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Séminaire impromptu annulé ! – Dominic Hare

mardi 5 février 2019 / 14:00

Mass spectrometry imaging and the ‘third wave’ of anatomical neuropathology

Lieu : CGFB (séminaire annulé)

While biologists view proteins, lipids, carbohydrates and nucleic acids as the building blocks of life, the chemical elements represent the fundamental constituents of a living organism. Cell types, biological functions and even disease processes have unique elemental signatures. In cases where minor and trace elements are directly implicated in the mechanism of a disease this signature can be stark, while other scenarios can arise where subtler changes are apparent. The emerging potential as a tool for clinical pathology will be discussed, highlighting how concurrent advances in technology, image analysis, machine learning, and a growing appreciation that the chemical elements are not regulated in isolation are converging to position elemental imaging as a valuable resource for digital pathology and the decision-making process in treating neurological disorders.


S. Genoud, B. Roberts, A. Gunn, G. Halliday, S. Lewis, H. Ball, D. Hare, K. Double. Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson’s disease brain. Metallomics, (2017), 9, 1447-1455.

B. Trist, K. Davies, V. Cottam, S. Genoud, R. Ortega, S. Roudeau, A. Carmona, K. De Silva, V. Wagner, S. Lewis, P. Sachdev, B. Smith, C. Troakes, C. Vance, C. Shaw, S. Al-Sarraj, H. Ball, G. Halliday, D. Hare, K. Double. Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain. Acta Neuropathologica, (2017), 134, 113-127.

D. Hare, E. Raven, B. Roberts, M. Bogeski, S. Portbury, C. McLean, C. Masters, J. Connor, A. Bush, P. Crouch, P. Doble. Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer’s disease
frontal cortex. NeuroImage, (2016), 137, 124-134.

B. Paul, D. Hare, D. Bishop, C. Paton, V. Nguyen, N. Cole, M. Niedzwiecki, E. Andreozzi, A. Vais, J. Billings, L. Bray, A. Bush, G. McColl, B. Roberts, P. Adlard, D. Finkelstein, J. Hellstrom, J. Hergt, J. Woodhead, P. Doble*. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical Science, (2015), 6, 5383-5393.

D. Hare, J. Doecke, N. Faux, A. Rembach, I. Volitakis, C. Fowler, R. Grimm, P. Doble, R. Cherny, C. Masters, A. Bush, B. Roberts. Decreased plasma iron in Alzheimer’s disease is due to transferrin desaturation. ACS Chemical Neuroscience (2015) 6, 398-402.



  1. Séminaire – Suzana Herculano-Houzel

    vendredi 26 avril 2019 / 11:30

    Life slows down with more neurons in the cerebral cortex

  2. XIIIth IBAGS Meeting

    dimanche 28 avril 2019 - jeudi 2 mai 2019

    The XIIIth edition of the IBAGS meeting will be held in Biarritz from the 28th of April to the 2nd of May. In this meeting, we gather outstanding scientists and clinicians from all over the world to discuss about topics related to basal ganglia pathways, physiology, reinforcement learning and related disorders. Tutorials on basic science and clinical aspects of the basal ganglia will be given on the introducing day of the meeting.

  3. Séminaire impromptu – Maxime Assous

    vendredi 3 mai 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  4. Conférence mensuelle – Richard Robitaille

    vendredi 3 mai 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial cells in health and disease

  5. Séminaire – Stéphanie Trouche

    vendredi 10 mai 2019 / 11:30 - 12:30

    Invitant : Catherine Le Moine


Date :
mardi 5 février 2019
Heure :
Catégorie d’Évènement:


38 rue Albert Marquet
Bordeaux, 33000 France