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V. Nägerl, J.B. Sibarita et al in Nature Methods

V. V. G. Krishna Inavalli, Martin O. Lenz, Corey Butler, Julie Angibaud, Benjamin Compans, Florian Levet, Jan Tønnesen, Olivier Rossier, Gregory Giannone, Olivier Thoumine, Eric Hosy, Daniel Choquet, Jean-Baptiste Sibarita & U. Valentin Nägerl ; Nature Methods (2019)

Abstract

Multi-modal super-resolution imaging to reveal nanoscale morphology and molecular organisation of synapses
Multi-modal super-resolution imaging to reveal nanoscale morphology and molecular organisation of synapses

Super-resolution microscopy offers tremendous opportunities to unravel the complex and dynamic architecture of living cells. However, current super-resolution microscopes are well suited for revealing protein distributions or cell morphology, but not both. We present a super-resolution platform that permits correlative single-molecule imaging and stimulated emission depletion microscopy in live cells. It gives nanoscale access to the positions and movements of synaptic proteins within the morphological context of growth cones and dendritic spines.

https://www.nature.com/articles/s41592-019-0611-8

Contacts:

Jean-Baptiste Sibarita & Valentin Nägerl, IINS

13/11/19