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Séminaire impromptu annulé ! – Dominic Hare

mardi 5 février 2019 / 14:00

Mass spectrometry imaging and the ‘third wave’ of anatomical neuropathology

Lieu : CGFB (séminaire annulé)


While biologists view proteins, lipids, carbohydrates and nucleic acids as the building blocks of life, the chemical elements represent the fundamental constituents of a living organism. Cell types, biological functions and even disease processes have unique elemental signatures. In cases where minor and trace elements are directly implicated in the mechanism of a disease this signature can be stark, while other scenarios can arise where subtler changes are apparent. The emerging potential as a tool for clinical pathology will be discussed, highlighting how concurrent advances in technology, image analysis, machine learning, and a growing appreciation that the chemical elements are not regulated in isolation are converging to position elemental imaging as a valuable resource for digital pathology and the decision-making process in treating neurological disorders.

Publications

S. Genoud, B. Roberts, A. Gunn, G. Halliday, S. Lewis, H. Ball, D. Hare, K. Double. Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson’s disease brain. Metallomics, (2017), 9, 1447-1455.

B. Trist, K. Davies, V. Cottam, S. Genoud, R. Ortega, S. Roudeau, A. Carmona, K. De Silva, V. Wagner, S. Lewis, P. Sachdev, B. Smith, C. Troakes, C. Vance, C. Shaw, S. Al-Sarraj, H. Ball, G. Halliday, D. Hare, K. Double. Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain. Acta Neuropathologica, (2017), 134, 113-127.

D. Hare, E. Raven, B. Roberts, M. Bogeski, S. Portbury, C. McLean, C. Masters, J. Connor, A. Bush, P. Crouch, P. Doble. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer’s disease
frontal cortex. NeuroImage, (2016), 137, 124-134.

B. Paul, D. Hare, D. Bishop, C. Paton, V. Nguyen, N. Cole, M. Niedzwiecki, E. Andreozzi, A. Vais, J. Billings, L. Bray, A. Bush, G. McColl, B. Roberts, P. Adlard, D. Finkelstein, J. Hellstrom, J. Hergt, J. Woodhead, P. Doble*. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science, (2015), 6, 5383-5393.

D. Hare, J. Doecke, N. Faux, A. Rembach, I. Volitakis, C. Fowler, R. Grimm, P. Doble, R. Cherny, C. Masters, A. Bush, B. Roberts. Decreased plasma iron in Alzheimer’s disease is due to transferrin desaturation. ACS Chemical Neuroscience (2015) 6, 398-402.

 

Prochainement

  1. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    mardi 25 juin 2019 - mardi 9 juillet 2019

    Les séminaires sont ouverts à tous.

  2. Conférence Labex Trail – Goran Angelovski

    vendredi 28 juin 2019 / 14:30

    Molecular fMRI with Bioresponsive Probes

  3. Atout neurones

    samedi 29 juin 2019 / 14:00 - 20:00

    Tournoi de bridge au profit de la recherche sur le cerveau et conférence d'Olivier Nicole (IMN)

  4. Ramène (pas) ta science ! à la kermesse des sciences

    dimanche 30 juin 2019 / 14:00 - 23:00

    Parc Peixotto, Talence

  5. Séminaire – Anne Brunet

    mardi 2 juillet 2019 / 11:30

    Understanding and modeling aging

Détails

Date :
mardi 5 février 2019
Heure :
14:00
Catégorie d’Évènement:

Lieu

CGFB
38 rue Albert Marquet
Bordeaux, 33000 France