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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190607T113000
DTEND;TZID=Europe/Paris:20190607T123000
DTSTAMP:20260409T003205
CREATED:20190125T153240Z
LAST-MODIFIED:20190522T153643Z
UID:102567-1559907000-1559910600@www.bordeaux-neurocampus.fr
SUMMARY:Monthly PhD seminar - Matthew Hill
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine / Salle de Conférence \n\nMatthew Hill\nHotchkiss Brain Institute\,\nMathison Centre for Mental Health Research.\nDepartments of Cell Biology and Anatomy and Psychiatry. \nInvited by the NBA and Bordeaux Neurocampus.\n \n\nAbstract\nEndocannabinoids are well established to buffer stress responses in the brain\, with emerging evidence suggest that they exhibit both tonic control of stress responses at rest\, as well as phasic control in response to stress itself. Converging evidence has indicated that anandamide may be the primary endocannabinoid regulating tonic control of the stress response\, and that disruption of anandamide signaling may facilitate generation of a stress response. Our work has suggested that this effect may particularly mediated by local actions within the amygdala. Translational work in human populations\, using both genetics and pharmacology as a window into the effects of anandamide signaling in humans\, has suggested that similar to rodents\, anandamide may constrain stress\, anxiety and fear\, in part through regulating amygdala reactivity to threat and challenge. Together\, these data would suggest that approaches to regulating anandamide signaling in humans may be a novel approach to treating stress-related psychiatric illnesses. \nSelected publications\nProtective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.\nMol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1. \nIntegrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder\nNeuropsychopharmacology. 2018 Jan;43(1):80-102. doi: 10.1038/npp.2017.162. \nCorticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. \nJ Neurosci. 2015 Mar 4;35(9):3879-92. doi: 10.1523/JNEUROSCI \nFAAH genetic variation enhances fronto-amygdala function in mouse and human.\nNat Commun. 2015 Mar 3;6:6395. doi: 10.1038/ncomms7395. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/monthly-phd-seminar-matthew-hill/
CATEGORIES:For scientists,home-event,Monthly conferences
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