W.Mazier, D. Cota et al. inTrends Endocrinol Metab.

The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease. Mazier W, Saucisse N, Gatta-Cherifi B, Cota D. Trends Endocrinol Metab. 2015 Oct;26(10):524-37. doi: 10.1016/j.tem.2015.07.007. Review. Daniela Cota: The first reports of increased appetite induced by cannabis (also known as marijuana) in humans were documented in 300 AD. Pharmacological studies carried out in different animal models between the late seventies and the early nineties had further shown that peripheral or central administration of Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana, or other synthetic cannabinoids increased food intake, especially for palatable food. However, understanding of the biological mechanisms underlying the “munchies”…

Clémentine Bosch-Bouju,Thomas Larrieu, Sophie Layé inCell Reports

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress.  (Pdf file) Clementine Bosch-Bouju,Thomas Larrieu, Louisa Linders,Olivier J. Manzoni and Sophie Laye / Cell Reports 16, 1–6 August 2, 2016   Laboratoire NutriNeuro / Bordeaux Neurocampus La relation entre la consommation d’Oméga 3 et l’adaptation au stress ou à l’anxiété se précise. En 2011…

Benard G, Bezard E, Marsicano G, Pouvreau S. in Neurobiol Dis.

MitoBrain, Putting energy into the brain. Benard G, Bezard E, Marsicano G, Pouvreau S. Neurobiol Dis. 2016 Jun;90:1-2. doi: 10.1016/j.nbd.2016.03.021.   The MitoBrain meeting, which was held in Bordeaux on October 1-3 2014, brought together worldwide experts on the different aspects of mitochondrial physiology and pathology in the brain. The special issue of Neurobiology of Disease covers…

P. de Deurwaerdère et G. Di Giovanni inProg Neurobiol

  De Deurwaerdère P, Di Giovanni G. Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications. Review. Prog Neurobiol. 2016 Mar 22. pii: S0301-0082(15)30096-4. 2016 review.     Philippe de Deurwaerdère : Professeur de Neurosciences et Neuropharmacologie /  Team leader : Neurochemistry, deep brain stimulation and Parkinson’s disease / Université de Bordeaux / Institut des Maladies Neurodégénératives…

Thomas Tourdias et al. inStroke

Bigourdan A, Munsch F, Coupé P, Guttmann CR, Sagnier S, Renou P, Debruxelles S, Poli M, Dousset V, Sibon I, Tourdias T. Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke. Stroke. 2016 Apr;47(4):1053-9. 2016 Thomas Tourdias est membre du Team 'Glia-neuron interactions' Group leader: Stéphane Oliet, PhD…

How does fear freezes us?

Midbrain circuits for defensive behaviour. Tovote P, Esposito MS, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SB, Ramakrishnan C, Fenno L, Deisseroth K, Herry C, Arber S, Lüthi A, Friedrich Miescher Nature. 2016 Jun 1;534(7606):206-12. doi: 10.1038/nature17996. Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland. INSERM, Neurocentre Magendie, U862, 146…

A.Contarino et N. Morisot inNeuropharmacology

The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal. Morisot N, Contarino A. Neuropharmacology. 2016 Feb 18;105:500-507. doi: 10.1016/j.neuropharm.2016.02.021 Nadège Morisot est  post-doc  au Dorit Ron's Lab, Department of Neurology, University of California San Francisco, California, 94158, United States. Angelo Contarino /Bordeaux University, PhD, Team leader: Stress Cognitive…

P.Branchereau, D.Cattaert et al. in Scientific Reports

Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. Branchereau P, Cattaert D, Delpy A, Allain AE, Martin E, Meyrand P. Sci Rep. 2016 Feb 25;6:21753. doi: 10.1038/srep21753. By acting on their ionotropic chloride channel receptor, GABA and glycine represent the major inhibitory amino acid transmitters of the central nervous system. These…

Daniela Cota et al. in Diabetes

Inhibiting Microglia Expansion Prevents Diet-induced Hypothalamic and Peripheral Inflammation.  André C, Guzman-Quevedo O, Rey C, Rémus-Borel J, Clark S, Castellanos-Jankiewicz A, Ladeveze E, Leste-Lasserre T, Nadjar A, Abrous DN, Laye S, Cota D.  Diabetes. 2016 Nov 30. pii: db160586. [Epub ahead of print] PMID: 27903745 This work was carried out in collaboration with the laboratories of…