Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress

Clémentine Bosch-Bouju, Thomas Larrieu, Louisa Linders, Olivier J. Manzoni, Sophie Layé
Cell Reports. 2016-08-01; 16(5): 1237-1242
DOI: 10.1016/j.celrep.2016.06.082

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1. Cell Rep. 2016 Aug 2;16(5):1237-1242. doi: 10.1016/j.celrep.2016.06.082. Epub
2016 Jul 21.

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability
to Anxiety after Social Defeat Stress.

Bosch-Bouju C(1), Larrieu T(1), Linders L(1), Manzoni OJ(2), Layé S(3).

Author information:
(1)Nutrition et Neurobiologie Intégrée, UMR 1286, INRA, 33000 Bordeaux, France;
Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux University, 33000
Bordeaux, France.
(2)Aix-Marseille Université, 13009 Marseille, France; INSERM, 13009 Marseille,
France; INMED UMR S 901, 13009 Marseille, France. Electronic address:
.
(3)Nutrition et Neurobiologie Intégrée, UMR 1286, INRA, 33000 Bordeaux, France;
Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux University, 33000
Bordeaux, France. Electronic address: .

Chronic social defeat stress (CSDS) is a clinically relevant model of mood
disorders. The relationship between the CSDS model and a physiologically
pertinent paradigm of synaptic plasticity is not known. Here, we found that
cluster analysis of the emotional behavior states of mice exposed to CSDS allowed
their segregation into anxious and non-anxious groups. Endocannabinoid-mediated
spike-timing dependent plasticity (STDP) in the nucleus accumbens was attenuated
in non-anxious mice and abolished in anxious mice. Anxiety-like behavior in
stressed animals was specifically correlated with their ability to produce STDP.
Pharmacological enhancement of 2-arachidonoyl glycerol (2-AG) signaling in the
nucleus accumbens normalized the anxious phenotype and STDP in anxious mice.
These data reveal that endocannabinoid modulation of synaptic efficacy in
response to a naturalistic activity pattern is both a molecular correlate of
behavioral adaptability and a crucial factor in the adaptive response to chronic
stress.

Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

DOI: 10.1016/j.celrep.2016.06.082
PMID: 27452462 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus