Quentin Leyrolle

Scientific articles

• Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study.
  Camille Amadieu, Quentin Leyrolle, Milena Farneti, Andrea Anesi, Eva Bruchet, Juliette Montet, Sandra Dexpert, David Gaudout, Fulvio Mattivi, Line Pourtau, Nathalie Castanon, Lucile Capuron.
  The American Journal of Clinical Nutrition. 2025-12-01. 122(6) : 1625-1635.
  10.1016/j.ajcnut.2025.09.050
• Obesity-induced emotional alterations in mice are associated with impairments of tryptophan metabolism along the kynurenine and indole pathways
  Nathalie Castanon, Sylvie Vancassel, Camille Amadieu, Sofia Cussotto, Quentin Leyrolle, Céline Lucas, Antoine Lefevre, Patrick Emond, Anne-Laure Dinel, Lucile Capuron.
  Brain, Behavior, and Immunity. 2025-11-01. 130 : 106107.
  10.1016/j.bbi.2025.106107
• Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
  Audrey M. Neyrinck, Hany Ahmed, Quentin Leyrolle, Sophie Leclercq, Camille Amadieu, Topi Meuronen, Sophie Layé, Patrice D. Cani, Olli Kärkkäinen, Laure B. Bindels, Kati Hanhineva, Nathalie M. Delzenne.
  Sci Rep. 2025-05-02. 15(1)
  10.1038/s41598-025-99047-z
• Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
  Camille Amadieu, Hany Ahmed, Sophie Leclercq, Ville Koistinen, Quentin Leyrolle, Peter Stärkel, Laure B. Bindels, Sophie Layé, Audrey M. Neyrinck, Olli Kärkkäinen, Philippe De Timary, Kati Hanhineva, Nathalie M. Delzenne.
  Clinical Nutrition ESPEN. 2025-04-01. 66 : 361-371.
  10.1016/j.clnesp.2025.01.046
• Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
  Sophie Leclercq, Hany Ahmed, Camille Amadieu, Géraldine Petit, Ville Koistinen, Quentin Leyrolle, Marie Poncin, Peter Stärkel, Eloise Kok, Pekka J Karhunen, Philippe de Timary, Sophie Laye, Audrey M Neyrinck, Olli K Kärkkäinen, Kati Hanhineva, Nathalie Delzenne.
  eLife. 2024-11-29. 13
  10.7554/eLife.96937
• Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging
  Camille Mougin, Mathilde Chataigner, Céline Lucas, Quentin Leyrolle, Véronique Pallet, Sophie Layé, Elodie Bouvret, Anne-Laure Dinel, Corinne Joffre.
  Foods. 2023-11-21. 12(23) : 4199.
  10.3390/foods12234199
• The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain.
  Quentin Leyrolle, Lucia Prado-Perez, Sophie Layé.
  Front. Nutr.. 2023-06-09. 10
  10.3389/fnut.2023.1155533
• Microbiota-derived metabolites as drivers of gut-brain communication.
  Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Kärkkäinen, Sophie Layé, Nathalie Delzenne, Kati Hanhineva.
  Gut Microbes. 2022-07-28. 14(1)
  10.1080/19490976.2022.2102878
• Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
  Quentin Leyrolle, Renata Cserjesi, Romane Demeure, Audrey M. Neyrinck, Camille Amadieu, Julie Rodriguez, Olli Kärkkäinen, Kati Hanhineva, Nicolas Paquot, Miriam Cnop, Patrice D. Cani, Jean-Paul Thissen, Laure B. Bindels, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne.
  Nutrients. 2021-12-29. 14(1) : 147.
  10.3390/nu14010147
• Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients
  Camille Amadieu, Valentin Coste, Audrey M. Neyrinck, Victoria Thijssen, Quentin Leyrolle, Laure B. Bindels, Hubert Piessevaux, Peter Stärkel, Philippe de Timary, Nathalie M. Delzenne, Sophie Leclercq.
  Gut Microbes. 2021-12-20. 14(1)
  10.1080/19490976.2021.2007042
• Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
  Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar.
  Cannabis and Cannabinoid Research. 2021-12-01. 6(6) : 488-507.
  10.1089/can.2020.0170
• N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
  Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar.
  Glia. 2021-09-14.
  10.1002/glia.24088
• Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial
  Quentin Leyrolle, Renata Cserjesi, Maria D.G.H. Mulders, Giorgia Zamariola, Sophie Hiel, Marco A. Gianfrancesco, Daphné Portheault, Camille Amadieu, Laure B. Bindels, Sophie Leclercq, Julie Rodriguez, Audrey M. Neyrinck, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Jérome Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne.
  Brain, Behavior, and Immunity. 2021-05-01. 94 : 289-298.
  10.1016/j.bbi.2021.01.014
• Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients
  Quentin Leyrolle, Renata Cserjesi, Maria D.G.H. Mulders, Giorgia Zamariola, Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Camille Amadieu, Sophie Leclercq, Laure B. Bindels, Audrey M. Neyrinck, Patrice D. Cani, Olli Karkkainen, Kati Hanhineva, Nicolas Lanthier, Pierre Trefois, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M. Delzenne.
  Clinical Nutrition. 2021-04-01. 40(4) : 2035-2044.
  10.1016/j.clnu.2020.09.025
• Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice
  Christelle Knudsen, Audrey M Neyrinck, Quentin Leyrolle, Pamela Baldin, Sophie Leclercq, Julie Rodriguez, Martin Beaumont, Patrice D Cani, Laure B Bindels, Nicolas Lanthier, Nathalie M Delzenne.
  The Journal of Nutrition. 2021-03-10. 151(6) : 1507-1516.
  10.1093/jn/nxab032
• Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial
  Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle, Laure B. Bindels, Carolina Gomes da Silveira Cauduro, Maria D.G.H. Mulders, Giorgia Zamariola, Anne-Sophie Azzi, Gaetan Kalala, Barbara D. Pachikian, Camille Amadieu, Audrey M. Neyrinck, Audrey Loumaye, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Olivier Klein, Olivier Luminet, Jérôme Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Nathalie M. Delzenne.
  Clinical Nutrition. 2020-12-01. 39(12) : 3618-3628.
  10.1016/j.clnu.2020.04.005
• Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
  C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé.
  Nat Commun. 2020-11-30. 11(1)
  10.1038/s41467-020-19861-z
• Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder
  Sophie Leclercq, Tiphaine Le Roy, Sonia Furgiuele, Valentin Coste, Laure B. Bindels, Quentin Leyrolle, Audrey M. Neyrinck, Caroline Quoilin, Camille Amadieu, Géraldine Petit, Laurence Dricot, Vanessa Tagliatti, Patrice D. Cani, Kristin Verbeke, Jean-Marie Colet, Peter Stärkel, Philippe de Timary, Nathalie M. Delzenne.
  Cell Reports. 2020-10-01. 33(2) : 108238.
  10.1016/j.celrep.2020.108238
• Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
  Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar.
  Neuropsychopharmacol.. 2020-08-11.
  10.1038/s41386-020-00793-7
• Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
  Julie Rodriguez, Sophie Hiel, Audrey M Neyrinck, Tiphaine Le Roy, Sarah A Pötgens, Quentin Leyrolle, Barbara D Pachikian, Marco A Gianfrancesco, Patrice D Cani, Nicolas Paquot, Miriam Cnop, Nicolas Lanthier, Jean-Paul Thissen, Laure B Bindels, Nathalie M Delzenne.
  Gut. 2020-02-10. 69(11) : 1975-1987.
  10.1136/gutjnl-2019-319726
• Food4Gut multicenter randomized placebo-controlled trial. v1
  Sophie Hiel, Marco A. Gianfrancesco, Julie Rodriguez, Daphnée Portheault, Quentin Leyrolle, Laure B. Bindels, Carolina Gomes da Silveira Cauduro, Maria D.G.H. Mulders, Giorgia Zamariola, Anne-Sophie Azzi, Gaetan Kalala, Barbara D. Pachikian, Camille Amadieu, Audrey M. Neyrinck, Audrey Loumaye, Patrice D. Cani, Nicolas Lanthier, Pierre Trefois, Olivier Klein, Olivier Luminet, Jérôme Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Nathalie M. Delzenne.
  . 2019-12-16.
  10.17504/protocols.io.baidica6
• SUN-PO285: Implication of the Gut Microbiota in Personalized Metabolic Response to Dietary Inulin in Obese Patients
  J. Rodriguez, A. Neyrinck, T. Le roy, S. Hiel, Q. Leyrolle, L. Bindels, P. Cani, M. Cnop, N. Paquot, N. Lanthier, J.P. Thissen, N. Delzenne.
  Clinical Nutrition. 2019-09-01. 38 : S164.
  10.1016/s0261-5614(19)32915-2
• Direct and indirect effects of lipids on microglia function
  Q. Leyrolle, S. Layé, A. Nadjar.
  Neuroscience Letters. 2019-08-01. 708 : 134348.
  10.1016/j.neulet.2019.134348
• Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
  F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar.
  Brain, Behavior, and Immunity. 2019-05-01.
  10.1016/j.bbi.2019.05.016
• Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
  V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé.
  Brain, Behavior, and Immunity. 2018-10-01. 73 : 427-440.
  10.1016/j.bbi.2018.06.004
• Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
  Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé.
  Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. . : 367-384.
  10.1016/b978-0-12-811959-4.00024-9
• Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
  A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 19-26.
  10.1016/j.pnpbp.2016.07.004
• Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
  Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra.
  PLoS Biol. . 14(9) : e1002554.
  10.1371/journal.pbio.1002554
• Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
  Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra.
  PLOS Biology. 2016-06-30. 14(6) : e1002508.
  10.1371/journal.pbio.1002508
• Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
  Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra.
  PLoS Biol. 2016-05-26. 14(5) : e1002466.
  10.1371/journal.pbio.1002466
• N-3 PUFAs and neuroinflammatory processes in cognitive disorders
  Quentin Leyrolle, Sophie Layé, Agnès Nadjar.
  OCL. 2016-01-01. 23(1) : D103.
  10.1051/ocl/2015064
• Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota
  Charlotte Madore, Quentin Leyrolle, Chloé Lacabanne, Anouk Benmamar-Badel, Corinne Joffre, Agnes Nadjar, Sophie Layé.
  Neural Plasticity. 2016-01-01. 2016 : 1-15.
  10.1155/2016/3597209