Receptor mobility under the spotlight

Friday June 12th, the review Linking glutamate receptor movements and synapse function by Daniel Choquet and Laurent Groc was published in Science.


Membrane dynamics of glutamatergic receptors actively participate in many physiological processes (e.g. synaptic plasticity), and is likely to be one of the molecular disorders associated with the etiology of neurological and psychiatric diseases.

Regulation of neurotransmitter receptor content at synapses is achieved through a dynamic equilibrium between biogenesis and degradation pathways, receptor stabilization at synaptic sites, and receptor trafficking in and out synapses. In the past 20 years, the movements of receptors to and from synapses have emerged as a series of highly regulated processes that mediate postsynaptic plasticity. Our understanding of the properties and roles of receptor movements has benefited from technological advances in receptor labeling and tracking capacities, as well as from new methods to interfere with their movements. Focusing on two key glutamatergic receptors, we review here our latest understanding of the characteristics of receptor movements and their role in tuning the efficacy of synaptic transmission in health and brain disease..

Linking glutamate receptor movements and synapse function
Laurent Groc & Daniel Choquet
Science 368, eaay4631 , June 2020
Doi : 10.1126/science.aay4631

Laurent Groc :
Daniel Choquet :

A topic under the spotlight!

Receptor mobility is currently the topic of several reviews and articles recently or soon published. We’ll come back quite soon about that!

Review on “AMPA receptor nanoscale dynamic organization and synaptic plasticities”
D. Choquet, E. Hozy ; Current Opinion in Neurobiology – Volume 63, August 2020, p 137-145

– Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses
Julia Goncalves, Tomas M. Bartol, Côme Camus, Florian Levet, Ana Paula Menegolla, Terrence J. Sejnowski, Jean-Baptiste Sibarita, Michel Vivaudou, Daniel Choquet, Eric Hosy
Proc Natl Acad Sci USA. 2020-06-08 : 201922563
DOI: 10.1073/pnas.1922563117

Press release in french

By the CNRS

Publication: 12/06/20
Last update 22/07/20