Nutrition and psychoneuroimmunology: experimental and clinical approaches
Topic 1: depression /
Our multidisciplinary team aims at understanding how nutrition may modulate brain functions and vulnerability to psychiatric disorders with a particular attention paid to major depression. We test the hypothesis that Western diet, diabetes or obesity through the modulation of inflammatory and metabolic pathways participate to the pathophysiology of depression and impact response to antidepressant treatments. We are currently exploring the specific role of: i) enzymatic pathways involved in inflammatory processes, such as the indoleamine2,3-dioxygenase (IDO) and the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) ; ii) gut-brain axis dysfunctions and iii) early life stress in the pathophysiology of depression in a context of altered nutritional status. For this purpose, we adopt a translational research approach from humans to animal models and vice versa, combining the skills and expertise of researchers and clinicians.
Topic 2: Molecular and cellular mechanisms of nutrients/micronutrients in the brain; role in mood and cognitive disorders (Equipe FRM) /
The research program develop aims to unravel the mechanisms underlying nutrients (sugar, fatty acids, amino-acids) and micronutrients (vitamins) activities in the brain, at the cellular (neurons, microglia) and brain circuit level. This knowledge will help to decipher how nutrition promotes brain health and protects from mood and cognitive disorders. We study in particular how:
1 / Omega 3 and their metabolites (oxylipins, endocannabinoids) regulate neuroinflammation and neuronal networks (focusing on the hippocampus and fronto-striatal circuits),
2/ sugar (glucose, fructose) control of food intake (hypothalamus) and emotional behavior (raphe nucleus)
3/ micronutrients or plant extracts protect from cognitive decline, with clinical approaches developed in aged subjects with V Pallet (team 2).
Mots clés
Bioénergétique du cerveau et physiologie, Cognition, Comportement alimentaire, Contaminants alimentaires, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Développement du système nerveux, Effet signal des nutriments dans le cerveau, Emotion, Interactions nutriments et traitement neuropharmacologique, Maladies Neuro-développementales, Motivation, Mémoire, Neuroimagerie chez l’humain, Nutrition protectrice et vieillissement cognitif, Relations microbiote-intestin-cerveau, Troubles du comportement, Troubles métaboliques et obésitéSelected publications
- Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output. Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet. J. Lipid Res.. 2020-08-21. : jlr.RA120001024.
- In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties. Mathieu Di Miceli, Zoé Husson, Philippe Ruel, Sophie Layé, Daniela Cota, Xavier Fioramonti, Clémentine Bosch-Bouju, Benjamin Gronier. Front. Neural Circuits. 2020-08-13. 14
- Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime. Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar. Neuropsychopharmacol.. 2020-08-11.
- Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses. Orsolya Inczefi, Valérie Bacquié, Maïwenn Olier-Pierre, Marion Rincel, Belinda Ringot-Destrez, Sandrine Ellero-Simatos, Hélène Eutamène, Colette Bétoulières, Julie Thomas, Justin Laine, Louise Gros, Mathilde Lévêque, Renaud Leonard, Cherryl Harkat, Catherine Robbe-Masselot, Richard Roka, Muriel Mercier-Bonin, Vassilia Theodorou, Muriel Darnaudéry, Jerrold R. Turner, Laurent Ferrier. Cellular and Molecular Gastroenterology and Hepatology. 2020-03-01.
- Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Sørensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschöp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa, Serge H. Luquet. Cell Metabolism. 2020-03-01.
- n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging. Corinne Joffre, Anne-Laure Dinel, Mathilde Chataigner, Véronique Pallet, Sophie Layé. Nutrients. 2020-02-28. 12 (3) : 647.
- Reward-related brain activity and behavior are associated with peripheral ghrelin levels in obesity. Volodymyr B. Bogdanov, Olena V. Bogdanova, Sandra Dexpert, Ines Delgado, Helen Beyer, Agnès Aubert, Bixente Dilharreguy, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Bruno Aouizerate, Sophie Layé, Guillaume Ferreira, Jennifer Felger, Giuseppe Pagnoni, Lucile Capuron. Psychoneuroendocrinology. 2020-02-01. 112 : 104520.
- N-3 Polyunsaturated Fatty Acids and the Resolution of Neuroinflammation. . Front Pharmacol.. 2019-09-13.
