Roles of the endocannabinoid system in learning and memory.

1. Curr Top Behav Neurosci. 2009;1:201-30. doi: 10.1007/978-3-540-88955-7_8.

Roles of the endocannabinoid system in learning and memory.

Marsicano G(1), Lafenêtre P.

Author information:
(1)Group Molecular Mechanisms of Behavioural Adaptation, Research Centre INSERM
U862 NeuroCentre Magendie Université Bordeaux 2, 146, rue Léo Saignat, Bordeaux,
France.

The endocannabinoid system (ECS) plays a central role in the regulation of
learning and memory processes. The fine-tuned regulation of neural transmission
by the system is likely to be the mechanism underlying this important function.
In this chapter, we review the data in the literature showing the direct
involvement of the physiological activation of cannabinoid receptors in the
modulation of different forms of learning and memory. When possible, we also
address the likely mechanisms of this involvement. Finally, given the apparent
special role of the ECS in the extinction of fear, we propose a reasonable model
to assess how neuronal networks could be influenced by the endocannabinoids in
these processes. Overall, the data reviewed indicate that, despite the enormous
progress of recent years, much is still to be done to fully elucidate the
mechanisms of the ECS influence on learning and memory processes.

DOI: 10.1007/978-3-540-88955-7_8
PMID: 21104385 [Indexed for MEDLINE]

Know more about