Subcellular localization and trafficking of kainate receptors.

Frédéric Jaskolski, Françoise Coussen, Christophe Mulle
Trends in Pharmacological Sciences. 2005-01-01; 26(1): 20-26
DOI: 10.1016/j.tips.2004.11.008

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1. Trends Pharmacol Sci. 2005 Jan;26(1):20-6.

Subcellular localization and trafficking of kainate receptors.

Jaskolski F(1), Coussen F, Mulle C.

Author information:
(1)Laboratoire ‘Physiologie Cellulaire de la Synapse’, CNRS UMR 5091, Institut
François Magendie, Université Bordeaux 2, rue C. Saint-Saëns, 33077 Bordeaux
Cedex, France.

Glutamate receptors of the kainate type have been identified recently as key
players in the modulation of neuronal-network activity. The role of kainate
receptors depends on their precise subcellular localization in presynaptic,
postsynaptic and extrasynaptic domains. Subcellular localization of kainate
receptors has been inferred mainly from electrophysiological studies with the
help of selective pharmacological tools and kainate receptor mutant mice. These
studies, combined with recent ultrastructural data, highlight the diversity of
subcellular localizations of kainate receptors. It is important to understand the
molecular mechanisms that underlie the polarized trafficking of kainate receptors
in distinct neuronal domains. In this article, we review recent data that shed
light on the trafficking and membrane delivery of kainate receptor isoforms, and
on the identification of proteins that interact with kainate receptors and might
regulate this trafficking.

DOI: 10.1016/j.tips.2004.11.008
PMID: 15629201 [Indexed for MEDLINE]

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