Do schizophrenia patients with low P50-suppression report more perceptual anomalies with the sensory gating inventory?

Jean-Arthur Micoulaud-Franchi, William P. Hetrick, Mitsuko Aramaki, Amanda Bolbecker, Laurent Boyer, Sølvi Ystad, Richard Kronland-Martinet, Raphaëlle Richieri, Catherine Faget, Mélanie Faugere, Alexandre El-Kaim, Michel Cermolacce, Christophe Lancon, Jean Vion-Dury
Schizophrenia Research. 2014-08-01; 157(1-3): 157-162
DOI: 10.1016/j.schres.2014.05.013

PubMed
Read on PubMed



1. Schizophr Res. 2014 Aug;157(1-3):157-62. doi: 10.1016/j.schres.2014.05.013. Epub
2014 Jun 2.

Do schizophrenia patients with low P50-suppression report more perceptual
anomalies with the sensory gating inventory?

Micoulaud-Franchi JA(1), Hetrick WP(2), Aramaki M(3), Bolbecker A(2), Boyer L(4),
Ystad S(3), Kronland-Martinet R(3), Richieri R(4), Faget C(4), Faugere M(5),
El-Kaim A(5), Cermolacce M(5), Lancon C(4), Vion-Dury J(5).

Author information:
(1)Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Unité de
Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU
Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Laboratoire
de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université,
Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France. Electronic
address: .
(2)Department of Psychological and Brain Sciences, Indiana University, 1101 East
Tenth Street, Bloomington, IN 47405, United States; Department of Psychiatry,
Indiana University School of Medicine, Indianapolis, IN, United States; Larue D.
Carter Memorial Hospital, Indianapolis, IN, United States.
(3)Laboratoire de Mécanique et d’Acoustique, LMA, CNRS, UPR 7051, Aix-Marseille
Univ., Centrale Marseille, F-13402 Marseille Cedex 20, France.
(4)Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de santé publique évaluation des systèmes de soins et santé perçue,
Université de la Méditerranée, EA 3279, Faculté de Médecine, 27 bd Jean Moulin,
13385 Marseille cedex 05, France.
(5)Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Unité de
Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU
Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Laboratoire
de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université,
Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.

BACKGROUND: P50 amplitude changes in dual click conditioning-testing procedure
might be a neurophysiological marker of deficient sensory gating in
schizophrenia. However, the relationship between abnormalities in the
neurophysiological and phenomenological dimensions of sensory gating in
schizophrenia remains unclear. The aim of the present study was to determine if
patients with low P50-suppression (below 50%) report more perceptual anomalies.
METHODS: Three groups were compared: twenty-nine schizophrenia patients with high
P50-suppression (above 50% amplitude suppression), twenty-three schizophrenia
patients with low P50-suppression (below 50%) and twenty-six healthy subjects.
The Sensory Gating Inventory (SGI), a four-factor self-report questionnaire, was
used to measure perceptual anomalies related to sensory gating. A comparison of
demographic and clinical data was also carried out.
RESULTS: Patients with low P50-suppression presented: i) significantly higher
scores on the SGI (for the overall SGI score and for each of the 4 factors) and
ii) significantly larger P50 amplitude at the second click, than both patients
with high P50-suppression and healthy subjects. There were no group differences
in the most of demographic and clinical data.
DISCUSSION: The finding offers support for conceptual models wherein abnormal
neurophysiologic responses to repetitive stimuli give rise to clinically relevant
perceptions of being inundated and overwhelmed by external sensory stimuli.
Further studies are needed to explore the contributions of clinical symptoms,
medication and neuropsychological functions to the relationship between
P50-suppression and the SGI, and the role of sensory “gating in” versus “gating
out”.

Copyright © 2014 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.schres.2014.05.013
PMID: 24893905 [Indexed for MEDLINE]

Know more about