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Seminar – Csaba Foldy

Friday 19 April 2019 / 11:30

Cell Adhesion Molecules at the Intersection of Cell Type Identity and Circuit Connectivity: From Neurexin Isoforms to OLM interneuron Identities

Venue : Centre Broca Nouvelle-Aquitaine / Salle de conférence


Csaba Foldy

Csaba Foldy
Assistant Professor and a Co-Director of the Brain Research Institute (UTH Zurich).
https://www.hifo.uzh.ch/en/research/foldy.html

Abstract

Cell adhesion molecules (CAMs) play critical roles in neural circuit assembly and are frequently associated with neurodevelopmental and psychiatric disorders. Because hundreds of CAMs exist in the brain, their functional analysis has been challenging. Single-cell RNAseq, gene isoform-specific, and synapse-specific analyses are now breaking barriers. In this talk, I focus on the ontogenetic stability of neurexin isoform profiles and how this led to insights about the origin of hippocampal OLM cells.

Selected publications

Földy, C., Darmanis, S., Aoto, J., Malenka, R.C., Quake, S.R., Südhof, T.C. (2016) Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. PNAS, 113(35):E5222-31.

Anderson, G.R., Aoto, J., Tabuchi, K., Földy, C., Covy, J., Yee, A.X., Wu, D., Chen., L., Malenka, R.C., Südhof, T.C. (2015) β-Neurexins control neuronal dynamics by regulating endocannabinoid signaling at excitatory synapses. Cell, 162(3):593-606.

Fuccillo, M*, Földy, C*., Gökce*, M., Rothwell, P, Sun, G., Malenka, R.C., Südhof, T.C. (2015) Single-cell mRNA profiling reveals cell-type specific expression of neurexin isoforms. Neuron, 87(2):326-340. (*Co-first author)

Aoto, J., Földy, C., Ciurea-Ilcus, S.M., Tabuchi, K., Südhof, T.C. (2015) Distinct circuit-dependent essential functions of neurexin-3 in regulating presynaptic release or postsynaptic AMPA-receptor stability. Nature Neuroscience, 18(7):997-1007.

Lammel, S.*, Steinberg, E.E.*, Földy, C.*, Wall, N.R., Beier, K., Luo, L., Malenka, R.C. (2015) Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron, 85(2):429-438. (*Co-first author)

Földy, C., Malenka, R.C., Südhof, T.C. (2013) Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron, 78(3):498-509.

Etherton, M., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R.C., Südhof, T.C. (2011) Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. PNAS, 108(33): 13764-9.

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Details

Date:
Friday 19 April 2019
Time:
11:30
Event Category: