Energy balance and obesity
Obesity represents a global epidemic lacking efficient therapeutic options. This highlights the insufficient knowledge of the biological mechanisms regulating energy balance and the absence of therapeutically relevant targets. The brain and in particular the hypothalamus plays a key role in the regulation of energy balance. Hence, the main scope of our research is to understand how exactly hypothalamic cells and circuits adapt and respond to energy availability in order to control food intake, body weight and peripheral metabolism. To reach this goal, we study energy-sensing mechanisms, such as the mechanistic target of rapamycin (mTOR) pathway and the endocannabinoid system (ECS), and use an integrated approach spanning from the generation and in depth metabolic characterization of genetic animals models to the use of state-of-the-art neuroscience techniques for the investigation of the neuronal circuits of interest. In addition, we perform clinical research studies aimed at better characterizing obese phenotypes in humans, which will lead to better, personalized therapies.
Selected publications
- Anti-obesity therapy with peripheral CB1 blockers: from promise to safe(?) practice. Carmelo Quarta, Daniela Cota. Int J Obes. 2020-04-21.
- POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?. Carmelo Quarta, Xavier Fioramonti, Daniela Cota. Neuroscience. 2019-11-01.
- mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability. Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa, Daniela Cota. Molecular Metabolism. 2019-10-01. 28 : 151-159.
- Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study. Lea Tischmann, Mathijs Drummen, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Bolette Hartmann, Jens J. Holst, Isabelle Matias, Daniela Cota, Ronald P. Mensink, Peter J. Joris, Margriet S. Westerterp-Plantenga, Tanja C. Adam. Nutrients. 2019-09-21. 11 (10) : 2269.
- Top-down control of water intake by the endocannabinoid system. Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano. Preprint bioRxiv. 2019-08-09.
- The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system. Khalil Bouyakdan, Hugo Martin, Fabienne Liénard, Lionel Budry, Bouchra Taib, Demetra Rodaros, Chloé Chrétien, Éric Biron, Zoé Husson, Daniela Cota, Luc Pénicaud, Stephanie Fulton, Xavier Fioramonti, and Thierry Alquier. J Clin Invest. 2019-04-02.
- The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.. Mazier W, Saucisse N, Gatta-Cherifi B, Cota D.. Trends Endocrinol Metab.. . 26 (10) : 524-537.
- Role of the endocannabinoid system in energy balance regulation and obesity.. . . .
- mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin. Haissaguerre M, Ferrière A, Simon V, Saucisse N, Dupuy N, André C, Clark S, Guzman-Quevedo O, Tabarin A, Cota D. . . 12 : 98-106.
- Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation.. Lucie Blaszczyk, Marlène Maître, Thierry Lesté-Lasserre, Samantha Clark, Daniela Cota, Stéphane H. R. Oliet, Valérie S. Fénelon. J Neuroinflammation. 2018-12-15. 15 (1)
- Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.. Chelsea R. Hutch, Danielle R. Trakimas, Karen Roelofs, Joshua Pressler, Joyce Sorrell, Daniela Cota, Silvana Obici, Darleen A. Sandoval. Annals of Surgery. 2018-11-01. : 1.
- mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin.. Magalie Haissaguerre, Amandine Ferrière, Vincent Simon, Nicolas Saucisse, Nathalie Dupuy, Caroline André, Samantha Clark, Omar Guzman-Quevedo, Antoine Tabarin, Daniela Cota. Molecular Metabolism. 2018-06-01. 12 : 98-106.
- NPV-BSK805, an Antineoplastic Jak2 Inhibitor Effective in Myeloproliferative Disorders, Causes Adiposity in Mice by Interfering With the Action of Leptin.. Magalie Haissaguerre, Amandine Ferriere, Samantha Clark, Omar Guzman-Quevedo, Antoine Tabarin, Daniela Cota. Front. Pharmacol.. 2018-05-15. 9
- Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.. Joaquim Javary, Nathalie Allain-Courtois, Nicolas Saucisse, Pierre Costet, Capucine Heraud, Fadila Benhamed, Rémi Pierre, Corinne Bure, Nestor Pallares-Lupon, Marcio Do Cruzeiro, Catherine Postic, Daniela Cota, Pierre Dubus, Jean Rosenbaum, Samira Benhamouche-Trouillet. Gut. 2017-10-26. 67 (12) : 2192-2203.
- Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.. Inigo Ruiz de Azua, Giacomo Mancini, Raj Kamal Srivastava, Alejandro Aparisi Rey, Pierre Cardinal, Laura Tedesco, Cristina Maria Zingaretti, Antonia Sassmann, Carmelo Quarta, Claudia Schwitter, Andrea Conrad, Nina Wettschureck, V. Kiran Vemuri, Alexandros Makriyannis, Jens Hartwig, Maria Mendez-Lago, Laura Bindila, Krisztina Monory, Antonio Giordano, Saverio Cinti, Giovanni Marsicano, Stefan Offermanns, Enzo Nisoli, Uberto Pagotto, Daniela Cota, Beat Lutz. Journal of Clinical Investigation. 2017-10-16. 127 (11) : 4148-4162.
- Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.. Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S. Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S. Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M. Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M. Strom, Valerie Gailus-Durner, Ingo Bechmann, Diego Perez-Tilve, Jan Tuckermann, Martin Hrabě de Angelis, Darleen Sandoval, Daniela Cota, Eicke Latz, Randy J. Seeley, Timo D. Müller, Richard D. DiMarchi, Brian Finan, Matthias H. Tschöp. Cell Metabolism. 2017-10-01. 26 (4) : 620-632.e6.
- The brain strikes back: Hypothalamic targets for peripheral CB1 receptor inverse agonism.. Daniela Cota. Molecular Metabolism. 2017-10-01. 6 (10) : 1077-1078.
- Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.. Benjamin K. Lau, Daniela Cota, Luigia Cristino, Stephanie L. Borgland. Neuropharmacology. 2017-09-01. 124 : 38-51.
- MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future.. Vincent Simon, Daniela Cota. European Journal of Endocrinology. 2017-06-01. 176 (6) : R309-R324.
- Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.. Abdessattar Khlaifia, Isabelle Matias, Daniela Cota, Fabien Tell. J Physiol. 2017-03-27. 595 (11) : 3267-3285.
- Islet Endothelial Cell: Friend and Foe.. Wilfrid Mazier, Daniela Cota. Endocrinology. 2017-02-01. 158 (2) : 226-228.
- Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.. Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota. Diabetes. 2016-11-30. 66 (4) : 908-919.
- Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.. Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota. Diabetes. 2016-11-30. 66 (4) : 908-919.
- Characterization of cutaneous and articular sensory neurons. Ines da Silva Serra, Zoé Husson, Jonathan D. Bartlett, Ewan St. John Smith. Mol Pain. 2016-01-01. 12 : 174480691663638.
- The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease.. Wilfrid Mazier, Nicolas Saucisse, Blandine Gatta-Cherifi, Daniela Cota. Trends in Endocrinology & Metabolism. 2015-10-01. 26 (10) : 524-537.
- New insights on the role of the endocannabinoid system in the regulation of energy balance.. B Gatta-Cherifi, D Cota. Int J Obes. 2015-09-16. 40 (2) : 210-219.
- The naked mole-rat as an animal model in biomedical research: current perspectives. Ewan St John Smith, Laura-Nadine Schuhmacher, Zoé Husson. OAAP. 2015-08-01. : 137.
- A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity.. Lea Ankri, Zoé Husson, Katarzyna Pietrajtis, Rémi Proville, Clément Léna, Yosef Yarom, Stéphane Dieudonné, Marylka Yoe Uusisaari. eLife. 2015-05-12. 4
- Endocannabinoids and Metabolic Disorders.. Blandine Gatta-Cherifi, Daniela Cota. Handbook of Experimental Pharmacology. 2015-01-01. : 367-391.
- Influence of mTOR in energy and metabolic homeostasis.. Magalie Haissaguerre, Nicolas Saucisse, Daniela Cota. Molecular and Cellular Endocrinology. 2014-11-01. 397 (1-2) : 67-77.
- CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.. Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota. Molecular Metabolism. 2014-10-01. 3 (7) : 705-716.
- Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.. Z. Husson, C. V. Rousseau, I. Broll, H. U. Zeilhofer, S. Dieudonne. Journal of Neuroscience. 2014-07-09. 34 (28) : 9418-9431.
- mTORC2, the “other” mTOR, is a new player in energy balance regulation.. Daniela Cota. Molecular Metabolism. 2014-07-01. 3 (4) : 349-350.
- Leucine supplementation protects from insulin resistance by regulating adiposity levels.. Elke Binder, Francisco J. Bermúdez-Silva, Caroline André, Melissa Elie, Silvana Y. Romero-Zerbo, Thierry Leste-Lasserre, llaria Belluomo, Adeline Duchampt, Samantha Clark, Agnes Aubert, Marco Mezzullo, Flaminia Fanelli, Uberto Pagotto, Sophie Layé, Gilles Mithieux, Daniela Cota. PLoS ONE. 2013-09-25. 8 (9) : e74705.
- Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice.. Elke Binder, Francisco Javier Bermúdez-Silva, Melissa Elie, Thierry Leste-Lasserre, Ilaria Belluomo, Samantha Clark, Adeline Duchampt, Gilles Mithieux, Daniela Cota. Obesity. 2013-09-05. 22 (3) : 713-720.
- Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.. L. Bellocchio, E. Soria-Gomez, C. Quarta, M. Metna-Laurent, P. Cardinal, E. Binder, A. Cannich, A. Delamarre, M. Haring, M. Martin-Fontecha, D. Vega, T. Leste-Lasserre, D. Bartsch, K. Monory, B. Lutz, F. Chaouloff, U. Pagotto, M. Guzman, D. Cota, G. Marsicano. Proceedings of the National Academy of Sciences. 2013-03-04. 110 (12) : 4786-4791.
- Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.. C. Bories, Z. Husson, M. J. Guitton, Y. De Koninck. Journal of Neuroscience. 2013-01-23. 33 (4) : 1344-1356.
- Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of rapamycin complex 1 pathway.. Caroline André, Daniela Cota. Proc. Nutr. Soc.. 2012-08-09. 71 (04) : 502-510.
- Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells.. David Gaucher, Emilie Arnault, Zoé Husson, Nicolas Froger, Elisabeth Dubus, Pauline Gondouin, Diane Dherbécourt, Julie Degardin, Manuel Simonutti, Stéphane Fouquet, M. A. Benahmed, K. Elbayed, Izzie-Jacques Namer, Pascale Massin, José-Alain Sahel, Serge Picaud. Amino Acids. 2012-04-04. 43 (5) : 1979-1993.
- Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice.. M. Bajzer, M. Olivieri, M. K. Haas, P. T. Pfluger, I. J. Magrisso, M. T. Foster, M. H. Tschöp, K. A. Krawczewski-Carhuatanta, D. Cota, S. Obici. Diabetologia. 2011-10-11. 54 (12) : 3121-3131.
- The role of the endocannabinoid system in the neuroendocrine regulation of energy balance.. Francisco Javier Bermudez-Silva, Pierre Cardinal, Daniela Cota. J Psychopharmacol. 2011-08-08. 26 (1) : 114-124.
- mTORC1 signaling in energy balance and metabolic disease.. C Catania, E Binder, D Cota. Int J Obes. 2010-09-28. 35 (6) : 751-761.
- Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.. Eneida C. Villanueva, Heike Münzberg, Daniela Cota, Rebecca L. Leshan, Keely Kopp, Ryoko Ishida-Takahashi, Justin C. Jones, Diane C. Fingar, Randy J. Seeley, Martin G. Myers. Endocrinology. 2009-10-01. 150 (10) : 4541-4551.
- Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity.. Daniela Cota. Physiology & Behavior. 2009-07-01. 97 (5) : 520-524.
- Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.. Daniela Cota, Darleen A. Sandoval, Massimiliano Olivieri, Elena Prodi, David A. D'Alessio, Stephen C. Woods, Randy J. Seeley, Silvana Obici. Obesity. 2009-03-26. 17 (8) : 1641-1645.
- Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system.. K. Proulx, D. Cota, S. C. Woods, R. J. Seeley. Diabetes. 2008-09-05. 57 (12) : 3231-3238.
- Regulation of food intake through hypothalamic signaling networks involving mTOR.. Stephen C Woods, Randy J Seeley, Daniela Cota. Annu. Rev. Nutr.. 2008-08-01. 28 (1) : 295-311.
- The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity.. D. Cota, E. K. Matter, S. C. Woods, R. J. Seeley. Journal of Neuroscience. 2008-07-09. 28 (28) : 7202-7208.
- The role of the endocannabinoid system in the regulation of hypothalamic-pituitary-adrenal axis activity.. D. Cota. J Neuroendocrinol. 2008-05-01. 20 (s1) : 35-38.
- The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.. Darleen Sandoval, Daniela Cota, Randy J. Seeley. Annu. Rev. Physiol.. 2008-03-01. 70 (1) : 513-535.
- The role of CNS fuel sensing in energy and glucose regulation.. Daniela Cota, Karine Proulx, Randy J. Seeley. Gastroenterology. 2007-05-01. 132 (6) : 2158-2168.
- CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health.. Daniela Cota. Diabetes Metab. Res. Rev.. 2007-01-01. 23 (7) : 507-517.
- Leptin in energy balance and reward: two faces of the same coin?. Daniela Cota, Jason G. Barrera, Randy J. Seeley. Neuron. 2006-09-01. 51 (6) : 678-680.
- Cannabinoids, opioids and eating behavior: the molecular face of hedonism?. Daniela Cota, Matthias H. Tschöp, Tamas L. Horvath, Allen S. Levine. Brain Research Reviews. 2006-06-01. 51 (1) : 85-107.
- Hypothalamic mTOR signaling regulates food intake.. D. Cota. Science. 2006-05-12. 312 (5775) : 927-930.
- Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.. Karine Proulx, Daniela Cota, Tamara R. Castañeda, Matthias H. Tschöp, David A. D'Alessio, Patrick Tso, Stephen C. Woods, Randy J. Seeley. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2005-09-01. 289 (3) : R729-R737.
- Antagonizing the cannabinoid receptor type 1: a dual way to fight obesity.. D. Cota, S. Genghini, R. Pasquali, U. Pagotto. J Endocrinol Invest. 2003-10-01. 26 (10) : 1041-1044.
- The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.. Daniela Cota, Giovanni Marsicano, Matthias Tschöp, Yvonne Grübler, Cornelia Flachskamm, Mirjam Schubert, Dorothee Auer, Alexander Yassouridis, Christa Thöne-Reineke, Sylvia Ortmann, Federica Tomassoni, Cristina Cervino, Enzo Nisoli, Astrid C.E. Linthorst, Renato Pasquali, Beat Lutz, Günter K. Stalla, Uberto Pagotto. J. Clin. Invest.. 2003-08-01. 112 (3) : 423-431.
- Relationship between socio-economic and cultural status, psychological factors and body fat distribution in middle-aged women living in Northern Italy.. D. Cota, V. Vicennati, L. Ceroni, A. M. Morselli-Labate, Renato Pasquali. Eat Weight Disord. 2001-12-01. 6 (4) : 205-213.
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Agnès Nadjar
Nadjar
(University Teacher- Researcher)
Antoine Tabarin Tabarin (Professor - Hospital practitioner)
Blandine Cherifi-Gatta Cherifi-Gatta (Professor - Hospital practitioner)
Valérie Fenelon Fenelon (University Teacher- Researcher)
Carmelo Quarta Quarta (Researcher)
Antoine Tabarin Tabarin (Professor - Hospital practitioner)
Blandine Cherifi-Gatta Cherifi-Gatta (Professor - Hospital practitioner)
Valérie Fenelon Fenelon (University Teacher- Researcher)
Carmelo Quarta Quarta (Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Ashley Castellanos Jankiewicz
Castellanos Jankiewicz
Cristina Miralpeix Miralpeix
Camille Allard Allard
Cristina Miralpeix Miralpeix
Camille Allard Allard
Doctorant(s)