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Seminar – Isabelle Brunet

Friday 23 September / 11:30

Venue: Centre Broca Nouvelle-Aquitaine


Isabelle Brunet
Center for Interdisciplinary Research in Biology (CIRB)
College de France
https://www.college-de-france.fr/molecular-control-of-neuro-vascular-development

Invited by Sandrine Bertrand

Title

Neuro-vascular interactions in health and diseases

Abstract

Our laboratory studies vascular and neuronal development, with particular interests in mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features, including extension of filopodia that explore the tip cell environment, lack of a lumen and a slow proliferation rate. Capillary sprouting shows morphological similarities to axon guidance. Our research is focused on the relationship between vascular and nervous system and how they develop interactions at a molecular. This approach led us to investigate how neuro-vascular interactions become functional and how deregulation of each component, vascular or neuronal, could affect the organism in health and diseases. Our reasearch program aims to decipher neurovascular interactions in mice, molecular determinant regulating those interactions, and how neuro-vascular development can affect physiological functions. Neuronal and vascular developments require a refined spatio-temporal orchestration to guide axons and vascular plexus through the organism, align vessels with nerves, and allow appropriate functional connections to establish between the two systems. Indeed, accurate neurovascular crosstalk is of tremendous importance as it regulates many vital aspects of body homeostasis such as neuronal activity and plasticity, blood pressure and heart rate.

Key publications

Ephrin-A4/EphA4 signaling in arterial innervation development and physiology
Simonnet, E.*, Martin-Pires, S.*, Pardanaud, L. , Eichmann, A., Henrion, D., Silvestre, J.S. and Brunet I. Ephrin-A4/EphA4 signaling in arterial innervation development and physiology. Submitted

Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain
Karam, M. Malkinson G., & Brunet, I. Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain. JCBFM (2022) doi: 10.1101/2021.10.08.463501

Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve
Taïb, S. , Lamandé, N., Martin, S., Topilko, P.&  Brunet, I.  Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve. Elife (2022)
Neuropathie périphérique induite par l’oxaliplatine
Taïb, S., Durand, J. & Brunet, I. Neuropathie périphérique induite par l’oxaliplatine. Médecine/sciences 36, 33–37 (2020)
Tissue-cleared 3D imaging followed by protein analysis: a single biopsy for multiple information
Azar S., Letaïef, L., Malkinson, G., Martin, S., Validire, P., Teillaud, J.L., Dieu-Nosjean, M.C. & Brunet, I. Tissue-cleared 3D imaging followed by protein analysis: a single biopsy for multiple information. In revision to NatureCom (2020)
The functions of arterial sympathetic innervation: From development to pathology
Simonnet, É. & Brunet, I. The functions of arterial sympathetic innervation: From development to pathology. Medecine/Sciences 35, 643–650 (2019) 
Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity
Pardanaud, L., Pibouin-Fragner, L., Dubrac, A., Mathivet, T., English, I., Brunet I, Simons, M., Eichmann, A.. Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Circulation Research119,607–620 (2016)
NG2 glia are required for vessel network formation during embryonic development
Minocha, S., Valloton, D., Brunet, I., Eichmann, A., Hornung, J.P., Lebrand, C. NG2 glia are required for vessel network formation during embryonic development. Elife 4, 1–23 (2015)
Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons
Fortuna, V., Pardanaud, L., Brunet, I, Ola, R., Ristori, E., Nicoli, S., Eichmann, A. Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Rep 11, 1786-1796 (2015)
Arterial innervation in development and disease
Eichmann, A. & Brunet, I. Arterial innervation in development and disease. Sci. Transl. Med. 6, 1–5 (2014)
Netrin-1 guides sympathetic arterial innervation
Brunet, I#Gordon,E., Han J., Broqueres-You, D.…, Simons, M., Levy, B.I., Tessier-Lavigne, M., Grenz, A., Eltzschig, H. and  Eichmann, A.#. Netrin-1 guides sympathetic arterial innervation. Journal of Clinical Investigation124(7), 3230-3240 (2014) #: corresponding author
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Details

Date:
Friday 23 September
Time:
11:30
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