Nutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)
The overarching scientific objective of the Nutripsy team is to understand how nutrition can contribute to mental health, and to identify the mechanisms by which nutritional imbalances promote the development of neuropsychiatric symptoms, focusing on inflammatory processes. For this purpose, we propose a translational and integrative research program with the following complementary specific aims:
- to elucidate the mechanisms by which inflammation, in relation to dietary habits, leads to neuropsychiatric symptom dimensions and antidepressant resistance
- to determine the influence of environmental factors and genetic variants related to inflammation on depressive symptoms and antidepressant response in clinical and preclinical models of nutritional imbalances,
- to propose innovative personalized treatment strategies through targeted nutritional approaches guided by the clinical, biological/inflammatory, and nutritional profiles of patients.
This research program represents a critical step toward a precision medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.
Mots clés
Bioénergétique du cerveau et physiologie, Cognition, Comportement alimentaire, Contaminants alimentaires, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Développement du système nerveux, Effet signal des nutriments dans le cerveau, Emotion, Interactions nutriments et traitement neuropharmacologique, Maladies Neuro-développementales, Metabolism, Motivation, Mémoire, Neuroimagerie chez l’humain, Nutrition protectrice et vieillissement cognitif, Relations microbiote-intestin-cerveau, Troubles du comportement, Troubles métaboliques et obésitéSelected publications
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A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudéry, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron.
J Neuroinflammation. 2021-12-01. 18 (1)
DOI: 10.1186/s12974-021-02330-9 -
Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry
H. Fanet, L. Capuron, N. Castanon, F. Calon, S. Vancassel.
CN. 2021-04-29. 19 (5) : 591-609.
DOI: 10.2174/1570159x18666200729103529 -
Transcriptomic signaling pathways involved in a naturalistic model of inflammation-related depression and its remission
Marie-Pierre Moisan, Aline Foury, Sandra Dexpert, Steve W. Cole, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Lucile Capuron.
Transl Psychiatry. 2021-04-06. 11 (1)
DOI: 10.1038/s41398-021-01323-9 -
Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout, Nathalie Castanon.
Nutrients. 2021-03-11. 13 (3) : 904.
DOI: 10.3390/nu13030904 -
Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M..
Brain Behav Immun.. 2019-03-11.
DOI: 10.1016/j.bbi.2019.03.006 -
Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity.
Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon.
Brain, Behavior, and Immunity. 2018-11-01.
DOI: 10.1016/j.bbi.2018.11.316
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Bruno Aouizerate
Aouizerate
(University teacher - researcher - Hospital practitioner)
Jean-Benoît Corcuff Corcuff (University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Sylvie Vancassel Vancassel (Researcher)
Julie Bernard Bernard (Hospital Practitionner)
Alexandra Bouvard Bouvard (Hospital Practitionner)
Hélène Thibault Thibault (Hospital Practitionner)
Jean-Benoît Corcuff Corcuff (University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Nathalie Castanon Castanon (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Sylvie Vancassel Vancassel (Researcher)
Julie Bernard Bernard (Hospital Practitionner)
Alexandra Bouvard Bouvard (Hospital Practitionner)
Hélène Thibault Thibault (Hospital Practitionner)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Juliette Montet
Montet
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC