Physiology and pathophysiology of executive functions


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Our objective is to unravel the neural mechanisms underlying cognitive and motor executive functions. Our main interests are the physiology of the planning, decision making, learning processes and their pathophysiological aspects such as dystonia and obsessive-compulsive disorder. We adopted a phylogenetic approach that drive us to address the question in a broad variety of vertebrates such as salamander, rodents, primates (both human and non-human) and songbirds in order to unravel the emerging complexity of the system studied along the evolution tree. We based our research on system level theoretical models validated by experimental data. Our experimental procedures range from optognetic approaches coupled with single cell electrophysiology in anaesthetized animals to multiple electrode recording in awake and behaving primates. We also conduct several clinical studies in the fields of dystonia, OCD and Parkinson’s disease.

Selected publications

Team leader

Team member(s)

Pierre Burbaud (Team leader)
Thomas Boraud (Team leader)

Chercheurs, Praticiens hospitaliers...

Arthur Leblois (Researcher)
Dominique Guehl (University Teacher- Researcher)
Emmanuel Cuny (University Teacher - Researcher - Hospital practitioner)
François Gonon (Researcher)
Nathalie Damon Perrière (Hospital practitioner)
Nicolas Mallet (Researcher)
Véronique Michel (Hospital practitioner)
Jérôme Aupy (Maître de conférence universitaire - Personnel hospitalier)

Ingénieur(e)s, technicien(ne)s


Asier Aristieta
Aude Retailleau
Estelle Dumas-Mallet
Marc Deffains


Sophie Gauthier
Roman Ursu
Lise Guilhemsang
Clara Besserer
Eduarda Gervini Zampieri Centeno
Fjola Hyseni