Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex.
Brain Struct Funct. 2020-07-29; 225(7): 2203-2218
DOI: 10.1007/s00429-020-02121-7
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1. Brain Struct Funct. 2020 Sep;225(7):2203-2218. doi: 10.1007/s00429-020-02121-7.
Epub 2020 Jul 29.
Age-related change in episodic memory: role of functional and structural
connectivity between the ventral posterior cingulate and the parietal cortex.
Edde M(1)(2)(3), Dilharreguy B(4), Theaud G(5), Chanraud S(6)(4)(7), Helmer C(8),
Dartigues JF(7)(8)(9), Amieva H(8), Allard M(6)(4)(9), Descoteaux M(5), Catheline
G(6)(4)(7).
Author information:
(1)EPHE, PSL, 33000, Bordeaux, France. .
(2)CNRS, INCIA, UMR 5287, 33000, Bordeaux, France. .
(3), Bât. 2A – 2ème Étage – Case 22, 146 Rue Léo Saignat, 33076, Bordeaux cedex,
France. .
(4)CNRS, INCIA, UMR 5287, 33000, Bordeaux, France.
(5)Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke,
Sherbrooke, QC, Canada.
(6)EPHE, PSL, 33000, Bordeaux, France.
(7)INCIA, UMR 5287, Université de Bordeaux, 33000, Bordeaux, France.
(8)Inserm, Bordeaux Population Health Research Center, UMR 1219, Université de
Bordeaux, 33000, Bordeaux, France.
(9)CHU de Bordeaux, Bordeaux, France.
While the neural correlates of age-related episodic memory decline have been
extensively studied, the precise involvement of the Posterior Cingulate Cortex
(PCC) and posterior parietal cortex (the precuneus and the angular gyrus),
remains unclear. The present study examined functional and structural neural
correlates of age-related episodic memory change assessed over 12 years in 120
older adults (range 76-90 years). Episodic memory performance was measured using
the Free and Cued Selective Reminding Test (FCSRT); functional connectivity
metrics were computed from resting-state fMRI images and structural connectivity
metrics were assessed through microstructural properties of reconstructed tract
using a native space pipeline. We found that FCSRT change was significantly
associated with the functional connectivity between the ventral PCC and three
parietal regions, the ventral superior, the inferior part of the precuneus, and
the rostro dorsal part of the angular gyrus. This association was independent of
hippocampal volume. In addition, we found the that change in FCSRT scores was
associated with fractional anisotropy of the tract connecting the ventral PCC and
the ventral superior part of the precuneus. Change in episodic memory in aging
was therefore related to a combination of high functional connectivity and low
structural connectivity between the ventral PCC and the ventral superior part of
the precuneus.
DOI: 10.1007/s00429-020-02121-7
PMID: 32728934