Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease.
Journal of Neuroradiology. 2021-05-01; 48(3): 170-175
DOI: 10.1016/j.neurad.2019.03.015
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Ameli R(1), Guttmann CRG(2), Prieto JC(2), Rollot F(3), Palotai M(2), Vukusic
S(4), Marignier R(5), Cotton F(6); Group Members for OFSEP Imaging Working
Group; COPIL of OFSEP; NOMADMUS study group.
Collaborators: Anxionnat R(7), Armspach JP(8), Audoin B(9), Barillot C(10),
Berry I(11), Bonneville F(12), Boutet C(13), Castelnovo G(14), Cervenanski
F(15), Cohen M(16), Commowick O(17), De Seze J(18), Dousset V(19), Durand-Dubief
F(20), Edan G(21), Ferre JC(22), Galanaud D(23), Glattard T(24), Grand S(25),
Guillaumont J(26), Guillevin R(27), Hannoun S(28), Heitz F(29), Krainik A(30),
Kremer S(31), Labauge P(32), Menjot De Champfleur N(33), Ranjeva JP(34), Roch
JA(35), Sappey-Marinier D(36), Savatovsky J(37), Stankoff B(38), Tourbah A(39),
Tourdias T(40), Brochet B(41), Clanet M(42), Dufay N(43), Laplaud D(44), Maze
MC(45), Moreau T(46), Trolliet C(47), Frangoulis B(48), Olaiz J(49), Pelletier
J(50), Audoin B(51), Bourre B(52), Brassat D(53), Cabre P(54), Camdessanche
JP(55), Camu W(56), Casez O(57), Castelnovo G(58), Clavelou P(59), Collongues
N(60), Creange A(61), Defer G(62), Debouverie M(63), Edan G(64), Gout O(65),
Labauge P(66), Lebrun-Frenay C(67), Lubetzki C(68), Papeix C(68), Stankoff
B(69), Tourbah A(70), Vermersch P(71), Zephir H(71).
Author information:
(1)Hôpital Neurologique et Neurochirurgical, Service de Radiologie, Bron,
France. Electronic address: .
(2)Center for Neurological Imaging, Department of Radiology, Brigham and Women’s
Hospital, Harvard Medical School, Boston, USA.
(3)Observatoire Français de la Sclérose en Plaques (OFSEP), Lyon, France.
(4)Université Lyon 1, Hospices Civils de Lyon, Hôpital Neurologique, Service de
Neurologie A, Bron, France.
(5)Université Lyon 1, Hospices Civils de Lyon, Hôpital Neurologique, Service de
Neurologie A, Bron, France; Neuroscience Research center INSERM UMR-S1028,
CNRS/UMR/5292, Lyon, France.
(6)Université Lyon 1, Laboratoire d’Anatomie de Rockefeller; Centre Hospitalier
Lyon Sud, Service de Radiologie, Pierre Bénite; CREATIS-LRMN,
CNRS/UMR/5220-INSERM U630, Villeurbanne, France.
(7)INSERM U947 Imagerie Adaptative Diagnostique et Interventionnelle, Service de
neuroradiologie, CHU de Nancy, 29 avenue du Maréchal de Lattre de Tassigny,
54035 Nancy, France. Electronic address: .
(8)Université de Strasbourg, IPB-ICube, CNRS UMR 7357, FMTS, 4, rue Kirschleger,
67085 Strasbourg Cedex, France. Electronic address:
.
(9)APHM, Hôpital de la Timone, 264 Rue Saint-Pierre, 13005 Marseille, France.
Electronic address: .
(10)Université Rennes I, Université Européenne de Bretagne, INSERM, CNRS, INRIA
Rennes – Bretagne Atlantique, Campus de Beaulieu, 263 Avenue Général Leclerc,
35042 Rennes, France. Electronic address: .
(11)Université Toulouse III, INSERM, Service de médecine nucléaire CHU de
Toulouse – Hôtel Dieu, 2 rue Viguerie, TSA 80035, 31059 Toulouse, France.
Electronic address: .
(12)Université Toulouse III, Service de Neuroradiologie, Hôpital Pierre Paul
Riquet, et Inserm, U 825, CHU Purpan, 1, Place du Dr Baylac, 31000 Toulouse,
France. Electronic address: .
(13)Service de Radiologie, CHU Saint Etienne-Hôpital Nord, 42055 Saint Etienne
Cedex 2, France. Electronic address: .
(14)APHP, Université Pierre et Marie Curie, INSERM, CNRS, Service de
neuroradiologie GH, Pitié Salpêtrière, 47 boulevard de l’hôpital, 75651 Paris
cedex 13, France. Electronic address: .
(15)CREATIS, CNRS UMR 5220& INSERM – Bât L. de Vinci (‘401’), 21 avenue Jean
Cappelle, 69621 Villeurbanne cedex, France. Electronic address:
.