- Rapeseed oil fortified with micronutrients improves cognitive alterations associated with metabolic syndrome. Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie Castanon. Brain, Behavior, and Immunity. 2019-11-01.
- Reduction of acute mild stress corticosterone response and changes in stress‐responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Anne‐Laure Dinel, Isabelle Guinobert, Céline Lucas, Claude Blondeau, Valérie Bardot, Isabelle Ripoche, Lucile Berthomier, Véronique Pallet, Sophie Layé, Corinne Joffre. Food Sci Nutr. 2019-10-22. 7 (11) : 3827-3841.
- Prenatal retinoic acid exposure reveals candidate genes for craniofacial disorders. Berenguer Marie, Darnaudery Muriel, Claverol Stéphane, Bonneu Marc, Lacombe Didier & Rooryck Caroline.. . 2018-11. Scientific Reports
- Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation.. . Psychopharmacology (Berl). 2019 May;(5): doi: . Epub. 2019-05-23. 236 (5) : 1583-1596.
- Visualizing and Profiling Lipids in the OVLT of Fat-1 and Wild Type Mouse Brains during LPS-Induced Systemic Inflammation Using AP-SMALDI MSI. Janne Bredehöft, Dhaka Ram Bhandari, Fabian Johannes Pflieger, Sabine Schulz, Jing X. Kang, Sophie Layé, Joachim Roth, Rüdiger Gerstberger, Konstantin Mayer, Bernhard Spengler, Christoph Rummel. ACS Chem. Neurosci.. 2019-09-12. 10 (10) : 4394-4406.
- Direct and indirect effects of lipids on microglia function. Q. Leyrolle, S. Layé, A. Nadjar. Neuroscience Letters. 2019-08-01. 708 : 134348.
- Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression. Richard P. Bazinet, Adam H. Metherel, Chuck T. Chen, Saame Raza Shaikh, Agnes Nadjar, Corinne Joffre, Sophie Layé. Brain, Behavior, and Immunity. 2019-07-01.
- Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids. Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard. J. Neurosci.. 2019-06-03. 39 (30) : 5935-5948.
- Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner. Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M.. Brain Behav Immun.. 2019-03-11.
- Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Marion Rincel, Maïwenn Olier, Amandine Minni, Camille Monchaux de Oliveira, Yann Matime, Eric Gaultier, Isabelle Grit, Jean-Christophe Helbling, Anna Maria Costa, Amandine Lépinay, Marie-Pierre Moisan, Sophie Layé, Laurent Ferrier, Patricia Parnet, Vassilia Theodorou, Muriel Darnaudéry. Psychopharmacology. 2019-05-01. 236 (5) : 1583-1596.
- Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice. F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar. Brain, Behavior, and Immunity. 2019-05-01.
- Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender. . Journal of Neurobiology. 1999-09-01. 40 (3) : 302-315.
- Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory. Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, Bruno Bontempi. Science. 2011-02-18. 331 (619) : 924-928.
- Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain. C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre. Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
- Food for mood: Relevance of nutritional omega-3 fatty acids for depression and anxiety. Thomas Larrieu, Sophie Layé. Front. Physiol.. 2018-08-06. 9
- Assessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study).. Antoine Yrondi, Bruno Aouizerate, Wissam El-Hage, Fanny Moliere, Claire Thalamas, Nicolas Delcourt, Marie Sporer, Simon Taib, Laurent Schmitt, Nicolas Arlicot, Deborah Meligne, Agnes Sommet, Anne S. Salabert, Sebastien Guillaume, Philippe Courtet, Florence Galtier, Denis Mariano-Goulart, Nicolas Menjot De Champfleur, Emmanuelle Le Bars, Thomas Desmidt, Mathieu Lemaire, Vincent Camus, Maria J. Santiago-Ribeiro, Jean P. Cottier, Philippe Fernandez, Marie Meyer, Vincent Dousset, Olivier Doumy, Didier Delhaye, Lucile Capuron, Marion Leboyer, Emmanuel Haffen, Patrice Péran, Pierre Payoux, Christophe Arbus. Front. Psychiatry. 2018-07-24. 9
- Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms.. Sylvie Vancassel, Lucile Capuron, Nathalie Castanon. Front. Neurosci.. 2018-07-24. 12
- Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study.. Julien Bensalem, Stéphanie Dudonné, Nicole Etchamendy, Hermine Pellay, Camille Amadieu, David Gaudout, Séverine Dubreuil, Marie-Eve Paradis, Sonia Pomerleau, Lucile Capuron, Carol Hudon, Sophie Layé, Yves Desjardins, Véronique Pallet. The Journals of Gerontology: Series A. 2018-07-19.
