Polymodal activation of the endocannabinoid system in the extended amygdala.
Nat Neurosci. 2011-11-06; 14(12): 1542-1547
DOI: 10.1038/nn.2974
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1. Nat Neurosci. 2011 Nov 6;14(12):1542-7. doi: 10.1038/nn.2974.
Polymodal activation of the endocannabinoid system in the extended amygdala.
Puente N(1), Cui Y, Lassalle O, Lafourcade M, Georges F, Venance L, Grandes P,
Manzoni OJ.
Author information:
(1)INSERM U862, Physiopathology of Synaptic Plasticity, Neurocentre Magendie,
Bordeaux Cedex, France.
The reason why neurons synthesize more than one endocannabinoid (eCB) and how
this is involved in the regulation of synaptic plasticity in a single neuron is
not known. We found that 2-arachidonoylglycerol (2-AG) and anandamide mediate
different forms of plasticity in the extended amygdala of rats. Dendritic L-type
Ca(2+) channels and the subsequent release of 2-AG acting on presynaptic CB1
receptors triggered retrograde short-term depression. Long-term depression was
mediated by postsynaptic mGluR5-dependent release of anandamide acting on
postsynaptic TRPV1 receptors. In contrast, 2-AG/CB1R-mediated retrograde
signaling mediated both forms of plasticity in the striatum. These data
illustrate how the eCB system can function as a polymodal signal integrator to
allow the diversification of synaptic plasticity in a single neuron.
DOI: 10.1038/nn.2974
PMID: 22057189 [Indexed for MEDLINE]