(16)Service de neurologie, Hôpital Pasteur, 30 avenue de la voie romaine, 06000
Nice, France. Electronic address: .
(17)Inria Rennes- Bretagne Atlantique (Unité/Projet VisAGeS U746), Campus de
Beaulieu, 263 Avenue Général Leclerc, 35042 Rennes, France. Electronic address:
.
(18)Université de Strasbourg, CNRS, CHU de Strasbourg, 1 place de l’hôpital,
67091 Strasbourg Cedex, France. Electronic address:
.
(19)University of Bordeaux, Institut de Bio-Imagerie de Bordeaux UMS 3428, 33000
Bordeaux, France; INSERM, U862, Physiopathologie de la plasticité neuronale,
33000 Bordeaux, France; CHU de Bordeaux, Service de NeuroImagerie Diagnostique
de Thérapeutique, 33000 Bordeaux, France. Electronic address:
.
(20)CREATIS, CNRS UMR 5220& INSERM U1044, Hôpital Neurologique – service de
neurologie A, 59 boulevard Pinel, 69677 Bron Cedex, France. Electronic address:
.
(21)Service de neurologie CHU de Rennes, 2 rue Henri le Guilloux, 35033 Rennes
Cedex 9, France. Electronic address: .
(22)Service de neurologie CHU de Rennes, 2 rue Henri le Guilloux, 35033 Rennes
Cedex 9, France. Electronic address: .
(23)APHP, Université Pierre et Marie Curie, INSERM, CNRS, Service de
neuroradiologie GH, Pitié Salpêtrière, 47 boulevard de l’hôpital, 75651 Paris
cedex 13, France. Electronic address: .
(24)CREATIS, CNRS UMR 5220& INSERM U1044- Bât L. de Vinci (‘401’), 21 avenue
Jean Cappelle, 69621 Villeurbanne cedex, France. Electronic address:
.
(25)University Grenoble Alpes, Grenoble Institute of Neurosciences, Grenoble,
France; Grenoble University Hospital, Department of Neuroradiology and MRI,
Grenoble, Inserm, U836, 38042, Grenoble, France. Electronic address:
.
(26)Inria Rennes- Bretagne Atlantique (Unité/Projet VisAGeS U746), Campus de
Beaulieu, 263 Avenue Général Leclerc, 35042 Rennes, France. Electronic address:
.
(27)Service de neuroradiologie CHU de Poitiers, 2 Rue de la Milétrie, 86021
Poitiers, France. Electronic address: .
(28)OFSEP/CREATIS, CNRS UMR 5220& INSERM U1044, CERMEP-Imagerie du Vivant, 59
Boulevard Pinel, 69677 Bron Cedex, France. Electronic address:
.
(29)ICube, UMR CNRS 7357, Université de Strasbourg, Télécom Physique Strasbourg,
300 Bd Sébastien Brant, CS 10413, 67412 Illkirch Cedex, France. Electronic
address: .
(30)University Grenoble Alpes, Grenoble Institute of Neurosciences, Grenoble
University Hospital, Department of Neuroradiology and MRI, Inserm, U836, 38042
Grenoble, France. Electronic address: .
(31)Université de Strasbourg, ICube CNRS UMR 7357, FMTS, CHU de Strasbourg, 1
place de l’hôpital, 67091 Strasbourg Cedex, France. Electronic address:
.
(32)Université Montpellier-Nîmes I, INSERM, CNRS, Service de neurologie, CHU de
Montpellier – Centre A. Benech, avenue Doyen Giraud, 34295 Montpellier cedex 5,
France. Electronic address: .
(33)Institut d’Imagerie Fonctionnelle Humaine (I2FH) Hôpital Gui de Chauliac, 80
avenue Augustin Fliche, 34295 Montpellier cedex 5, France. Electronic address:
.
(34)APHM, Université Aix-Marseille II, CRMBM UMR CNRS 7339, Faculté de Médecine,
27 Bvd Jean Moulin, 13385 Marseille cedex 05, France. Electronic address:
.
(35)CHU de Lyon, Hôpital Jean Mermoz, 55 Avenue Jean Mermoz, 69008 Lyon 08,
France. Electronic address: .
(36)Université Claude Bernard Lyon 1, CREATIS, CNRS UMR 5220& INSERM U1044,
CERMEP-Imagerie du Vivant, 59 Boulevard Pinel, 69677 Bron Cedex, France.
Electronic address: .
(37)Fondation Rothschild, 25 rue Manin, 75019 Paris, France. Electronic address:
.
(38)APHP, Université Pierre et Marie Curie, INSERM, HUEP Hôpital Tenon, 4 rue de
la Chine, 75020 Paris, France. Electronic address: .
(39)URCA, INSERM, CNRS, CHU de Reims, 45 rue Cognacq-Jay, 51092 Reims Cedex,
France. Electronic address: .
(40)University Bordeaux, 33000 Bordeaux, France; INSERM, U862, Physiopathologie
de la plasticité neuronale, 33000 Bordeaux, France; CHU de Bordeaux, Service de
NeuroImagerie Diagnostique de Thérapeutique, 33000 Bordeaux, France. Electronic
address: .
(41)Department of Neurology, CHU Bordeaux, Bordeaux, France. Electronic address:
.
(42)Department of Neurology, CHU Toulouse, Toulouse, France. Electronic address:
.
(43)Hospices Civils de Lyon, Hôpital Neurologique, Service de Neurologie A,
69677 Bron, France. Electronic address: .
(44)INSERM, UMR 1064, 44093 Nantes, France; Neurology Department, Nantes
Hospital Nantes, 44093 Nantes, France; INSERM 004, Centre d’Investigation
Clinique Nantes, 44093 Nantes, France. Electronic address:
.
(45)Hospices Civils de Lyon, Hôpital Neurologique, Service de Neurologie A,
69677 Bron, France. Electronic address: .
(46)Service de Neurologie, CHU de Dijon, Dijon, France. Electronic address:
.
(47)Observatoire Français de la Sclérose en Plaques (OFSEP), 69677 Lyon, France.
Electronic address: .
(48)Service de Neurologie A and Fondation Eugène Devic EDMUS contre la Sclérose
en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,
Lyon, France; Centre des Neurosciences de Lyon, INSERM 1028 et CNRS UMR5292,
Equipe Neuro-oncologie et Neuro-inflammation, Université de Lyon, Lyon, France;
Université Lyon 1, Lyon, France. Electronic address: .
(49)Service de Neurologie A and Fondation Eugène Devic EDMUS contre la Sclérose
en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon,
Lyon, France. Electronic address: .
(50)APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Department of
Neurology, Marseille, France. Electronic address: .
(51)Department of Neurology, La Timone University Hospital, Marseille, France.
(52)Departement of Neurology, Charles Nicolle University Hospital, Rouen,
France.
(53)Department of Neurology, Toulouse-Purpan University Hospital, Toulouse,
France.
(54)University Hospital, Fort de France, Martinique.
(55)University Hospital, Saint Etienne, France.
(56)UNCD Molecular Inut, INSERM V336, Institute of Biology, Montpellier, France.
(57)Departement of Neurology, Grenoble University Hospital, Grenoble, France.
(58)Departement of Neurology, Nîmes University Hospital, Nîmes, France.
(59)Department of Neurology, Montpied University Hospital, Clermont-Ferrand,
France.
(60)UF 6961 Inflammatory diseases of the CNS, Hautepierre Hospital, Strasbourg,
France.
(61)Neurosciences Department, Mondor University Hospital, Creteil, France.
(62)Department of Neurology, Caen University Hospital, Caen, France.
(63)Department of Neurology, Nancy University Hospital, Nancy, France.
(64)Department of Neurology, Rennes University Hospital, Rennes, France.
(65)Rothschild Foundation, Paris, France.
(66)Department of Neurology, Gui de Chauliac Hospital, Montpellier University
Hospital, Montpellier, France.
(67)Department of Neurology, Nice University Hospital, Nice, France.
(68)Neurology Unit 4, Pitié-Salpétrière University Hospital, Paris, France.
(69)Department of Neurology, Tenon Hospital, Paris, France.
(70)Department of Neurology, Reims University Hospital, Reims, France.
(71)Department of Neurology, EA 2686, Lille University Hospital, Lille, France.
BACKGROUND AND PURPOSE: To determine the precise incidence of lesions at sites
of high Aquaporin-4 expression (hAQP4) and their possible association with known
neuromyelitis optica spectrum disease (NMOSD) lesions patterns.
MATERIALS AND METHODS: A retrospective analysis of brain and, when available,
spinal cord MRI scans of 54 NMOSD patients recruited among the French NMOSD
cohort was performed. Brain lesions were annotated as MS-like, non-specific, or
evocative of NMOSD. The topography of hAQP4 was reassessed by human brain atlas.
The incidence of lesions in hAQP4 and their association with lesions evocative
of NMOSD was estimated.
RESULTS: Among those included (41/54 female, mean age: 45 years) 47/54 (87%)
presented brain lesions. Twenty-six/47 (55%) had lesions in hAQP4. Thirty-two/54
patients (60%) had lesions considered evocative of NMOSD. The majority of them
also presented lesions in hAQP4 (65%, 21/32). Patients with lesions in hAQP4 and
lesions evocative of NMOSD demonstrated more extensive myelitis compared to the
other patients (7 [6-10] versus 4 [3-5] vertebral segments, P=0.009).
CONCLUSION: The coexistence of lesions evocative of NMOSD and in hAQP4 is
associated with significantly more extensive myelitis, and might have
pathophysiological and clinical significance.
Copyright © 2019. Published by Elsevier Masson SAS.
DOI: 10.1016/j.neurad.2019.03.015
PMID: 30981824 [Indexed for MEDLINE]