Magnetisation transfer parameters and stroke outcome.
Journal of Clinical Neuroscience. 2015-06-01; 22(6): 1012-1017
DOI: 10.1016/j.jocn.2014.11.035
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1. J Clin Neurosci. 2015 Jun;22(6):1012-7. doi: 10.1016/j.jocn.2014.11.035. Epub
2015 Apr 16.
Magnetisation transfer parameters and stroke outcome.
Sibon I(1), Tourdias T(2), Felix S(3), Asselineau J(4), Bracoud L(5), Vivot A(4),
Rouanet F(3), Renou P(3), Orgogozo JM(6), Dousset V(2).
Author information:
(1)Unité Neurovasculaire, Pôle de Neurosciences Cliniques, Hôpital Pellegrin,
Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen,
Bordeaux 33076, France. Electronic address: .
(2)Unité Neurovasculaire, Pôle de Neurosciences Cliniques, Hôpital Pellegrin,
Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen,
Bordeaux 33076, France; Service de NeuroImagerie Diagnostique de Thérapeutique,
Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
(3)Unité Neurovasculaire, Centre Hospitalier Universitaire de Bordeaux, Bordeaux,
France.
(4)Unité de soutien méthodologique à la recherche clinique et épidémiologique,
Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
(5)Bioclinica, Lyon, France.
(6)Unité Neurovasculaire, Pôle de Neurosciences Cliniques, Hôpital Pellegrin,
Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen,
Bordeaux 33076, France; Unité Neurovasculaire, Centre Hospitalier Universitaire
de Bordeaux, Bordeaux, France.
Our aim was to evaluate the association between magnetisation transfer imaging
(MTI) parameters measured 30 to 45 days after a cerebrovascular insult and
post-stroke functional outcome at the same time. MTI offers the opportunity to
depict subtle microstructural changes in infarcted areas. The clinical
significance of the heterogeneity of brain damage within ischaemic stroke lesions
is unknown. We prospectively included 58 patients with acute middle cerebral
artery stroke. Diffusion-weighted imaging was performed within 12 hours after
onset and the final infarct was documented by MRI with fluid-attenuated inversion
recovery (FLAIR) and MTI at 30 to 45 days follow-up. We evaluated the association
between MTI histogram parameters and the clinical outcome assessed by
dichotomised (threshold >2) modified rankin scale (mRS) using multivariable
logistic regression models adjusted on baseline characteristics. In multivariable
analyses, stroke outcome was mostly driven by initial National Institutes of
Health Stroke Scale (odds ratio [OR]=1.23; 95% confidence interval
[CI]=1.07-1.41; p