Daniela Cota
Team leader
Researcher - PhD (CR) / INSERM/ Contact
+33 5 57 57 37 05
www.orcid.org/0000-0002-6909-2156
/ Address of work
Neurocentre Magendie - INSERM U 1215 - 146, rue Léo Saignat - 33077 Bordeaux
Scientific articles
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Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
Nat Commun. 2024-04-24. 15(1)
10.1038/s41467-024-47877-2 -
A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion
Nat Commun. 2024-08-13. 15(1)
10.1038/s41467-024-51076-4 -
A sympathetic brake on gut GLP-1 release
Neuron. 2024-03-01. 112(6) : 865-867.
10.1016/j.neuron.2024.02.015 -
Antiobesity effects of intestinal gluconeogenesis are mediated by the brown adipose tissue sympathetic nervous system
Obesity. 2024-02-04. 32(4) : 710-722.
10.1002/oby.23985 -
mTORC1 in energy expenditure: consequences for obesity
Nat Rev Endocrinol. 2024-01-15.
10.1038/s41574-023-00934-0 -
Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges
Drugs. 2023-12-21.
10.1007/s40265-023-01982-6 -
Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity
J Endocrinol Invest. 2023-11-04.
10.1007/s40618-023-02228-8 -
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials.
Nat Med. 2023-06-01. 29(6) : 1487-1499.
10.1038/s41591-023-02381-w -
The CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
Biol Res. 2023-03-25. 56(1)
10.1186/s40659-023-00426-5 -
Chemogenetic stimulation of adult neurogenesis, and not neonatal neurogenesis, is sufficient to improve long-term memory accuracy
Progress in Neurobiology. 2022-12-01. 219 : 102364.
10.1016/j.pneurobio.2022.102364 -
Food intake and body weight in rodent studies: the devil is in the details
Nat Metab. 2022-10-17.
10.1038/s42255-022-00658-x -
Insulin modulates emotional behavior through a serotonin-dependent mechanism
Mol Psychiatry. 2022-10-07.
10.1038/S41380-022-01812-3 -
Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes
Cells. 2022-08-19. 11(16) : 2582.
10.3390/cells11162582 -
Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
Front. Endocrinol.. 2022-08-08. 13
10.3389/fendo.2022.934347 -
Paracrine actions of GLP1 in the gut unraveled
Life Metabolism. 2022-07-01.
10.1093/lifemeta/loac010 -
Yin-Yang control of energy balance by lipids in the hypothalamus: The endocannabinoids vs bile acids case
Biochimie. 2022-07-01.
10.1016/j.biochi.2022.07.006 -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
Biomedicine & Pharmacotherapy. 2022-06-01. 150 : 112994.
10.1016/j.biopha.2022.112994 -
Le récepteur hypothalamique TGR5 des acides biliaires
Med Sci (Paris). 2022-05-01. 38(5) : 413-415.
10.1051/medsci/2022052 -
Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model
Molecular and Cellular Neuroscience. 2022-03-01. 119 : 103705.
10.1016/j.mcn.2022.103705 -
The GhsrQ343X allele favors the storage of fat by acting on nutrient partitioning
Journal of Endocrinology. 2021-12-01. 251(3) : 181-194.
10.1530/joe-20-0576 -
Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
Nutrients. 2021-11-13. 13(11) : 4061.
10.3390/nu13114061 -
Hypothalamic endocannabinoids in obesity: an old story with new challenges
Cell. Mol. Life Sci.. 2021-10-31. 78(23) : 7469-7490.
10.1007/s00018-021-04002-6 -
Mass spectrometry imaging of mice brain lipid profile changes over time under high fat diet
Sci Rep. 2021-10-04. 11(1)
10.1038/s41598-021-97201-x -
Functional heterogeneity of POMC neurons relies on mTORC1 signaling
Cell Reports. 2021-10-01. 37(2) : 109800.
