Daniela Cota et al. in Diabetes
This work was carried out in collaboration with the laboratories of Nora Abrous (INSERM U1215) and Sophie Layé (INRA UMR 1286) and was financially supported by the Labex BRAIN.
Daniela Cota: “Cell proliferation, neurogenesis and neuroinflammation within the arcuate nucleus (ARC) of the hypothalamus, are all processes that have been proposed to play a role in the development of diet-induced obesity. Whether and how diets with different quantity and quality of macronutrients may affect these cellular responses is poorly understood.
In this study, which was just published in Diabetes, we investigated in mice whether the intertwining between cell proliferation and neuroinflammation may be relevant in determining behavioral and metabolic responses associated with the consumption of a high saturated fat, high carbohydrate diet (HFD), which classically leads to obesity.
Our data demonstrate that cell proliferation in the ARC of the hypothalamus depends upon the type of diet consumed and that exposure to a HFD for a short period of time causes an increase in cell proliferation, resulting in microglia expansion.
Conversely, pharmacological blockade of cell proliferation prevents both hypothalamic and peripheral inflammation, restores hypothalamic leptin sensitivity and blunts hyperphagia and body weight gain.
By linking consumption of a HFD with hypothalamic pro-inflammatory microglia proliferation and body weight gain, these findings have physiological relevance to humans, many of whom eat food rich in carbohydrates and saturated fats”
Daniela Cota, MD, HDR Group Leader, Group “Energy Balance and Obesity” INSERM U1215, Université de Bordeaux