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Conférence mensuelle – Matthew Hill

vendredi 7 juin 2019 / 11:30 - 12:30

Encannabinoids: multi-modal regulators of the stress response

Lieu : Centre Broca Nouvelle-Aquitaine / Salle de Conférence

Matthew Hill
Hotchkiss Brain Institute,
Mathison Centre for Mental Health Research.
Departments of Cell Biology and Anatomy and Psychiatry.

Invité par la NBA et Bordeaux Neurocampus dans le cadre des PHD seminar.


Endocannabinoids are well established to buffer stress responses in the brain, with emerging evidence suggest that they exhibit both tonic control of stress responses at rest, as well as phasic control in response to stress itself. Converging evidence has indicated that anandamide may be the primary endocannabinoid regulating tonic control of the stress response, and that disruption of anandamide signaling may facilitate generation of a stress response. Our work has suggested that this effect may particularly mediated by local actions within the amygdala. Translational work in human populations, using both genetics and pharmacology as a window into the effects of anandamide signaling in humans, has suggested that similar to rodents, anandamide may constrain stress, anxiety and fear, in part through regulating amygdala reactivity to threat and challenge. Together, these data would suggest that approaches to regulating anandamide signaling in humans may be a novel approach to treating stress-related psychiatric illnesses.

Selected publications

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice.
Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0215-1.

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder
Neuropsychopharmacology. 2018 Jan;43(1):80-102. doi: 10.1038/npp.2017.162.

Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
J Neurosci. 2015 Mar 4;35(9):3879-92. doi: 10.1523/JNEUROSCI

FAAH genetic variation enhances fronto-amygdala function in mouse and human.
Nat Commun. 2015 Mar 3;6:6395. doi: 10.1038/ncomms7395.


  1. Séminaire – Cordelia Imig

    lundi 22 juillet 2019 / 11:00

    IINS group leader candidate

  2. Seminaire – Shi-Wei CHU

    vendredi 26 juillet 2019 / 11:00 - 12:00

    Faster, deeper, higher resolution optical microscopy for brain imaging

  3. Conférence mensuelle (PhD seminar series) – Laurent Bourdieu

    vendredi 6 septembre 2019 / 11:30

    Fast 3D imaging of neuronal activity in visual cortex across multiple layers in awake mice

  4. Cajal lectures : Whole brain imaging

    lundi 9 septembre 2019 - vendredi 27 septembre 2019

    Free entrance lectures / Venue: CGFB

  5. Séminaire – Francisco Papaleo

    vendredi 13 septembre 2019 / 11:30

    Bottom-Up and Top-Down Control of Emotion Recognition.

Conférence internationale : REWARD

Du 2 au 4 octobre

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Date :
vendredi 7 juin 2019
Heure :
11:30 - 12:30
Catégorie d’Évènement: