Benjamin Dehay et al. dans Movement Disorders
Dehay B, Vila M, Bezard E, Brundin P, Kordower JH. Alpha-synuclein propagation: New insights from animal models. Mov Disord. 2015 Sep 8. doi: 10.1002/mds.26370 Abstract PubMed: Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. ….more « In 2008, observations of Lewy pathology in post-mortem studies of dopamine neurons grafted to the brains of Parkinson’s disease (PD) patients kindled the idea that PD is a prion-like disorder. The alpha-synuclein (α-syn) aggregates found in the transplanted neurons displayed several features that are characteristic of…
Mise en ligne : 6 octobre 2015