Loading Events

« All Events

  • This event has passed.

Monthly PhD seminar – Matthew Hill

Friday 7 June 2019 / 11:30 - 12:30

Encannabinoids: multi-modal regulators of the stress response

Venue: Centre Broca Nouvelle-Aquitaine / Salle de Conférence

Matthew Hill
Hotchkiss Brain Institute,
Mathison Centre for Mental Health Research.
Departments of Cell Biology and Anatomy and Psychiatry.

Invited by the NBA and Bordeaux Neurocampus.


Endocannabinoids are well established to buffer stress responses in the brain, with emerging evidence suggest that they exhibit both tonic control of stress responses at rest, as well as phasic control in response to stress itself. Converging evidence has indicated that anandamide may be the primary endocannabinoid regulating tonic control of the stress response, and that disruption of anandamide signaling may facilitate generation of a stress response. Our work has suggested that this effect may particularly mediated by local actions within the amygdala. Translational work in human populations, using both genetics and pharmacology as a window into the effects of anandamide signaling in humans, has suggested that similar to rodents, anandamide may constrain stress, anxiety and fear, in part through regulating amygdala reactivity to threat and challenge. Together, these data would suggest that approaches to regulating anandamide signaling in humans may be a novel approach to treating stress-related psychiatric illnesses.

Selected publications

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.
Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1.

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder
Neuropsychopharmacology. 2018 Jan;43(1):80-102. doi: 10.1038/npp.2017.162.

Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
J Neurosci. 2015 Mar 4;35(9):3879-92. doi: 10.1523/JNEUROSCI

FAAH genetic variation enhances fronto-amygdala function in mouse and human.
Nat Commun. 2015 Mar 3;6:6395. doi: 10.1038/ncomms7395.

Coming soon

  1. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    Tuesday 25 June 2019 - Tuesday 9 July 2019

    Talks are open to everyone

  2. Conference – Stuart Firestein

    Thursday 27 June 2019 / 14:00

    How Biology Perceives Chemistry: The Mammalian Olfactory System

  3. Conference Labex Trail – Goran Angelovski

    Friday 28 June 2019 / 14:30

    Molecular fMRI with Bioresponsive Probes

  4. Atout neurones

    Saturday 29 June 2019 / 14:00 - 20:00

    Tournoi de bridge au profit de la recherche sur le cerveau et conférence d'Olivier Nicole (IMN)

  5. Seminar – Anne Brunet

    Tuesday 2 July 2019 / 11:30

    Understanding and modeling aging


Friday 7 June 2019
11:30 - 12:30
Event Category: