Choice, Addiction and Neurodysfunctions (Candy)
Our research aims at studying the environmental, psychological and neurobiological determinants of the hallmark stages and behavioral features of addiction, including transition to addiction, individual drug preferences, loss of control, craving and vulnerability to relapse. To pursue our research goals, we resort to a wide array of relevant methods, procedures and techniques ranging from innovative behavioral procedures, specially designed to probe addiction-related behavioral processes (e.g., decision-making, choice and attention), state-of-the-art methods for in vivo recording and manipulation of neuronal activity in discrete brain circuits in behaving rats, to transcriptomic approaches. We also participate to clinically-oriented research projects, mainly by offering consulting to study design and/or data interpretation.
Mots clés
Assemblées neuronales, Attention, Comportement, Craving, Neurophysiologie, Optogénétique, Rechute, addiction, choix, circuits neuronaux, decision-making, preference, transcriptomiqueSelected publications
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Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats
Youna Vandaele, Magalie Lenoir, Caroline Vouillac-Mendoza, Karine Guillem, Serge H Ahmed.
eLife. 2021-04-26. 10
DOI: 10.7554/eLife.64993 -
Habit, choice and addiction
Y. Vandaele, S. H. Ahmed.
Neuropsychopharmacol.. 2020-11-09.
DOI: 10.1038/s41386-020-00899-y -
Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration
Michel Engeln, Swarup Mitra, Ramesh Chandra, Utsav Gyawali, Megan E. Fox, David M. Dietz, Mary Kay Lobo.
Biological Psychiatry. 2020-06-01. 87 (11) : 992-1000.
DOI: 10.1016/j.biopsych.2019.10.019 -
Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
Ludivine Canchy, Paul Girardeau, Audrey Durand, Caroline Vouillac-Mendoza, Serge H. Ahmed.
Neuropsychopharmacology. 2021-01. 46 : 288-296.
DOI: 10.1038/s41386-020-0786-9 -
Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse.
Karine Guillem, Serge H Ahmed.
Neuropsychopharmacology. 2017-09-18. 43 (5) : 1059-1065.
DOI: 10.1038/npp.2017.224 -
Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons.
Karine Guillem, Serge H. Ahmed.
Cereb. Cortex. 2017-01-04.
DOI: 10.1093/cercor/bhw398 -
Cocaine addiction as a homeostatic reinforcement learning disorder.
Mehdi Keramati, Audrey Durand, Paul Girardeau, Boris Gutkin, Serge H. Ahmed.
Psychological Review. 2017-01-01. 124 (2) : 130-153.
DOI: 10.1037/rev0000046 -
Choosing under the influence: A drug-specific mechanism by which the setting controls drug choices in rats
Youna Vandaele, Lauriane Cantin, Fuschia Serre, Caroline Vouillac-Mendoza, Serge H Ahmed.
Neuropsychopharmacol. 2015-07-01. 41 (2) : 646-657.
DOI: 10.1038/npp.2015.195 -
Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions.
Karine Guillem, Serge H. Ahmed, Laura L. Peoples.
Biological Psychiatry. 2014-07-01. 76 (1) : 31-39.
DOI: 10.1016/j.biopsych.2013.08.032 -
Extended heroin access increases heroin choices over a potent nondrug alternative
Magalie Lenoir, Lauriane Cantin, Nathalie Vanhille, Fuschia Serre, Serge H Ahmed.
Neuropsychopharmacol. 2013-01-15. 38 (7) : 1209-1220.
DOI: 10.1038/npp.2013.17
Team member(s)
Chercheurs, Praticiens hospitaliers...
Magalie Lenoir Lenoir (Researcher)
Michel Engeln Englen (Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC