Karine Guillem

Scientific articles

• Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects in male rats
  Caroline Vouillac-Mendoza, Nathalie Biendon, Sandra Dovero, Karine Guillem.
  Front. Neural Circuits. 2025-03-07. 19
  10.3389/fncir.2025.1540975
• Bidirectional relationship between attentional deficits and escalation of nicotine intake in male rats
  Caroline Vouillac-Mendoza, Serge H. Ahmed, Karine Guillem.
  Psychopharmacology. 2024-05-14.
  10.1007/s00213-024-06604-x
• Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
  Caroline Vouillac-Mendoza, Audrey Durand, Serge H. Ahmed, Karine Guillem.
  Psychopharmacology. 2024-03-06.
  10.1007/s00213-024-06564-2
• Large‐scale brain correlates of sweet versus cocaine reward in rats
  Magalie Lenoir, Sylvia Navailles, Youna Vandaele, Caroline Vouillac‐Mendoza, Karine Guillem, Serge H. Ahmed.
  Eur J of Neuroscience. 2022-12-01.
  10.1111/ejn.15879
• Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation
  Myriam Abarkan, Giulia R. Fois, Caroline Vouillac-Mendoza, Serge H. Ahmed, Karine Guillem.
  Neuropsychopharmacol.. 2022-08-30.
  10.1038/s41386-022-01428-9
• Large-scale brain correlates of sweet versus cocaine reward in rats
  Magalie Lenoir, Sylvia Navailles, Youna Vandaele, Caroline Vouillac-Mendoza, Karine Guillem, Serge H. Ahmed.
  Preprint bioRxiv. 2022-06-02.
  10.1101/2022.06.01.494287
• Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats
  Youna Vandaele, Magalie Lenoir, Caroline Vouillac-Mendoza, Karine Guillem, Serge H Ahmed.
  eLife. 2021-04-26. 10
  10.7554/eLife.64993
• Habitual Preference for the Nondrug Reward in a Drug Choice Setting
  Youna Vandaele, Karine Guillem, Serge H. Ahmed.
  Front. Behav. Neurosci.. 2020-05-25. 14
  10.3389/fnbeh.2020.00078
• Reorganization of Theta Phase-Locking in the Orbitofrontal Cortex Drives Cocaine Choice Under the Influence
  Karine Guillem, Serge H Ahmed.
  Sci Rep. 2020-05-15. 10(1) : 8041.
  10.1038/s41598-020-64962-w
• Relapse to cocaine use persists following extinction of drug-primed craving
  Paul Girardeau, Sylvia Navailles, Audrey Durand, Caroline Vouillac-Mendoza, Karine Guillem, Serge H. Ahmed.
  Neuropharmacology. 2019-06-01.
  10.1016/j.neuropharm.2019.05.036
• A neuronal population code for resemblance between drug and nondrug reward outcomes in the orbitofrontal cortex
  Karine Guillem, Serge H. Ahmed.
  Brain Struct Funct. 2018-12-11.
  10.1007/s00429-018-1809-8
• Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option
  Luana Freese, Audrey Durand, Karine Guillem, Serge H. Ahmed.
  Pharmacology Biochemistry and Behavior. 2018-07-01.
  10.1016/j.pbb.2018.07.010
• Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse.
  Karine Guillem, Serge H Ahmed.
  Neuropsychopharmacology. 2017-09-18. 43(5) : 1059-1065.
  10.1038/npp.2017.224
• Neuronal representation of individual heroin choices in the orbitofrontal cortex
  Karine Guillem, Viridiana Brenot, Audrey Durand, Serge H. Ahmed.
  Addiction Biology. 2017-07-13. 23(3) : 880-888.
  10.1111/adb.12536
• Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons.
  Karine Guillem, Serge H. Ahmed.
  Cereb. Cortex. 2017-01-04.
  10.1093/cercor/bhw398
• Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity by resting state MRI.
  Hanbing Lu, Qihong Zou, Svetlana Chefer, Thomas J. Ross, D. Bruce Vaupel, Karine Guillem, William P. Rea, Yihong Yang, Laura L. Peoples, Elliot A. Stein.
  Brain Connectivity. 2014-09-01. 4(7) : 499-510.
  10.1089/brain.2014.0264
• Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions.
  Karine Guillem, Serge H. Ahmed, Laura L. Peoples.
  Biological Psychiatry. 2014-07-01. 76(1) : 31-39.
  10.1016/j.biopsych.2013.08.032
• Coordinated Recruitment of Cortical-Subcortical Circuits and Ascending Dopamine and Serotonin Neurons During Inhibitory Control of Cocaine Seeking in Rats.
  Sylvia Navailles, Karine Guillem, Caroline Vouillac-Mendoza, Serge H. Ahmed.
