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DTSTART;TZID=Europe/Paris:20220923T113000
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DTSTAMP:20260410T180323
CREATED:20220722T132541Z
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UID:149917-1663932600-1663932600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Isabelle Brunet
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nIsabelle Brunet\nCenter for Interdisciplinary Research in Biology (CIRB)College de France\nhttps://www.college-de-france.fr/molecular-control-of-neuro-vascular-development \nInvited by Sandrine Bertrand \nTitle\nNeuro-vascular interactions in health and diseases \nAbstract\nOur laboratory studies vascular and neuronal development\, with particular interests in mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features\, including extension of filopodia that explore the tip cell environment\, lack of a lumen and a slow proliferation rate. Capillary sprouting shows morphological similarities to axon guidance. Our research is focused on the relationship between vascular and nervous system and how they develop interactions at a molecular. This approach led us to investigate how neuro-vascular interactions become functional and how deregulation of each component\, vascular or neuronal\, could affect the organism in health and diseases. Our reasearch program aims to decipher neurovascular interactions in mice\, molecular determinant regulating those interactions\, and how neuro-vascular development can affect physiological functions. Neuronal and vascular developments require a refined spatio-temporal orchestration to guide axons and vascular plexus through the organism\, align vessels with nerves\, and allow appropriate functional connections to establish between the two systems. Indeed\, accurate neurovascular crosstalk is of tremendous importance as it regulates many vital aspects of body homeostasis such as neuronal activity and plasticity\, blood pressure and heart rate. \nKey publications\n\n\n\nEphrin-A4/EphA4 signaling in arterial innervation development and physiology\n\nSimonnet\, E.*\, Martin-Pires\, S.*\, Pardanaud\, L. \, Eichmann\, A.\, Henrion\, D.\, Silvestre\, J.S. and Brunet I. Ephrin-A4/EphA4 signaling in arterial innervation development and physiology. Submitted\n\n\n\n\n\n\n\nHeterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain\nKaram\, M. Malkinson G.\, & Brunet\, I. Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain. JCBFM (2022) doi: 10.1101/2021.10.08.463501 \n\n\n\n\n\n\nMyelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve\n\nTaïb\, S. \, Lamandé\, N.\, Martin\, S.\, Topilko\, P.&  Brunet\, I.  Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve. Elife (2022)\n\n\n\n\n\n\n\n\nNeuropathie périphérique induite par l’oxaliplatine\n\nTaïb\, S.\, Durand\, J. & Brunet\, I. Neuropathie périphérique induite par l’oxaliplatine. Médecine/sciences 36\, 33–37 (2020)\n\n\n\n\n\n\n\n\nTissue-cleared 3D imaging followed by protein analysis: a single biopsy for multiple information\n\nAzar S.\, Letaïef\, L.\, Malkinson\, G.\, Martin\, S.\, Validire\, P.\, Teillaud\, J.L.\, Dieu-Nosjean\, M.C. & Brunet\, I. Tissue-cleared 3D imaging followed by protein analysis: a single biopsy for multiple information. In revision to NatureCom (2020)\n\n\n\n\n\n\n\n\nThe functions of arterial sympathetic innervation: From development to pathology\n\nSimonnet\, É. & Brunet\, I. The functions of arterial sympathetic innervation: From development to pathology. Medecine/Sciences 35\, 643–650 (2019) \n\n\n\n\n\n\n\n\nSympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity\n\nPardanaud\, L.\, Pibouin-Fragner\, L.\, Dubrac\, A.\, Mathivet\, T.\, English\, I.\, Brunet I\, Simons\, M.\, Eichmann\, A.. Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Circulation Research. 119\,607–620 (2016)\n\n\n\n\n\n\n\n\nNG2 glia are required for vessel network formation during embryonic development\n\nMinocha\, S.\, Valloton\, D.\, Brunet\, I.\, Eichmann\, A.\, Hornung\, J.P.\, Lebrand\, C. NG2 glia are required for vessel network formation during embryonic development. Elife 4\, 1–23 (2015)\n\n\n\n\n\n\n\n\nVascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons\n\nFortuna\, V.\, Pardanaud\, L.\, Brunet\, I\, Ola\, R.\, Ristori\, E.\, Nicoli\, S.\, Eichmann\, A. Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Rep 11\, 1786-1796 (2015)\n\n\n\n\n\n\n\n\nArterial innervation in development and disease\n\nEichmann\, A. & Brunet\, I. Arterial innervation in development and disease. Sci. Transl. Med. 6\, 1–5 (2014)\n\n\n\n\n\n\n\n\nNetrin-1 guides sympathetic arterial innervation\n\nBrunet\, I#\, Gordon\,E.\, Han J.\, Broqueres-You\, D.…\, Simons\, M.\, Levy\, B.I.\, Tessier-Lavigne\, M.\, Grenz\, A.\, Eltzschig\, H. and  Eichmann\, A.#. Netrin-1 guides sympathetic arterial innervation. Journal of Clinical Investigation\, 124(7)\, 3230-3240 (2014) #: corresponding author\n\n\n\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-isabelle-brunet-sept-2022/
CATEGORIES:For scientists,home-event,Seminars
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