- Impact of dietary fats on brain functions. Rosanna Chianese, Roberto Coccurello, Andrea Viggiano, Marika Scafuro, Marco Fiore, Giangennaro Coppola, Francesca Felicia Operto, Silvia Fasano, Sophie Laye, Riccardo Pierantoni, Rosaria Meccariello. CN. 2018-07-12. 16 (7) : 1059-1085.
- Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring. Charlotte Rey, Agnès Nadjar, Florent Joffre, Camille Amadieu, Agnès Aubert, Carole Vaysse, Véronique Pallet, Sophie Layé, Corinne Joffre. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01. 133 : 1-7.
- Depressive symptoms in obesity: Relative contribution of low-grade inflammation and metabolic health.. Ines Delgado, Lison Huet, Sandra Dexpert, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Agnès Aubert, Julie Sauvant, Bruno Aouizerate, Eric Magne, Lucile Capuron. Psychoneuroendocrinology. 2018-05-01. 91 : 55-61.
- Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions. Sophie Miquel, Claire Champ, Jon Day, Esther Aarts, Ben A. Bahr, Martijntje Bakker, Diána Bánáti, Vittorio Calabrese, Tommy Cederholm, John Cryan, Louise Dye, Jonathan A. Farrimond, Aniko Korosi, Sophie Layé, Stuart Maudsley, Dragan Milenkovic, M.Hasan Mohajeri, John Sijben, Alina Solomon, Jeremy P.E. Spencer, Sandrine Thuret, Wim Vanden Berghe, David Vauzour, Bruno Vellas, Keith Wesnes, Peter Willatts, Raphael Wittenberg, Lucie Geurts. Ageing Research Reviews. 2018-03-01. 42 : 40-55.
- Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice. Julien Bensalem, Stéphanie Dudonné, David Gaudout, Laure Servant, Frédéric Calon, Yves Desjardins, Sophie Layé, Pauline Lafenetre, Véronique Pallet. J Nutr Sci. 2018-01-01. 7
- Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology. Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet. Pharmacol Rev. 2017-12-07. 70 (1) : 12-38.
- Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.. Philip C. Calder, Nabil Bosco, Raphaëlle Bourdet-Sicard, Lucile Capuron, Nathalie Delzenne, Joel Doré, Claudio Franceschi, Markus J. Lehtinen, Tobias Recker, Stefano Salvioli, Francesco Visioli. Ageing Research Reviews. 2017-11-01. 40 : 95-119.
- Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases. Olivier Kerdiles, Sophie Layé, Frédéric Calon. Trends in Food Science & Technology. 2017-11-01. 69 : 203-213.
- Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology. A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 19-26.
- Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro. Célia Fourrier, Julie Remus-Borel, Andrew D. Greenhalgh, Michel Guichardant, Nathalie Bernoud-Hubac, Michel Lagarde, Corinne Joffre, Sophie Layé. J Neuroinflammation. 2017-08-24. 14 (1)
- Amplification of mGlu5-Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance. Antonia Manduca, Anissa Bara, Thomas Larrieu, Olivier Lassalle, Corinne Joffre, Sophie Layé, Olivier J. Manzoni. J. Neurosci.. 2017-06-19. 37 (29) : 6851-6868.
- Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the fatty acid composition of pups’ brain and peripheral tissues. C. Joffre, A.L. Dinel, A. Aubert, C. Fressange-Mazda, P. Le Ruyet, S. Layé. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-12-01. 115 : 24-34.
- Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.. Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota. Diabetes. 2016-11-30. 66 (4) : 908-919.
- Modulation of brain PUFA content in different experimental models of mice. Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01. 114 : 1-10.
- Maternal high-fat diet prevents developmental programming by early-life stress. M Rincel, A L Lépinay, P Delage, J Fioramonti, V S Théodorou, S Layé, M Darnaudéry. Transl Psychiatry. 2016-11-01. 6 (11) : e966-e966.
- Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. Clémentine Bosch-Bouju, Thomas Larrieu, Louisa Linders, Olivier J. Manzoni, Sophie Layé. Cell Reports. 2016-08-01. 16 (5) : 1237-1242.
- Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro. C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre. Brain, Behavior, and Immunity. 2016-07-01. 55 : 249-259.
- Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice. A.L. Dinel, C. Rey, C. Bonhomme, P. Le Ruyet, C. Joffre, S. Layé. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-06-01. 109 : 29-38.
- Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra. PLoS Biol. 2016-05-26. 14 (5) : e1002466.
- EPA/DHA and vitamin A supplementation improves spatial memory and alleviates the age-related decrease in hippocampal RXRγ and kinase expression in rats. Anne Létondor, Benjamin Buaud, Carole Vaysse, Emmanuel Richard, Sophie Layé, Véronique Pallet, Serge Alfos. Front. Aging Neurosci.. 2016-05-09. 8
- Dietary polyphenol supplementation prevents alterations of spatial navigation in middle-aged mice. Julien Bensalem, Laure Servant, Serge Alfos, David Gaudout, Sophie Layé, Pauline Lafenetre, Véronique Pallet. Front. Behav. Neurosci.. 2016-02-09. 10
- Examining techniques for measuring the effects of nutrients on mental performance and mood state. Mark Hamer, Louise Dye, E. Siobhan Mitchell, Sophie Layé, Caroline Saunders, Neil Boyle, Jeroen Schuermans, John Sijben. Eur J Nutr. 2016-01-07. 55 (6) : 1991-2000.
- N-3 PUFAs and neuroinflammatory processes in cognitive disorders. Quentin Leyrolle, Sophie Layé, Agnès Nadjar. OCL. 2016-01-01. 23 (1) : D103.
- Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota. Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé. Neural Plasticity. 2016-01-01. 2016 : 1-15.
- Nutritional Omega-3 deficiency alters glucocorticoid receptor-signaling pathway and neuronal morphology in regionally distinct brain structures associated with emotional deficits. Thomas Larrieu, Muna L. Hilal, Véronique De Smedt-Peyrusse, Nathalie Sans, Sophie Layé. Neural Plasticity. 2016-01-01. 2016 : 1-9.
- Role of n-3 PUFAs in inflammation via resolvin biosynthesis. Corinne Joffre, Charlotte Rey, Agnès Nadjar, Sophie Layé. OCL. 2015-12-18. 23 (1) : D104.
- Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?. David Vauzour, Anneloes Martinsen, Sophie Layé. Neurochemistry International. 2015-10-01. 89 : 63-74.
- Microglia in neuronal plasticity: Influence of stress. Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé. Neuropharmacology. 2015-09-01. 96 : 19-28.
- Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity. Nathalie Castanon, Giamal Luheshi, Sophie Layé. Front. Neurosci.. 2015-07-03. 9
- Omega 3, the necessary fatty acids for the brain,Les oméga 3, ces acides gras indispensables au cerveau. Sophie Layé. Cahiers de Nutrition et de Diététique. 2015-04-01. 50 (2) : 61-62.
- Behavioral and transcriptomic fingerprints of an enriched environment in horses (Equus caballus). Léa Lansade, Mathilde Valenchon, Aline Foury, Claire Neveux, Steve W. Cole, Sophie Layé, Bruno Cardinaud, Frédéric Lévy, Marie-Pierre Moisan. PLoS ONE. 2014-12-10. 9 (12) : e114384.
- Polyunsaturated fatty acids and their metabolites in brain function and disease. Richard P. Bazinet, Sophie Layé. Nat Rev Neurosci. 2014-11-12. 15 (12) : 771-785.
- Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats. Anne Létondor, Benjamin Buaud, Carole Vaysse, Laurence Fonseca, Coralie Herrouin, Benjamin Servat, Sophie Layé, Véronique Pallet, Serge Alfos. Br J Nutr. 2014-10-21. 112 (11) : 1805-1818.
- Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes. Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé. Brain, Behavior, and Immunity. 2014-10-01. 41 : 22-31.
- Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood. Anne-Laure Dinel, Corinne Joffre, Pierre Trifilieff, Agnes Aubert, Aline Foury, Pascale Le Ruyet, Sophie Layé. J Neuroinflammation. 2014-09-17. 11 (1)
- Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé. Neuropsychopharmacol. 2014-08-05. 40 (3) : 525-536.
- N-3 LCPUFA improves cognition: The young, the old and the sick. C. Joffre, A. Nadjar, M. Lebbadi, F. Calon, S. Laye. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014-07-01. 91 (1-2) : 1-20.
- SFRP CO-10 – Milk fat in the perinatal period and inflammation,SFRP CO-10 – Lipides laitiers en période périnatale et inflammation. C. Joffre, A.L. Dinel, P. Le Ruyet, S. Laye. Archives de Pédiatrie. 2014-05-01. 21 (5) : 988.
- Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar. PLoS ONE. 2014-02-05. 9 (2) : e87421.
- N-3 polyunsaturated fatty acid and neuroinflammation in aging: Role in cognition. Sophie Layé, Charlotte Madore, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar. Pharma-Nutrition. 2014-01-01. : 91-112.
- Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide. C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar. Brain, Behavior, and Immunity. 2013-11-01. 34 : 151-158.
- Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome. Nathalie Castanon, Sophie Layé. Metabolic Syndrome and Neurological Disorders. 2013-10-11. : 515-527.
- Leucine supplementation protects from insulin resistance by regulating adiposity levels.. Elke Binder, Francisco J. Bermúdez-Silva, Caroline André, Melissa Elie, Silvana Y. Romero-Zerbo, Thierry Leste-Lasserre, llaria Belluomo, Adeline Duchampt, Samantha Clark, Agnes Aubert, Marco Mezzullo, Flaminia Fanelli, Uberto Pagotto, Sophie Layé, Gilles Mithieux, Daniela Cota. PLoS ONE. 2013-09-25. 8 (9) : e74705.
- Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response. Agnes Nadjar, Tamara Blutstein, Agnes Aubert, Sophie Laye, Philip G. Haydon. Glia. 2013-02-04. 61 (5) : 724-731.
- What do you eat? Dietary omega 3 can help to slow the aging process. Sophie Layé. Brain, Behavior, and Immunity. 2013-02-01. 28 : 14-15.
- Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice. Aurélie Moranis, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Agnès Aubert, Philippe Guesnet, Monique Lavialle, Corinne Joffre, Sophie Layé. Brain, Behavior, and Immunity. 2012-07-01. 26 (5) : 721-731.
- Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice. Thomas Larrieu, Charlotte Madore, Corinne Joffre, Sophie Layé. J Physiol Biochem. 2012-06-16. 68 (4) : 671-681.
- Short-term long chain Omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. Virginie F. Labrousse, Agnès Nadjar, Corinne Joffre, Laurence Costes, Agnès Aubert, Stéphane Grégoire, Lionel Bretillon, Sophie Layé. PLoS ONE. 2012-05-25. 7 (5) : e36861.
- Neurobiology of inflammation-associated anorexia,Neurobiologie de l’anorexie inflammatoire. L. Gautron, S. Layé. Obes. 2011-04-20. 6 (2) : 105-113.
- Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid. Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron. OCL. 2011-11-15. 18 (6)
- Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Mathieu Lafourcade, Thomas Larrieu, Susana Mato, Anais Duffaud, Marja Sepers, Isabelle Matias, Veronique De Smedt-Peyrusse, Virginie F Labrousse, Lionel Bretillon, Carlos Matute, Rafael Rodríguez-Puertas, Sophie Layé, Olivier J Manzoni. Nat Neurosci. 2011-01-30. 14 (3) : 345-350.
- Polyunsaturated fatty acids, neuroinflammation and well being. Sophie Layé. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2010-04-01. 82 (4-6) : 295-303.
- Age-related changes in nestin immunoreactivity in the rat pituitary gland. Laurent Gautron, Véronique De-Smedt, Sophie Layé. Neuroendocrinology. 2009-01-01. 90 (1) : 19-30.
- Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Rozenn Mingam, Aurélie Moranis, Rose-Marie Bluthé, Véronique De Smedt-Peyrusse, Keith W. Kelley, Philippe Guesnet, Monique Lavialle, Robert Dantzer, Sophie Layé. European Journal of Neuroscience. 2008-11-01. 28 (9) : 1877-1886.
- Study of Helicobacter pullorum proinflammatory Properties on human epithelial cells in vitro. C Varon, A Duriez, P Lehours, A Menard, S Laye, F Zerbib, F Megraud, D Laharie. Gut. 2008-06-25. 58 (5) : 629-635.
- Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. Véronique De Smedt-Peyrusse, Françoise Sargueil, Aurélie Moranis, Hedi Harizi, Sébastien Mongrand, Sophie Layé. J Neurochem. 2008-04-01. 105 (2) : 296-307.
- In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain. Rozenn Mingam, Véronique De Smedt, Thierry Amédée, Rose-Marie Bluthé, Keith W. Kelley, Robert Dantzer, Sophie Layé. Brain, Behavior, and Immunity. 2008-02-01. 22 (2) : 234-244.
- Cytokines, sickness behavior, and depression. ROBERT DANTZER, ROSE-MARIE BLUTHÉ, NATHALIE CASTANON, KEITH W. KELLEY, JAN-PIETER KONSMAN, SOPHIE LAYE, JACQUES LESTAGE, PATRICIA PARNET. Psychoneuroimmunology. 2007-01-01. : 281-318.
- Characterization of STAT3-expressing cells in the postnatal rat brain. Laurent Gautron, Véronique De Smedt-Peyrusse, Sophie Layé. Brain Research. 2006-07-01. 1098 (1) : 26-32.
- Pituitary cocaine- and amphetamine-regulated transcript expression depends on the strain, sex and oestrous cycle in the rat. L. Kappeler, L. Gautron, S. Laye, R. Dantzer, P. Zizzari, J. Epelbaum, M. T. Bluet-Pajot. J Neuroendocrinol. 2006-06-01. 18 (6) : 426-433.
- Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats. L. Gautron, R. Mingam, A. Moranis, C. Combe, S. Layé. Neuroscience. 2005-01-01. 134 (3) : 933-946.
- Nuclear factor κB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse. Agnès Nadjar, Chantal Combe, Sophie Layé, Viviane Tridon, Robert Dantzer, Thierry Amédée, Patricia Parnet. Journal of Neurochemistry. 2004-02-04. 87 (4) : 1024-1036.
- Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus. Laurent Gautron, Michel Chaigniau, Sophie Layé. Brain Research. 2003-12-01. 994 (2) : 260-264.
- NFκB activation in mouse pituitary: Comparison of response to interleukin-1β and lipopolysaccharide. P. Parnet, F. Pousset, S. Laye. Journal of Neuroendocrinology. 2003-02-13. 15 (3) : 304-314.
- Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge. L Gautron, P Lafon, M Chaigniau, G Tramu, S Layé. Neuroscience. 2002-07-01. 112 (3) : 717-729.
- Physiological significance of the interleukin 1 receptor accessory protein. Sophie Layé, Stéphane Liège, Kang-Sheng Li, Elisabeth Moze, Pierre J. Neveu. Neuroimmunomodulation. 2001-01-01. 9 (4) : 225-230.
- Role of interleukin-1β and tumour necrosis factor-α in lipopolysaccharide-induced sickness behaviour: A study with interleukin-1 type I receptor-deficient mice. Rose-Marie Bluthe, Sophie Laye, Bruno Michaud, Chantal Combe, Robert Dantzer, Patricia Parnet. Eur J Neurosci. 2000-12-01. 12 (12) : 4447-4456.
- Interleukin 1 receptor accessory protein (IL-1RAcP) is necessary for centrally mediated neuroendocrine and immune responses to IL-1β. Stéphane Liège, Sophie Layé, Kang-Sheng Li, Elisabeth Moze, Pierre J Neveu. Journal of Neuroimmunology. 2000-10-01. 110 (1-2) : 134-139.
- Human/mouse interleukin-1 receptor/receptor accessory protein interactions in IL-1β-induced NFκB activation. Sophie Layé, Johan Lundkvist, Tamas Bartfai. FEBS Letters. 1998-06-16. 429 (3) : 307-311.
- Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor. David Malinowsky, Johan Lundkvist, Sophie Layé, Tamas Bartfai. FEBS Letters. 1998-06-16. 429 (3) : 299-302.
- Cytokines and sickness behavior. ROBERT DANTZER, ROSE-MARIE BLUTHÉ, SOPHIE LAYÉ, JEAN-LUC BRET-DIBAT, PATRICIA PARNET, KEITH W. KELLEY. Annals of the New York Academy of Sciences. 1998-05-01. 840 (1) : 586-590.
- Regulation of cytokine gene expression in the central nervous system by glucocorticoids: Mechanisms and functional consequences. E.Goujon, S.Layé, P.Parnet, R.Dantzer. Psychoneuroendocrinology. 1997-01-01. 22 : S75-S80.
- Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice. S Layé, E Goujon, C Combe, R VanHoy, K.W Kelley, P Parnet, R Dantzer. Journal of Neuroimmunology. 1996-08-01. 68 (1-2) : 61-66.
- Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Emmanuelle Goujon, Patricia Parnet, Sophie Layé, Chantal Combe, Robert Dantzer. Molecular Brain Research. 1996-02-01. 36 (1) : 53-62.
- Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary, and brain of mice. E. Goujon, P. Parnet, S. Laye, C. Combe, K.W. Kelley, R. Dantzer. Brain, Behavior, and Immunity. 1995-12-01. 9 (4) : 292-303.
- Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Sophie Layé, Patricia Parnet, Emmanuelle Goujon, Robert Dantzer. Molecular Brain Research. 1994-11-01. 27 (1) : 157-162.
Team leader
Team member(s)
Personnel(s) de recherche
Bruno Aouizerate
Aouizerate
(University teacher - researcher - Hospital practitioner)
Corinne Joffre Joffre (Researcher)
Didier Delhaye Delhaye (Hospital head assistant)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Olivier Doumy Doumy (Hospital practitioner)
Pierre Trifilieff Trifilieff (Researcher)
Sylvie Vancassel Vancassel (Researcher)
Xavier Fioramonti Fioramonti (Researcher)
Jean-Christophe Delpech Delpech (Researcher)
David Jarriault Jarriault (Researcher)
Corinne Joffre Joffre (Researcher)
Didier Delhaye Delhaye (Hospital head assistant)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Olivier Doumy Doumy (Hospital practitioner)
Pierre Trifilieff Trifilieff (Researcher)
Sylvie Vancassel Vancassel (Researcher)
Xavier Fioramonti Fioramonti (Researcher)
Jean-Christophe Delpech Delpech (Researcher)
David Jarriault Jarriault (Researcher)
Personnel(s) technique
Agnès Aubert
Aubert
Alexandra Séré Séré
Julie Sauvant Sauvant
Sandra Dexpert Dexpert
Véronique De Smedt Peyrusse De Smedt Peyrusse
Marion Graland Graland
Alexandra Séré Séré
Julie Sauvant Sauvant
Sandra Dexpert Dexpert
Véronique De Smedt Peyrusse De Smedt Peyrusse
Marion Graland Graland
Post-doctorant(s)
Andrea Contini
Contini
Andrew GreenHalgh GreenHalgh
Mathieu Di Miceli Di Miceli
Mathilde Henry Henry
Moïra Rossitto Rossitto
Sofia Cussotto Cussotto
Charlotte Madore-Delpech Madore-Delpech
Andrew GreenHalgh GreenHalgh
Mathieu Di Miceli Di Miceli
Mathilde Henry Henry
Moïra Rossitto Rossitto
Sofia Cussotto Cussotto
Charlotte Madore-Delpech Madore-Delpech
Doctorant(s)
Camille Monchaux
Monchaux
Hugo Martin Martin
Ines Delgado Delgado
Mathilde Chataigner Chataigner
Roman Walle Walle
Fanny Decoeur Decoeur
Maud Martinat Martinat
Anna Petitbon Petitbon
Farah Younes Younes
Adeline Coursan Coursan
Hugo Martin Martin
Ines Delgado Delgado
Mathilde Chataigner Chataigner
Roman Walle Walle
Fanny Decoeur Decoeur
Maud Martinat Martinat
Anna Petitbon Petitbon
Farah Younes Younes
Adeline Coursan Coursan