10.1016/j.celrep.2021.109800 -
The temporal origin of dentate granule neurons dictates their role in spatial memory
Mol Psychiatry. 2021-09-15.
10.1038/s41380-021-01276-x -
Chemogenetic stimulation of hippocampal adult-born neurons improves long-term memory accuracy
. 2021-06-11.
10.21203/rs.3.rs-613256/v1 -
Central anorexigenic actions of bile acids are mediated by TGR5
Nat Metab. 2021-05-01. 3(5) : 595-603.
10.1038/s42255-021-00398-4 -
Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats
Nat Commun. 2021-03-19. 12(1)
10.1038/s41467-021-22069-4 -
Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice
Transl Psychiatry. 2021-03-15. 11(1)
10.1038/s41398-020-01187-5 -
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Nat Metab. 2021-02-25.
10.1038/s42255-021-00345-3 -
A Novel Cortical Mechanism for Top-Down Control of Water Intake.
Current Biology. 2020-12-01. 30(23) : 4789-4798.e4.
10.1016/j.cub.2020.09.011 -
CB1 and GLP-1 Receptors Cross-Talk Provides New Therapies for Obesity
Diabetes. 2020-10.
10.2337/db20-0162 -
In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
Front. Neural Circuits. 2020-08-13. 14
10.3389/fncir.2020.00051 -
Calcitonin gene-related peptide-induced phosphorylation of STAT3 in arcuate neurons is a link in the metabolic benefits of portal glucose.
Neuroendocrinology. 2020-06-09.
10.1159/000509230 -
Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study.
Nutrients. 2020-05-22. 12(5) : 1512.
10.3390/nu12051512 -
Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.
The Journal of Clinical Endocrinology & Metabolism. 2020-04-25. 105(7) : e2511-e2520.
10.1210/clinem/dgaa193 -
Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice
Int J Obes. 2020-04-21.
10.1038/s41366-020-0577-8 -
POMC neurons functional heterogeneity relies on mTORC1 signaling.
. 2020-03-26.
10.1101/2020.03.25.007765 -
Inhibition of mTOR signaling by genetic removal of p70 S6 Kinase 1 leads to anxiety-like disorders
. 2020-03-25.
10.1101/2020.03.25.007427 -
POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Neuroscience. 2019-11-01.
10.1016/j.neuroscience.2019.09.031 -
mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability
Molecular Metabolism. 2019-10-01. 28 : 151-159.
10.1016/j.molmet.2019.08.005 -
Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study
Nutrients. 2019-09-21. 11(10) : 2269.
10.3390/nu11102269 -
Top-down control of water intake by the endocannabinoid system
Preprint bioRxiv. 2019-08-09.
10.1101/729970 -
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
J Clin Invest. 2019-04-02.
10.1172/JCI123454 -
Role of the endocannabinoid system in energy balance regulation and obesity.
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10.1159/0000115362 -
The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.
Trends Endocrinol Metab.. . 26(10) : 524-537.
https://doi.org/10.1016/j.tem.2015.07.007 -
Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation.
J Neuroinflammation. 2018-12-15. 15(1)
10.1186/s12974-018-1378-z -
Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.
Annals of Surgery. 2018-11-01. : 1.
10.1097/sla.0000000000003093 -
Étude des interactions entre le système endocannabinoïde et la pathologie de l’axe corticotrope chez l’Homme
Annales d'Endocrinologie. 2018-09-01. 79(4) : 286.
10.1016/j.ando.2018.06.271 -
mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin.
Molecular Metabolism. 2018-06-01. 12 : 98-106.
10.1016/j.molmet.2018.04.002 -
NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin.
Front. Pharmacol.. 2018-05-15. 9
10.3389/fphar.2018.00527 -
NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin.
Front. Pharmacol.. 2018-05-15. 9
10.3389/fphar.2018.00527 -
mTORC1 pathway disruption abrogates the effects of the ciliary neurotrophic factor on energy balance and hypothalamic neuroinflammation.
Brain, Behavior, and Immunity. 2018-05-01. 70 : 325-334.
10.1016/j.bbi.2018.03.014 -
Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.
Gut. 2017-10-26. 67(12) : 2192-2203.
10.1136/gutjnl-2017-314208 -
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.
Journal of Clinical Investigation. 2017-10-16. 127(11) : 4148-4162.
10.1172/jci83626 -
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.
Cell Metabolism. 2017-10-01. 26(4) : 620-632.e6.
10.1016/j.cmet.2017.08.023 -
The brain strikes back: Hypothalamic targets for peripheral CB1 receptor inverse agonism.
Molecular Metabolism. 2017-10-01. 6(10) : 1077-1078.
10.1016/j.molmet.2017.07.003 -
Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.
Neuropharmacology. 2017-09-01. 124 : 38-51.
10.1016/j.neuropharm.2017.05.033 -
MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future.
European Journal of Endocrinology. 2017-06-01. 176(6) : R309-R324.
10.1530/eje-16-1044 -
Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.
J Physiol. 2017-03-27. 595(11) : 3267-3285.
10.1113/jp273484 -
The CB1 Receptor as the Cornerstone of Exostasis.
Neuron. 2017-03-01. 93(6) : 1252-1274.
10.1016/j.neuron.2017.02.002 -
Islet Endothelial Cell: Friend and Foe.
Endocrinology. 2017-02-01. 158(2) : 226-228.
10.1210/en.2016-1925 -
The Fat Side of the Endocannabinoid System: Role of Endocannabinoids in the Adipocyte
Cannabis and Cannabinoid Research. 2016-12-01. 1(1) : 176-185.
10.1089/can.2016.0014 -
Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Diabetes. 2016-11-30. 66(4) : 908-919.
10.2337/db16-0586 -
The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.
Trends in Endocrinology & Metabolism. 2015-10-01. 26(10) : 524-537.
10.1016/j.tem.2015.07.007 -
New insights on the role of the endocannabinoid system in the regulation of energy balance.
Int J Obes. 2015-09-16. 40(2) : 210-219.
10.1038/ijo.2015.179 -
Endocannabinoids and Metabolic Disorders.
Handbook of Experimental Pharmacology. 2015-01-01. : 367-391.
10.1007/978-3-319-20825-1_13 -
Influence of mTOR in energy and metabolic homeostasis.
Molecular and Cellular Endocrinology. 2014-11-01. 397(1-2) : 67-77.
10.1016/j.mce.2014.07.015 -
CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.
Molecular Metabolism. 2014-10-01. 3(7) : 705-716.
10.1016/j.molmet.2014.07.004 -
mTORC2, the “other” mTOR, is a new player in energy balance regulation.
Molecular Metabolism. 2014-07-01. 3(4) : 349-350.
10.1016/j.molmet.2014.04.002 -
Leucine supplementation protects from insulin resistance by regulating adiposity levels.
PLoS ONE. 2013-09-25. 8(9) : e74705.
10.1371/journal.pone.0074705 -
Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice.
Obesity. 2013-09-05. 22(3) : 713-720.
10.1002/oby.20578 -
Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.
Proceedings of the National Academy of Sciences. 2013-03-04. 110(12) : 4786-4791.
10.1073/pnas.1218573110 -
P2101 Effet d’un régime hypoglucidique sur le métabolisme et les concentrations plasmatiques des endocannabinoïdes chez des patients diabétiques de type 2
Diabetes & Metabolism. 2013-03-01. 39 : A92.
10.1016/s1262-3636(13)72011-1 -
Un nouveau biomarqueur de l’obésité humaine : les endocannabinoïdes salivaires
Annales d'Endocrinologie. 2012-09-01. 73(4) : 424.
10.1016/j.ando.2012.07.733 -
Obesity and the Endocannabinoid System: Circulating Endocannabinoids and Obesity
Curr Obes Rep. 2012-08-17. 1(4) : 229-235.
