr;12(4):748-763 Abstract Recent progress in super-resolution imaging (SRI) has created a strong need to improve protein labeling with probes of small size that minimize the target-to-label…
Mise en ligne : 12 April 2017
Le 3 avril 2017 Virtual human as a new diagnostic tool, a proof of concept study in the field of major depressive disorders. Pierre Philip, Jean-Arthur Micoulaud-Franchi, Patricia Sagaspe, Etienne De Sevin, Jérôme Olive, Stéphanie Bioulac & Alain Sauteraud Scientific Reports 7, Article number: 42656 (2017) doi:10.1038/srep4265 12 January 2017 Dans Sciences et Avenir…
Mise en ligne : 3 April 2017
February 23rd, 2017 Rosendale M, Jullié D, Choquet D, Perrais D. (2017) Spatial and temporal regulation of receptor endocytosis in neuronal dendrites revealed by imaging of single vesicle formation. Cell Reports, Feb 21 David Perrais /IINS Bordeaux / Nano-scale organization, dynamics of synaptic proteins and membrane trafficking. Morgane Rosendale: Brain Research Institute RIKEN, Japon …
Mise en ligne : 23 February 2017
Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects. Lasselin J, Magne E, Beau C, Aubert A, Dexpert S, Carrez J, Layé S, Forestier D, Ledaguenel P, Capuron L. Brain Behav Immun. 2016 May 17. pii: S0889-1591(16)30122-2. doi: 10.1016/j.bbi.2016.05.013. [Epub ahead of print] PMID:27223095 Historique : Obesity represents currently a major public health concern. Not…
Mise en ligne : 20 June 2016
Altered morphological dynamics of activated microglia after induction of status epilepticus.
Mise en ligne : 30 December 2015
Synaptic F-Actin Network Controls Otoferlin-Dependent Exocytosis in Auditory Inner Hair Cells.
Mise en ligne : 14 December 2015
Identification de gènes pour la neuroanatomie de l’hippocampe et l’apprentissage spatiale
Mise en ligne : 1 December 2015
Implementation of a new parcellation of the orbitofrontal cortex in the automated anatomical labeling atlas.
Mise en ligne : 22 October 2015
SR-Tesseler: a method to segment and quantify localization-based super-resolution microscopy data.
Mise en ligne : 23 September 2015
Two-tiered coupling between flowing actin and immobilized N-cadherin/catenin complexes in neuronal growth cones.
Mise en ligne : 16 June 2015
Targeting α-synuclein for treatment of Parkinson’s disease: mechanistic and therapeutic considerations
Mise en ligne : 10 June 2015