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Seminar – Sandrine Humbert

Friday 8 February 2019 / 11:30 - 13:00

Lieu: Amphi CGFB, Campus Carreire

Abstract :

Comprendre comment une protéine d’échafaudage telle que la huntingtine (dont la mutation est à l’origine de la maladie de Huntington) coordonne les mécanismes cellulaires et moléculaires gouvernant la division cellulaire de progéniteurs neuraux et leur différenciation au cours du développement embryonnaire et chez l’adulte.

Selected publications

Barnat M, Le Friec J, Benstaali C and Humbert, S (2017). Huntingtin-mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons is Critical for their Postnatal Neuronal Morphology. Neuron, 93, 99-114.

Thion MS, McGuire JR, Sousa CM, Fuhrmann L, Fitamant J, Leboucher S, Vacher S, Tezenas du Montcel S, Bièche I, Bernet A, Patrick Mehlen P, Anne Vincent-Salomon A, and Humbert, S (2015). Unravelling the role of huntingtin in breast cancer metastasis. J. Natl. Cancer Inst., doi: 10.1093/jnci/djv208.

Elias S, McGuire JR, Yu H and Humbert S (2015). Huntingtin is required for epithelial polarity through RAB11A mediated apical trafficking of PAR3-aPKC. Plos Biol., 13:e1002142.

Molina-Calavita M, Barnat M, Elias S, Aparicio E, Piel M and Humbert S (2014). Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex. J. Neurosci., 34, 10034-10040.

Elias S, Thion MS, Yu H, Moreira Sousa C, Lasgi C, Morin X and Humbert S (2014). Huntingtin Regulates Mammary Stem Cell Division and Differentiation. Stem Cell Reports, 2, 491-506.

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Details

Date:
Friday 8 February 2019
Time:
11:30 - 13:00
Event Category:

Venue

CGFB
38 rue Albert Marquet
Bordeaux, 33000 France