Physiopathology and therapeutic approaches of stress-related diseases
Our team aims to characterize the neurobiological basis of stress-related diseases, especially traumatic memories, and addiction and cognitive deficits targeting the CB1 receptor. By applying a translational research, our work is dedicated to design and develop innovative therapeutic approaches. The first line of research focuses on the study of the biological system involving glucocorticoid hormones (GC) and more specifically on the identification of the molecular and cellular signaling pathways mediating the memory modulating effects of these hormones. The second line of research focuses on the study of the biological system involving the neurosteroid pregnenolone (PREG) and aims to characterize the cellular and molecular mechanisms involved with regard to the harmful effects of cannabis and cognitive deficits.
Innovative techniques: in vitro and in vivo High Throughout Screening of cell signaling pathways, transgenic mice, mice behavior.
Mots clés
Apprentissage, Biochemistry, Cognition, Comportement, Emotion, Fonctions exécutives, Imagerie cellulaire in vitro ou in vivo, Maladies Neuro-développementales, Modèle génétique, Mémoire, Retard mental, Signalisation, Stress, Trafic intracellulaire, Troubles anxieux, Troubles du comportement, addictionSelected publications
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PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory.
C. Bouarab, V. Roullot-Lacarrière, M. Vallée, A. Le Roux, C. Guette, M. Mennesson, A. Marighetto, A. Desmedt, P. V. Piazza, J. M. Revest.
Mol Psychiatry. 2021-01-28.
DOI: 10.1038/s41380-021-01024-1 -
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib.
JM Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt and P V Piazza..
Molecular Psychiatry. 2010-4-6. 15 (12) : 1140-1151.
DOI: 10.1038/mp.2010.40 -
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, Maldonado R, Ozaita A..
Neurobiol Dis.. 2019-01-24. 125 : 92-106.
DOI: 10.1016/j.nbd.2019.01.014 -
Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior.
Véronique Deroche-Gamonet, Jean-Michel Revest, Jean-François Fiancette, Eric Balado, Muriel Koehl, Noëlle Grosjean, Djoher Nora Abrous, Pier-Vincenzo Piazza.
Mol Psychiatry. 2018-03-05. 24 (2) : 312-320.
DOI: 10.1038/s41380-018-0038-0 -
Pregnenolone can protect the brain from cannabis intoxication.
Monique Vallée, Sergio Vitiello, Luigi Bellocchio, Etienne Hébert-Chatelain, Stéphanie Monlezun, Elena Martin-Garcia, Fernando Kasanetz, Gemma L. Baillie, Francesca Panin, Adeline Cathala, Valérie Roullot-Lacarrière, Sandy Fabre, Dow P. Hurst, Diane L. Lynch, Derek M. Shore, Véronique Deroche-Gamonet, Umberto Spampinato, Jean-Michel Revest, Rafael Maldonado, Patricia H. Reggio, Ruth A. Ross, Giovanni Marsicano, Pier Vincenzo Piazza.
Science. 2014-01-02. 343 (6166) : 94-98.
DOI: 10.1126/science.1243985 -
BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
J-M Revest, A Le Roux, V Roullot-Lacarrière, N Kaouane, M Vallée, F Kasanetz, F Rougé-Pont, F Tronche, A Desmedt & P V Piazza.
Molecular Psychiatry. . 19 : 1001–1009.
DOI: 10.1038/mp.2013.134 -
Western blot detection of brain phosphoproteins after performing Laser Microdissection and Pressure Catapulting (LMPC).
Maitre M, Roullot-Lacarrière V, Piazza PV, Revest JM..
J Neurosci Methods.. 2011-06-15. 198 (2) : 204-12.
DOI: 10.1016/j.jneumeth.2011.04.001 -
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib.
JM Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt and P V Piazza..
Molecular Psychiatry. 2010-4-6. 15 (12) : 1140-1151.
DOI: 10.1038/mp.2010.40 -
Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors.
Sarrazin N, Di Blasi F, Roullot-Lacarrière V, Rougé-Pont F, Le Roux A, Costet P, Revest JM, Piazza PV..
PLoS One. 2009-11-02. 4 (11) : 7704.
DOI: 10.1371/journal.pone.0007704 -
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
Revest JM, Di Blasi F, Kitchener P, Rouge-Pont F, Desmedt A, Turiault M, Tronche F, Piazza PV..
Nat Neurosci.. 2005-04-17. 8 (5) : 664-72.
DOI: 10.1038/nn1441
Team member(s)
Chercheurs, Praticiens hospitaliers...
Monique Vallée Vallée (Researcher)
Umberto Spampinato Spampinato (Professor - Hospital practitioner)
Ingénieur(e)s, technicien(ne)s
Agnès Grel Grel
Joelle Hoang-Chauhong Hoang-Chauhong
Valérie Lacarrière Lacarrière
Valérie Lalanne Lalanne
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC