Aline Desmedt

Scientific articles

• The correct connectivity of the DG-CA3 circuits involved in declarative memory processes depends on Vangl2-dependent planar cell polarity signaling
  Noémie Depret, Marie Gleizes, Maïté Marie Moreau, Sonia Poirault-Chassac, Anne Quiedeville, Steve Dos Santos Carvalho, Vasika Venugopal, Alice Shaam Al Abed, Jérôme Ezan, Gael Barthet, Christophe Mulle, Aline Desmedt, Aline Marighetto, Claudia Racca, Mireille Montcouquiol, Nathalie Sans.
  Progress in Neurobiology. 2025-03-01. 246 : 102728.
  10.1016/j.pneurobio.2025.102728
• An extended amygdala circuit at the core of long-term post-sepsis psychiatric disorders
  Aline Desmedt .
  Brain. 2022-04-01. 145(4) : 1202-1203.
  10.1093/brain/awac112
• Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
  Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias.
  Neurobiology of Disease. 2021-12-01. 160 : 105533.
  10.1016/j.nbd.2021.105533
• PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory.
  C. Bouarab, V. Roullot-Lacarrière, M. Vallée, A. Le Roux, C. Guette, M. Mennesson, A. Marighetto, A. Desmedt, P. V. Piazza, J. M. Revest.
  Mol Psychiatry. 2021-01-28.
  10.1038/s41380-021-01024-1
• (Re)contextualizing the Trauma to Prevent or Treat PTSD-Related Hypermnesia
  Aline Desmedt.
  Chronic Stress. 2021-01-01. 5 : 247054702110210.
  10.1177/24705470211021073
• Age-related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1.
  l Abed AS, Sellami A, Potier M, Ducourneau EG, Gerbeaud-Lassau P, Brayda-Bruno L, Lamothe V, Sans N, Desmedt A, Vanhoutte P, Bennetau-Pelissero C, Trifilieff P, Marighetto A..
  Aging Cell. 2020 Oct 3. 19(10) : e13243.
  10.1111/acel.13243
• Preventing and treating PTSD-like memory by trauma contextualization
  Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto, Aline Desmedt.
  Nat Commun. 2020-08-24. 11(1) : 4220.
  10.1038/s41467-020-18002-w.
• Brexpiprazole blocks post-traumatic stress disorder-like memory while promoting normal fear memory
  Eva-Gunnel Ducourneau, Christelle Guette, Damien Perrot, Miguel Mondesir, Cédric Mombereau, Jorn Arnt, Aline Desmedt & Pier-Vincenzo Piazza.
  Molecular Psychiatry. 2020-08-19.
  10.1038/s41380-020-0852-z
• False Opposing Fear Memories Are Produced as a Function of the Hippocampal Sector Where Glucocorticoid Receptors Are Activated
  Nadia Kaouane, Eva-Gunnel Ducourneau, Aline Marighetto, Menahem Segal, Aline Desmedt.
  Front. Behav. Neurosci. 2020-08-26.
  10.3389/fnbeh.2020.00144
• Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
  Benjamin J.A. Robert, Maïté M. Moreau, Steve Dos Santos Carvalho, Gael Barthet, Claudia Racca, Mehdi Bhouri, Anne Quiedeville, Maurice Garret, Bénédicte Atchama, Alice Shaam Al Abed, Christelle Guette, Deborah J. Henderson, Aline Desmedt, Christophe Mulle, Aline Marighetto, Mireille Montcouquiol, Nathalie Sans.
  Cell Reports. 2020-06-01. 31(10) : 107743.
  10.1016/j.celrep.2020.107743
• The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
  Revest JM, Di Blasi F, Kitchener P, Rouge-Pont F, Desmedt A, Turiault M, Tronche F, Piazza PV..
  Nat Neurosci.. 2005-04-17. 8(5) : 664-72.
  10.1038/nn1441
• The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib.
  JM Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt and P V Piazza..
  Molecular Psychiatry. 2010-4-6. 15(12) : 1140-1151.
  10.1038/mp.2010.40
• BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
  J-M Revest, A Le Roux, V Roullot-Lacarrière, N Kaouane, M Vallée, F Kasanetz, F Rougé-Pont, F Tronche, A Desmedt & P V Piazza.
  Molecular Psychiatry. . 19 : 1001–1009.
  10.1038/mp.2013.134
• Selective dentate gyrus disruption causes memory impairment at the early stage of experimental multiple sclerosis.
  Vincent Planche, Aude Panatier, Bassem Hiba, Eva-Gunnel Ducourneau, Gerard Raffard, Nadège Dubourdieu, Marlène Maitre, Thierry Lesté-Lasserre, Bruno Brochet, Vincent Dousset, Aline Desmedt, Stéphane H. Oliet, Thomas Tourdias.
  Brain, Behavior, and Immunity. 2017-02-01. 60 : 240-254.
  10.1016/j.bbi.2016.11.010
• Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder
  Aline Desmedt, Aline Marighetto, Pier-Vincenzo Piazza.
  Biological Psychiatry. 2015-09-01. 78(5) : 290-297.
  10.1016/j.biopsych.2015.06.017
• Adaptive emotional memory: The key hippocampal-amygdalar interaction
  Aline Desmedt, Aline Marighetto, Gal Richter-Levin, Ludovic Calandreau.
  Stress. 2015-05-04. 18(3) : 297-308.
  10.3109/10253890.2015.1067676
• Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat.
  Morgan Lucas, Yana Ilin, Rachel Anunu, Orli Kehat, Lin Xu, Aline Desmedt, Gal Richter-Levin.
  Stress. 2014-08-11. 17(5) : 423-430.
  10.3109/10253890.2014.930430
• Glucocorticoids can induce PTSD-like memory impairments in mice
  N. Kaouane, Y. Porte, M. Vallee, L. Brayda-Bruno, N. Mons, L. Calandreau, A. Marighetto, P. V. Piazza, A. Desmedt.
  Science. 2012-02-23. 335(6075) : 1510-1513.
  10.1126/science.1207615
• Effect of one week of stress on emotional reactivity and learning and memory performances in Japanese quail.
  Ludovic Calandreau, Aline Bertin, Alain Boissy, Cécile Arnould, Paul Constantin, Aline Desmedt, Daniel Guémené, Raymond Nowak, Christine Leterrier.
  Behavioural Brain Research. 2011-02-01. 217(1) : 104-110.
  10.1016/j.bbr.2010.10.004
• Glucocorticoid treatment induces expression of Egr-1 and synapsin-I proteins in primary culture of hippocampal neurons
  J-M Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt, P V Piazza.
  Mol Psychiatry. 2010-11-19. 15(12) : 1125-1125.
  10.1038/mp.2010.118
• Switching from contextual to tone fear conditioning and vice versa: the key role of the glutamatergic hippocampal-lateral septal neurotransmission.
  L. Calandreau, B. Desgranges, R. Jaffard, A. Desmedt.
  Learning & Memory. 2010-08-26. 17(9) : 440-443.
  10.1101/lm.1859810
• Plasma transcortin influences endocrine and behavioral stress responses in mice.
  Elodie M. Richard, Jean-Christophe Helbling, Claudine Tridon, Aline Desmedt, Amandine M. Minni, Martine Cador, Line Pourtau, Jan-Pieter Konsman, Pierre Mormède, Marie-Pierre Moisan.
  Endocrinology. 2010-02-01. 151(2) : 649-659.
  10.1210/en.2009-0862
• Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice
  A. Marighetto, S. Valerio, A. Desmedt, J. N. Philippin, C. Trocmé-Thibierge, P. Morain.
  Psychopharmacology. 2008-02-12. 197(3) : 499-508.
  10.1007/s00213-007-1063-x
• Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning.
  L. Calandreau, R. Jaffard, A. Desmedt.
  Learning & Memory. 2007-06-06. 14(6) : 422-429.
  10.1101/lm.531407
• Extracellular hippocampal acetylcholine level controls amygdala function and promotes adaptive conditioned emotional response
  L. Calandreau, P. Trifilieff, N. Mons, L. Costes, M. Marien, A. Marighetto, J. Micheau, R. Jaffard, A. Desmedt.
  Journal of Neuroscience. 2006-12-27. 26(52) : 13556-13566.
  10.1523/JNEUROSCI.3713-06.2006
• Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation.
  P. Trifilieff.
  Learning & Memory. 2006-05-01. 13(3) : 349-358.
  10.1101/lm.80206
• A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning.
  L. Calandreau.
  Learning & Memory. 2005-07-18. 12(4) : 383-388.
  10.1101/lm.92305
• The amygdala and appraisal processes: stimulus and response complexity as an organizing factor.
  Dan Yaniv, Aline Desmedt, Robert Jaffard, Gal Richter-Levin.
  Brain Research Reviews. 2004-03-01. 44(2-3) : 179-186.
  10.1016/j.brainresrev.2003.08.008
• Differential pattern of cAMP response element-binding protein activation in the rat brain after conditioned aversion as a function of the associative process engaged: taste versus context association.
  Aline Desmedt, Shoshi Hazvi, Yadin Dudai.
  J. Neurosci.. 2003-07-09. 23(14) : 6102-6110.
  10.1523/jneurosci.23-14-06102.2003
• An 8-day extensive elemental, but not contextual, fear conditioning potentiates hippocampal-lateral septal synaptic efficacy in mice.
  Aline Desmedt, René Garcia, Robert Jaffard.
  Synapse. 2003-06-20. 49(4) : 270-278.
  10.1002/syn.10243
• The effects of ibotenic hippocampal lesions on discriminative fear conditioning to context in mice: Impairment or facilitation depending on the associative value of a phasic explicit cue
  Aline Desmedt, Aline Marighetto, René Garcia, Robert Jaffard.
  European Journal of Neuroscience. 2003-05-01. 17(9) : 1953-1963.
  10.1046/j.1460-9568.2003.02615.x
• Hippocampal lesions and discrimination performance of mice in the radial maze: Sparing or impairment depending on the representational demands of the task
  Nicole Etchamendy, Aline Desmedt, Cedric Cortes-Torrea, Aline Marighetto, Robert Jaffard.
  Hippocampus. 2003-01-01. 13(2) : 197-211.
  10.1002/hipo.10055
• Vasopressin in the lateral septum promotes elemental conditioning to the detriment of contextual fear conditioning in mice.
  Aline Desmedt, René Garcia, Robert Jaffard.
  European Journal of Neuroscience. 1999-11-01. 11(11) : 3913-3921.
  10.1046/j.1460-9568.1999.00815.x
• Differential modulation of changes in hippocampal-septal synaptic excitability by the amygdala as a function of either elemental or contextual fear conditioning in mice.
  Aline Desmedt, René Garcia, Robert Jaffard.
  J. Neurosci.. 1998-01-01. 18(1) : 480-487.
  10.1523/jneurosci.18-01-00480.1998