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Seminar – Dominic Hare

Tuesday 5 February 2019 / 14:00

Mass spectrometry imaging and the ‘third wave’ of anatomical neuropathology

While biologists view proteins, lipids, carbohydrates and nucleic acids as the building blocks of life, the chemical elements represent the fundamental constituents of a living organism. Cell types, biological functions and even disease processes have unique elemental signatures. In cases where minor and trace elements are directly implicated in the mechanism of a disease this signature can be stark, while other scenarios can arise where subtler changes are apparent. The emerging potential as a tool for clinical pathology will be discussed, highlighting how concurrent advances in technology, image analysis, machine learning, and a growing appreciation that the chemical elements are not regulated in isolation are converging to position elemental imaging as a valuable resource for digital pathology and the decision-making process in treating neurological disorders.

Publications

S. Genoud, B. Roberts, A. Gunn, G. Halliday, S. Lewis, H. Ball, D. Hare, K. Double. Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson’s disease brain. Metallomics, (2017), 9, 1447-1455.

B. Trist, K. Davies, V. Cottam, S. Genoud, R. Ortega, S. Roudeau, A. Carmona, K. De Silva, V. Wagner, S. Lewis, P. Sachdev, B. Smith, C. Troakes, C. Vance, C. Shaw, S. Al-Sarraj, H. Ball, G. Halliday, D. Hare, K. Double. Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain. Acta Neuropathologica, (2017), 134, 113-127.

D. Hare, E. Raven, B. Roberts, M. Bogeski, S. Portbury, C. McLean, C. Masters, J. Connor, A. Bush, P. Crouch, P. Doble. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer’s disease
frontal cortex. NeuroImage, (2016), 137, 124-134.

B. Paul, D. Hare, D. Bishop, C. Paton, V. Nguyen, N. Cole, M. Niedzwiecki, E. Andreozzi, A. Vais, J. Billings, L. Bray, A. Bush, G. McColl, B. Roberts, P. Adlard, D. Finkelstein, J. Hellstrom, J. Hergt, J. Woodhead, P. Doble*. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science, (2015), 6, 5383-5393.

D. Hare, J. Doecke, N. Faux, A. Rembach, I. Volitakis, C. Fowler, R. Grimm, P. Doble, R. Cherny, C. Masters, A. Bush, B. Roberts. Decreased plasma iron in Alzheimer’s disease is due to transferrin desaturation. ACS Chemical Neuroscience (2015) 6, 398-402.

 

Coming soon

  1. Seminar – Suzana Herculano-Houzel

    Friday 26 April 2019 / 11:30

    Life slows down with more neurons in the cerebral cortex.

  2. Seminar – Maxime Assous

    Friday 3 May 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  3. Monthly conference – Richard Robitaille

    Friday 3 May 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial celles in health and disease

  4. Seminar – Stéphanie Trouche

    Friday 10 May 2019 / 11:30 - 12:30

    Invited by : Catherine Le Moine

  5. Bordeaux Neurocampus Day

    Wednesday 15 May 2019 / 09:00 - 18:00

    (Haut Carré, Talence)

Details

Date:
Tuesday 5 February 2019
Time:
14:00
Event Category:

Venue

CGFB
38 rue Albert Marquet
Bordeaux, 33000 France