  Cereb. Cortex. 2014-05-28. 25(9) : 3167-3181.
  10.1093/cercor/bhu112
• Neurobiology of addiction versus drug use driven by lack of choice.
  Serge H Ahmed, Magalie Lenoir, Karine Guillem.
  Current Opinion in Neurobiology. 2013-08-01. 23(4) : 581-587.
  10.1016/j.conb.2013.01.028
• Sugar addiction: pushing the drug-sugar analogy to the limit.
  Serge H. Ahmed, Karine Guillem, Youna Vandaele.
  Current Opinion in Clinical Nutrition and Metabolic Care. 2013-07-01. 16(4) : 434-439.
  10.1097/mco.0b013e328361c8b8
• Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues.
  H.-S. Liu, S. Chefer, H. Lu, K. Guillem, W. Rea, P. Kurup, Y. Yang, L. Peoples, E. A. Stein.
  Proceedings of the National Academy of Sciences. 2013-02-19. 110(10) : 4093-4098.
  10.1073/pnas.1207531110
• Discriminative inhibitory control of cocaine seeking involves the prelimbic prefrontal cortex.
  Claudia Mihindou, Karine Guillem, Sylvia Navailles, Caroline Vouillac, Serge H. Ahmed.
  Biological Psychiatry. 2013-02-01. 73(3) : 271-279.
  10.1016/j.biopsych.2012.08.011
• fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history.
  Hanbing Lu, Svetlana Chefer, Pradeep K. Kurup, Karine Guillem, D. Bruce Vaupel, Thomas J. Ross, Anna Moore, Yihong Yang, Laura L. Peoples, Elliot A. Stein.
  NeuroImage. 2012-09-01. 62(3) : 1857-1866.
  10.1016/j.neuroimage.2012.05.076
• Drug specificity in extended access cocaine and heroin self-administration.
  Magalie Lenoir, Karyn Guillem, George F. Koob, Serge H. Ahmed.
  Addiction Biology. 2011-10-13. 17(6) : 964-976.
  10.1111/j.1369-1600.2011.00385.x
• Acute effects of nicotine amplify accumbal neural responses during nicotine-taking behavior and nicotine-paired environmental cues.
  Karine Guillem, Laura L. Peoples.
  PLoS ONE. 2011-09-22. 6(9) : e24049.
  10.1371/journal.pone.0024049
• Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention.
  K. Guillem, B. Bloem, R. B. Poorthuis, M. Loos, A. B. Smit, U. Maskos, S. Spijker, H. D. Mansvelder.
  Science. 2011-08-11. 333(6044) : 888-891.
  10.1126/science.1207079
• Varenicline effects on cocaine self administration and reinstatement behavior.
  Karine Guillem, Laura L. Peoples.
  Behavioural Pharmacology. 2010-03-01. 21(2) : 96-103.
  10.1097/fbp.0b013e328336e9c5
• Progressive and lasting amplification of accumbal nicotine-seeking neural signals.
  K. Guillem, L. L. Peoples.
  Journal of Neuroscience. 2010-01-06. 30(1) : 276-286.
  10.1523/jneurosci.2820-09.2010
• Orbitofrontal and insular cortex: neural responses to cocaine-associated cues and cocaine self-administration.
  Karine Guillem, Alexxai V. Kravitz, David E. Moorman, Laura L. Peoples.
  Synapse. 2010-01-01. 64(1) : 1-13.
  10.1002/syn.20698
• Voluntary nicotine consumption triggers in vivo potentiation of cortical excitatory drives to midbrain dopaminergic neurons.
  S. Caille, K. Guillem, M. Cador, O. Manzoni, F. Georges.
  Journal of Neuroscience. 2009-08-19. 29(33) : 10410-10415.
  10.1523/jneurosci.2950-09.2009
• Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion.
  Karine Guillem, Caroline Vouillac, George F. Koob, Martine Cador, Luis Stinus.
  Biological Psychiatry. 2008-01-01. 63(2) : 158-163.
  10.1016/j.biopsych.2007.04.029
• The role of accumbal hypoactivity in cocaine addiction.
  L. L. Peoples, A. V. Kravitz, K. Guillem.
  The Scientific World JOURNAL. 2007-01-01. 7 : 22-45.
  10.1100/tsw.2007.266
• Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats.
  Karine Guillem, Caroline Vouillac, Marc R. Azar, Loren H. Parsons, George F. Koob, Martine Cador, Luis Stinus.
  European Journal of Neuroscience. 2006-12-01. 24(12) : 3532-3540.
  10.1111/j.1460-9568.2006.05217.x
• Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats.
  K. Guillem.
  Journal of Neuroscience. 2005-09-21. 25(38) : 8593-8600.
  10.1523/jneurosci.2139-05.2005