10.1007/s13679-012-0027-6 -
Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway.
Proc. Nutr. Soc.. 2012-08-09. 71(04) : 502-510.
10.1017/s0029665112000754 -
Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice.
Diabetologia. 2011-10-11. 54(12) : 3121-3131.
10.1007/s00125-011-2302-6 -
Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity.
Int J Obes Relat Metab Disord. 2011-08-16. 36(6) : 880-885.
10.1038/ijo.2011.165 -
The role of the endocannabinoid system in the neuroendocrine regulation of energy balance.
J Psychopharmacol. 2011-08-08. 26(1) : 114-124.
10.1177/0269881111408458 -
Synergistic post-prandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity
Appetite. 2011-07-01. 57 : S17.
10.1016/j.appet.2011.05.174 -
mTORC1 signaling in energy balance and metabolic disease.
Int J Obes. 2010-09-28. 35(6) : 751-761.
10.1038/ijo.2010.208 -
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.
Endocrinology. 2009-10-01. 150(10) : 4541-4551.
10.1210/en.2009-0642 -
Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity.
Physiology & Behavior. 2009-07-01. 97(5) : 520-524.
10.1016/j.physbeh.2009.03.006 -
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.
Obesity. 2009-03-26. 17(8) : 1641-1645.
10.1038/oby.2009.84 -
Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system.
Diabetes. 2008-09-05. 57(12) : 3231-3238.
10.2337/db07-1690 -
Regulation of food intake through hypothalamic signaling networks involving mTOR.
Annu. Rev. Nutr.. 2008-08-01. 28(1) : 295-311.
10.1146/annurev.nutr.28.061807.155505 -
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.
Journal of Neuroscience. 2008-07-09. 28(28) : 7202-7208.
10.1523/JNEUROSCI.1389-08.2008 -
The role of the endocannabinoid system in the regulation of hypothalamic-pituitary-adrenal axis activity.
J Neuroendocrinol. 2008-05-01. 20(s1) : 35-38.
10.1111/j.1365-2826.2008.01673.x -
The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.
Annu. Rev. Physiol.. 2008-03-01. 70(1) : 513-535.
10.1146/annurev.physiol.70.120806.095256 -
The role of CNS fuel sensing in energy and glucose regulation.
Gastroenterology. 2007-05-01. 132(6) : 2158-2168.
10.1053/j.gastro.2007.03.049 -
CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health.
Diabetes Metab. Res. Rev.. 2007-01-01. 23(7) : 507-517.
10.1002/dmrr.764 -
Leptin in energy balance and reward: two faces of the same coin?
Neuron. 2006-09-01. 51(6) : 678-680.
10.1016/j.neuron.2006.09.009 -
Cannabinoids, opioids and eating behavior: the molecular face of hedonism?
Brain Research Reviews. 2006-06-01. 51(1) : 85-107.
10.1016/j.brainresrev.2005.10.004 -
Hypothalamic mTOR signaling regulates food intake.
Science. 2006-05-12. 312(5775) : 927-930.
10.1126/science.1124147 -
Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2005-09-01. 289(3) : R729-R737.
10.1152/ajpregu.00029.2005 -
Antagonizing the cannabinoid receptor type 1: a dual way to fight obesity.
J Endocrinol Invest. 2003-10-01. 26(10) : 1041-1044.
10.1007/bf03348205 -
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
J. Clin. Invest.. 2003-08-01. 112(3) : 423-431.
10.1172/JCI200317725 -
Cannabinoids in energy balance and prospectives in the therapy of obesity
CMCCNSA. 2003-06-01. 3(2) : 81-87.
10.2174/1568015033477839 -
Relationship between socio-economic and cultural status, psychological factors and body fat distribution in middle-aged women living in Northern Italy.
Eat Weight Disord. 2001-12-01. 6(4) : 205-213.
10.1007/bf03339744