Spatial Relational Memory Requires Hippocampal Adult Neurogenesis
PLoS ONE. 2008-04-09; 3(4): e1959
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The dentate gyrus of the hippocampus is one of the few regions of the mammalian
brain where new neurons are generated throughout adulthood. This adult
neurogenesis has been proposed as a novel mechanism that mediates spatial memory.
However, data showing a causal relationship between neurogenesis and spatial
memory are controversial. Here, we developed an inducible transgenic strategy
allowing specific ablation of adult-born hippocampal neurons. This resulted in an
impairment of spatial relational memory, which supports a capacity for flexible,
inferential memory expression. In contrast, less complex forms of spatial
knowledge were unaltered. These findings demonstrate that adult-born neurons are
necessary for complex forms of hippocampus-mediated learning.