Nutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)
The NutriPsy team aims to advance the understanding of the relationship between nutrition and mental health, focusing on how nutritional imbalances contribute to neuropsychiatric symptoms through their impact on inflammatory processes. To this end, we have designed a translational and integrative research program with three core objectives:
- Mechanistic Insights: Investigate how inflammation, influenced by dietary habits, triggers neuropsychiatric symptoms—particularly depression—and contributes to resistance to antidepressants. This includes linking inflammation to specific clinical dimensions.
- Environmental and Genetic Influences: Examine the role of environmental factors and genetic variants associated with inflammation in the onset of depressive symptoms and their response to antidepressants, in both clinical and preclinical models of nutritional imbalance.
- Targeted Treatment Strategies: propose innovative and targeted treatment strategies, based on personalized nutritional interventions, guided by the environmental, clinical (symptomatic dimensions), biological/inflammatory and nutritional profiles of patients, previously identified. This research is a pivotal step towards advancing precision medicine in mental health, addressing the critical need for effective treatments, as standard therapies currently fail in approximately one-third of cases.
Mots clés
Bioénergétique du cerveau et physiologie, Cognition, Comportement alimentaire, Contaminants alimentaires, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Développement du système nerveux, Effet signal des nutriments dans le cerveau, Emotion, Interactions nutriments et traitement neuropharmacologique, Maladies Neuro-développementales, Metabolism, Motivation, Mémoire, Neuroimagerie chez l’humain, Nutrition protectrice et vieillissement cognitif, Relations microbiote-intestin-cerveau, Troubles du comportement, Troubles métaboliques et obésitéSelected publications
-
Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon.
Front. Nutr.. 2023-10-05. 10
DOI: 10.3389/fnut.2023.1267839 -
Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.
Simon Benoit, Mathilde Henry, Sara Fneich, Alexia Mathou, Lin Xia, Aline Foury, Mélanie Jouin, Claudine Junien, Lucile Capuron, Luc Jouneau, Marie-Pierre Moisan, Cyrille Delpierre, Anne Gabory, Muriel Darnaudéry.
Front. Nutr.. 2023-07-26. 10
DOI: 10.3389/fnut.2023.1190392 -
Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study
Camille Pouchieu, Line Pourtau, Julie Brossaud, David Gaudout, Jean-Benoit Corcuff, Lucile Capuron, Nathalie Castanon, Pierre Philip.
Nutrients. 2023-06-27. 15 (13) : 2921.
DOI: 10.3390/nu15132921 -
Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Julie Brossaud, Clémentine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoît Corcuff, Marie-Pierre Moisan.
Diabetologia. 2023-06-10.
DOI: 10.1007/s00125-023-05942-3 -
Structural basis of glucocorticoid receptor signaling bias
Freddy Jeanneteau, Onno C. Meijer, Marie‐Pierre Moisan.
J Neuroendocrinology. 2022-10-11.
DOI: 10.1111/jne.13203
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Bruno Aouizerate
Aouizerate
(University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Sylvie Vancassel Vancassel (Researcher)
Quentin Leyrolle Leyrolle (Enseignant-chercheur)
Amandine Ferrière Ferrière (Associate professor / hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Sylvie Vancassel Vancassel (Researcher)
Quentin Leyrolle Leyrolle (Enseignant-chercheur)
Amandine Ferrière Ferrière (Associate professor / hospital practitioner)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Enrica Montalban
Montalban
Rachel Ginieis Ginieis
Camille Amadieu Amadieu
Cassandra Gheorghe Gheorghe
Rachel Ginieis Ginieis
Camille Amadieu Amadieu
Cassandra Gheorghe Gheorghe
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC