Jean-Michel Revest

Team leader

Researcher - PhD (CR) / CNRS

/ Contact

+33 5 57 57 36 72/36 78


/ Address of work
Neurocentre Magendie - INSERM U 1215 - 146, rue Léo Saignat - 33077 Bordeaux

Selected publications

  • Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, Maldonado R, Ozaita A. Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.Neurobiol Dis. 2019 Jan 24. pii: S0969-9961(18)30685-5. doi: 10.1016/j.nbd.2019.01.014.
  • Cathala A, Devroye C, Drutel G, Revest JM, Artigas F, Spampinato U. Serotonin2B receptors in the rat dorsal raphe nucleus exert a GABA-mediated tonic inhibitory control on serotonin neurons. Exp Neurol. 2018 Sep 23. pii: S0014-4886(18)30282-6. doi: 10.1016/j.expneurol.2018.09.015.
  • Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.
  • Devroye C, Cathala A, Maitre M, Piazza PV, Abrous DN, Revest JM, Spampinato U. Serotonin2C receptor stimulation inhibits cocaine-induced Fos expression and DARPP-32 phosphorylation in the rat striatum independently of dopamine outflow. Neuropharmacology. 2015 Feb;89:375-81.
  • Cathala A, Devroye C, Maitre M, Piazza PV, Abrous DN, Revest JM, Spampinato U. Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine. Addict Biol. 2015 May;20(3):445-57. doi: 10.1111/adb.12137. Epub 2014 Mar 24.
  • Vallée M, Vitiello S*, Bellocchio L*, Hébert-Chatelain E*, Monlezun S*, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G*, Piazza PV*. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985.
  • JM Revest, A Le Roux, V Roullot-Lacarrière, N Kaouane, M Vallée, F Kasanetz, F Rougé-Pont, F Tronche, A Desmedt and PV Piazza. BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Molecular Psychiatry. 2013 Oct 15. doi: 10.1038/mp.2013.134.
  • Kasanetz F*, Lafourcade M*, Deroche-Gamonet V*, Revest JM, Berson N, Balado E, Fiancette JF, Renault P, Piazza PV*, Manzoni OJ*. Prefrontal synaptic markers of cocaine addiction-like behavior in rats. Molecular Psychiatry. Epub 2012 May 15. *= have equally contributed to the work.
  • Maitre M, Roullot-Lacarrière V, Piazza PV, Revest JM. Western blot detection of brain phosphoproteins after performing Laser Microdissection and Pressure Catapulting (LMPC). J Neurosci Methods. 2011 Jun 15;198(2):204-12. Epub 2011 Apr 12.
  • Massa F, Koelh M, Wiesner T, Grosjean N, Revest JM, Piazza PV, Abrous DN, Oliet SH. Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6644-9. Epub 2011 Apr 4.
  • JM Revest, Kaouane N, Mondin M, Le Roux A, Rougé-Pont F, Vallée M, Barik J, Tronche F, Desmedt A, Piazza PV. Glucocorticoid treatment induces expression of Egr-1 and synapsin-I proteins in primary culture of hippocampal neurons. Molecular Psychiatry. 2010 Dec;15(12):1125. Epub 2010 Apr 6.
  • S Tronel, L Belnoue, N Grosjean, JM Revest, PV Piazza, M Koehl, DN Abrous. Adult-born neurons are necessary for extended contextual discrimination. Hippocampus. 2012 Feb;22(2):292-8. Epub 2010 Nov 3.
  • JM Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt and P V Piazza. The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib. Molecular Psychiatry. 2010. Dec;15(12): 1140-1151.
  • Sarrazin N*, Di Blasi F*, Roullot-Lacarrière V, Rougé-Pont F, Le Roux A, Costet P, Revest JM*, Piazza PV*. Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. PLoS One. 2009. Nov 2;4(11):e7704. *= have equally contributed to the work.
  • Revest JM*, David Dupret *, Muriel Koehl, Cindy Funk-Reiter, Noelle Grosjean, Koehl M, Piazza PV* and Abrous DN*. Adult Hippocampal Neurogenesis is involved in Anxiety-related Behaviors. Molecular Psychiatry. 2009. 14(10):959-67. *= have equally contributed to the work. Cover page.
  • Dupret D*, Revest JM*, Koehl M, Ichas F, De Giorgi F, Costet P, Abrous DN* and Piazza PV*. Spatial relational memory requires hippocampal adult neurogenesis. PLoSOne. 2008. 3(4): e1959. *= have equally contributed to the work.
  • Revest JM, Di Blasi F, Kitchener P, Rouge-Pont F, Desmedt A, Turiault M, Tronche F, Piazza PV. The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci. 2005. May;8(5):664-72.
  • Petiot A., Conti F. J. A.,. Grose R, Revest JM., Hodivala-Dilke K. M., and Dickson C. A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development. 2003. 130: 5493-5501.
  • Murakami A, Ishida S, Thurlow J, Revest JM and Dickson C. SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter. Nucleic Acids Res. 2001. 29: 3347-3355.
  • Revest JM, Suniara RK, Kerr K, Owen JJT, and Dickson C. Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb. J Immunol. 2001. 167: 1954-1961.
  • Revest JM, Spencer-Dene B, Kerr K, De Moerlooze L, Rosewell I, Dickson C. Fibroblast Growth Factor Receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx-1 or Bmp4. Dev. Biol. 2001. 1;231(1):47-62.
  • Beer HD, Vindevoghel L, Gait MJ, Revest JM, Duan DR, Mason I, Dickson C, Werner S. Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain. J Biol Chem. 2000. 26;275(21):16091-7.
  • Revest JM, DeMoerlooze L, Dickson C. Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence. J Biol Chem. 2000. 17;275(11):8083-90.
  • De Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, Dickson C. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development. 2000. 127(3):483-92.
  • Revest JM, Faivre-Sarrailh C, Schachner M, Rougon G. Bidirectional signaling between neurons and glial cells via the F3 neuronal adhesion molecule. Adv Exp Med Biol. 1999; 468:309-18. Review.
  • Revest JM, Faivre-Sarrailh C, Maeda N, Noda M, Schachner M, Rougon G. The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells. Eur J Neurosci. 1999. 11(4):1134-47.
  • Buttiglione M, Revest JM, Pavlou O, Karagogeos D, Furley A, Rougon G, Faivre-Sarrailh C. A functional interaction between the neuronal adhesion molecules TAG-1 and F3 modulates neurite outgrowth and fasciculation of cerebellar granule cells. J Neurosci. 1998. 1;18(17):6853-70.

    Xiao ZC, Revest JM, Laeng P, Rougon G, Schachner M, Montag D. Defasciculation of neurites is mediated by tenascin-R and its neuronal receptor F3/11. J Neurosci Res. 1998. 15;52(4):390-404.

  • Buttiglione M, Revest JM, Rougon G, Faivre-Sarrailh C. F3 neuronal adhesion molecule controls outgrowth and fasciculation of cerebellar granule cell neurites: a cell-type-specific effect mediated by the Ig-like domains. Mol Cell Neurosci. 1996. 8(1):53-69.