Sophie Layé

Selected publications

• Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain.
  C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre. Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
• Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. 
  V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé. Brain, Behavior, and Immunity. 2018-10-01. 73 : 427-440.
• Food for mood: Relevance of nutritional omega-3 fatty acids for depression and anxiety.
  Thomas Larrieu, Sophie Layé. Front. Physiol.. 2018-08-06. 9
  
• Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases.
  Olivier Kerdiles, Sophie Layé, Frédéric Calon. Trends in Food Science & Technology. 2017-11-01. 69 : 203-213.
• Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology.
  Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet. Pharmacol Rev. 2017-12-07. 70(1) : 12-38.
• Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress.
  Clémentine Bosch-Bouju, Thomas Larrieu, Louisa Linders, Olivier J. Manzoni, Sophie Layé. Cell Reports. 2016-08-01. 16 (5) : 1237-1242.
• Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro.
  C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre. Brain, Behavior, and Immunity. 2016-07-01. 55 : 249-259.
• Nutritional n-3 PUFA Deficiency Abolishes Endocannabinoid Gating of Hippocampal Long-Term Potentiation.
  Aurore Thomazeau, Clémentine Bosch-Bouju, Olivier Manzoni, Sophie Layé. Cereb. Cortex. 2016-03-05. : bhw052.
• Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota.
  Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé. Neural Plasticity. 2016-01-01. 2016 : 1-15.
• Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment.
  Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé. Neuropsychopharmacol. 2015-05-07. 40(12) : 2774-2787.
• Polyunsaturated fatty acids and their metabolites in brain function and disease.
  Richard P. Bazinet, Sophie Layé. Nat Rev Neurosci. 2014-11-12. 15(12) : 771-785.
• Early-life inflammation is a vulnerability factor for lipoplysaccharide-induced memory and neurogenesis impairment later in life
  Dinel A.L, Joffre C., Aubert A., Foury A., Le Ruyet P., Layé S., , Journal of Neuroinflammation, 2014, 17;11(1):155
• Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation.
  Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé. Neuropsychopharmacol. 2014-08-05. 40 (3) : 525-536.
• Hypothalamo-pituitary-adrenal axis mediates n-3 polyunsaturated fatty acids deficient-diet induced depressive- and anxiety-like symptoms along with neuronal atrophy,
  Larrieu, T., Hilal, M., de Smedt-Peyrusse, V., Sans, N., Capuron, L., Layé. S.Translational Psychiatry, 2014, 4:e437
• Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice.
  Susanna Pietropaolo, Mena Goubran, Corinne Joffre, Agnes Aubert, Valerie Lemaire-Mayo, Wim E. Crusio, Sophie Layé. Psychoneuroendocrinology. 2014-11-01. 49 : 119-129.
• Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
  Madore C, Nadjar A, Delpech JC, Portal C, Joffre C and Layé S. , Brain Behav Immun, 2014, 41:22-31