Pathophysiology of proteinopathies
The team has authored or co-authored over 300 professional publications in the field of neurobiology, most of which are on Parkinson’s disease and related disorders, since 2014 only, placing it at the forefront of international translational research in neurology (2021 Highly Cited Researcher Clarivate Award). The team is known for his work on the compensatory mechanisms that mask the progression Parkinson’s disease, on the pathophysiology of levodopa-induced dyskinesia, on the intimate mechanisms of cell death in Parkinson’s disease, on the modelling of disease progression and for the development of new strategies to alleviate symptoms and/or to slow disease progression. Even more important is the translational nature of the work, from bench to bedside, in close proximity with IMNc.
Mots clés
Alzheimer, Atrophie multi-systématisée, Démences, Motricité, Mouvement, Parkinson, Tau, alpha-synucléineSelected publications
-
Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay.
npj Parkinsons Dis.. 2023-09-19. 9 (1)
DOI: 10.1038/s41531-023-00579-w -
GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
Miguel Lopez‐Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard.
Movement Disorders. 2023-04-24.
DOI: 10.1002/mds.29422 -
Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease
Rémi Kinet, Benjamin Dehay.
Cells. 2023-02-15. 12 (4) : 621.
DOI: 10.3390/cells12040621 -
Monitoring α-synuclein aggregation.
Juan Estaun-Panzano, Marie-Laure Arotcarena, Erwan Bezard.
Neurobiology of Disease. 2023-01-01. 176 : 105966.
DOI: 10.1016/j.nbd.2022.105966 -
A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
Sabine Schmidhuber, Sandra Scheiblhofer, Richard Weiss, Mihály Cserepes, József Tóvári, Gabriele Gadermaier, Erwan Bezard, Francesca De Giorgi, Francois Ichas, Dirk Strunk, Markus Mandler.
Vaccines. 2022-08-30. 10 (9) : 1432.
DOI: 10.3390/vaccines10091432 -
The Zinc Ionophore Clioquinol Reduces Parkinson’s Disease Patient-Derived Brain Extracts-Induced Neurodegeneration
Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Dehay.
Mol Neurobiol. 2022-08-02.
DOI: 10.1007/s12035-022-02974-5 -
Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén.
npj Parkinsons Dis.. 2022-04-13. 8 (1)
DOI: 10.1038/s41531-022-00299-7 -
Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.
Arotcarena ML, Soria FN, Cunha A, Doudnikoff E, Prévot G, Daniel J, Blanchard-Desce M, Barthélémy P, Bezard E, Crauste-Manciet S, Dehay B..
Aging cell. .
DOI: 10.1111/acel.13584 -
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay.
Brain. 2022-03-14. 145 (3) : 1001-1017.
DOI: 10.1093/brain/awab374 -
Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas.
Biomolecules. 2022-03-11. 12 (3) : 436.
DOI: 10.3390/biom12030436 -
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism
Leyre Merino-Galan, Haritz Jimenez-Urbieta, Marta Zamarbide, Tatiana Rodríguez-Chinchilla, Arantzazu Belloso-Iguerategui, Enrique Santamaria, Joaquín Fernández-Irigoyen, Ana Aiastui, Evelyne Doudnikoff, Erwan Bézard, Alberto Ouro, Shira Knafo, Belén Gago, Ana Quiroga-Varela, María Cruz Rodríguez-Oroz.
Brain. 2022-03-04.
DOI: 10.1093/brain/awac087 -
The different autophagy degradation pathways and neurodegeneration
Angeleen Fleming, Mathieu Bourdenx, Motoki Fujimaki, Cansu Karabiyik, Gregory J. Krause, Ana Lopez, Adrián Martín-Segura, Claudia Puri, Aurora Scrivo, John Skidmore, Sung Min Son, Eleanna Stamatakou, Lidia Wrobel, Ye Zhu, Ana Maria Cuervo, David C. Rubinsztein.
Neuron. 2022-03-01. 110 (6) : 935-966.
DOI: 10.1016/j.neuron.2022.01.017 -
How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research
Erwan Bezard.
Biomolecules. 2022-01-28. 12 (2) : 228.
DOI: 10.3390/biom12020228 -
Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas.
npj Parkinsons Dis.. 2022-01-13. 8 (1)
DOI: 10.1038/s41531-021-00264-w -
Maladie de Parkinson
Erwan Bezard, Benjamin Dehay.
Med Sci (Paris). 2022-01-01. 38 (1) : 45-51.
DOI: 10.1051/medsci/2021241 -
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Javier Blesa, Guglielmo Foffani, Benjamin Dehay, Erwan Bezard, Jose A. Obeso.
Nat Rev Neurosci. 2021-12-14.
DOI: 10.1038/s41583-021-00542-9 -
Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay.
Front. Bioeng. Biotechnol.. 2021-11-15. 9
DOI: 10.3389/fbioe.2021.762209 -
Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
Morgane Darricau, Marie-Hélène Canron, Marion Bosc, Marie-Laure Arotçarena, Mégane Le Quang, Benjamin Dehay, Erwan Bezard, Vincent Planche.
Neurobiology of Aging. 2021-11-01. 107 : 53-56.
DOI: 10.1016/j.neurobiolaging.2021.07.009 -
An Item Response Theory analysis of the Unified Multiple System Atrophy Rating Scale
Alexandra Foubert-Samier, Anne Pavy-Le Traon, Tiphaine Saulnier, Mélanie Le-Goff, Margherita Fabbri, Catherine Helmer, Olivier Rascol, Cécile Proust-Lima, Wassilios G. Meissner.
Parkinsonism & Related Disorders. 2021-11-01.
DOI: 10.1016/j.parkreldis.2021.11.024 -
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
Lauren Malave, Dustin R. Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H. Kottmann.
Commun Biol. 2021-09-22. 4 (1)
DOI: 10.1038/s42003-021-02567-3 -
US Food and Drug Administration Approval of Aducanumab—Is Amyloid Load a Valid Surrogate End Point for Alzheimer Disease Clinical Trials?
Vincent Planche, Nicolas Villain.
JAMA Neurol. 2021-09-13.
DOI: 10.1001/jamaneurol.2021.3126 -
Nucleolipid Acid-Based Nanocarriers Restore Neuronal Lysosomal Acidification Defects
Mathias Brouillard, Philippe Barthélémy, Benjamin Dehay, Sylvie Crauste-Manciet, Valérie Desvergnes.
Front. Chem.. 2021-08-20. 9
DOI: 10.3389/fchem.2021.736554 -
Impaired brain insulin signalling in Parkinson’s disease
Fares Bassil, Anna Delamarre, Marie‐Helene Canron, Nathalie Dutheil, Anne Vital, Marie‐Laure Négrier‐Leibreich, Erwan Bezard, Pierre‐Olivier Fernagut, Wassilios G. Meissner.
Neuropathol Appl Neurobiol. 2021-08-17.
DOI: 10.1111/nan.12760 -
Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson’s Disease: A Randomized, Placebo-Controlled, Phase 1 Study
Werner Poewe, Dieter Volc, Klaus Seppi, Rossella Medori, Petra Lührs, Alexandra Kutzelnigg, Atbin Djamshidian, Caroline Thun-Hohenstein, Wassilios G. Meissner, Olivier Rascol, Achim Schneeberger, Günther Staffler, Roberto deMarzi, Beatrice Heim, Stephanie Mangesius, Raphaela Stolz, Katarzyna Wachowicz, Constanze Riha, Vera Bürger, Gergana Galabova,.
JPD. 2021-08-02. 11 (3) : 1079-1089.
DOI: 10.3233/JPD-212594 -
Serum miR-96-5P and miR-339-5P Are Potential Biomarkers for Multiple System Atrophy and Parkinson’s Disease
Annamaria Vallelunga, Tommaso Iannitti, Sabrina Capece, Gerardina Somma, Maria Claudia Russillo, Alexandra Foubert-Samier, Brice Laurens, Igor Sibon, Wassilios G. Meissner, Paolo Barone, Maria Teresa Pellecchia.
Front. Aging Neurosci.. 2021-07-26. 13
DOI: 10.3389/fnagi.2021.632891 -
PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases
Anthony Cunha, Alexandra Gaubert, Laurent Latxague, Benjamin Dehay.
Pharmaceutics. 2021-07-08. 13 (7) : 1042.
DOI: 10.3390/pharmaceutics13071042 -
Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas.
Preprint bioRxiv. 2021-06-22.
DOI: 10.1101/2021.06.22.449410 -
Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
Mathieu Bourdenx, Evripidis Gavathiotis, Ana Maria Cuervo.
Autophagy. 2021-06-10. 17 (8) : 2040-2042.
DOI: 10.1080/15548627.2021.1935007 -
Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson’s Disease.
Stefanie Hagenow, Anna Affini, Elsa Y. Pioli, Sonja Hinz, Yan Zhao, Gregory Porras, Vigneshwaran Namasivayam, Christa E. Müller, Jian-Sheng Lin, Erwan Bezard, Holger Stark.
J. Med. Chem.. 2021-06-09.
DOI: 10.1021/acs.jmedchem.0c00914 -
Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson’s Disease
Anais Marie, Morgane Darricau, Katia Touyarot, Louise C. Parr-Brownlie, Clémentine Bosch-Bouju.
JPD. 2021-06-05. : 1-22.
DOI: 10.3233/JPD-212671 -
Amyloid beta oligomers modulate neuronal autophagy through the primary cilium
Olatz Pampliega, Federico N. Soria, Narayana Pineda-Ramírez, Erwan Bezard.
Preprint bioRxiv. 2021-06-02.
DOI: 10.1101/2021.06.02.446758 -
Why and how evaluating driving abilities in patients with neurodegenerative diseases?
Chloé Lazeras, Mégane Cartier, Marie Bonnet, Brice Laurens, Wassilios G. Meissner, Vincent Planche.
Gériatrie et Psychologie Neuropsychiatrie du Viellissement. 2021-06-01. 19 (2) : 191-201.
DOI: 10.1684/pnv.2021.0933 -
Dysphagia in multiple system atrophy consensus statement on diagnosis, prognosis and treatment
Giovanna Calandra-Buonaura, Enrico Alfonsi, Luca Vignatelli, Eduardo E. Benarroch, Giulia Giannini, Alex Iranzo, Phillip A. Low, Paolo Martinelli, Federica Provini, Niall Quinn, Eduardo Tolosa, Gregor K. Wenning, Giovanni Abbruzzese, Pamela Bower, Angelo Antonini, Kailash P. Bhatia, Jacopo Bonavita, Maria Teresa Pellecchia, Nicole Pizzorni, François Tison, Imad Ghorayeb, Wassilios G. Meissner, Tetsutaro Ozawa, Claudio Pacchetti, Nicolò Gabriele Pozzi, Claudio Vicini, Antonio Schindler, Pietro Cortelli, Horacio Kaufmann.
Parkinsonism & Related Disorders. 2021-05-01. 86 : 124-132.
DOI: 10.1016/j.parkreldis.2021.03.027 -
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
Mathieu Bourdenx, Adrián Martín-Segura, Aurora Scrivo, Jose A. Rodriguez-Navarro, Susmita Kaushik, Inmaculada Tasset, Antonio Diaz, Nadia J. Storm, Qisheng Xin, Yves R. Juste, Erica Stevenson, Enrique Luengo, Cristina C. Clement, Se Joon Choi, Nevan J. Krogan, Eugene V. Mosharov, Laura Santambrogio, Fiona Grueninger, Ludovic Collin, Danielle L. Swaney, David Sulzer, Evripidis Gavathiotis, Ana Maria Cuervo.
Cell. 2021-05-01. 184 (10) : 2696-2714.e25.
DOI: 10.1016/j.cell.2021.03.048 -
Fluoxetine for the Symptomatic Treatment of Multiple System Atrophy: The MSA-FLUO Trial
Olivier Rascol, Valérie Cochen de Cock, Anne Pavy‐Le Traon, Alexandra Foubert‐Samier, Claire Thalamas, Agnes Sommet, Vanessa Rousseau, Santiago Perez‐Lloret, Margherita Fabbri, Jean Philippe Azulay, Jean‐Christophe Corvol, Philippe Couratier, Philippe Damier, Luc Defebvre, Franck Durif, Christian Geny, Jean‐Luc Houeto, Philippe Remy, Christine Tranchant, Marc Verin, François Tison, Wassilios G. Meissner.
Mov Disord. 2021-04-01. 36 (7) : 1704-1711.
DOI: 10.1002/mds.28569 -
Factors associated with health‐related quality of life in late stage Parkinson’s disease
Kristina Rosqvist, Per Odin, Stefan Lorenzl, Wassilios G. Meissner, Bastiaan R. Bloem, Joaquim J. Ferreira, Richard Dodel, Anette Schrag,.
Mov Disord Clin Pract. 2021-03-11.
DOI: 10.1002/mdc3.13186 -
A New Rise of Non-Human Primate Models of Synucleinopathies
Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay.
Biomedicines. 2021-03-09. 9 (3) : 272.
DOI: 10.3390/biomedicines9030272 -
Laboratory‐supported multiple system atrophy beyond autonomic function testing and imaging: A systematic review by the modimsa study group
I. Stankovic, A. Fanciulli, V. S. Kostic, F. Krismer, W. G. Meissner, J.A. Palma, J. N. Panicker, K. Seppi, G. K. Wenning, A. Antonini, S. Bajaj, J. Bang, P. Barone, A. Berardelli, D. Berg, I. Biaggioni, B. Bloem, D. J. Brooks, G. Calandra‐Buonaura, C. Colosimo, P. Cortelli, J. Ferreira, S. Fox, B. Frauscher, R. Freeman, V. Fung, T. Gasser, A. Gerhard, D. Goldstein, M. Hallett, G. Halliday, G. U. Höglinger, H. Houlden, V. Iodice, H. Kaufmann, T. Klockgether, A. Lang, H. Ling, P. Low, I. Litvan, Y. Miki, T. Nomura, S. Orimo, T. Ozawa, A. Pantelyat, M. Teresa Pellecchia, R. Postuma, N. Quinn, O. Rascol, M. Sabanovic, R. Sakakibara, C. Sampaio, Jeremy D. Schmahmann, S. Scholz, J-M. Senard, M. Sharma, W. Singer, M. Stamelou, A. Takeda, E. Tolosa, S. Tsuji, L. Vignatelli, U. Walter, T. Warner, H. Watanabe, D. Weintraub, U. Siebert, W. Poewe.
Mov Disord Clin Pract. 2021-02-01.
DOI: 10.1002/mdc3.13158 -
Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin.
Heliyon. 2021-02-01. 7 (2) : e06302.
DOI: 10.1016/j.heliyon.2021.e06302 -
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
J. W. Squair, M. Gautier, L. Mahe, J.E. Soriano, A Rowald, A. Bichat, N. Cho, M. A. Anderson, N. D. James, J. Gandar, A. V. Incognito, G. Schiavone, Z. K. Sarafis, A. Laskaratos, K. Bartholdi, R. Demesmaeker, S. Komi, C. Moerman, B. Vaseghi, B. Scott, R. Rosentreter, C. Kathe, J. Ravier, L. McCracken, X. Kang, N. Vachicouras, F. Fallegger, I. Jelescu, Y. Cheng, Q. Li, R. Buschman, N. Buse, T. Denison, S. Dukelow, R. Charbonneau, I. Rigby, S. K. Boyd, P.J. Millar, E. M. Moraud, M. Capogrosso, F. B. Wagner, Q. Barraud, E. Bezard, S. P. Lacour, J. Bloch, G. Courtine, A. A. Phillips.
Nature. 2021-01-27.
DOI: 10.1038/s41586-020-03180-w -
Involvement of Autophagy in Levodopa‐Induced Dyskinesia
Michael Feyder, Carina Plewnia, Ori J. Lieberman, Giada Spigolon, Alessandro Piccin, Lidia Urbina, Benjamin Dehay, Qin Li, Per Nilsson, Mikael Altun, Emanuela Santini, David Sulzer, Erwan Bezard, Anders Borgkvist, Gilberto Fisone.
Mov Disord. 2021-01-18.
DOI: 10.1002/mds.28480 -
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
David J. Marmion, Angela A. Rutkowski, Diptaman Chatterjee, Benjamin M. Hiller, Milton H. Werner, Erwan Bezard, Deniz Kirik, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower.
Neurobiology of Disease. 2021-01-01. 148 : 105184.
DOI: 10.1016/j.nbd.2020.105184 -
Evaluation of blood flow as a route for propagation in experimental synucleinopathy
Xuan Yu, Marine Persillet, Ling Zhang, Yu Zhang, Sun Xiuping, Xianglei Li, Gao Ran, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Benjamin Dehay, Erwan Bezard, Chuan Qin.
Neurobiology of Disease. 2021-01-01. : 105255.
DOI: 10.1016/j.nbd.2021.105255 -
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia
Elva Fridjonsdottir, Reza Shariatgorji, Anna Nilsson, Theodosia Vallianatou, Luke R. Odell, Luke S. Schembri, Per Svenningsson, Pierre-Olivier Fernagut, Alan R. Crossman, Erwan Bezard, Per E. Andrén.
Sci. Adv.. 2021-01-01. 7 (2) : eabe5948.
DOI: 10.1126/sciadv.abe5948 -
Clinical relevance of brain atrophy subtypes categorization in memory clinics
Vincent Planche, Vincent Bouteloup, Jean‐François Mangin, Bruno Dubois, Julien Delrieu, Florence Pasquier, Frédéric Blanc, Claire Paquet, Olivier Hanon, Audrey Gabelle, Matthieu Ceccaldi, Cédric Annweiler, Pierre Krolak‐Salmon, Marie‐Odile Habert, Clara Fischer, Marie Chupin, Yannick Béjot, Olivier Godefroy, David Wallon, Mathilde Sauvée, Isabelle Bourdel‐Marchasson, Isabelle Jalenques, François Tison, Geneviève Chêne, Carole Dufouil,.
Alzheimer's & Dementia. 2020-12-15. 17 (4) : 641-652.
DOI: 10.1002/alz.12231 -
L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
Marc Deffains, Marie‐Hélène Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre‐Olivier Fernagut.
Neuropathol Appl Neurobiol. 2020-12-04.
DOI: 10.1111/nan.12678 -
NRF-1 and HIF-1α contribute to modulation of human VDAC1 gene promoter during starvation and hypoxia in HeLa cells
Francesca Guarino, Federica Zinghirino, Lia Mela, Xena Giada Pappalardo, François Ichas, Vito De Pinto, Angela Messina.
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2020-12-01. 1861 (12) : 148289.
DOI: 10.1016/j.bbabio.2020.148289 -
Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson’s disease
Anna Delamarre, Cliona MacSweeney, Rie Suzuki, Alastair JH. Brown, Qin Li, Elsa Y. Pioli, Erwan Bezard.
Heliyon. 2020-12-01. 6 (12) : e05771.
DOI: 10.1016/j.heliyon.2020.e05771 -
A Phase 2 Randomized Trial of Asleep versus Awake Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease
Julien Engelhardt, François Caire, Nathalie Damon-Perrière, Dominique Guehl, Olivier Branchard, Nicolas Auzou, François Tison, Wassilios G. Meissner, Elsa Krim, Stéphanie Bannier, Antoine Bénard, Rémi Sitta, Denys Fontaine, Xavier Hoarau, Pierre Burbaud, Emmanuel Cuny.
Stereotact Funct Neurosurg. 2020-11-30. 99 (3) : 230-240.
DOI: 10.1159/000511424 -
Insulin resistance, diabetes and Parkinson’s disease: The match continues
Anna Delamarre, Vincent Rigalleau, Wassilios G. Meissner.
Parkinsonism & Related Disorders. 2020-11-01. 80 : 199-200.
DOI: 10.1016/j.parkreldis.2020.10.013 -
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas.
Cells. 2020-10-29. 9 (11) : 2371.
DOI: 10.3390/cells9112371 -
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas.
Sci. Adv.. 2020-10-01. 6 (40) : eabc4364.
DOI: 10.1126/sciadv.abc4364 -
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins.
Nat Commun. 2020-09-28. 11 (1)
DOI: 10.1038/s41467-020-18689-x -
Clinical Conditions “Suggestive of Progressive Supranuclear Palsy”—Diagnostic Performance
Max‐Joseph Grimm, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Leslie Ferguson, Ellen Gelpi, Armin Giese, Murray Grossman, David J. Irwin, Alexander Pantelyat, Alex Rajput, Sigrun Roeber, John C. Swieten, Claire Troakes, Wassilios G. Meissner, Christer Nilsson, Ines Piot, Yaroslau Compta, James B. Rowe, Günter U. Höglinger,.
Mov Disord. 2020-09-11. 35 (12) : 2301-2313.
DOI: 10.1002/mds.28263 -
Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders
Alexia Duveau, Eléonore Bertin, Eric Boué-Grabot.
Neurosci. Bull.. 2020-09-05.
DOI: 10.1007/s12264-020-00570-y -
A Phase 1 Randomized Trial of Specific Active α‐Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy
Wassilios G. Meissner et al.
Mov Disord. 2020-09-03.
DOI: 10.1002/mds.28218 -
Excessive buccal saliva in patients with Parkinson’s disease of the French COPARK cohort
Olivier Rascol, , Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Margherita Fabbri, Wassilios G. Meissner, Amine Rachdi, François Tison, Santiago Perez-Lloret.
J Neural Transm. 2020-09-02. 127 (12) : 1607-1617.
DOI: 10.1007/s00702-020-02249-0 -
Can autonomic testing and imaging contribute to the early diagnosis of MSA ? A systematic review and recommendations by the MDS multiple system atrophy ( MoDiMSA ) study group
M.T. Pellecchia, I. Stankovic, A. Fanciulli, F. Krismer, W.G. Meissner, J.A. Palma, J. Panicker, K. Seppi, G.K. Wenning, A. Antonini, S. Bajaj, J. Bang, P. Barone, A. Berardelli, D. Berg, I. Biaggioni, B. Bloem, D.J. Brooks, G. Calandra‐Buonaura, C. Colosimo, P. Cortelli, J. Ferreira, S. Fox, B. Frauscher, R. Freeman, V. Fung, T. Gasser, A. Gerhard, D. Goldstein, M. Hallett, G. Halliday, G.U. Höglinger, J.L. Holton, H. Houlden, V. Iodice, H. Kaufmann, T. Klockgether, V. Kostic, A. Lang, H. Ling, P. Low, I. Litvan, Y. Miki, T. Nomura, S. Orimo, T. Ozawa, A. Pantelyat, R. Postuma, N. Quinn, O. Rascol, D. Robertson, M. Sabanovic, R. Sakakibara, C. Sampaio, J.D. Schmahmann, S. Scholz, J.M. Senard, M. Sharma, W. Singer, M. Stamelou, A. Takeda, E. Tolosa, S. Tsuji, L. Vignatelli, U. Walter, H. Watanabe, D. Weintraub, U. Siebert, W. Poewe,.
Mov Disord Clin Pract. 2020-08-17.
DOI: 10.1002/mdc3.13052 -
Addressing knowledge gaps in Parkinson’s disease: a report on the Movement Disorder Society’s Centre-to-Centre initiative to improve Parkinson’s disease services in Lao People’s Democratic Republic
Onanong Phokaewvarangkul, Somchit Vorachit, Appasone Phoumindr, Saysavath Keosodsay, Ronald B. Postuma, Wassilios G. Meissner, Roongroj Bhidayasiri.
BMC Med Educ. 2020-07-29. 20 (1)
DOI: 10.1186/s12909-020-02161-x -
µ opioid receptor agonism for L-DOPA-induced dyskinesia in Parkinson’s disease
Erwan Bezard, Qin Li, Heather Hulme, Elva Fridjonsdottir, Anna Nilsson, Elsa Pioli, Per E. Andren, Alan R. Crossman.
J. Neurosci.. 2020-07-20. : JN-RM-0610-20.
DOI: 10.1523/JNEUROSCI.0610-20.2020 -
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard.
Nat Commun. 2020-07-10. 11 (1)
DOI: 10.1038/s41467-020-17328-9 -
Management of rare movement disorders in Europe: outcome of surveys of the European Reference Network for Rare Neurological Diseases
C. Painous, N. J. H. Os, A. Delamarre, I. Michailoviene, M. J. Marti, B. P. Warrenburg, W. G. Meissner, A. Utkus, C. Reinhard, H. Graessner, MAJ Tijssen.
Eur J Neurol. 2020-06-19.
DOI: 10.1111/ene.14302 -
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
Zhenwei Yu, Min Shi, Tessandra Stewart, Pierre-Olivier Fernagut, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, François Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner, Jing Zhang.
Brain. 2020-05-18.
DOI: 10.1093/brain/awaa110 -
Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates
Philippe Gosset, Alexander Maxan, Melanie Alpaugh, Ludivine Breger, Benjamin Dehay, Zhu Tao, Zhang Ling, Chuan Qin, Giulia Cisbani, Nadia Fortin, Jean-Paul G. Vonsattel, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti.
Neurobiology of Disease. 2020-05-01. : 104941.
DOI: 10.1016/j.nbd.2020.104941 -
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard.
Brain. 2020-05-01. 143 (5) : 1462-1475.
DOI: 10.1093/brain/awaa096 -
Looking into the prediagnostic phase of progressive supranuclear palsy
Wassilios G. Meissner, Günter U. Höglinger.
Parkinsonism & Related Disorders. 2020-05-01. 74 : 74-75.
DOI: 10.1016/j.parkreldis.2020.04.006 -
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Miguel Lopez-Cuina, Paul A. Guerin, Marie-Hélène Canron, Anna Delamarre, Benjamin Dehay, Erwan Bezard, Wassilios G. Meissner, Pierre-Olivier Fernagut.
Mov Disord. 2020-04-14.
DOI: 10.1002/mds.28034 -
Synthesis and Intracellular Uptake of Rhodamine–Nucleolipid Conjugates into a Nanoemulsion Vehicle
Anthony Cunha, Geoffrey Prévot, Yannick Mousli, Philippe Barthélémy, Sylvie Crauste-Manciet, Benjamin Dehay, Valérie Desvergnes.
ACS Omega. 2020-03-12. 5 (11) : 5815-5823.
DOI: 10.1021/acsomega.9b03992 -
Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
Margaux Teil, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, Benjamin Dehay.
Biomolecules. 2020-03-03. 10 (3) : 391.
DOI: 10.3390/biom10030391 -
Utilization Patterns of Amantadine in Parkinson’s Disease Patients Enrolled in the French COPARK Study
Olivier Rascol, , Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Margherita Fabbri, Wassilios G. Meissner, Amine Rachdi, François Tison, Santiago Perez-Lloret.
Drugs Aging. 2020-01-10. 37 (3) : 215-223.
DOI: 10.1007/s40266-019-00740-2 -
Subjective cognitive and non‐cognitive complaints and brain MRI biomarkers in the MEMENTO cohort
Virginie Dauphinot, Vincent Bouteloup, Jean‐François Mangin, Bruno Vellas, Florence Pasquier, Frédéric Blanc, Olivier Hanon, Audrey Gabelle, Cédric Annweiler, Renaud David, Vincent Planche, Olivier Godefroy, Thérèse Rivasseau‐Jonveaux, Marie Chupin, Clara Fischer, Geneviève Chêne, Carole Dufouil, Pierre Krolak‐Salmon.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2020-01-01. 12 (1)
DOI: 10.1002/dad2.12051 -
Dystonia and dopamine: From phenomenology to pathophysiology
Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl, Pierre Burbaud.
Progress in Neurobiology. 2019-11-01. 182 : 101678.
DOI: 10.1016/j.pneurobio.2019.101678 -
Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment
Pietro Cortelli, Giovanna Calandra-Buonaura, Eduardo E. Benarroch, Giulia Giannini, Alex Iranzo, Phillip A. Low, Paolo Martinelli, Federica Provini, Niall Quinn, Eduardo Tolosa, Gregor K. Wenning, Giovanni Abbruzzese, Pamela Bower, Enrico Alfonsi, Imad Ghorayeb, Tetsutaro Ozawa, Claudio Pacchetti, Nicolò Gabriele Pozzi, Claudio Vicini, Angelo Antonini, Kailash P. Bhatia, Jacopo Bonavita, Horacio Kaufmann, Maria Teresa Pellecchia, Nicole Pizzorni, Antonio Schindler, François Tison, Luca Vignatelli, Wassilios G. Meissner.
Neurology. 2019-09-30. 93 (14) : 630-639.
DOI: 10.1212/WNL.0000000000008208 -
Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family
Camille Blanchard, Eric Boué-Grabot, Karine Massé.
Front. Cell. Neurosci.. 2019-07-26. 13
DOI: 10.3389/fncel.2019.00340 -
Evolution of brain atrophy subtypes during aging predicts long-term cognitive decline and future Alzheimer’s clinical syndrome
Vincent Planche, Pierrick Coupé, Catherine Helmer, Mélanie Le Goff, Helene Amieva, François Tison, Jean-François Dartigues, Gwénaëlle Catheline.
Neurobiology of Aging. 2019-07-01. 79 : 22-29.
DOI: 10.1016/j.neurobiolaging.2019.03.006 -
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Marie-Laure Arotcarena, Margaux Teil, Benjamin Dehay.
Cells. 2019-06-09. 8 (6) : 565.
DOI: 10.3390/cells8060565 -
Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
Chiara Paviolo, Federico N. Soria, Joana S. Ferreira, Antony Lee, Laurent Groc, Erwan Bezard, Laurent Cognet.
Methods. 2019-03-09.
DOI: 10.1016/j.ymeth.2019.03.005 -
Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate
Lucie Chansel-Debordeaux, Erwan Bezard.
Anim Models Exp Med. 2019-01-29.
DOI: 10.1002/ame2.12055 -
The hidden side of Parkinson’s disease: studying pain, anxiety and depression in animal models.
Fanny Faivre, Anil Joshi, Erwan Bezard, Michel Barrot.
Neuroscience & Biobehavioral Reviews. 2019-01-01. 96 : 335-352.
DOI: 10.1016/j.neubiorev.2018.10.004 -
Genetically engineered animal models of Parkinson’s disease: From worm to rodent
Ludivine S Breger, Marie T Fuzzati Armentero.
Eur J Neurosci. 2019-02.
DOI: 10.1111/ejn.14300 -
Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics
Thibaud Thiollier, Caisheng Wu, Gregory Porras, Erwan Bezard, Qin Li, Jinlan Zhang, Hugues Contamin.
Anim Models Exp Med. 2018-12-01. 1 (4) : 314-321.
DOI: 10.1002/ame2.12046 -
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.
Salvatore Novello, Ludovico Arcuri, Sandra Dovero, Nathalie Dutheil, Derya R. Shimshek, Erwan Bezard, Michele Morari.
Neurobiology of Disease. 2018-12-01. 120 : 21-33.
DOI: 10.1016/j.nbd.2018.08.018 -
LRP10 in α-synucleinopathies
Lasse Pihlstrøm, Lucia Schottlaender, Viorica Chelban, Henry Houlden, Safa Al-Sarraj, Thomas Arzberger, Conceicao Bettencourt, Kailash Bhatia, Dennis W Dickson, Monica Federoff, Ellen Gelpi, Steve Gentleman, John Hardy, Janice Holton, Inge Huitinga, Allan Levey, David Mann, Wassilios Meissner, Huw Morris, Chris Morris, Alan Pittman, Olivier Rascol, Peter Riederer, Ekaterina Rogaeva, Owen Ross, Sonja Scholtz, Andrew B Singleton, John Trojanowski, Jana Vandrovcova, Tom Warner, Nick Wood.
The Lancet Neurology. 2018-12-01. 17 (12) : 1033-1034.
DOI: 10.1016/S1474-4422(18)30407-1 -
Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain
Luis Quintino, Angrit Namislo, Marcus Davidsson, Ludivine S. Breger, Patrick Kavanagh, Martino Avallone, Erika Elgstrand-Wettergren, Christina Isaksson, Cecilia Lundberg.
Molecular Therapy - Methods & Clinical Development. 2018-12-01. 11 : 29-39.
DOI: 10.1016/j.omtm.2018.08.008 -
Levodopa-induced dyskinesia in Parkinson disease: Current and Evolving Concepts.
Alberto J. Espay, Francesca Morgante, Aristide Merola, Alfonso Fasano, Luca Marsili, Susan H. Fox, Erwan Bezard, Barbara Picconi, Paolo Calabresi, Anthony E. Lang.
Ann Neurol.. 2018-11-30. 84 (6) : 797-811.
DOI: 10.1002/ana.25364 -
Multiple system atrophy | L’atrophie multisystématisée
Damon-Perrière N, Tison F, Meissner WG..
. .
DOI: 10.1684/pnv.2010.0212 -
Etiological assessment of cerebral infarcts in young subjects. Propositions of the French Neurovascular Society Working Group (December 2008) | Bilan étiologique des infarctus cérébraux du sujet jeune. Propositions du Groupe de travail de la Société française neuro-vasculaire (décembre 2008)
.
. .
DOI: RN-12-2009-165-HS4-0035-3787-101019-200908769 -
Case Study 7
Wassilios Meissner.
Parkinsonian Disorders in Clinical Practice. . : 63-192.
DOI: 10.1002/9781444306385.ch3 -
Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-related Neurodegenerative Diseases.
Geoffrey Prévot, Federico N. Soria, Marie-Laure Thiolat, Jonathan Daniel, Jean Baptiste Verlhac, Mireille Blanchard-Desce, Erwan Bezard, Philippe Barthélémy, Sylvie Crauste-Manciet, Benjamin Dehay.
Bioconjugate Chem.. 2018-11-13. 29 (12) : 4083-4089.
DOI: 10.1021/acs.bioconjchem.8b00697 -
Study protocol: Care of Late-Stage Parkinsonism (CLaSP): A longitudinal cohort study 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sciences 1109 Neurosciences
Monika Balzer-Geldsetzer, Joaquim Ferreira, Per Odin, Bastiaan R. Bloem, Wassilios G. Meissner, Stefan Lorenzl, Michael Wittenberg, Richard Dodel, Anette Schrag.
BMC Neurol. 2018-11-05. 18 (1)
DOI: 10.1186/s12883-018-1184-3 -
Naftazone in advanced Parkinson’s disease: An acute L-DOPA challenge randomized controlled trial
Jean-Christophe Corvol, Franck Durif, Wassilios G. Meissner, Jean-Philippe Azulay, Raphaël Haddad, Raquel Guimarães-Costa, Louise-Laure Mariani, Florence Cormier-Dequaire, Claire Thalamas, Monique Galitzky, Thomas Boraud, Bérengère Debilly, Alexandre Eusebio, Marion Houot, Estelle Dellapina, Véronique Chaigneau, Alexandrine Salis, Lucette Lacomblez, Laurent Benel, Olivier Rascol.
Parkinsonism & Related Disorders. 2018-10-01.
DOI: 10.1016/j.parkreldis.2018.10.005 -
The expression of cannabinoid type 1 receptor and 2-arachidonoyl glycerol synthesizing/degrading enzymes is altered in basal ganglia during the active phase of levodopa-induced dyskinesia.
Estefania Rojo-Bustamante, Miguel Angel Abellanas, Pedro Clavero, Marie-Laure Thiolat, Qin Li, Maria Rosario Luquin, Erwan Bezard, Maria S. Aymerich.
Neurobiology of Disease. 2018-10-01. 118 : 64-75.
DOI: 10.1016/j.nbd.2018.06.019 -
Meta-analysis of amantadine efficacy for improving preclinical research reliability.
Philip Stanley, Elsa Y. Pioli, Rouba Kozak, Michael Popiolek, Erwan Bezard.
Mov Disord.. 2018-10-01. 33 (10) : 1555-1557.
DOI: 10.1002/mds.27486 -
Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy
Miguel Lopez-Cuina, Pierre-Olivier Fernagut, Marie-Hélène Canron, Anne Vital, Béatrice Lannes, André Maues De Paula, Nathalie Streichenberger, Dominique Guehl, Philippe Damier, Alexandre Eusebio, Jean-Luc Houeto, François Tison, Christine Tranchant, François Viallet, Tatiana Witjas, Stéphane Thobois, Wassilios G. Meissner.
Neurobiology of Disease. 2018-10-01. 118 : 155-160.
DOI: 10.1016/j.nbd.2018.07.016 -
An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates.
Delphine Charvin, Therese Di Paolo, Erwan Bezard, Laurent Gregoire, Akihiro Takano, Guillaume Duvey, Elsa Pioli, Christer Halldin, Rossella Medori, François Conquet.
Mov Disord.. 2018-09-14. 33 (10) : 1619-1631.
DOI: 10.1002/mds.27462 -
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine.
Nat Protoc. 2018-09-01. 13 (9) : 2031-2061.
DOI: 10.1038/s41596-018-0030-9 -
Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis
Ali Jawaid, Bisrat T. Woldemichael, Eloïse A. Kremer, Florent Laferriere, Niharika Gaur, Tariq Afroz, Magdalini Polymenidou, Isabelle M. Mansuy.
Mol Neurobiol. 2018-08-20.
DOI: 10.1007/s12035-018-1314-3 -
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan.
Nat Rev Drug Discov. 2018-08-17. 17 (9) : 660-688.
DOI: 10.1038/nrd.2018.109 -
Systemic Gene Delivery by Single-Dose Intracardiac Administration of scAAV2/9 and scAAV2/rh10 Variants in Newborn Rats.
Lucie Chansel-Debordeaux, Mathieu Bourdenx, Nathalie Dutheil, Sandra Dovero, Marie-Helene Canron, Clement Jimenez, Erwan Bezard, Benjamin Dehay.
Human Gene Therapy Methods. 2018-08-01. 29 (4) : 189-199.
DOI: 10.1089/hgtb.2017.192.r3 -
Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats
T. Fieblinger, L. Zanetti, I. Sebastianutto, L. S. Breger, L. Quintino, M. Lockowandt, C. Lundberg, M. A. Cenci.
Sci Rep. 2018-07-03. 8 (1)
DOI: 10.1038/s41598-018-28273-5 -
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function
Eva-Maria Hock, Zuzanna Maniecka, Marian Hruska-Plochan, Stefan Reber, Florent Laferrière, Sonu Sahadevan M.K., Helena Ederle, Lauren Gittings, Lucas Pelkmans, Luc Dupuis, Tammaryn Lashley, Marc-David Ruepp, Dorothee Dormann, Magdalini Polymenidou.
Cell Reports. 2018-07-01. 24 (4) : 987-1000.e7.
DOI: 10.1016/j.celrep.2018.06.094 -
Cardinal Motor Features of Parkinson’s Disease Coexist with Peak-Dose Choreic-Type Drug-Induced Dyskinesia.
Etienne Goubault, Hung P. Nguyen, Sarah Bogard, Pierre J. Blanchet, Erwan Bézard, Claude Vincent, Mélanie Langlois, Christian Duval.
JPD. 2018-06-13. 8 (2) : 323-331.
DOI: 10.3233/JPD-181312 -
Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism.
Jérôme Baufreton, Tomislav Milekovic, Qin Li, Steve McGuire, Eduardo Martin Moraud, Grégory Porras, Shiqi Sun, Wai Kin D. Ko, Marine Chazalon, Stéphanie Morin, Elisabeth Normand, Géraldine Farjot, Aude Milet, Jan Pype, Elsa Pioli, Gregoire Courtine, Baptiste Bessière, Erwan Bezard.
Mov Disord.. 2018-05-14.
DOI: 10.1002/mds.27404 -
Lysosomal storage disorder gene variants in multiple system atrophy
Lasse Pihlstrøm, Lucia Schottlaender, Viorica Chelban, Wassilios G Meissner, Monica Federoff, Andy Singleton, Henry Houlden,.
Brain. 2018-05-07. 141 (7) : e53-e53.
DOI: 10.1093/brain/awy124 -
Present and future of disease-modifying therapies in multiple system atrophy.
Miguel Lopez-Cuina, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner.
Autonomic Neuroscience. 2018-05-01. 211 : 31-38.
DOI: 10.1016/j.autneu.2017.12.008 -
The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.
David Castonguay, Julien Dufort-Gervais, Caroline Ménard, Manavi Chatterjee, Rémi Quirion, Bruno Bontempi, Jay S. Schneider, Amy F.T. Arnsten, Angus C. Nairn, Christopher M. Norris, Guylaine Ferland, Erwan Bézard, Pierrette Gaudreau, Paul J. Lombroso, Jonathan Brouillette.
Current Biology. 2018-04-01. 28 (7) : 1079-1089.e4.
DOI: 10.1016/j.cub.2018.02.047 -
MRI supervised and unsupervised classification of Parkinson’s disease and multiple system atrophy
Patrice Péran, Gaetano Barbagallo, Federico Nemmi, Maria Sierra, Monique Galitzky, Anne Pavy-Le Traon, Pierre Payoux, Wassilios G. Meissner, Olivier Rascol.
Mov Disord.. 2018-02-23. 33 (4) : 600-608.
DOI: 10.1002/mds.27307 -
Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models.
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli.
Cell Reports. 2018-02-01. 22 (8) : 2066-2079.
DOI: 10.1016/j.celrep.2018.01.089 -
Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.
Jennifer Stanic, Manuela Mellone, Francesco Napolitano, Claudia Racca, Elisa Zianni, Daiana Minocci, Veronica Ghiglieri, Marie-Laure Thiolat, Qin Li, Annalisa Longhi, Arianna De Rosa, Barbara Picconi, Erwan Bezard, Paolo Calabresi, Monica Di Luca, Alessandro Usiello, Fabrizio Gardoni.
Neurobiology of Disease. 2017-12-01. 108 : 54-64.
DOI: 10.1016/j.nbd.2017.08.001 -
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease.
L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil, A Espana, L Groc, C Jimenez, E Bezard, B Dehay.
Gene Ther. 2017-11-16. 24 (12) : 801-809.
DOI: 10.1038/gt.2017.84 -
L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of life: the COPARK survey.
S. Perez-Lloret, L. Negre-Pages, P. Damier, A. Delval, P. Derkinderen, A. Destée, W. G. Meissner, F. Tison, O. Rascol,.
Eur J Neurol. 2017-10-09. 24 (12) : 1532-1538.
DOI: 10.1111/ene.13466 -
A preclinical study on the combined effects of repeated eltoprazine and preladenant treatment for alleviating L-DOPA-induced dyskinesia in Parkinson’s disease.
Wai Kin D. Ko, Qin Li, Long Yun Cheng, Micaela Morelli, Manolo Carta, Erwan Bezard.
European Journal of Pharmacology. 2017-10-01. 813 : 10-16.
DOI: 10.1016/j.ejphar.2017.07.030 -
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.
Poonam Thakur, Ludivine S. Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, Anders Björklund.
Proc Natl Acad Sci USA. 2017-09-12. 114 (39) : E8284-E8293.
DOI: 10.1073/pnas.1710442114 -
Past, present, and future of Parkinson’s disease: A special essay on the 200th Anniversary of the Shaking Palsy.
J.A. Obeso, M. Stamelou, C.G. Goetz, W. Poewe, A.E. Lang, D. Weintraub, D. Burn, G.M. Halliday, E. Bezard, S. Przedborski, S. Lehericy, D.J. Brooks, J.C. Rothwell, M. Hallett, M.R. DeLong, C. Marras, C.M. Tanner, G.W. Ross, J.W. Langston, C. Klein, V. Bonifati, J. Jankovic, A.M. Lozano, G. Deuschl, H. Bergman, E. Tolosa, M. Rodriguez-Violante, S. Fahn, R.B. Postuma, D. Berg, K. Marek, D.G. Standaert, D.J. Surmeier, C.W. Olanow, J.H. Kordower, P. Calabresi, A.H.V. Schapira, A.J. Stoessl.
Mov Disord.. 2017-09-01. 32 (9) : 1264-1310.
DOI: 10.1002/mds.27115 -
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease
Simone Bido, Federico N. Soria, Rebecca Z. Fan, Erwan Bezard, Kim Tieu.
Sci Rep. 2017-08-08. 7 (1)
DOI: 10.1038/s41598-017-07181-0 -
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bezard, Benjamin Dehay, Anthony Tsarbopoulos.
Progress in Neurobiology. 2017-08-01. 155 : 171-193.
DOI: 10.1016/j.pneurobio.2015.07.003 -
Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques.
Francesco Napolitano, Emily Booth Warren, Sara Migliarini, Daniela Punzo, Francesco Errico, Qin Li, Marie-Laure Thiolat, Angelo Luigi Vescovi, Paolo Calabresi, Erwan Bezard, Micaela Morelli, Christine Konradi, Massimo Pasqualetti, Alessandro Usiello.
PLoS ONE. 2017-07-25. 12 (7) : e0181677.
DOI: 10.1371/journal.pone.0181677 -
Alterations in functional cortical hierarchy in hemiparkinsonian rats.
Borbála Nóra Jávor-Duray, Martin Vinck, Marcel van der Roest, Erwan Bezard, Henk W. Berendse, Thomas Boraud, Pieter Voorn.
J. Neurosci.. 2017-07-07. 37 (32) : 7669-7681.
DOI: 10.1523/jneurosci.3257-16.2017 -
Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution
T. Afroz, E.-M. Hock, P. Ernst, C. Foglieni, M. Jambeau, L. Gilhespy, F. Laferriere, Z. Maniecka, A. Plueckthun, P. Mittl, P. Paganetti, F.H.T. Allain, M. Polymenidou.
. 2017-07-05.
DOI: 10.2210/pdb5mdi/pdb -
In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains.
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard.
Neurobiology of Disease. 2017-07-01. 103 : 101-112.
DOI: 10.1016/j.nbd.2017.04.011 -
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie Jambeau, Larissa A. B. Gilhespy, Florent Laferriere, Zuzanna Maniecka, Andreas Plückthun, Peer Mittl, Paolo Paganetti, Frédéric H. T. Allain, Magdalini Polymenidou.
Nat Commun. 2017-06-29. 8 (1)
DOI: 10.1038/s41467-017-00062-0 -
U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells
Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia-Ladona.
Synapse. 2017-06-20. 71 (9) : e21980.
DOI: 10.1002/syn.21980 -
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.
Fares Bassil, Paul A. Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, Wassilios G. Meissner, Erwan Bezard, Pierre-Olivier Fernagut.
Mov Disord.. 2017-05-29. 32 (8) : 1230-1239.
DOI: 10.1002/mds.27041 -
Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia
Matthieu F. Bastide, Christelle Glangetas, Evelyne Doudnikoff, Qin Li, Mathieu Bourdenx, Pierre-Olivier Fernagut, Éric C. Dumont, François Georges, Erwan Bézard.
Sci Rep. 2017-05-24. 7 (1)
DOI: 10.1038/s41598-017-02572-9 -
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.
Federico N. Soria, Michel Engeln, Marta Martinez-Vicente, Christelle Glangetas, María José López-González, Sandra Dovero, Benjamin Dehay, Elisabeth Normand, Miquel Vila, Alexandre Favereaux, François Georges, Christophe Lo Bianco, Erwan Bezard, Pierre-Olivier Fernagut.
Human Molecular Genetics. 2017-05-17. 26 (14) : 2603-2615.
DOI: 10.1093/hmg/ddx120 -
Which ante mortem clinical features predict progressive supranuclear palsy pathology?
Gesine Respondek, Carolin Kurz, Thomas Arzberger, Yaroslau Compta, Elisabet Englund, Leslie W. Ferguson, Ellen Gelpi, Armin Giese, David J. Irwin, Wassilios G. Meissner, Christer Nilsson, Alexander Pantelyat, Alex Rajput, John C. van Swieten, Claire Troakes, Keith A. Josephs, Anthony E. Lang, Brit Mollenhauer, Ulrich Müller, Jennifer L. Whitwell, Angelo Antonini, Kailash P. Bhatia, Yvette Bordelon, Jean-Christophe Corvol, Carlo Colosimo, Richard Dodel, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw Morris, Peter Nestor, Wolfgang H. Oertel, Gil D. Rabinovici, James B. Rowe, Thilo van Eimeren, Gregor K. Wenning, Adam Boxer, Lawrence I. Golbe, Irene Litvan, Maria Stamelou, Günter U. Höglinger,.
Mov Disord.. 2017-05-13. 32 (7) : 995-1005.
DOI: 10.1002/mds.27034 -
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Günter U. Höglinger, Gesine Respondek, Maria Stamelou, Carolin Kurz, Keith A. Josephs, Anthony E. Lang, Brit Mollenhauer, Ulrich Müller, Christer Nilsson, Jennifer L. Whitwell, Thomas Arzberger, Elisabet Englund, Ellen Gelpi, Armin Giese, David J. Irwin, Wassilios G. Meissner, Alexander Pantelyat, Alex Rajput, John C. van Swieten, Claire Troakes, Angelo Antonini, Kailash P. Bhatia, Yvette Bordelon, Yaroslau Compta, Jean-Christophe Corvol, Carlo Colosimo, Dennis W. Dickson, Richard Dodel, Leslie Ferguson, Murray Grossman, Jan Kassubek, Florian Krismer, Johannes Levin, Stefan Lorenzl, Huw R. Morris, Peter Nestor, Wolfgang H. Oertel, Werner Poewe, Gil Rabinovici, James B. Rowe, Gerard D. Schellenberg, Klaus Seppi, Thilo van Eimeren, Gregor K. Wenning, Adam L. Boxer, Lawrence I. Golbe, Irene Litvan,.
Mov Disord.. 2017-05-03. 32 (6) : 853-864.
DOI: 10.1002/mds.26987 -
Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model.
Mathieu Bourdenx, Sandra Dovero, Marie-Laure Thiolat, Erwan Bezard, Benjamin Dehay.
Sci Rep. 2017-04-04. 7 (1)
DOI: 10.1038/srep45831 -
Multiple System Atrophy – State of the Art.
Brice Laurens, Sylvain Vergnet, Miguel Cuina Lopez, Alexandra Foubert-Samier, François Tison, Pierre-Olivier Fernagut, Wassilios G. Meissner.
Curr Neurol Neurosci Rep. 2017-04-04. 17 (5)
DOI: 10.1007/s11910-017-0751-0 -
Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate.
Anna Migdalska-Richards, Wai Kin D. Ko, Qin Li, Erwan Bezard, Anthony H. V. Schapira.
Synapse. 2017-03-17. 71 (7) : e21967.
DOI: 10.1002/syn.21967 -
Insulin resistance and exendin-4 treatment for multiple system atrophy.
Fares Bassil, Marie-Hélène Canron, Anne Vital, Erwan Bezard, Yazhou Li, Nigel H Greig, Seema Gulyani, Dimitrios Kapogiannis, Pierre-Olivier Fernagut, Wassilios G Meissner.
Brain. 2017-03-14. 140 (5) : 1420-1436.
DOI: 10.1093/brain/awx044 -
Impulse control disorders and levodopa-induced dyskinesias in Parkinson’s disease: an update.
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut.
The Lancet Neurology. 2017-03-01. 16 (3) : 238-250.
DOI: 10.1016/s1474-4422(17)30004-2 -
Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson’s disease
Ludivine S. Breger, Korbinian Kienle, Gaynor A. Smith, Stephen B. Dunnett, Emma L. Lane.
Brain, Behavior, and Immunity. 2017-03-01. 61 : 155-164.
DOI: 10.1016/j.bbi.2016.11.014 -
Epidemiology, environmental risk factors and genetics of Parkinson’s disease | Épidémiologie, facteurs de risque environnementaux et génétiques de la maladie de Parkinson
Anna Delamarre, Wassilios G. Meissner.
La Presse Médicale. 2017-03-01. 46 (2) : 175-181.
DOI: 10.1016/j.lpm.2017.01.001 -
Impulse control disorders and levodopa-induced dyskinesias in Parkinson’s disease: an update.
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut.
The Lancet Neurology. 2017-03-01. 16 (3) : 238-250.
DOI: 10.1016/s1474-4422(17)30004-2 -
Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.
Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich, Adriano Aguzzi.
PLoS ONE. 2017-02-16. 12 (2) : e0170503.
DOI: 10.1371/journal.pone.0170503 -
Impact of sleep apnea syndrome on survival in patients with multiple system atrophy.
Olivier Flabeau, Imad Ghorayeb, Paul Perez, Aline Maillard, Jacques Taillard, Pierre Philip, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner.
Parkinsonism & Related Disorders. 2017-02-01. 35 : 92-95.
DOI: 10.1016/j.parkreldis.2016.12.013 -
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases.
Federico N. Soria, Olatz Pampliega, Mathieu Bourdenx, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay.
Front. Neurosci.. 2017-01-31. 11
DOI: 10.3389/fnins.2017.00026 -
The many faces of autonomic failure in multiple system atrophy
Wassilios G. Meissner, Anne Pavy-Le Traon.
Mov Disord.. 2017-01-16. 32 (3) : 368-370.
DOI: 10.1002/mds.26917 -
Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.
Daniel Ysselstein, Benjamin Dehay, Isabel M. Costantino, George P. McCabe, Matthew P. Frosch, Julia M. George, Erwan Bezard, Jean-Christophe Rochet.
acta neuropathol commun. 2017-01-10. 5 (1)
DOI: 10.1186/s40478-016-0403-7 -
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
Eric Boué-Grabot, Yuriy Pankratov.
Neural Plasticity. 2017-01-01. 2017 : 1-11.
DOI: 10.1155/2017/9454275 -
Analysis of the prion protein gene in multiple system atrophy
Viorica Chelban, Andreea Manole, Lasse Pihlstrøm, Lucia Schottlaender, Stephanie Efthymiou, Emer OConnor, Wassilios G. Meissner, Janice L. Holton, Henry Houlden.
Neurobiology of Aging. 2017-01-01. 49 : 216.e15-216.e18.
DOI: 10.1016/j.neurobiolaging.2016.09.021 -
What lysosomes actually tell us about Parkinson’s disease?
Mathieu Bourdenx, Benjamin Dehay.
Ageing Research Reviews. 2016-12-01. 32 : 140-149.
DOI: 10.1016/j.arr.2016.02.008 -
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
W. Danquah, C. Meyer-Schwesinger, B. Rissiek, C. Pinto, A. Serracant-Prat, M. Amadi, D. Iacenda, J.-H. Knop, A. Hammel, P. Bergmann, N. Schwarz, J. Assuncao, W. Rotthier, F. Haag, E. Tolosa, P. Bannas, E. Boue-Grabot, T. Magnus, T. Laeremans, C. Stortelers, F. Koch-Nolte.
Science Translational Medicine. 2016-11-23. 8 (366) : 366ra162-366ra162.
DOI: 10.1126/scitranslmed.aaf8463 -
Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.
Anna Migdalska-Richards, Liam Daly, Erwan Bezard, Anthony H. V. Schapira.
Ann Neurol.. 2016-11-01. 80 (5) : 766-775.
DOI: 10.1002/ana.24790 -
An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque models
Wai Kin D. Ko, Sandrine M. Camus, Qin Li, Jianzhong Yang, Steve McGuire, Elsa Y. Pioli, Erwan Bezard.
Neuropharmacology. 2016-11-01. 110 : 48-58.
DOI: 10.1016/j.neuropharm.2016.07.012 -
An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system.
Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF..
J Neurochem. 1997-04-02. 68 (4) : 1382-9.
DOI: -
Intracellular cross talk and physical interaction between two classes of neurotransmitter-gated channels.
.
J Neurosci.. 2003-02-15. 23 (4) : 1246-53.
DOI: -
Molecular and electrophysiological evidence for a GABAc receptor in thyrotropin-secreting cells.
Boue-Grabot E, Taupignon A, Tramu G, Garret M..
Endocrinology.. 2000-05-01. 141 (5) : 1627-32.
DOI: 10.1210/en.141.5.1627 -
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine.
Nature. 2016-11. 539 (7628) : 284:288.
DOI: 10.1038/nature20118 -
Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy.
Michel Engeln, Solène Ansquer, Emilie Dugast, Erwan Bezard, David Belin, Pierre-Olivier Fernagut.
Neuropharmacology. 2016-10-01. 109 : 69-77.
DOI: 10.1016/j.neuropharm.2016.05.013 -
P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons.
Johan-Till Pougnet, Benjamin Compans, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot.
Sci Rep. 2016-09-14. 6 (1)
DOI: 10.1038/srep31836 -
A genome-wide association study in multiple system atrophy
Anna Sailer, Sonja W. Scholz, Michael A. Nalls, Claudia Schulte, Monica Federoff, T. Ryan Price, Andrew Lees, Owen A. Ross, Dennis W. Dickson, Kin Mok, Niccolo E. Mencacci, Lucia Schottlaender, Viorica Chelban, Helen Ling, Sean S. O'Sullivan, Nicholas W. Wood, Bryan J. Traynor, Luigi Ferrucci, Howard J. Federoff, Timothy R. Mhyre, Huw R. Morris, Günther Deuschl, Niall Quinn, Hakan Widner, Alberto Albanese, Jon Infante, Kailash P. Bhatia, Werner Poewe, Wolfgang Oertel, Günter U. Höglinger, Ullrich Wüllner, Stefano Goldwurm, Maria Teresa Pellecchia, Joaquim Ferreira, Eduardo Tolosa, Bastiaan R. Bloem, Olivier Rascol, Wassilios G. Meissner, John A. Hardy, Tamas Revesz, Janice L. Holton, Thomas Gasser, Gregor K. Wenning, Andrew B. Singleton, Henry Houlden.
Neurology. 2016-09-14. 87 (15) : 1591-1598.
DOI: 10.1212/WNL.0000000000003221 -
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
René Fuertig, Angelo Ceci, Sandrine M Camus, Erwan Bezard, Andreas H Luippold, Bastian Hengerer.
Bioanalysis. 2016-09-01. 8 (18) : 1903-1917.
DOI: 10.4155/bio-2016-0111 -
Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Alain Pruvost, Thierry Leste-Lasserre, Quyen Q. Hoang, Dagmar Ringe, Gregory A. Petsko, Wassilios G. Meissner.
Proc Natl Acad Sci USA. 2016-08-01. 113 (34) : 9593-9598.
DOI: 10.1073/pnas.1609291113 -
Is near-infrared light neuroprotective?
Erwan Bezard.
Ann Neurol.. 2016-06-24. 80 (2) : 310-310.
DOI: 10.1002/ana.24698 -
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bezard, M. Angela Cenci, D. James Surmeier.
Neuron. 2016-06-01. 90 (5) : 1139.
DOI: 10.1016/j.neuron.2016.05.017 -
MitoBrain, Putting energy into the brain.
Giovanni Benard, Erwan Bezard, Giovanni Marsicano, Sandrine Pouvreau.
Neurobiology of Disease. 2016-06-01. 90 : 1-2.
DOI: 10.1016/j.nbd.2016.03.021 -
Cystine/glutamate antiporter blockage induces myelin degeneration
Federico N. Soria, Alazne Zabala, Olatz Pampliega, Aitor Palomino, Cristina Miguelez, Luisa Ugedo, Hideyo Sato, Carlos Matute, María Domercq.
Glia. 2016-06-01. 64 (8) : 1381-1395.
DOI: 10.1002/glia.23011 -
Alpha-synuclein-based models of Parkinson’s disease
B. Dehay, P.-O. Fernagut.
Revue Neurologique. 2016-06-01. 172 (6-7) : 371-378.
DOI: 10.1016/j.neurol.2016.04.003 -
A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson’s Disease.
François Tison, Charlotte Keywood, Mark Wakefield, Franck Durif, Jean-Christophe Corvol, Karla Eggert, Mark Lew, Stuart Isaacson, Erwan Bezard, Sonia-Maria Poli, Christopher G. Goetz, Claudia Trenkwalder, Olivier Rascol.
Mov Disord.. 2016-05-23. 31 (9) : 1373-1380.
DOI: 10.1002/mds.26659 -
CD154 Induces Matrix Metalloproteinase-9 Secretion in Human Podocytes.
Claire Rigothier, Richard Daculsi, Sébastien Lepreux, Patrick Auguste, Julien Villeneuve, Antoine Dewitte, Evelyne Doudnikoff, Moin Saleem, Chantal Bourget, Christian Combe, Jean Ripoche.
J. Cell. Biochem.. 2016-05-05. 117 (12) : 2737-2747.
DOI: 10.1002/jcb.25571 -
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson’s disease.
Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bezard, Michele Morari.
Neurobiology of Disease. 2016-05-01. 89 : 55-64.
DOI: 10.1016/j.nbd.2016.01.016 -
Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease.
Thibaud Thiollier, Caisheng Wu, Hugues Contamin, Qin Li, Jinlan Zhang, Erwan Bezard.
Synapse. 2016-03-15. 70 (6) : 231-239.
DOI: 10.1002/syn.21889 -
Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
Michel Engeln, Matthieu F. Bastide, Estelle Toulmé, Benjamin Dehay, Mathieu Bourdenx, Evelyne Doudnikoff, Qin Li, Christian E. Gross, Eric Boué-Grabot, Antonio Pisani, Erwan Bezard, Pierre-Olivier Fernagut.
Biological Psychiatry. 2016-03-01. 79 (5) : 354-361.
DOI: 10.1016/j.biopsych.2014.07.007 -
Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.
Matthieu F. Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre-Olivier Fernagut, Christian E. Gross, Nicolas Mallet, Thomas Boraud, Erwan Bézard.
Biological Psychiatry. 2016-03-01. 79 (5) : 345-353.
DOI: 10.1016/j.biopsych.2014.08.022 -
Targeting α-synuclein: Therapeutic options.
Benjamin Dehay, Mickael Decressac, Mathieu Bourdenx, Irene Guadagnino, Pierre-Olivier Fernagut, Anna Tamburrino, Fares Bassil, Wassilios G. Meissner, Erwan Bezard.
Mov Disord.. 2016-03-01. 31 (6) : 882-888.
DOI: 10.1002/mds.26568 -
Outcome of deep brain stimulation in slowly progressive multiple system atrophy: A clinico-pathological series and review of the literature
Wassilios G. Meissner, Chloé Laurencin, Christine Tranchant, Tatiana Witjas, François Viallet, Dominique Guehl, Philippe Damier, Jean-Luc Houeto, François Tison, Alexandre Eusebio, Anne Vital, Nathalie Streichenberger, Béatrice Lannes, André Maues de Paula, Stéphane Thobois.
Parkinsonism & Related Disorders. 2016-03-01. 24 : 69-75.
DOI: 10.1016/j.parkreldis.2016.01.005 -
Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson’s disease.
Annalisa Pinna, Wai Kin D. Ko, Giulia Costa, Elisabetta Tronci, Camino Fidalgo, Nicola Simola, Qin Li, Mojgan Aghazadeh Tabrizi, Erwan Bezard, Manolo Carta, Micaela Morelli.
Mov Disord.. 2016-02-12. 31 (4) : 501-511.
DOI: 10.1002/mds.26475 -
A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels
Michel Boris Emerit, Camille Baranowski, Jorge Diaz, Audrey Martinez, Julie Areias, Jeanine Alterio, Justine Masson, Eric Boué-Grabot, Michèle Darmon.
J. Neurosci.. 2016-02-03. 36 (5) : 1456-1470.
DOI: 10.1523/JNEUROSCI.2390-15.2016 -
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
Nikolaus Wenger, Eduardo Martin Moraud, Jerome Gandar, Pavel Musienko, Marco Capogrosso, Laetitia Baud, Camille G Le Goff, Quentin Barraud, Natalia Pavlova, Nadia Dominici, Ivan R Minev, Leonie Asboth, Arthur Hirsch, Simone Duis, Julie Kreider, Andrea Mortera, Oliver Haverbeck, Silvio Kraus, Felix Schmitz, Jack DiGiovanna, Rubia van den Brand, Jocelyne Bloch, Peter Detemple, Stéphanie P Lacour, Erwan Bézard, Silvestro Micera, Grégoire Courtine.
Nat Med. 2016-01-18. 22 (2) : 138-145.
DOI: 10.1038/nm.4025 -
Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Mathieu Bourdenx, Jonathan Daniel, Emilie Genin, Federico N. Soria, Mireille Blanchard-Desce, Erwan Bezard, Benjamin Dehay.
Autophagy. 2016-01-13. 12 (3) : 472-483.
DOI: 10.1080/15548627.2015.1136769 -
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F. Javier Garcia-Ladona.
Synapse. 2016-01-06. 70 (3) : 71-86.
DOI: 10.1002/syn.21881 -
Striatal NELF-mediated RNA polymerase II stalling controls L-dopa induced dyskinesia.
Matthieu F. Bastide, Simone Bido, Nathalie Duteil, Erwan Bézard.
Neurobiology of Disease. 2016-01-01. 85 : 93-98.
DOI: 10.1016/j.nbd.2015.10.013 -
A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses.
Abdelwahed Chtarto, Marie Humbert-Claude, Olivier Bockstael, Atze T Das, Sébastien Boutry, Ludivine S Breger, Bep Klaver, Catherine Melas, Pedro Barroso-Chinea, Tomas Gonzalez-Hernandez, Robert N Muller, Olivier DeWitte, Marc Levivier, Cecilia Lundberg, Ben Berkhout, Liliane Tenenbaum.
Molecular Therapy - Methods & Clinical Development. 2016-01-01. 3 : 16027.
DOI: 10.1038/mtm.2016.27 -
Regulated Gene Therapy.
Ludivine Breger, Erika Elgstrand Wettergren, Luis Quintino, Cecilia Lundberg.
Gene Therapy for Neurological Disorders. 2016-01-01. : 57-66.
DOI: 10.1007/978-1-4939-3271-9_4 -
Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease
Gaetano Barbagallo, Maria Sierra-Peña, Federico Nemmi, Anne Pavy-Le Traon, Wassilios G. Meissner, Olivier Rascol, Patrice Péran.
Mov Disord.. 2015-12-17. 31 (3) : 325-334.
DOI: 10.1002/mds.26471 -
Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque monkey.
Mathieu Bourdenx, Sandra Dovero, Philippe De DeurwAerdère, Qin Li, Erwan Bezard.
Synapse. 2015-12-04. 70 (2) : 52-56.
DOI: 10.1002/syn.21876 -
Unexpected toxicity of very low dose MPTP in mice: A clue to the etiology of Parkinson’s disease?
Sandra Dovero, Christian Gross, Erwan Bezard.
Synapse. 2015-12-01. 70 (2) : 49-51.
DOI: 10.1002/syn.21875 -
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Weixing Shen, Joshua L. Plotkin, Veronica Francardo, Wai Kin D. Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R. Neubig, Craig W. Lindsley, P. Jeffrey Conn, Paul Greengard, Erwan Bezard, M. Angela Cenci, D. James Surmeier.
Neuron. 2015-11-01. 88 (4) : 762-773.
DOI: 10.1016/j.neuron.2015.10.039 -
Why bother using non-human primate models of cognitive disorders in translational research?
Sandrine Camus, Wai Kin D. Ko, Elsa Pioli, Erwan Bezard.
Neurobiology of Learning and Memory. 2015-10-01. 124 : 123-129.
DOI: 10.1016/j.nlm.2015.06.012 -
Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson’s disease dementia
Nicolas Auzou, Kathy Dujardin, Roberta Biundo, Alexandra Foubert-Samier, Caroline Barth, Fanny Duval, François Tison, Luc Defebvre, Angelo Antonini, Wassilios G. Meissner.
Parkinsonism & Related Disorders. 2015-10-01. 21 (10) : 1273-1277.
DOI: 10.1016/j.parkreldis.2015.08.013 -
Delayed-onset Friedreich’s ataxia revisited
Claire Lecocq, Perrine Charles, Jean-Philippe Azulay, Wassilios Meissner, Myriam Rai, Karine N'Guyen, Yann Péréon, Nelly Fabre, Elsa Robin, Sylvie Courtois, Lucie Guyant-Maréchal, Fabien Zagnoli, Gabrielle Rudolf, Mathilde Renaud, Mathieu Sévin-Allouet, Fabien Lesne, Nick Alaerts, Cyril Goizet, Patrick Calvas, Alexandre Eusebio, Claire Guissart, Pascal Derkinderen, Francois Tison, Alexis Brice, Michel Koenig, Massimo Pandolfo, Christine Tranchant, Alexandra Dürr, Mathieu Anheim.
Mov Disord.. 2015-09-21. 31 (1) : 62-69.
DOI: 10.1002/mds.26382 -
Alpha-synuclein propagation: New insights from animal models.
Benjamin Dehay, Miquel Vila, Erwan Bezard, Patrik Brundin, Jeffrey H. Kordower.
Mov Disord.. 2015-09-08. 31 (2) : 161-168.
DOI: 10.1002/mds.26370 -
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson’s disease.
Matthieu F. Bastide, Wassilios G. Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, Michael Feyder, Veronica Francardo, Cristina Alcacer, Yunmin Ding, Riccardo Brambilla, Gilberto Fisone, A. Jon Stoessl, Mathieu Bourdenx, Michel Engeln, Sylvia Navailles, Philippe De Deurwaerdère, Wai Kin D. Ko, Nicola Simola, Micaela Morelli, Laurent Groc, Maria-Cruz Rodriguez, Eugenia V. Gurevich, Maryka Quik, Michele Morari, Manuela Mellone, Fabrizio Gardoni, Elisabetta Tronci, Dominique Guehl, François Tison, Alan R. Crossman, Un Jung Kang, Kathy Steece-Collier, Susan Fox, Manolo Carta, M. Angela Cenci, Erwan Bézard.
Progress in Neurobiology. 2015-09-01. 132 : 96-168.
DOI: 10.1016/j.pneurobio.2015.07.002 -
Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates.
Lucia Friedli, Ephron S. Rosenzweig, Quentin Barraud, Martin Schubert, Nadia Dominici, Lea Awai, Jessica L. Nielson, Pavel Musienko, Yvette Nout-Lomas, Hui Zhong, Sharon Zdunowski, Roland R. Roy, Sarah C. Strand, Rubia van den Brand, Leif A. Havton, Michael S. Beattie, Jacqueline C. Bresnahan, Erwan Bézard, Jocelyne Bloch, V. Reggie Edgerton, Adam R. Ferguson, Armin Curt, Mark H. Tuszynski, Grégoire Courtine.
Sci. Transl. Med.. 2015-08-26. 7 (302) : 302ra134-302ra134.
DOI: 10.1126/scitranslmed.aac5811 -
Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy
Fares Bassil, Arnaud Monvoisin, Marie-Helene Canron, Anne Vital, Wassilios G. Meissner, François Tison, Pierre-Olivier Fernagut.
Mov Disord.. 2015-08-11. 30 (13) : 1802-1812.
DOI: 10.1002/mds.26329 -
Targeting α-synuclein for treatment of Parkinson’s disease: Mechanistic and therapeutic considerations
Benjamin Dehay, Mathieu Bourdenx, Philippe Gorry, Serge Przedborski, Miquel Vila, Stéphane Hunot, Andrew Singleton, C Warren Olanow, Kalpana M Merchant, Erwan Bezard, Gregory A Petsko, Wassilios G Meissner.
The Lancet Neurology. 2015-08-01. 14 (8) : 855-866.
DOI: 10.1016/S1474-4422(15)00006-X -
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative
Brice Laurens, Radu Constantinescu, Roy Freeman, Alexander Gerhard, Kurt Jellinger, Andreas Jeromin, Florian Krismer, Brit Mollenhauer, Michael G. Schlossmacher, Leslie M. Shaw, Marcel M. Verbeek, Gregor K. Wenning, Kristian Winge, Jing Zhang, Wassilios G. Meissner.
Neurobiology of Disease. 2015-08-01. 80 : 29-41.
DOI: 10.1016/j.nbd.2015.05.004 -
Targeting α-synuclein for treatment of Parkinson’s disease: mechanistic and therapeutic considerations.
Benjamin Dehay, Mathieu Bourdenx, Philippe Gorry, Serge Przedborski, Miquel Vila, Stéphane Hunot, Andrew Singleton, C Warren Olanow, Kalpana M Merchant, Erwan Bezard, Gregory A Petsko, Wassilios G Meissner.
The Lancet Neurology. 2015-08-01. 14 (8) : 855-866.
DOI: 10.1016/s1474-4422(15)00006-x -
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay.
acta neuropathol commun. 2015-07-25. 3 (1)
DOI: 10.1186/s40478-015-0222-2 -
Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease
C. Fidalgo, W.K.D. Ko, E. Tronci, Q. Li, R. Stancampiano, Q. Chuan, E. Bezard, M. Carta.
Neuroscience. 2015-07-01. 298 : 389-396.
DOI: 10.1016/j.neuroscience.2015.04.027 -
D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly.
Pedro Barroso-Chinea, Marie-Laure Thiolat, Simone Bido, Audrey Martinez, Evelyne Doudnikoff, Jérôme Baufreton, Mathieu Bourdenx, Bertrand Bloch, Erwan Bezard, Marie-Laure Martin-Negrier.
Neurobiology of Disease. 2015-06-01. 78 : 77-87.
DOI: 10.1016/j.nbd.2015.02.024 -
New insights into orthostatic hypotension in multiple system atrophy: A European multicentre cohort study
A Pavy-Le Traon, A Piedvache, S Perez-Lloret, G Calandra-Buonaura, V Cochen-De Cock, C Colosimo, P Cortelli, R Debs, S Duerr, A Fanciulli, A Foubert-Samier, A Gerdelat, T Gurevich, F Krismer, W Poewe, F Tison, C Tranchant, G Wenning, O Rascol, WG Meissner.
J Neurol Neurosurg Psychiatry. 2015-05-14. 87 (5) : 554-561.
DOI: 10.1136/jnnp-2014-309999 -
Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson’s disease.
Nikhil M. Urs, Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, Marc G. Caron.
Proc Natl Acad Sci USA. 2015-04-27. 112 (19) : E2517-E2526.
DOI: 10.1073/pnas.1502740112 -
Falls in ambulatory non-demented patients with Parkinson’s disease
Olivier Rascol, Santiago Perez-Lloret, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Wassilios G. Meissner, Francois Tison, Laurence Negre-Pages.
J Neural Transm. 2015-04-07. 122 (10) : 1447-1455.
DOI: 10.1007/s00702-015-1396-2 -
Blood withdrawal affects iron store dynamics in primates with consequences on monoaminergic system function.
C. Hyacinthe, P. De Deurwaerdere, T. Thiollier, Q. Li, E. Bezard, I. Ghorayeb.
Neuroscience. 2015-04-01. 290 : 621-635.
DOI: 10.1016/j.neuroscience.2015.01.057 -
Multiple system atrophy | L’atrophie multisystématisée
A. Foubert-Samier, F. Tison, W.G. Meissner.
Pratique Neurologique - FMC. 2015-03-01. 6 (2) : 115-123.
DOI: 10.1016/j.praneu.2014.12.003 -
Could the serotonin theory give rise to a treatment for levodopa-induced dyskinesia in Parkinson’s disease?
Erwan Bezard, Manolo Carta.
Brain. 2015-02-05. 138 (4) : 829-830.
DOI: 10.1093/brain/awu407 -
Current Concepts in the Treatment of Multiple System Atrophy
Santiago Perez-Lloret, Olivier Flabeau, Pierre-Olivier Fernagut, Anne Pavy-Le Traon, María Verónica Rey, Alexandra Foubert-Samier, Francois Tison, Olivier Rascol, Wassilios G. Meissner.
Mov Disord Clin Pract. 2015-02-02. 2 (1) : 6-16.
DOI: 10.1002/mdc3.12145 -
Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis.
F Laferriere, M Polymenidou.
Swiss Med Wkly. 2015-01-30.
DOI: 10.4414/smw.2015.14054 -
Presumed tuberculous retrobulbar optic neuritis: a diagnosis challenge
Jérôme Aupy, Anne Vital, Marie-Benedicte Rougier, Antoine Gradel, Wassilios Meissner, Cecile Marchal, Guillaume Penchet, Bruno Brochet.
J Neurol. 2014-12-24. 262 (2) : 481-484.
DOI: 10.1007/s00415-014-7611-5 -
Alpha-synuclein spreading in Parkinson’s disease
Ariadna Recasens, Benjamin Dehay.
Front. Neuroanat.. 2014-12-18. 8
DOI: 10.3389/fnana.2014.00159 -
Relevance of corpus callosum splenium versus middle cerebellar peduncle hyperintensity for FXTAS diagnosis in clinical practice
Mathilde Renaud, Julien Perriard, Sarah Coudray, Mathieu Sévin-Allouet, Christophe Marcel, Wassilios G. Meissner, Jean-Baptiste Chanson, Nicolas Collongues, Nathalie Philippi, Odile Gebus, Véronique Quenardelle, Anna Castrioto, Paul Krack, Karine N’Guyen, François Lefebvre, Andoni Echaniz-Laguna, Jean-Philippe Azulay, Nicolas Meyer, Pierre Labauge, Christine Tranchant, Mathieu Anheim.
J Neurol. 2014-12-02. 262 (2) : 435-442.
DOI: 10.1007/s00415-014-7557-7 -
Wireless neurosensor for full-spectrum electrophysiology recordings during free behavior.
Ming Yin, David A. Borton, Jacob Komar, Naubahar Agha, Yao Lu, Hao Li, Jean Laurens, Yiran Lang, Qin Li, Christopher Bull, Lawrence Larson, David Rosler, Erwan Bezard, Grégoire Courtine, Arto V. Nurmikko.
Neuron. 2014-12-01. 84 (6) : 1170-1182.
DOI: 10.1016/j.neuron.2014.11.010 -
Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections.
Mohammadreza Shariatgorji, Anna Nilsson, Richard J.A. Goodwin, Patrik Källback, Nicoletta Schintu, Xiaoqun Zhang, Alan R. Crossman, Erwan Bezard, Per Svenningsson, Per E. Andren.
Neuron. 2014-11-01. 84 (4) : 697-707.
DOI: 10.1016/j.neuron.2014.10.011 -
RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson’s disease.
Wai Kin D. Ko, Marie-Laure Martin-Negrier, Erwan Bezard, Alan R. Crossman, Paula Ravenscroft.
Neurobiology of Disease. 2014-10-01. 70 : 138-148.
DOI: 10.1016/j.nbd.2014.06.013 -
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Giselle Charron, Evelyne Doudnikoff, Marie-Helene Canron, Qin Li, Céline Véga, Sebastien Marais, Jérôme Baufreton, Anne Vital, Stéphane H. R. Oliet, Erwan Bezard.
Front. Aging Neurosci.. 2014-09-24. 6
DOI: 10.3389/fnagi.2014.00258 -
Down-regulating α-synuclein for treating synucleopathies.
Mathieu Bourdenx, Benjamin Dehay, Erwan Bezard.
Mov Disord.. 2014-09-12. 29 (12) : 1463-1465.
DOI: 10.1002/mds.26028 -
Demyelination in a patient receiving ustekinumab for refractory Crohn’s disease
Yaeesh Badat, Wassilios G. Meissner, David Laharie.
J Crohns Colitis. 2014-09-01. 8 (9) : 1138-1139.
DOI: 10.1016/j.crohns.2014.02.004 -
Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.
Mathieu Bourdenx, Erwan Bezard, Benjamin Dehay.
Front. Neuroanat.. 2014-08-14. 8
DOI: 10.3389/fnana.2014.00083 -
Slowing of neurodegeneration in Parkinson’s disease and Huntington’s disease: future therapeutic perspectives.
Anthony H V Schapira, C Warren Olanow, J Timothy Greenamyre, Erwan Bezard.
The Lancet. 2014-08-01. 384 (9942) : 545-555.
DOI: 10.1016/s0140-6736(14)61010-2 -
Slowing of neurodegeneration in Parkinson’s disease and Huntington’s disease: future therapeutic perspectives.
Anthony H V Schapira, C Warren Olanow, J Timothy Greenamyre, Erwan Bezard.
The Lancet. 2014-08-01. 384 (9942) : 545-555.
DOI: 10.1016/s0140-6736(14)61010-2 -
Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage
Federico N. Soria, Alberto Pérez-Samartín, Abraham Martin, Kiran Babu Gona, Jordi Llop, Boguslaw Szczupak, Juan Carlos Chara, Carlos Matute, María Domercq.
J. Clin. Invest.. 2014-07-18. 124 (8) : 3645-3655.
DOI: 10.1172/JCI71886 -
Mutant COQ2 in multiple-system atrophy.
.
N Engl J Med. 2014-07-03. 371 (1) : 80-83.
DOI: 10.1056/NEJMc1311763#SA3 -
ATP P2X receptors downregulate AMPA receptor trafficking and postsynaptic efficacy in hippocampal neurons.
Johan-Till Pougnet, Estelle Toulme, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot.
Neuron. 2014-07-01. 83 (2) : 417-430.
DOI: 10.1016/j.neuron.2014.06.005 -
Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Wassilios G. Meissner.
Progress in Neurobiology. 2014-07-01. 118 : 1-18.
DOI: 10.1016/j.pneurobio.2014.02.005 -
Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.
Pierre-Olivier Fernagut, Benjamin Dehay, Aline Maillard, Erwan Bezard, Paul Perez, Anne Pavy-Le Traon, Olivier Rascol, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner.
Neurobiology of Disease. 2014-07-01. 67 : 133-139.
DOI: 10.1016/j.nbd.2014.03.021 -
Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease.
Santiago Perez-Lloret, Laurence Negre-Pages, Philippe Damier, Arnaud Delval, Pascal Derkinderen, Alain Destée, Wassilios G. Meissner, Ludwig Schelosky, Francois Tison, Olivier Rascol.
JAMA Neurol. 2014-07-01. 71 (7) : 884.
DOI: 10.1001/jamaneurol.2014.753 -
Coordinated reset neuromodulation for Parkinson’s disease: Proof-of-concept study.
Ilya Adamchic, Christian Hauptmann, Utako Brigit Barnikol, Norbert Pawelczyk, Oleksandr Popovych, Thomas Theo Barnikol, Alexander Silchenko, Jens Volkmann, Günter Deuschl, Wassilios G Meissner, Mohammad Maarouf, Volker Sturm, Hans-Joachim Freund, Peter Alexander Tass.
Mov Disord.. 2014-06-28. 29 (13) : 1679-1684.
DOI: 10.1002/mds.25923 -
Systemic gene delivery to the central nervous system using Adeno-associated virus.
Mathieu Bourdenx, Nathalie Dutheil, Erwan Bezard, Benjamin Dehay.
Front. Mol. Neurosci.. 2014-06-02. 7
DOI: 10.3389/fnmol.2014.00050 -
The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Erwan Bezard, Elsa Y. Pioli, Qin Li, Françoise Girard, Vincent Mutel, Charlotte Keywood, Francois Tison, Olivier Rascol, Sonia M. Poli.
Mov Disord.. 2014-05-27. 29 (8) : 1074-1079.
DOI: 10.1002/mds.25920 -
Restless legs syndrome in multiple system atrophy.
Imad Ghorayeb, Sandrine Dupouy, François Tison, Wassilios G. Meissner.
J Neural Transm. 2014-05-13. 121 (12) : 1523-1527.
DOI: 10.1007/s00702-014-1232-0 -
Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
Michel Engeln, Philippe De Deurwaerdère, Qin Li, Erwan Bezard, Pierre-Olivier Fernagut.
Cereb. Cortex. 2014-04-25. 25 (9) : 2783-2792.
DOI: 10.1093/cercor/bhu076 -
Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.
Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G. Brown, David J. Burn, Janice L. Holton, Horacio Kaufmann, Vladimir S. Kostic, Helen Ling, Wassilios G. Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K. Wenning,.
Mov Disord.. 2014-04-18. 29 (7) : 857-867.
DOI: 10.1002/mds.25880 -
Effects of L-tryptophan on L-DOPA-induced dyskinesia in the L-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson’s disease.
Wai Kin D. Ko, Qin Li, Erwan Bezard.
Neuroscience Letters. 2014-04-01. 566 : 72-76.
DOI: 10.1016/j.neulet.2014.02.027 -
Accuracy of portable polygraphy for the diagnosis of sleep apnea in multiple system atrophy.
Wassilios G. Meissner, Olivier Flabeau, Paul Perez, Jacques Taillard, Fabienne Marquant, Sandrine Dupouy, François Tison, Pierre Philip, Imad Ghorayeb.
Sleep Medicine. 2014-04-01. 15 (4) : 476-479.
DOI: 10.1016/j.sleep.2013.12.013 -
A cross-sectional study on drug use in multiple system atrophy
María Verónica Rey, Santiago Perez-Lloret, Anne Pavy-Le Traon, Wassilios G. Meissner, Francois Tison, Olivier Rascol.
CNS Drugs. 2014-03-29. 28 (5) : 483-490.
DOI: 10.1007/s40263-014-0159-1 -
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Jordi Bové, Marta Martínez-Vicente, Benjamin Dehay, Celine Perier, Ariadna Recasens, Agnes Bombrun, Bruno Antonsson, Miquel Vila.
Autophagy. 2014-03-26. 10 (5) : 889-900.
DOI: 10.4161/auto.28286 -
Combined fenobam and amantadine treatment promotes robust antidyskinetic effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson’s disease.
Wai Kin D. Ko, Elsa Pioli, Qin Li, Steve McGuire, Audrey Dufour, Todd B. Sherer, Erwan Bezard, Maurizio F. Facheris.
Mov Disord.. 2014-03-07. 29 (6) : 772-779.
DOI: 10.1002/mds.25859 -
D1 receptor agonist improves sleep-wake parameters in experimental parkinsonism.
Carole Hyacinthe, Quentin Barraud, François Tison, Erwan Bezard, Imad Ghorayeb.
Neurobiology of Disease. 2014-03-01. 63 : 20-24.
DOI: 10.1016/j.nbd.2013.10.029 -
Intra-axonal protein aggregation in the peripheral nervous system.
Anne Vital, Wassillios G. Meissner, Marie-Hélène Canron, Marie-Laure Martin-Negrier, Erwan Bezard, François Tison, Claude Vital.
J Peripher Nerv Syst. 2014-03-01. 19 (1) : 44-49.
DOI: 10.1111/jns5.12056 -
Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila.
Ann Neurol.. 2014-02-18. 75 (3) : 351-362.
DOI: 10.1002/ana.24066 -
Abnormal structure-specific peptide transmission and processing in a primate model of Parkinson’s disease and l-DOPA-induced dyskinesia.
Mathieu Bourdenx, Anna Nilsson, Henrik Wadensten, Maria Fälth, Qin Li, Alan R. Crossman, Per E. Andrén, Erwan Bezard.
Neurobiology of Disease. 2014-02-01. 62 : 307-312.
DOI: 10.1016/j.nbd.2013.10.016 -
Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard.
Neurobiology of Disease. 2014-02-01. 62 : 179-192.
DOI: 10.1016/j.nbd.2013.09.020 -
Long distance effect on ligand-gated ion channels extracellular domain may affect interactions with the intracellular machinery.
Maurice Garret, Eric Boué-Grabot, Antoine Taly.
Communicative & Integrative Biology. 2014-01-30. 7 (1) : e27984.
DOI: 10.4161/cib.27984 -
Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy.
Olivier Flabeau, Wassilios G. Meissner, Annaig Ozier, Patrick Berger, François Tison, Pierre-Olivier Fernagut.
Mov Disord.. 2014-01-17. 29 (3) : 388-395.
DOI: 10.1002/mds.25804 -
L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Gregory Porras, Philippe De Deurwaerdere, Qin Li, Matteo Marti, Rudolf Morgenstern, Reinhard Sohr, Erwan Bezard, Michele Morari, Wassilios G. Meissner.
Sci Rep. 2014-01-16. 4 (1)
DOI: 10.1038/srep03730 -
Movement disorders in 2013: Diagnosing and treating PD-the earlier the better?
François Tison, Wassilios G. Meissner.
Nat Rev Neurol. 2014-01-07. 10 (2) : 65-66.
DOI: 10.1038/nrneurol.2013.273 -
Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison.
Sandrine M. J. Camus, Céline Rochais, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard.
Front. Behav. Neurosci.. 2014-01-01. 8
DOI: 10.3389/fnbeh.2014.00047 -
Premotor parkinsonism models.
Erwan Bezard, Pierre-Olivier Fernagut.
Parkinsonism & Related Disorders. 2014-01-01. 20 : S17-S19.
DOI: 10.1016/s1353-8020(13)70007-5 -
Intraoperative Neurophysiological Evidence of Hydrogen Peroxide-Induced Stroke in Insular Tumor Surgery.
Alba Leon Jorba, Miguel Lopez Cuina, Gloria Villalba Martinez, Alessandro Principe.
Turkish Neurosurgery. 2014-01-01.
DOI: 10.5137/1019-5149.jtn.11387-14.1 -
Premotor parkinsonism models.
Erwan Bezard, Pierre-Olivier Fernagut.
Parkinsonism & Related Disorders. 2014-01-01. 20 : S17-S19.
DOI: 10.1016/s1353-8020(13)70007-5 -
Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification.
M. Moudjou, P. Sibille, G. Fichet, F. Reine, J. Chapuis, L. Herzog, E. Jaumain, F. Laferriere, C.-A. Richard, H. Laude, O. Andreoletti, H. Rezaei, V. Beringue.
mBio. 2013-12-31. 5 (1)
DOI: 10.1128/mbio.00829-13 -
Withdrawing amantadine in dyskinetic patients with Parkinson disease : The AMANDYSK trial
F. Ory-Magne, J.-C. Corvol, J.-P. Azulay, A.-M. Bonnet, C. Brefel-Courbon, P. Damier, E. Dellapina, A. Destee, F. Durif, M. Galitzky, T. Lebouvier, W. Meissner, C. Thalamas, F. Tison, A. Salis, A. Sommet, F. Viallet, M. Vidailhet, O. Rascol,.
Neurology. 2013-12-26. 82 (4) : 300-307.
DOI: 10.1212/WNL.0000000000000050 -
Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia.
Erwan Bézard, Ana Muñoz, Elisabetta Tronci, Elsa Y. Pioli, Qin Li, Gregory Porras, Anders Björklund, Manolo Carta.
Neuroscience Research. 2013-12-01. 77 (4) : 242-246.
DOI: 10.1016/j.neures.2013.10.002 -
Standard strategies for diagnosis and treatment of patients with newly diagnosed Parkinson disease
F. Tison, W. G. Meissner.
Neurology: Clinical Practice. 2013-12-01. 3 (6) : 480-481.
DOI: 10.1212/01.CPJ.0000437017.29917.c9 -
Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy
P.O. Fernagut, W.G. Meissner, M. Biran, M. Fantin, F. Bassil, J.M. Franconi, F. Tison.
Synapse. 2013-11-15. 68 (3) : 98-106.
DOI: 10.1002/syn.21719 -
Facial emotion recognition is inversely correlated with tremor severity in essential tremor
Nicolas Auzou, Alexandra Foubert-Samier, Sandrine Dupouy, Wassilios G. Meissner.
J Neural Transm. 2013-11-01. 121 (4) : 347-351.
DOI: 10.1007/s00702-013-1110-1 -
Single-molecule imaging of the functional crosstalk between surface NMDA and dopamine D1 receptors.
L. Ladepeche, J. P. Dupuis, D. Bouchet, E. Doudnikoff, L. Yang, Y. Campagne, E. Bezard, E. Hosy, L. Groc.
Proceedings of the National Academy of Sciences. 2013-10-14. 110 (44) : 18005-18010.
DOI: 10.1073/pnas.1310145110 -
Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics
Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Jérôme Chapuis, Pierre Sibille, Laetitia Herzog, Fabienne Reine, Emilie Jaumain, Hubert Laude, Human Rezaei, Vincent Béringue.
PLoS Pathog. 2013-10-10. 9 (10) : e1003702.
DOI: 10.1371/journal.ppat.1003702 -
Inhibition of P2X4 function by P2Y6 UDP receptors in microglia.
Louis-Philippe Bernier, Ariel R. Ase, Éric Boué-Grabot, Philippe Séguéla.
Glia. 2013-10-07. 61 (12) : 2038-2049.
DOI: 10.1002/glia.22574 -
Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.
Severine Chaumont, Caroline André, David Perrais, Eric Boué-Grabot, Antoine Taly, Maurice Garret.
J. Biol. Chem.. 2013-08-09. 288 (39) : 28254-28265.
DOI: 10.1074/jbc.M113.470807 -
D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in rats.
M. Krawczyk, X. Mason, J. DeBacker, R. Sharma, C. P. Normandeau, E. R. Hawken, C. Di Prospero, C. Chiang, A. Martinez, A. A. Jones, E. Doudnikoff, S. Caille, E. Bezard, F. Georges, E. C. Dumont.
Journal of Neuroscience. 2013-07-17. 33 (29) : 11960-11971.
DOI: 10.1523/jneurosci.1784-13.2013 -
Birth origin differentially affects depressive-like behaviours: are captive-born cynomolgus monkeys more vulnerable to depression than their wild-born counterparts?
Sandrine MJ. Camus, Céline Rochais, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard.
PLoS ONE. 2013-07-04. 8 (7) : e67711.
DOI: 10.1371/journal.pone.0067711 -
Relevance of stroke subtype in vascular risk prediction.
A. Ois, E. Cuadrado-Godia, A. Rodriguez-Campello, E. Giralt-Steinhauer, J. Jimenez-Conde, M. Lopez-Cuina, M. Ley, C. Soriano, J. Roquer.
Neurology. 2013-07-03. 81 (6) : 575-580.
DOI: 10.1212/wnl.0b013e31829e6f37 -
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Michel Engeln, Stefania Fasano, Serge H. Ahmed, Martine Cador, Veerle Baekelandt, Erwan Bezard, Pierre-Olivier Fernagut.
Ann Neurol.. 2013-07-01. 74 (1) : 140-144.
DOI: 10.1002/ana.23881 -
L-DOPA and graft-induced dyskinesia: different treatment, same story?
Ludivine S Breger, Emma L Lane.
Exp Biol Med (Maywood). 2013-07-01. 238 (7) : 725-732.
DOI: 10.1177/1535370213488478 -
Levodopa-induced dyskinesias in the absence of nigrostriatal degeneration.
Erwan Bézard, C. Warren Olanow, José A. Obeso.
Mov Disord.. 2013-06-20. 28 (8) : 1023-1024.
DOI: 10.1002/mds.25533 -
Isolated generalized dystonia in biallelic missense mutations of the ATM gene
Wassilios G. Meissner, Marie Fernet, Jérôme Couturier, Janet Hall, Anthony Laugé, Patrick Henry, Dominique Stoppa-Lyonnet, François Tison.
Mov Disord.. 2013-05-02. 28 (13) : 1897-1899.
DOI: 10.1002/mds.25487 -
Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
Sandrine M. J. Camus, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard.
PLoS ONE. 2013-04-29. 8 (4) : e62141.
DOI: 10.1371/journal.pone.0062141 -
Lysosomal impairment in Parkinson’s disease.
Benjamin Dehay, Marta Martinez-Vicente, Guy A. Caldwell, Kim A. Caldwell, Zhenyue Yue, Mark R. Cookson, Christine Klein, Miquel Vila, Erwan Bezard.
Mov Disord.. 2013-04-11. 28 (6) : 725-732.
DOI: 10.1002/mds.25462 -
Effects of memantine and galantamine on cognitive performance in aged rhesus macaques.
Jay S. Schneider, Elsa Y. Pioli, Yang Jianzhong, Qin Li, Erwan Bezard.
Neurobiology of Aging. 2013-04-01. 34 (4) : 1126-1132.
DOI: 10.1016/j.neurobiolaging.2012.10.020 -
Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over (“n-of-1”) exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson’s disease patients.
François Tison, Laurence Nègre-Pagès, Wassilios G. Meissner, Sandrine Dupouy, Qin Li, Marie-Laure Thiolat, Thibaud Thiollier, Monique Galitzky, Fabienne Ory-Magne, Agathe Milhet, Laurent Marquine, Umberto Spampinato, Olivier Rascol, Erwan Bezard.
Parkinsonism & Related Disorders. 2013-04-01. 19 (4) : 416-421.
DOI: 10.1016/j.parkreldis.2012.12.003 -
The natural history of multiple system atrophy: A prospective European cohort study
Gregor K Wenning, Felix Geser, Florian Krismer, Klaus Seppi, Susanne Duerr, Sylvia Boesch, Martin Köllensperger, Georg Goebel, Karl P Pfeiffer, Paolo Barone, Maria Teresa Pellecchia, Niall P Quinn, Vasiliki Koukouni, Clare J Fowler, Anette Schrag, Christopher J Mathias, Nir Giladi, Tanya Gurevich, Erik Dupont, Karen Ostergaard, Christer F Nilsson, Håkan Widner, Wolfgang Oertel, Karla Maria Eggert, Alberto Albanese, Francesca del Sorbo, Eduardo Tolosa, Adriana Cardozo, Günther Deuschl, Helge Hellriegel, Thomas Klockgether, Richard Dodel, Cristina Sampaio, Miguel Coelho, Ruth Djaldetti, Eldad Melamed, Thomas Gasser, Christoph Kamm, Giuseppe Meco, Carlo Colosimo, Olivier Rascol, Wassilios G Meissner, François Tison, Werner Poewe.
The Lancet Neurology. 2013-03-01. 12 (3) : 264-274.
DOI: 10.1016/S1474-4422(12)70327-7 -
Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia.
Erwan Bezard, Elisabetta Tronci, Elsa Y. Pioli, Qin Li, Gregory Porras, Anders Björklund, Manolo Carta.
Mov Disord.. 2013-02-06. 28 (8) : 1088-1096.
DOI: 10.1002/mds.25366 -
Comparison of rating scales used to evaluate L-DOPA-induced dyskinesia in the 6-OHDA lesioned rat.
Ludivine S. Breger, Stephen B. Dunnett, Emma L. Lane.
Neurobiology of Disease. 2013-02-01. 50 : 142-150.
DOI: 10.1016/j.nbd.2012.10.013 -
Reinforcing properties of Pramipexole in normal and parkinsonian rats.
Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut.
Neurobiology of Disease. 2013-01-01. 49 : 79-86.
DOI: 10.1016/j.nbd.2012.08.005 -
Validation of the French version of the MSA health-related Quality of Life scale (MSA-QoL)
W.G. Meissner, A. Foubert-Samier, S. Dupouy, R. Debs, A. Gerdelat-Mas, V. Cochen De Cock, A. Schrag, O. Rascol, F. Tison, A. Pavy-Le Traon.
Revue Neurologique. 2013-01-01. 169 (1) : 53-58.
DOI: 10.1016/j.neurol.2012.02.011 -
Zn2+ -induced ERK activation mediates PARP-1-dependent ischemic-reoxygenation damage to oligodendrocytes
Maria Domercq, Susana Mato, Federico N. Soria, M. Victoria Sánchez-gómez, Elena Alberdi, Carlos Matute.
Glia. 2012-12-22. 61 (3) : 383-393.
DOI: 10.1002/glia.22441 -
Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.
Jay S. Schneider, Elsa Y. Pioli, Yang Jianzhong, Qin Li, Erwan Bezard.
Mov Disord.. 2012-12-12. 28 (5) : 663-667.
DOI: 10.1002/mds.25258 -
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.
Marie-Hélène Canron, Martine Perret, Anne Vital, Erwan Bézard, Benjamin Dehay.
Sci Rep. 2012-11-30. 2 (1)
DOI: 10.1038/srep00910 -
Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias.
M. Marti, D. Rodi, Q. Li, R. Guerrini, S. Fasano, I. Morella, A. Tozzi, R. Brambilla, P. Calabresi, M. Simonato, E. Bezard, M. Morari.
Journal of Neuroscience. 2012-11-14. 32 (46) : 16106-16119.
DOI: 10.1523/jneurosci.6408-11.2012 -
Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias.
M. Marti, D. Rodi, Q. Li, R. Guerrini, S. Fasano, I. Morella, A. Tozzi, R. Brambilla, P. Calabresi, M. Simonato, E. Bezard, M. Morari.
Journal of Neuroscience. 2012-11-14. 32 (46) : 16106-16119.
DOI: 10.1523/jneurosci.6408-11.2012 -
Experimental reappraisal of continuous dopaminergic stimulation against L-dopa-induced dyskinesia.
Erwan Bezard.
Mov Disord.. 2012-11-09. 28 (8) : 1021-1022.
DOI: 10.1002/mds.25251 -
Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner.
Ann Neurol.. 2012-11-01. 72 (5) : 816-820.
DOI: 10.1002/ana.23663 -
When does Parkinson’s disease begin? from prodromal disease to motor signs
W.G. Meissner.
Revue Neurologique. 2012-11-01. 168 (11) : 809-814.
DOI: 10.1016/j.neurol.2012.07.004 -
New insights and the need for revised diagnostic criteria
E. Apartis, A. Blancher, W. G. Meissner, L. Guyant-Marechal, D. Maltete, T. De Broucker, A.-P. Legrand, H. Bouzenada, H. T. Thanh, M. Sallansonnet-Froment, A. Wang, F. Tison, C. Roue-Jagot, F. Sedel, P. Charles, S. Whalen, D. Heron, S. Thobois, A. Poisson, G. Lesca, A.-M. Ouvrard-Hernandez, V. Fraix, S. Palfi, M.-O. Habert, B. Gaymard, J.-C. Dussaule, P. Pollak, M. Vidailhet, A. Durr, J.-C. Barbot, V. Gourlet, A. Brice, M. Anheim.
Neurology. 2012-10-17. 79 (18) : 1898-1907.
DOI: 10.1212/WNL.0b013e318271f7ff -
PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
Gregory Porras, Amandine Berthet, Benjamin Dehay, Qin Li, Laurent Ladepeche, Elisabeth Normand, Sandra Dovero, Audrey Martinez, Evelyne Doudnikoff, Marie-Laure Martin-Négrier, Qin Chuan, Bertrand Bloch, Daniel Choquet, Eric Boué-Grabot, Laurent Groc, Erwan Bezard.
J. Clin. Invest.. 2012-10-08. 122 (11) : 3977-3989.
DOI: 10.1172/JCI59426 -
Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats.
Gaynor A. Smith, Ludivine S. Breger, Emma L. Lane, Stephen B. Dunnett.
Neuropharmacology. 2012-10-01. 63 (5) : 818-828.
DOI: 10.1016/j.neuropharm.2012.06.011 -
Assessment of quality of life with the multiple system atrophy health-related quality of life scale
Wassilios G. Meissner, Alexandra Foubert-Samier, Sandrine Dupouy, Angélique Gerdelat-Mas, Rachel Debs, Fabienne Marquant, Valérie Cochen De Cock, Olivier Rascol, François Tison, Anne Pavy-Le Traon.
Mov. Disord.. 2012-10-01. 27 (12) : 1574-1577.
DOI: 10.1002/mds.25174 -
Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson’s disease.
Cristina Miguelez, Stéphanie Morin, Audrey Martinez, Michel Goillandeau, Erwan Bezard, Bernard Bioulac, Jérôme Baufreton.
The Journal of Physiology. 2012-09-25. 590 (22) : 5861-5875.
DOI: 10.1113/jphysiol.2012.241331 -
Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove.
Benjamin Dehay, Marta Martinez-Vicente, Alfredo Ramirez, Celine Perier, Christine Klein, Miquel Vila, Erwan Bezard.
Autophagy. 2012-09-14. 8 (9) : 1389-1391.
DOI: 10.4161/auto.21011 -
A critique of available scales and presentation of the Non-Human Primate Dyskinesia Rating Scale.
Susan H. Fox, Tom H. Johnston, Qin Li, Jonathan Brotchie, Erwan Bezard.
Mov. Disord.. 2012-09-13. 27 (11) : 1373-1378.
DOI: 10.1002/mds.25133 -
The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: An experimental study in the monkey
J Y Rotge, B Aouizerate, V Amestoy, V Lambrecq, N Langbour, T H Nguyen, S Dovero, L Cardoit, J Tignol, B Bioulac, P Burbaud, D Guehl.
Transl Psychiatry. 2012-09-01. 2 (9) : e161-e161.
DOI: 10.1038/tp.2012.88 -
A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family.
Louis-Philippe Bernier, Dominique Blais, Éric Boué-Grabot, Philippe Séguéla.
PLoS ONE. 2012-07-11. 7 (7) : e40595.
DOI: 10.1371/journal.pone.0040595 -
Animal models of Parkinson’s disease: limits and relevance to neuroprotection studies.
Erwan Bezard, Zhenyu Yue, Deniz Kirik, Maria Grazia Spillantini.
Mov Disord. 2012-07-02. 28 (1) : 61-70.
DOI: 10.1002/mds.25108 -
Methods for treating neurological conditions (WO2011159945)
Wassilios G Meissner.
Expert Opinion on Therapeutic Patents. 2012-06-15. 22 (7) : 847-852.
DOI: 10.1517/13543776.2012.699524 -
Assessment of the Scopa-Aut questionnaire in multiple system atrophy: Relation to UMSARS scores and progression over time
Nathalie Damon-Perrière, Alexandra Foubert-Samier, Valérie Cochen De Cock, Angélique Gerdelat-Mas, Rachel Debs, Anne Pavy-Le Traon, Jean-Michel Senard, Olivier Rascol, François Tison, Wassilios G. Meissner.
Parkinsonism & Related Disorders. 2012-06-01. 18 (5) : 612-615.
DOI: 10.1016/j.parkreldis.2011.12.009 -
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.
B. Dehay, A. Ramirez, M. Martinez-Vicente, C. Perier, M.-H. Canron, E. Doudnikoff, A. Vital, M. Vila, C. Klein, E. Bezard.
Proceedings of the National Academy of Sciences. 2012-05-30. 109 (24) : 9611-9616.
DOI: 10.1073/pnas.1112368109 -
Localization of endogenous morphine-like compounds in the mouse spinal cord.
Alexis Laux, François Delalande, Jinane Mouheiche, Denise Stuber, Alain Van Dorsselaer, Enrica Bianchi, Erwan Bezard, Pierrick Poisbeau, Yannick Goumon.
J. Comp. Neurol.. 2012-03-06. 520 (7) : 1547-1561.
DOI: 10.1002/cne.22811 -
Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bezard.
Sci Rep. 2012-02-09. 2 (1)
DOI: 10.1038/srep00253 -
P2X4 receptor channels form large noncytolytic pores in resting and activated microglia.
Louis-Philippe Bernier, Ariel R. Ase, Éric Boué-Grabot, Philippe Séguéla.
Glia. 2012-02-08. 60 (5) : 728-737.
DOI: 10.1002/glia.22301 -
A long-term follow-up of weight changes in subthalamic nucleus stimulated Parkinson’s disease patients
A. Foubert-Samier, S. Maurice, S. Hivert, D. Guelh, V. Rigalleau, P. Burbaud, E. Cuny, W. Meissner, F. Tison.
Revue Neurologique. 2012-02-01. 168 (2) : 173-176.
DOI: 10.1016/j.neurol.2011.04.006 -
Toward an animal model of restless legs syndrome?
Imad Ghorayeb, Erwan Bezard.
Mov. Disord.. 2012-01-30. 27 (3) : 337-338.
DOI: 10.1002/mds.24905 -
Functional connectivity in human and monkey brain: new insights for understanding movement disorders?
Palma Pró-Sistiaga, Erwan Bézard.
Mov. Disord.. 2012-01-01. 27 (1) : 61-61.
DOI: 10.1002/mds.24063 -
Extrahypophyseal expression of gonadotropin subunits in pejerrey Odontesthes bonariensis and effects of high water temperatures on their expression
Mariano Elisio, Federico Nicolás Soria, Juan Ignacio Fernandino, Carlos Augusto Strüssmann, Gustavo Manuel Somoza, Leandro Andrés Miranda.
General and Comparative Endocrinology. 2012-01-01. 175 (2) : 329-336.
DOI: 10.1016/j.ygcen.2011.11.036 -
Modeling Parkinson’s disease in primates: The MPTP model.
G. Porras, Q. Li, E. Bezard.
Cold Spring Harbor Perspectives in Medicine. 2011-12-22. 2 (3) : a009308-a009308.
DOI: 10.1101/cshperspect.a009308 -
Contribution of pre-synaptic mechanisms to L-DOPA-induced dyskinesia.
M. Carta, E. Bezard.
Neuroscience. 2011-12-01. 198 : 245-251.
DOI: 10.1016/j.neuroscience.2011.07.070 -
Interplay between ionotropic receptors modulates inhibitory synaptic strength.
Young-Hwan Jo, Eric Boué-Grabot.
Communicative & Integrative Biology. 2011-11-01. 4 (6) : 706-709.
DOI: 10.4161/cib.17291 -
Interplay between ionotropic receptors modulates inhibitory synaptic strength.
Young-Hwan Jo, Eric Boué-Grabot.
Communicative & Integrative Biology. 2011-11-01. 4 (6) : 706-709.
DOI: 10.4161/cib.17291 -
What should be said to the lay public regarding ADHD etiology.
Francois Gonon, Erwan Bezard, Thomas Boraud.
Am. J. Med. Genet.. 2011-08-31. 156 (8) : 989-991.
DOI: 10.1002/ajmg.b.31236 -
Ambiguous mechanisms of dysphagia in multiple system atrophy
Pierre-Olivier Fernagut, Anne Vital, Marie-Hélène Canron, François Tison, Wassilios G. Meissner.
Brain. 2011-08-08. 135 (2) : e205-e205.
DOI: 10.1093/brain/awr185 -
The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research
Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner.
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
DOI: 10.1109/IEMBS.2011.6090148 -
Development of an implantable microstimulation system for chronic DBS in rodents
Raik Paulat, Wassilios Meissner, Rudolf Morgenstern, Andreas Kupsch, Daniel Harnack.
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
DOI: 10.1109/IEMBS.2011.6090147 -
Endogenous morphine-like compound immunoreactivity increases in parkinsonism.
G. Charron, E. Doudnikoff, A. Laux, A. Berthet, G. Porras, M.-H. Canron, P. Barroso-Chinea, Q. Li, C. Qin, M. Nosten-Bertrand, B. Giros, F. Delalande, A. Van Dorsselaer, A. Vital, Y. Goumon, E. Bezard.
Brain. 2011-07-08. 134 (8) : 2321-2338.
DOI: 10.1093/brain/awr166 -
A new cerebral hemorrhage model in cynomolgus macaques created by injection of autologous anticoagulated blood into the brain.
Hua Zhu, Qin Li, Ming Feng, Yun-Xin Chen, Hao Li, Jin-Jiang Sun, Chun-Hua Zhao, Ren-Zhi Wang, Erwan Bezard, Chuan Qin.
Journal of Clinical Neuroscience. 2011-07-01. 18 (7) : 955-960.
DOI: 10.1016/j.jocn.2010.11.038 -
Subthalamic deep brain stimulation increases pallidal firing rate and regularity
René Reese, Arthur Leblois, Frank Steigerwald, Monika Pötter-Nerger, Jan Herzog, H. Maximilian Mehdorn, Günther Deuschl, Wassilios G. Meissner, Jens Volkmann.
Experimental Neurology. 2011-06-01. 229 (2) : 517-521.
DOI: 10.1016/j.expneurol.2011.01.020 -
A tale on animal models of Parkinson’s disease.
Erwan Bezard, Serge Przedborski.
Mov. Disord.. 2011-05-01. 26 (6) : 993-1002.
DOI: 10.1002/mds.23696 -
Priorities in Parkinson’s disease research.
Wassilios G. Meissner, Mark Frasier, Thomas Gasser, Christopher G. Goetz, Andres Lozano, Paola Piccini, José A. Obeso, Olivier Rascol, Anthony Schapira, Valerie Voon, David M. Weiner, François Tison, Erwan Bezard.
Nat Rev Drug Discov. 2011-05-01. 10 (5) : 377-393.
DOI: 10.1038/nrd3430 -
Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse.
Young-Hwan Jo, Emmanuelle Donier, Audrey Martinez, Maurice Garret, Estelle Toulmé, Eric Boué-Grabot.
J. Biol. Chem.. 2011-04-11. 286 (22) : 19993-20004.
DOI: 10.1074/jbc.m111.231324 -
New animal models of Parkinson’s disease.
Benjamin Dehay, Erwan Bezard.
Mov. Disord.. 2011-04-05. 26 (7) : 1198-1205.
DOI: 10.1002/mds.23546 -
New animal models of Parkinson’s disease.
Benjamin Dehay, Erwan Bezard.
Mov. Disord.. 2011-04-05. 26 (7) : 1198-1205.
DOI: 10.1002/mds.23546 -
Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: the case of attention deficit hyperactivity disorder.
Francois Gonon, Erwan Bezard, Thomas Boraud.
PLoS ONE. 2011-01-31. 6 (1) : e14618.
DOI: 10.1371/journal.pone.0014618 -
Migration and differentiation of human mesenchymal stem cells in the normal rat brain.
Jia-Mei Li, Hua Zhu, Shan Lu, Ying Liu, Qin Li, Paula Ravenscroft, Yan-Feng Xu, Lan Huang, Chun-Mei Ma, Erwan Bezard, Robert Chun-Hua Zhao, Ren-zhi Wang, Chuan Qin.
Neurological Research. 2011-01-01. 33 (1) : 84-92.
DOI: 10.1179/016164110x12670144737819 -
Protein aggregation in the aging retina.
François Leger, Pierre-Olivier Fernagut, Marie-Hélène Canron, Sandy Léoni, Claude Vital, François Tison, Erwan Bezard, Anne Vital.
J Neuropathol Exp Neurol. 2011-01-01. 70 (1) : 63-68.
DOI: 10.1097/nen.0b013e31820376cc -
Molecular mechanisms of l-DOPA-induced dyskinesia.
Gilberto Fisone, Erwan Bezard.
International Review of Neurobiology. 2011-01-01. : 95-122.
DOI: 10.1016/b978-0-12-381328-2.00004-3 -
Double-dissociation of the catecholaminergic modulation of synaptic transmission in the oval bed nucleus of the stria terminalis.
Michal Krawczyk, François Georges, Robyn Sharma, Xenos Mason, Amandine Berthet, Erwan Bézard, Éric C. Dumont.
Journal of Neurophysiology. 2011-01-01. 105 (1) : 145-153.
DOI: 10.1152/jn.00710.2010 -
Acquired hepatocerebral degeneration
Wassilios Meissner, François Tison.
Handbook of Clinical Neurology. 2011-01-01. : 193-197.
DOI: 10.1016/B978-0-444-52014-2.00011-2 -
L-dopa-induced dyskinesia-clinical presentation, genetics, and treatment
L.K. Prashanth, Susan Fox, Wassilios G. Meissner.
International Review of Neurobiology. 2011-01-01. : 31-54.
DOI: 10.1016/B978-0-12-381328-2.00002-X -
Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.
Pierre-Olivier Fernagut, Quentin Barraud, Erwan Bezard, Imad Ghorayeb, Francois Tison.
Neurological Research. 2010-12-01. 32 (10) : 1050-1053.
DOI: 10.1179/016164110x12807570509934 -
Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
S. Fasano, E. Bezard, A. D'Antoni, V. Francardo, M. Indrigo, L. Qin, S. Dovero, M. Cerovic, M. A. Cenci, R. Brambilla.
Proceedings of the National Academy of Sciences. 2010-11-29. 107 (50) : 21824-21829.
DOI: 10.1073/pnas.1012071107 -
Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard.
PLoS ONE. 2010-11-22. 5 (11) : e14053.
DOI: 10.1371/journal.pone.0014053 -
Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate.
Quentin Barraud, Ibrahim Obeid, Incarnation Aubert, Gregory Barrière, Hugues Contamin, Steve McGuire, Paula Ravenscroft, Gregory Porras, François Tison, Erwan Bezard, Imad Ghorayeb.
PLoS ONE. 2010-10-13. 5 (10) : e13306.
DOI: 10.1371/journal.pone.0013306 -
Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.
Daniella Rylander, Martin Parent, Sean S. O'Sullivan, Sandra Dovero, Andrew J. Lees, Erwan Bezard, Laurent Descarries, M. Angela Cenci.
Ann Neurol.. 2010-09-29. 68 (5) : 619-628.
DOI: 10.1002/ana.22097 -
Pathogenic lysosomal depletion in Parkinson’s disease
B. Dehay, J. Bove, N. Rodriguez-Muela, C. Perier, A. Recasens, P. Boya, M. Vila.
Journal of Neuroscience. 2010-09-15. 30 (37) : 12535-12544.
DOI: 10.1523/JNEUROSCI.1920-10.2010 -
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Daniella Rylander, Hanna Iderberg, Qin Li, Andrzej Dekundy, Jinlan Zhang, Hao Li, Ren Baishen, Wojciech Danysz, Erwan Bezard, M. Angela Cenci.
Neurobiology of Disease. 2010-09-01. 39 (3) : 352-361.
DOI: 10.1016/j.nbd.2010.05.001 -
Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
Emanuela Santini, Veronique Sgambato-Faure, Qin Li, Marc Savasta, Sandra Dovero, Gilberto Fisone, Erwan Bezard.
PLoS ONE. 2010-08-23. 5 (8) : e12322.
DOI: 10.1371/journal.pone.0012322 -
Normal cerebrovascular reactivity in stroke-like migraine attacks after radiation therapy syndrome
Karim Farid, Wassilios G. Meissner, Alexandra Samier-Foubert, Olivier Barret, Patrice Menegon, François Rouanet, Philippe Fernandez, Jean Marc Orgogozo, Michèle Allard, François Tison, Igor Sibon.
Clinical Nuclear Medicine. 2010-08-01. 35 (8) : 583-585.
DOI: 10.1097/RLU.0b013e3181e4db6f -
Dyspnea as first sign of autonomic failure in postmortem confirmed multiple system atrophy
Wassilios G Meissner, Anne Vital, Imad Ghorayeb, Dominique Guehl, François Tison.
Mov. Disord.. 2010-07-28. 25 (12) : 1997-1998.
DOI: 10.1002/mds.23182 -
Multiple system atrophy: Current and future approaches to management
Olivier Flabeau, Wassilios G. Meissner, François Tison.
Ther Adv Neurol Disord. 2010-06-23. 3 (4) : 249-263.
DOI: 10.1177/1756285610375328 -
Genes regulated in MPTP-treated macaques and human Parkinson’s disease suggest a common signature in prefrontal cortex.
Markus Storvik, Marie-Jeanne Arguel, Sandra Schmieder, Audrey Delerue-Audegond, Qin Li, Chuan Qin, Anne Vital, Bernard Bioulac, Christian E. Gross, Garry Wong, Jean-Louis Nahon, Erwan Bezard.
Neurobiology of Disease. 2010-06-01. 38 (3) : 386-394.
DOI: 10.1016/j.nbd.2010.02.008 -
Deep brain stimulation changes basal ganglia output nuclei firing pattern in the dystonic hamster
Arthur Leblois, René Reese, David Labarre, Melanie Hamann, Angelika Richter, Thomas Boraud, Wassilios G. Meissner.
Neurobiology of Disease. 2010-05-01. 38 (2) : 288-298.
DOI: 10.1016/j.nbd.2010.01.020 -
Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson’s disease.
M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard.
Science Translational Medicine. 2010-04-21. 2 (28) : 28ra28-28ra28.
DOI: 10.1126/scitranslmed.3000664 -
Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Celine Perier, Jordi Bové, Benjamin Dehay, Vernice Jackson-Lewis, Peter S. Rabinovitch, Serge Przedborski, Miquel Vila.
Ann Neurol.. 2010-04-06. : n/a-n/a.
DOI: 10.1002/ana.22034 -
Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone.
Mathias De Roo, Eric Boué-Grabot, Rémy Schlichter.
Neuropharmacology. 2010-03-01. 58 (3) : 569-577.
DOI: 10.1016/j.neuropharm.2009.12.002 -
Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate.
Monty A. Silverdale, Christopher Kobylecki, Penelope J. Hallett, Qin Li, Anthone W. Dunah, Paula Ravenscroft, Erwan Bezard, Jonathan M. Brotchie.
Synapse. 2010-02-01. 64 (2) : 177-180.
DOI: 10.1002/syn.20739 -
Treating Parkinson’s disease: preserve the spines! (Commentary on Soderstrom et al.).
Erwan Bezard.
European Journal of Neuroscience. 2010-02-01. 31 (3) : 477-477.
DOI: 10.1111/j.1460-9568.2010.07117.x -
Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia.
Pedro Barroso-Chinea.
Front. Neuroanat.. 2010-01-01. 4
DOI: 10.3389/fnana.2010.00131 -
IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezard.
Neurobiology of Aging. 2009-12-01. 30 (12) : 2021-2030.
DOI: 10.1016/j.neurobiolaging.2008.02.009 -
Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms.
Maria C Rodriguez-Oroz, Marjan Jahanshahi, Paul Krack, Irene Litvan, Raúl Macias, Erwan Bezard, José A Obeso.
The Lancet Neurology. 2009-12-01. 8 (12) : 1128-1139.
DOI: 10.1016/s1474-4422(09)70293-5 -
Involvement of canonical and non-canonical D1 dopamine receptor signalling pathways in L-dopa-induced dyskinesia.
Céline Guigoni, Erwan Bezard.
Parkinsonism & Related Disorders. 2009-12-01. 15 : S64-S67.
DOI: 10.1016/s1353-8020(09)70783-7 -
Chronic dopaminergic stimulation in Parkinson’s disease: from dyskinesias to impulse control disorders.
Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard.
The Lancet Neurology. 2009-12-01. 8 (12) : 1140-1149.
DOI: 10.1016/s1474-4422(09)70287-x -
Dopamine receptors and L-dopa-induced dyskinesia.
Amandine Berthet, Erwan Bezard.
Parkinsonism & Related Disorders. 2009-12-01. 15 : S8-S12.
DOI: 10.1016/s1353-8020(09)70827-2 -
Chronic dopaminergic stimulation in Parkinson’s disease: from dyskinesias to impulse control disorders.
Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard.
The Lancet Neurology. 2009-12-01. 8 (12) : 1140-1149.
DOI: 10.1016/s1474-4422(09)70287-x -
Dopamine receptors and L-dopa-induced dyskinesia.
Amandine Berthet, Erwan Bezard.
Parkinsonism & Related Disorders. 2009-12-01. 15 : S8-S12.
DOI: 10.1016/s1353-8020(09)70827-2 -
Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms.
Maria C Rodriguez-Oroz, Marjan Jahanshahi, Paul Krack, Irene Litvan, Raúl Macias, Erwan Bezard, José A Obeso.
The Lancet Neurology. 2009-12-01. 8 (12) : 1128-1139.
DOI: 10.1016/s1474-4422(09)70293-5 -
Involvement of canonical and non-canonical D1 dopamine receptor signalling pathways in L-dopa-induced dyskinesia.
Céline Guigoni, Erwan Bezard.
Parkinsonism & Related Disorders. 2009-12-01. 15 : S64-S67.
DOI: 10.1016/s1353-8020(09)70783-7 -
Opsoclonus myoclonus syndrome in the context of Salmonellosis
Olivier Flabeau, Wassilios Meissner, Alexandra Foubert-Samier, Dominique Guehl, Patrice Desbordes, François Tison.
Mov Disord.. 2009-11-15. 24 (15) : 2306-2308.
DOI: 10.1002/mds.22832 -
Inhibitory transmission in locus coeruleus neurons expressing GABA a receptor epsilon subunit has a number of unique properties
P. Belujon, J. Baufreton, L. Grandoso, E. Boué-Grabot, T.F.C. Batten, L. Ugedo, M. Garret, A. I. Taupignon.
Journal of Neurophysiology. 2009-10-01. 102 (4) : 2312-2325.
DOI: 10.1152/jn.00227.2009 -
Sleep disorders in Parkinson’s disease: the contribution of the MPTP non-human primate model.
Quentin Barraud, Virginie Lambrecq, Claude Forni, Steve McGuire, Michael Hill, Bernard Bioulac, Emmanuel Balzamo, Erwan Bezard, François Tison, Imad Ghorayeb.
Experimental Neurology. 2009-10-01. 219 (2) : 574-582.
DOI: 10.1016/j.expneurol.2009.07.019 -
High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.
René Reese, Giselle Charron, Agnès Nadjar, Incarnation Aubert, Marie-Laure Thiolat, Melanie Hamann, Angelika Richter, Erwan Bezard, Wassilios G Meissner.
Neurobiology of Disease. 2009-09-01. 35 (3) : 399-405.
DOI: 10.1016/j.nbd.2009.05.022 -
Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.
Olivier Berton, Céline Guigoni, Qin Li, Bernard H. Bioulac, Incarnation Aubert, Christian E. Gross, Ralph J. DiLeone, Eric J. Nestler, Erwan Bezard.
Biological Psychiatry. 2009-09-01. 66 (6) : 554-561.
DOI: 10.1016/j.biopsych.2009.04.005 -
Axonal sensory motor neuropathy in copper-deficient wilson’s disease
Alexandra Foubert-Samier, Annabelle Kazadi, Marie Rouanet, Anne Vital, Alain Lagueny, FrançOis Tison, Wassilios Meissner.
Muscle Nerve. 2009-08-01. 40 (2) : 294-296.
DOI: 10.1002/mus.21425 -
The nigrostriatal pathway in Creutzfeldt-Jakob disease.
Anne Vital, Pierre-Olivier Fernagut, Marie-Hélène Canron, Julien Joux, Erwan Bezard, Marie-Laure Martin-Negrier, Claude Vital, François Tison.
J Neuropathol Exp Neurol. 2009-07-01. 68 (7) : 809-815.
DOI: 10.1097/nen.0b013e3181abdae8 -
Use of the Triage Stroke Panel in a neurologic emergency service
Igor Sibon, François Rouanet, Wassilios Meissner, Jean Marc Orgogozo.
The American Journal of Emergency Medicine. 2009-06-01. 27 (5) : 558-562.
DOI: 10.1016/j.ajem.2008.05.001 -
Dopamine transporter binding is reduced following disulfiram-induced striatal damage
Wassilios Meissner, Frédéric Macia, Alexandra Foubert-Samier, Martine Guyot, Emmanuel Bussy, Michèle Allard, François Tison.
Mov Disord.. 2009-04-30. 24 (6) : 941-943.
DOI: 10.1002/mds.22397 -
Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia.
A. Berthet, G. Porras, E. Doudnikoff, H. Stark, M. Cador, E. Bezard, B. Bloch.
Journal of Neuroscience. 2009-04-15. 29 (15) : 4829-4835.
DOI: 10.1523/jneurosci.5884-08.2009 -
The pathologic features of neurocutaneous melanosis in a cynomolgus macaque.
Y. Chen, W. Deng, H. Zhu, J. Li, Y. Xu, X. Dai, C. Jia, Q. Kong, L. Huang, Y. Liu, C. Ma, C. Xiao, Q. Li, E. Bezard, C. Qin.
Vet Pathol. 2009-03-09. 46 (4) : 773-775.
DOI: 10.1354/vp.08-vp-0243-q-bc -
Antagonizing L-type Ca2+ channel reduces development of abnormal involuntary movement in the rat model of L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Stefan Schuster, Evelyne Doudnikoff, Daniella Rylander, Amandine Berthet, Incarnation Aubert, Carina Ittrich, Bertrand Bloch, M. Angela Cenci, D. James Surmeier, Bastian Hengerer, Erwan Bezard.
Biological Psychiatry. 2009-03-01. 65 (6) : 518-526.
DOI: 10.1016/j.biopsych.2008.09.008 -
Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism.
t. chaumette, t. lebouvier, p. aubert, b. lardeux, c. qin, q. li, d. accary, e. bézard, s. bruley des varannes, p. derkinderen, m. neunlist.
Neurogastroenterology & Motility. 2009-02-01. 21 (2) : 215-222.
DOI: 10.1111/j.1365-2982.2008.01226.x -
Priming for l-dopa-induced dyskinesia in Parkinson’s disease: a feature inherent to the treatment or the disease?
Agnès Nadjar, Charles R. Gerfen, Erwan Bezard.
Progress in Neurobiology. 2009-01-01. 87 (1) : 1-9.
DOI: 10.1016/j.pneurobio.2008.09.013 -
The vascular endothelial cell is a new origin of melanin pigment on cynomolgus macaque with neurocutaneous melanosis.
Chuan Qin, Hua Zhu, Yunxin Chen, Jiamei Li, Wei Deng, Yanfeng Xu, Xiaowei Dai, Chunshi Jia, Qi Kong, Lan Huang, Yali Liu, Chunmei Ma, Chong Xiao, Ying Liu, Qin Li, Erwan Bezard.
Pigment Cell & Melanoma Research. 2008-12-01. 21 (6) : 710-711.
DOI: 10.1111/j.1755-148x.2008.00507.x -
Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions.
L.-P. Bernier, A. R. Ase, S. Chevallier, D. Blais, Q. Zhao, E. Boue-Grabot, D. Logothetis, P. Seguela.
Journal of Neuroscience. 2008-11-26. 28 (48) : 12938-12945.
DOI: 10.1523/jneurosci.3038-08.2008 -
High water temperatures impair the reproductive ability of the pejerrey fish Odontesthes bonariensis: effects on the hypophyseal-gonadal axis
Federico N. Soria, Carlos A. Strüssmann, Leandro A. Miranda.
Physiological and Biochemical Zoology. 2008-11-01. 81 (6) : 898-905.
DOI: 10.1086/588178 -
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
A. Munoz, Q. Li, F. Gardoni, E. Marcello, C. Qin, T. Carlsson, D. Kirik, M. Di Luca, A. Bjorklund, E. Bezard, M. Carta.
Brain. 2008-10-24. 131 (12) : 3380-3394.
DOI: 10.1093/brain/awn235 -
Hearing and seeing: Unusual early signs of Wernicke encephalopathy
O. Flabeau, A. Foubert-Samier, W. Meissner, F. Tison.
Neurology. 2008-08-25. 71 (9) : 694-694.
DOI: 10.1212/01.wnl.0000324599.66359.b1 -
Striatal histone modifications in models of levodopa-induced dyskinesia.
Anthony P. Nicholas, Farah D. Lubin, Penelope J. Hallett, Padmapriya Vattem, Paula Ravenscroft, Erwan Bezard, Shaobo Zhou, Susan H. Fox, Jonathan M. Brotchie, J. David Sweatt, David G. Standaert.
J Neurochem. 2008-07-01. 106 (1) : 486-494.
DOI: 10.1111/j.1471-4159.2008.05417.x -
Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats.
E.Y. Pioli, W. Meissner, R. Sohr, C.E. Gross, E. Bezard, B.H. Bioulac.
Neuroscience. 2008-06-01. 153 (4) : 1213-1224.
DOI: 10.1016/j.neuroscience.2008.01.084 -
Intratelencephalic corticostriatal neurons equally excite striatonigral and striatopallidal neurons and their discharge activity is selectively reduced in experimental parkinsonism.
Bérangère Ballion, Nicolas Mallet, Erwan Bézard, José Luis Lanciego, Francois Gonon.
European Journal of Neuroscience. 2008-04-25. 27 (9) : 2313-2321.
DOI: 10.1111/j.1460-9568.2008.06192.x -
The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor lovastatin reduces severity of L-DOPA-induced abnormal involuntary movements in experimental Parkinson’s disease.
S. Schuster, A. Nadjar, J. T. Guo, Q. Li, C. Ittrich, B. Hengerer, E. Bezard.
Journal of Neuroscience. 2008-04-23. 28 (17) : 4311-4316.
DOI: 10.1523/jneurosci.4720-07.2008 -
Deep-brain stimulation of the internal pallidum in multiple system atrophy | Stimulation cérébrale profonde du pallidum interne dans l’atrophie multisystématisée
V. Lambrecq, E. Krim, W. Meissner, D. Guehl, F. Tison.
Revue Neurologique. 2008-04-01. 164 (4) : 398-402.
DOI: 10.1016/j.neurol.2008.01.004 -
Measure of the regularity of events in stochastic point processes, application to neuron activity analysis
D. Labarre, W. Meissner, T. Boraud.
2008 IEEE International Conference on Acoustics, Speech and Signal Processing. 2008-03-01.
DOI: 10.1109/ICASSP.2008.4517653 -
Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism
Daniel Harnack, Wassilios Meissner, Julia A. Jira, Christine Winter, Rudolf Morgenstern, Andreas Kupsch.
Experimental Neurology. 2008-03-01. 210 (1) : 257-260.
DOI: 10.1016/j.expneurol.2007.10.002 -
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure.
Birger Scholz, Marcus Svensson, Henrik Alm, Karl Sköld, Maria Fälth, Kim Kultima, Céline Guigoni, Evelyne Doudnikoff, Qin Li, Alan R. Crossman, Erwan Bezard, Per E. Andrén.
PLoS ONE. 2008-02-13. 3 (2) : e1589.
DOI: 10.1371/journal.pone.0001589 -
Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson’s disease.
Dieter Scheller, Christine Stichel-Gunkel, Hermann Lübbert, Gregory Porras, Paula Ravenscroft, Michael Hill, Erwan Bezard.
Neuroscience Letters. 2008-02-01. 432 (1) : 30-34.
DOI: 10.1016/j.neulet.2007.12.001 -
Preclinical development of gene therapy for Parkinson’s disease.
Grégory Porras, Erwan Bezard.
Experimental Neurology. 2008-01-01. 209 (1) : 72-81.
DOI: 10.1016/j.expneurol.2007.08.003 -
Cytoplasmic expression of human telomerase catalytic protein (hTERT) in neutrophils: an immunoelectron microscopy study.
Sébastien Lepreux, Evelyne Doudnikoff, Incarnation Aubert, Paulette Bioulac-Sage, Bertrand Bloch, Marie-Laure Martin-Negrier.
Ultrastructural Pathology. 2008-01-01. 32 (5) : 178-183.
DOI: 10.1080/01913120802034504 -
Subthalamic stimulation increases striatal tyrosine hydroxylase phosphorylation
Rene Reese, Christine Winter, Agnes Nadjar, Daniel Harnack, Rudolf Morgenstern, Andreas Kupsch, Erwan Bezard, Wassilios Meissner.
NeuroReport. 2008-01-01. 19 (2) : 179-182.
DOI: 10.1097/WNR.0b013e3282f417b4 -
Continuous high-frequency stimulation in freely moving rats: Development of an implantable microstimulation system
Daniel Harnack, Wassilios Meissner, Raik Paulat, Hannes Hilgenfeld, Wolf-Dieter Müller, Christine Winter, Rudolf Morgenstern, Andreas Kupsch.
Journal of Neuroscience Methods. 2008-01-01. 167 (2) : 278-291.
DOI: 10.1016/j.jneumeth.2007.08.019 -
RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson’s disease.
S. J. Gold, C. V. Hoang, B. W. Potts, G. Porras, E. Pioli, K. W. Kim, A. Nadjar, C. Qin, G. J. LaHoste, Q. Li, B. H. Bioulac, J. L. Waugh, E. Gurevich, R. L. Neve, E. Bezard.
Journal of Neuroscience. 2007-12-26. 27 (52) : 14338-14348.
DOI: 10.1523/jneurosci.4223-07.2007 -
Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson’s disease through inhibition of ROS-NO pathway.
Shuhong Guo, Jingqi Yan, Tangbin Yang, Xianqiang Yang, Erwan Bezard, Baolu Zhao.
Biological Psychiatry. 2007-12-01. 62 (12) : 1353-1362.
DOI: 10.1016/j.biopsych.2007.04.020 -
High frequency stimulation of the subthalamic nucleus modulates neurotransmission in limbic brain regions of the rat
Christine Winter, Christoph Lemke, Reinhard Sohr, Wassilios Meissner, Daniel Harnack, Georg Juckel, Rudolf Morgenstern, Andreas Kupsch.
Exp Brain Res. 2007-10-26. 185 (3) : 497-507.
DOI: 10.1007/s00221-007-1171-1 -
Late emergence of synchronized oscillatory activity in the pallidum during progressive parkinsonism
Arthur Leblois, Wassilios Meissner, Bernard Bioulac, Christian E. Gross, David Hansel, Thomas Boraud.
European Journal of Neuroscience. 2007-09-14. 26 (6) : 1701-1713.
DOI: 10.1111/j.1460-9568.2007.05777.x -
Noradrenergic modulation of subthalamic nucleus activity: behavioral and electrophysiological evidence in intact and 6-hydroxydopamine-lesioned rats.
P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, A. Benazzouz.
Journal of Neuroscience. 2007-09-05. 27 (36) : 9595-9606.
DOI: 10.1523/jneurosci.2583-07.2007 -
An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons.
Estelle Toulmé, Dominique Blais, Claire Léger, Marc Landry, Maurice Garret, Philippe Séguéla, Eric Boué-Grabot.
J Neurochem. 2007-08-01. 102 (4) : 1357-1368.
DOI: 10.1111/j.1471-4159.2007.04640.x -
Differences in ultrastructural localization of dopaminergic D1 receptors between dorsal striatum and nucleus accumbens in the rat.
Brigitte Dumartin, Evelyne Doudnikoff, François Gonon, Bertrand Bloch.
Neuroscience Letters. 2007-06-01. 419 (3) : 273-277.
DOI: 10.1016/j.neulet.2007.04.034 -
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
C. Perier, J. Bove, D.-C. Wu, B. Dehay, D.-K. Choi, V. Jackson-Lewis, S. Rathke-Hartlieb, P. Bouillet, A. Strasser, J. B. Schulz, S. Przedborski, M. Vila.
Proceedings of the National Academy of Sciences. 2007-05-02. 104 (19) : 8161-8166.
DOI: 10.1073/pnas.0609874104 -
Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates.
Céline Guigoni, Evelyne Doudnikoff, Qin Li, Bertrand Bloch, Erwan Bezard.
Neurobiology of Disease. 2007-05-01. 26 (2) : 452-463.
DOI: 10.1016/j.nbd.2007.02.001 -
Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity
Benjamin Dehay, Chantal Weber, Yvon Trottier, Anne Bertolotti.
Biotechnol. J.. 2007-05-01. 2 (5) : 559-564.
DOI: 10.1002/biot.200600249 -
Impact of chronic subthalamic high-frequency stimulation on metabolic basal ganglia activity: a 2-deoxyglucose uptake and cytochrome oxidase mRNA study in a macaque model of Parkinson’s disease.
Wassilios Meissner, Celine Guigoni, Laetitia Cirilli, Maurice Garret, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard, Abdelhamid Benazzouz.
European Journal of Neuroscience. 2007-04-05. 25 (5) : 1492-1500.
DOI: 10.1111/j.1460-9568.2007.05406.x -
Enhanced preproenkephalin-B-derived opioid transmission in striatum and subthalamic nucleus converges upon globus pallidus internalis in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Qin Li, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Alan R. Crossman, Bertrand Bloch, Erwan Bezard.
Biological Psychiatry. 2007-04-01. 61 (7) : 836-844.
DOI: 10.1016/j.biopsych.2006.06.038 -
MRI versus CT in acute stroke
Wassilios Meissner, Igor Sibon, François Rouanet, Patrice Ménégon, Jean-Marc Orgogozo.
The Lancet. 2007-04-01. 369 (9570) : 1342.
DOI: 10.1016/S0140-6736(07)60623-0 -
Rotigotine treatment partially protects from MPTP toxicity in a progressive macaque model of Parkinson’s disease.
Dieter Scheller, Piu Chan, Qin Li, Tao Wu, Renling Zhang, Le Guan, Paula Ravenscroft, Celine Guigoni, Alan R. Crossman, Michael Hill, Erwan Bezard.
Experimental Neurology. 2007-02-01. 203 (2) : 415-422.
DOI: 10.1016/j.expneurol.2006.08.026 -
Shaping of motor responses by incentive values through the basal ganglia.
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, T. Boraud.
Journal of Neuroscience. 2007-01-31. 27 (5) : 1176-1183.
DOI: 10.1523/jneurosci.3745-06.2007 -
A gamma 2(R43Q) mutation, linked to epilepsy in humans, alters GABAA receptor assembly and modifies subunit composition on the cell surface.
G. Frugier, F. Coussen, M.-F. Giraud, M.-F. Odessa, M. B. Emerit, E. Boue-Grabot, M. Garret.
Journal of Biological Chemistry. 2006-11-30. 282 (6) : 3819-3828.
DOI: 10.1074/jbc.m608910200 -
Novel pharmacological targets for the treatment of Parkinson’s disease.
Anthony H. V. Schapira, Erwan Bezard, Jonathan Brotchie, Frédéric Calon, Graham L. Collingridge, Borris Ferger, Bastian Hengerer, Etienne Hirsch, Peter Jenner, Nicolas Le Novère, José A. Obeso, Michael A. Schwarzschild, Umberto Spampinato, Giora Davidai.
Nat Rev Drug Discov. 2006-10-01. 5 (10) : 845-854.
DOI: 10.1038/nrd2087 -
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast
Benjamin Dehay, Anne Bertolotti.
J. Biol. Chem.. 2006-09-14. 281 (47) : 35608-35615.
DOI: 10.1074/jbc.M605558200 -
A call for clinically driven experimental design in assessing neuroprotection in experimental Parkinsonism.
Erwan Bezard.
Behavioural Pharmacology. 2006-09-01. 17 (5-6) : 379-382.
DOI: 10.1097/00008877-200609000-00003 -
Traditional Chinese medicine for Parkinson’s disease: a review of Chinese literature.
Qin Li, Deming Zhao, Erwan Bezard.
Behavioural Pharmacology. 2006-09-01. 17 (5-6) : 403-410.
DOI: 10.1097/00008877-200609000-00006 -
Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou SB, Wang GJ, Ravenscroft P, Georges F, Crossman AR, Bezard E..
Journal of Neuroscience. 2006-08-23. 26 (34) : 8653-8661.
DOI: 10.1523/jneurosci.2582-06.2006 -
Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys.
Arthur Leblois, Wassilios Meissner, Erwan Bezard, Bernard Bioulac, Christian E. Gross, Thomas Boraud.
European Journal of Neuroscience. 2006-08-01. 24 (4) : 1201-1208.
DOI: 10.1111/j.1460-9568.2006.04984.x -
5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson’s disease.
Erwan Bezard, Irene Gerlach, Rosario Moratalla, Christian E. Gross, Reinhard Jork.
Neurobiology of Disease. 2006-07-01. 23 (1) : 77-86.
DOI: 10.1016/j.nbd.2006.02.003 -
Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine.
Wassilios Meissner, Paula Ravenscroft, René Reese, Daniel Harnack, Rudolf Morgenstern, Andreas Kupsch, Henrik Klitgaard, Bernard Bioulac, Christian E. Gross, Erwan Bezard, Thomas Boraud.
Neurobiology of Disease. 2006-06-01. 22 (3) : 586-598.
DOI: 10.1016/j.nbd.2006.01.009 -
Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia
A. Leblois.
Journal of Neuroscience. 2006-03-29. 26 (13) : 3567-3583.
DOI: 10.1523/JNEUROSCI.5050-05.2006 -
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Ainhoa Bilbao, Andrea Cippitelli, Ana Belén Martín, Noelia Granado, Oscar Ortiz, Erwan Bezard, Jiang-Fan Chen, Miguel Navarro, Fernando Rodríguez de Fonseca, R Moratalla.
Psychopharmacology. 2006-02-10. 185 (2) : 160-168.
DOI: 10.1007/s00213-005-0284-0 -
The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders.
L. Leriche, E. Bezard, C. Gross, O. Guillin, B. Foll, J. Diaz, P. Sokoloff.
CNSNDDT. 2006-02-01. 5 (1) : 25-43.
DOI: 10.2174/187152706784111551 -
The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders.
L. Leriche, E. Bezard, C. Gross, O. Guillin, B. Foll, J. Diaz, P. Sokoloff.
CNSNDDT. 2006-02-01. 5 (1) : 25-43.
DOI: 10.2174/187152706784111551 -
Normalization and expression changes in predefined sets of proteins using 2D gel electrophoresis: a proteomic study of L-DOPA induced dyskinesia in an animal model of Parkinson’s disease using DIGE.
Kim Kultima, Birger Scholz, Henrik Alm, Karl Skold, Marcus Svensson, Alan R Crossman, Erwan Bezard, Per E Andren, Ingrid Lonnstedt.
BMC Bioinformatics. 2006-01-01. 7 (1) : 475.
DOI: 10.1186/1471-2105-7-475 -
Fatal embolic myocardial infarction after systemic thrombolysis for stroke
Wassilios Meissner, Thomas Lempert, Sabine Saeuberlich-Knigge, Wolfgang Bocksch, Ulrich-Frank Pape.
Cerebrovasc Dis. 2006-01-01. 22 (2-3) : 213-214.
DOI: 10.1159/000093812 -
Subthalamic nucleus lesioning inhibits expression and phosphorylation of c-Jun in nigral neurons in the rat’s 6-OHDA model of Parkinson’s disease
Christine Winter, Kai Hosmann, Daniel Harnack, Wassilios Meissner, Gesine Paul, Rudolf Morgenstern, Andreas Kupsch.
Synapse. 2006-01-01. 60 (1) : 69-80.
DOI: 10.1002/syn.20269 -
Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin.
E. Toulme.
Molecular Pharmacology. 2005-11-17. 69 (2) : 576-587.
DOI: 10.1124/mol.105.018812 -
Unraveling substantia nigra sequential gene expression in a progressive MPTP-lesioned macaque model of Parkinson’s disease.
F BASSILANA, N MACE, Q LI, J STUTZMANN, C GROSS, L PRADIER, J BENAVIDES, J MENAGER, E BEZARD.
Neurobiology of Disease. 2005-10-01. 20 (1) : 93-103.
DOI: 10.1016/j.nbd.2005.02.005 -
Hepatic fibrosis and cirrhosis: the (myo)fibroblastic cell subpopulations involved.
C GUYOT, S LEPREUX, C COMBE, E DOUDNIKOFF, P BIOULACSAGE, C BALABAUD, A DESMOULIERE.
The International Journal of Biochemistry & Cell Biology. 2005-09-23.
DOI: 10.1016/j.biocel.2005.08.021 -
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Shuhong Guo, Erwan Bezard, Baolu Zhao.
Free Radical Biology and Medicine. 2005-09-01. 39 (5) : 682-695.
DOI: 10.1016/j.freeradbiomed.2005.04.022 -
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Shuhong Guo, Erwan Bezard, Baolu Zhao.
Free Radical Biology and Medicine. 2005-09-01. 39 (5) : 682-695.
DOI: 10.1016/j.freeradbiomed.2005.04.022 -
Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations
Wassilios Meissner, Arthur Leblois, David Hansel, Bernard Bioulac, Christian E. Gross, Abdelhamid Benazzouz, Thomas Boraud.
Brain. 2005-08-25. 128 (10) : 2372-2382.
DOI: 10.1093/brain/awh616 -
Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning.
Céline Guigoni, Sandra Dovero, Incarnation Aubert, Qin Li, Bernard H. Bioulac, Bertrand Bloch, Eugenia V. Gurevich, Christian E. Gross, Erwan Bezard.
European Journal of Neuroscience. 2005-07-01. 22 (1) : 283-287.
DOI: 10.1111/j.1460-9568.2005.04196.x -
Aging and subcellular localization of m2 muscarinic autoreceptor in basalocortical neurons in vivo.
Marion Décossas, Évelyne Doudnikoff, Bertrand Bloch, Véronique Bernard.
Neurobiology of Aging. 2005-07-01. 26 (7) : 1061-1072.
DOI: 10.1016/j.neurobiolaging.2004.09.007 -
Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria.
Yu-Xiang Xie, Erwan Bezard, Bao-Lu Zhao.
J. Biol. Chem.. 2005-06-27. 280 (37) : 32405-32412.
DOI: 10.1074/jbc.m504664200 -
Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.
C. Guigoni, I. Aubert, Q. Li, V.V. Gurevich, J.L. Benovic, S. Ferry, U. Mach, H. Stark, L. Leriche, K. Håkansson, Bernard H. Bioulac, Christian E. Gross, Pierre Sokoloff, Gilberto Fisone, E.V. Gurevich, Bertrand Bloch, Erwan Bezard.
Parkinsonism & Related Disorders. 2005-06-01. 11 : S25-S29.
DOI: 10.1016/j.parkreldis.2004.11.005 -
Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease.
P.J. Hallett, A.W. Dunah, P. Ravenscroft, S. Zhou, E. Bezard, A.R. Crossman, J.M. Brotchie, D.G. Standaert.
Neuropharmacology. 2005-03-01. 48 (4) : 503-516.
DOI: 10.1016/j.neuropharm.2004.11.008 -
L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain.
E. Bezard, C.E. Gross, Li Qin, V.V. Gurevich, J.L. Benovic, E.V. Gurevich.
Neurobiology of Disease. 2005-03-01. 18 (2) : 323-335.
DOI: 10.1016/j.nbd.2004.10.005 -
Dopamine depletion increases the power and coherence of β-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat
Andrew Sharott, Peter J. Magill, Daniel Harnack, Andreas Kupsch, Wassilios Meissner, Peter Brown.
European Journal of Neuroscience. 2005-03-01. 21 (5) : 1413-1422.
DOI: 10.1111/j.1460-9568.2005.03973.x -
Involvement of sensorimotor, limbic, and associative basal ganglia domains in L-3,4-dihydroxyphenylalanine-induced dyskinesia
C. Guigoni.
Journal of Neuroscience. 2005-02-23. 25 (8) : 2102-2107.
DOI: 10.1523/JNEUROSCI.5059-04.2005 -
Deep brain stimulation in late stage Parkinson’s disease: A retrospective cost analysis in Germany
Wassilios Meissner, Doreen Schreiter, Jens Volkmann, Thomas Trottenberg, Gerd-Helge Schneider, Volker Sturm, Guenther Deuschl, Andreas Kupsch.
J Neurol. 2005-02-01. 252 (2) : 218-223.
DOI: 10.1007/s00415-005-0640-3 -
Coherent spike-wave oscillations in the cortex and subthalamic nucleus of the freely moving rat
P.J. Magill, A. Sharott, D. Harnack, A. Kupsch, W. Meissner, P. Brown.
Neuroscience. 2005-01-01. 132 (3) : 659-664.
DOI: 10.1016/j.neuroscience.2005.01.006 -
Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the striatum and cortex.
Elsa Pioli, Reinhard Sohr, Wassilios Meissner, Nicole Barthe, Christian E. Gross, Erwan Bezard, Bernard H. Bioulac.
Neurochemistry International. 2004-12-01. 45 (7) : 995-1004.
DOI: 10.1016/j.neuint.2004.06.003 -
Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.
Incarnation Aubert, Céline Guigoni, Kerstin Håkansson, Qin Li, Sandra Dovero, Nicole Barthe, Bernard H. Bioulac, Christian E. Gross, Gilberto Fisone, Bertrand Bloch, Erwan Bezard.
Ann Neurol.. 2004-10-27. 57 (1) : 17-26.
DOI: 10.1002/ana.20296 -
Asymmetrically lesioned mesencephalon in healthy rodents: call for caution.
Elsa Y. Pioli, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard.
Brain Research. 2004-10-01. 1022 (1-2) : 251-253.
DOI: 10.1016/j.brainres.2004.07.014 -
Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels.
Éric Boué-Grabot, Estelle Toulmé, Michel B. Émerit, Maurice Garret.
J. Biol. Chem.. 2004-09-29. 279 (50) : 52517-52525.
DOI: 10.1074/jbc.m410223200 -
Rise and fall of minocycline in neuroprotection: need to promote publication of negative results.
Elsa Diguet, Christian E. Gross, François Tison, Erwan Bezard.
Experimental Neurology. 2004-09-01. 189 (1) : 1-4.
DOI: 10.1016/j.expneurol.2004.05.016 -
The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats
Daniel Harnack, Christine Winter, Wassilios Meissner, Torsten Reum, Andreas Kupsch, Rudolf Morgenstern.
Journal of Neuroscience Methods. 2004-09-01. 138 (1-2) : 207-216.
DOI: 10.1016/j.jneumeth.2004.04.019 -
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation
E. Rousseau, B. Dehay, L. Ben-Haiem, Y. Trottier, M. Morange, A. Bertolotti.
Proceedings of the National Academy of Sciences. 2004-06-21. 101 (26) : 9648-9653.
DOI: 10.1073/pnas.0403015101 -
Deleterious effects of minocycline in animal models of Parkinson’s disease and Huntington’s disease.
Elsa Diguet, Pierre-Olivier Fernagut, Xing Wei, Yansheng Du, Richard Rouland, Christian Gross, Erwan Bezard, François Tison.
European Journal of Neuroscience. 2004-06-01. 19 (12) : 3266-3276.
DOI: 10.1111/j.0953-816x.2004.03372.x -
High-frequency stimulation of the entopeduncular nucleus improves dystonia in dtsz hamsters
Daniel Harnack, Melanie Hamann, Wassilios Meissner, Rudolf Morgenstern, Andreas Kupsch, Angelika Richter.
NeuroReport. 2004-06-01. 15 (9) : 1391-1393.
DOI: 10.1097/01.wnr.0000130435.75715.64 -
Subthalamic high frequency stimulation induced rotations are differentially mediated by D1 and D2 receptors
Olaf Bergmann, Christine Winter, Wassilios Meissner, Daniel Harnack, Andreas Kupsch, Rudolf Morgenstern, Torsten Reum.
Neuropharmacology. 2004-06-01. 46 (7) : 974-983.
DOI: 10.1016/j.neuropharm.2004.01.007 -
Neuroprotective strategies for Parkinson’s disease: conceptual limits of animal models and clinical trials.
Wassilios Meissner, Michael P. Hill, François Tison, Christian E. Gross, Erwan Bezard.
Trends in Pharmacological Sciences. 2004-05-01. 25 (5) : 249-253.
DOI: 10.1016/j.tips.2004.03.003 -
Levetiracetam potentiates the antidyskinetic action of amantadine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned primate model of Parkinson’s disease.
M. P. Hill.
Journal of Pharmacology and Experimental Therapeutics. 2004-04-02. 310 (1) : 386-394.
DOI: 10.1124/jpet.104.066191 -
Selective knock-down of P2X7 ATP receptor function by dominant-negative subunits.
R. Raouf.
Molecular Pharmacology. 2004-03-01. 65 (3) : 646-654.
DOI: 10.1124/mol.65.3.646 -
High-frequency stimulation of both zona incerta and subthalamic nucleus induces a similar normalization of basal ganglia metabolic activity in experimental parkinsonism.
ABDELHAMID BENAZZOUZ, CHUN HWEI TAI, WASSILIOS MEISSNER, BERNARD BIOULAC, ERWAN BEZARD, CHRISTIAN GROSS.
The FASEB Journal. 2004-03-01. 18 (3) : 528-530.
DOI: 10.1096/fj.03-0576fje -
High frequency stimulation of the entopeduncular nucleus has no effect on striatal dopaminergic transmission
Wassilios Meissner, Daniel Harnack, Nora Hoessle, Erwan Bezard, Christine Winter, Rudolf Morgenstern, Andreas Kupsch.
Neurochemistry International. 2004-03-01. 44 (4) : 281-286.
DOI: 10.1016/S0197-0186(03)00138-4 -
High frequency stimulation of the entopeduncular nucleus has no effect on striatal dopaminergic transmission.
Wassilios Meissner, Daniel Harnack, Nora Hoessle, Erwan Bezard, Christine Winter, Rudolf Morgenstern, Andreas Kupsch.
Neurochemistry International. 2004-03-01. 44 (4) : 281-286.
DOI: 10.1016/s0197-0186(03)00138-4 -
Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
Erwan Bezard, Michael P. Hill, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée, Henrik Klitgaard.
European Journal of Pharmacology. 2004-02-01. 485 (1-3) : 159-164.
DOI: 10.1016/j.ejphar.2003.11.065 -
Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson’s disease
Gesine Paul, Wassilios Meissner, Susanne Rein, Daniel Harnack, Christine Winter, Kai Hosmann, Rudolf Morgenstern, Andreas Kupsch.
Experimental Neurology. 2004-02-01. 185 (2) : 272-280.
DOI: 10.1016/S0014-4886(03)00363-7 -
Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque.
Erwan Bezard, Michael P. Hill, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée, Henrik Klitgaard.
European Journal of Pharmacology. 2004-02-01. 485 (1-3) : 159-164.
DOI: 10.1016/j.ejphar.2003.11.065 -
Neuroprotective agents for clinical trials in Parkinson’s disease: a systematic assessment.
E. Diguet, C. E. Gross, E. Bezard, F. Tison, N. Stefanova, G. K. Wenning, B. Ravina, S. Fagan, R. Hart, C. Hovinga, D. Murphy, T. Dawson, J. Marler.
Neurology. 2004-01-12. 62 (1) : 158-159.
DOI: 10.1212/wnl.62.1.158 -
Neuroprotective agents for clinical trials in Parkinson’s disease: a systematic assessment.
E. Diguet, C. E. Gross, E. Bezard, F. Tison, N. Stefanova, G. K. Wenning, B. Ravina, S. Fagan, R. Hart, C. Hovinga, D. Murphy, T. Dawson, J. Marler.
Neurology. 2004-01-12. 62 (1) : 158-159.
DOI: 10.1212/wnl.62.1.158 -
Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway.
Oliver Guillin, Nathalie Griffon, Jorge Diaz, Bernard Le Foll, Erwan Bezard, Christian Gross, Chris Lammers, Holger Stark, Patrick Carroll, Jean-Charles Schwartz.
International Review of Neurobiology. 2004-01-01. : 425-444.
DOI: 10.1016/s0074-7742(04)59016-5 -
Levetiracetam Interferes With the L-dopa priming process in MPTP-lesioned drug-naive marmosets.
Michael P Hill, Jonathan M Brotchie, Alan R Crossman, Erwan Bezard, Anne Michel, Renee Grim??e, Henrik Klitgaard.
Clinical Neuropharmacology. 2004-01-01. 27 (4) : 171-177.
DOI: 10.1097/01.wnf.0000135478.70905.3d -
Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway.
Oliver Guillin, Nathalie Griffon, Jorge Diaz, Bernard Le Foll, Erwan Bezard, Christian Gross, Chris Lammers, Holger Stark, Patrick Carroll, Jean-Charles Schwartz.
International Review of Neurobiology. 2004-01-01. : 425-444.
DOI: 10.1016/s0074-7742(04)59016-5 -
Levetiracetam Interferes With the L-dopa priming process in MPTP-lesioned drug-naive marmosets.
Michael P Hill, Jonathan M Brotchie, Alan R Crossman, Erwan Bezard, Anne Michel, Renee Grim??e, Henrik Klitgaard.
Clinical Neuropharmacology. 2004-01-01. 27 (4) : 171-177.
DOI: 10.1097/01.wnf.0000135478.70905.3d -
Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels.
Éric Boué-Grabot, Michel B. Émerit, Estelle Toulmé, Philippe Séguéla, Maurice Garret.
J. Biol. Chem.. 2003-12-01. 279 (8) : 6967-6975.
DOI: 10.1074/jbc.m307772200 -
Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson’s disease.
Olivier Guillin, Nathalie Griffon, Erwan Bezard, Ludovic Leriche, Jorge Diaz, Christian Gross, Pierre Sokoloff.
European Journal of Pharmacology. 2003-11-01. 480 (1-3) : 89-95.
DOI: 10.1016/j.ejphar.2003.08.096 -
Brain-derived neurotrophic factor controls dopamine D3 receptor expression: therapeutic implications in Parkinson’s disease.
Olivier Guillin, Nathalie Griffon, Erwan Bezard, Ludovic Leriche, Jorge Diaz, Christian Gross, Pierre Sokoloff.
European Journal of Pharmacology. 2003-11-01. 480 (1-3) : 89-95.
DOI: 10.1016/j.ejphar.2003.08.096 -
Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata.
CHUN-HWEI TAI, THOMAS BORAUD, ERWAN BEZARD, BERNARD BIOULAC, CHRISTIAN GROSS, ABDELHAMID BENAZZOUZ.
The FASEB Journal. 2003-10-01. 17 (13) : 1820-1830.
DOI: 10.1096/fj.03-0163com -
Deep brain stimulation in dystonia
A. Kupsch, S. Klaffke, A. A. K�hn, W. Meissner, G. Arnold, G. H. Schneider, K. Maier-Hauff, T. Trottenberg.
Journal of Neurology. 2003-10-01. 250 (10) : 1201-1205.
DOI: 10.1007/s00415-003-0179-0 -
Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by L-dopa and ropinirole in the MPTP-lesioned marmoset.
Michael P. Hill, Erwan Bezard, Steven G. McGuire, Alan R. Crossman, Jonathan M. Brotchie, Ann Michel, Renee Grimée, Henrik Klitgaard.
Mov. Disord.. 2003-08-21. 18 (11) : 1301-1305.
DOI: 10.1002/mds.10542 -
Neuroprotection for Parkinson’s disease: a call for clinically driven experimental design.
Erwan Bezard.
The Lancet Neurology. 2003-07-01. 2 (7) : 393.
DOI: 10.1016/s1474-4422(03)00432-0 -
Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT.
Caroline Prunier, Erwan Bézard, Jérôme Montharu, Marina Mantzarides, Jean-Claude Besnard, Jean-Louis Baulieu, Christian Gross, Denis Guilloteau, Sylvie Chalon.
NeuroImage. 2003-07-01. 19 (3) : 810-816.
DOI: 10.1016/s1053-8119(03)00163-0 -
Neuroprotection for Parkinson’s disease: a call for clinically driven experimental design.
Erwan Bezard.
The Lancet Neurology. 2003-07-01. 2 (7) : 393.
DOI: 10.1016/s1474-4422(03)00432-0 -
Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT.
Caroline Prunier, Erwan Bézard, Jérôme Montharu, Marina Mantzarides, Jean-Claude Besnard, Jean-Louis Baulieu, Christian Gross, Denis Guilloteau, Sylvie Chalon.
NeuroImage. 2003-07-01. 19 (3) : 810-816.
DOI: 10.1016/s1053-8119(03)00163-0 -
Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard.
Neurobiology of Disease. 2003-06-01. 13 (1) : 46-54.
DOI: 10.1016/S0969-9961(03)00011-1 -
Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei.
Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard.
Neurobiology of Disease. 2003-06-01. 13 (1) : 46-54.
DOI: 10.1016/s0969-9961(03)00011-1 -
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.
Erwan Bézard, Sandrine Ferry, Ulrich Mach, Holger Stark, Ludovic Leriche, Thomas Boraud, Christian Gross, Pierre Sokoloff.
Nat Med. 2003-05-12. 9 (6) : 762-767.
DOI: 10.1038/nm875 -
Presymptomatic compensation in Parkinson’s disease is not dopamine-mediated.
Erwan Bezard, Christian E. Gross, Jonathan M. Brotchie.
Trends in Neurosciences. 2003-04-01. 26 (4) : 215-221.
DOI: 10.1016/s0166-2236(03)00038-9 -
Presymptomatic compensation in Parkinson’s disease is not dopamine-mediated.
Erwan Bezard, Christian E. Gross, Jonathan M. Brotchie.
Trends in Neurosciences. 2003-04-01. 26 (4) : 215-221.
DOI: 10.1016/s0166-2236(03)00038-9 -
Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard.
Journal of Neurochemistry. 2003-03-01. 84 (6) : 1246-1255.
DOI: 10.1046/j.1471-4159.2003.01600.x -
The deafferented nonhuman primate is not a reliable model of intractable pain.
Elsa Y. Pioli, Christian E. Gross, Wassilios Meissner, Bernard H. Bioulac, Erwan Bezard.
Neurological Research. 2003-03-01. 25 (2) : 127-129.
DOI: 10.1179/016164103101201274 -
Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard.
Journal of Neurochemistry. 2003-03-01. 84 (6) : 1246-1255.
DOI: 10.1046/j.1471-4159.2003.01600.x -
Time-Course of Nigrostriatal Degeneration in a Progressive MPTP-Lesioned Macaque Model of Parkinson’s Disease
Wassilios Meissner, Caroline Prunier, Denis Guilloteau, Sylvie Chalon, Christian E. Gross, Erwan Bezard.
MN. 2003-01-01. 28 (3) : 209-218.
DOI: 10.1385/MN:28:3:209 -
Time-course of nigrostriatal degeneration in a progressive MPTP-lesioned macaque model of Parkinson’s disease.
Wassilios Meissner, Caroline Prunier, Denis Guilloteau, Sylvie Chalon, Christian E. Gross, Erwan Bezard.
MN. 2003-01-01. 28 (3) : 209-218.
DOI: 10.1385/mn:28:3:209 -
Oscillatory local field potentials recorded from the subthalamic nucleus of the alert rat
Peter Brown, Andreas Kupsch, Peter J. Magill, Andrew Sharott, Daniel Harnack, Wassilios Meissner.
Experimental Neurology. 2002-10-01. 177 (2) : 581-585.
DOI: 10.1006/exnr.2002.7984 -
Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats
Wassilios Meissner, Daniel Harnack, Gesine Paul, Torsten Reum, Reinhard Sohr, Rudolf Morgenstern, Andreas Kupsch.
Neuroscience Letters. 2002-08-01. 328 (2) : 105-108.
DOI: 10.1016/S0304-3940(02)00463-9 -
From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross.
Progress in Neurobiology. 2002-03-01. 66 (4) : 265-283.
DOI: 10.1016/s0301-0082(01)00033-8 -
From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross.
Progress in Neurobiology. 2002-03-01. 66 (4) : 265-283.
DOI: 10.1016/s0301-0082(01)00033-8 -
Unique functional properties of a sensory neuronal P2X ATP-gated channel from zebrafish.
Éric Boué-Grabot, Marie-Andrée Akimenko, Philippe Séguéla.
Journal of Neurochemistry. 2002-01-04. 75 (4) : 1600-1607.
DOI: 10.1046/j.1471-4159.2000.0751600.x -
Apomorphine versus deep-brain stimulation: Clinical and economic aspects in late-stage Parkinson’s disease | Apomorphintherapie versus tiefe hirnstimulation: Klinische und ökonomische aspekte bei patienten mit fortgeschrittenem morbus Parkinson
W. Meissner, T. Trottenberg, S. Klaffke, G. Paul, A. A. Kuhn, G. Arnold, K.-M. Einhaupl, A. Kupsch.
Der Nervenarzt. 2001-12-01. 72 (12) : 924-927.
DOI: 10.1007/s001150170004 -
Pathophysiology of levodopa-induced dyskinesia: potential for new therapies.
Erwan Bezard, Jonathan M. Brotchie, Christian E. Gross.
Nat Rev Neurosci. 2001-08-01. 2 (8) : 577-588.
DOI: 10.1038/35086062 -
Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats
Wassilios Meissner, Torsten Reum, Gesine Paul, Daniel Harnack, Reinhard Sohr, Rudolf Morgenstern, Andreas Kupsch.
Neuroscience Letters. 2001-05-01. 303 (3) : 165-168.
DOI: 10.1016/S0304-3940(01)01758-X -
Upregulation of striatal preproenkephalin gene expression occurs before the appearance of parkinsonian signs in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine monkeys.
Erwan Bezard, Paula Ravenscroft, Christian E. Gross, Alan R. Crossman, Jonathan M. Brotchie.
Neurobiology of Disease. 2001-04-01. 8 (2) : 343-350.
DOI: 10.1006/nbdi.2000.0375 -
Pallidal and thalamic neurostimulation in severe tardive dystonia
T Trottenberg.
Journal of Neurology, Neurosurgery & Psychiatry. 2001-04-01. 70 (4) : 557-559.
DOI: 10.1136/jnnp.70.4.557 -
Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross.
Brain. 2001-03-01. 124 (3) : 546-557.
DOI: 10.1093/brain/124.3.546 -
Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian E. Gross.
Brain. 2001-03-01. 124 (3) : 546-557.
DOI: 10.1093/brain/124.3.546 -
Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
E Bezard, T Boraud, S Chalon, J.M Brotchie, D Guilloteau, C.E Gross.
Neuroscience. 2001-02-01. 103 (1) : 117-123.
DOI: 10.1016/s0306-4522(00)00546-7 -
Neurostimulation of the ventral intermediate thalamic nucleus in inherited myoclonus-dystonia syndrome
Thomas Trottenberg, Wassilios Meissner, Guy Arnold, Karl-Max Einhaupl, Andreas Kupsch, Christian Kabus, Thomas Funk.
Mov Disord.. 2001-01-01. 16 (4) : 769-771.
DOI: 10.1002/mds.1119 -
Erratum: Neurostimulation of the ventral intermediate thalamic nucleus in inherited myoclonus-dystonia syndrome (Movement Disorders (2001) vol. 16 (769-771))
.
Mov Disord.. 2001-01-01. 16 (6) : 1204-1204.
DOI: 10.1002/mds.1266 -
The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat
Wassilios Meissner, Gesine Paul, Torsten Reum, Rene Reese, Reinhard Sohr, Rudolf Morgenstern, Andreas Kupsch.
Neuroscience Letters. 2000-12-01. 296 (2-3) : 149-152.
DOI: 10.1016/S0304-3940(00)01659-1 -
Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice.
Erwan Bezard, Sra Dovero, Christelle Imbert, Thomas Boraud, Christian E. Gross.
Synapse. 2000-12-01. 38 (3) : 363-368.
DOI: 10.1002/1098-2396(20001201)38:3<363::aid-syn16>3.3.co;2-1 -
Multiple lesions originating from the ventricular wall
W. MEISSNER.
Journal of Neurology, Neurosurgery & Psychiatry. 2000-08-01. 69 (2) : 273-273.
DOI: 10.1136/jnnp.69.2.273 -
Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse.
Erwan Bezard, Mohamed Jaber, François Gonon, Alain Boireau, Bertrand Bloch, Christian E. Gross.
European Journal of Neuroscience. 2000-08-01. 12 (8) : 2892-2900.
DOI: 10.1046/j.1460-9568.2000.00180.x -
Molecular and electrophysiological evidence for a GABAC receptor in thyrotropin-secreting cells
E. Boue-Grabot.
Endocrinology. 2000-05-01. 141 (5) : 1627-1632.
DOI: 10.1210/en.141.5.1627 -
Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.
Imad Ghorayeb, Pierre O. Fernagut, Incarnation Aubert, Erwan Bezard, Werner Poewe, Gregor K. Wenning, François Tison.
Mov. Disord.. 2000-05-01. 15 (3) : 531-536.
DOI: 10.1002/1531-8257(200005)15:3<531::aid-mds1017>3.0.co;2-c -
A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X(2) ATP-gated channels.
Éric Boué-Grabot, Vincent Archambault, Philippe Séguéla.
J. Biol. Chem.. 2000-03-31. 275 (14) : 10190-10195.
DOI: 10.1074/jbc.275.14.10190 -
Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Christelle Imbert, Erwan Bezard, Stéphane Guitraud, Thomas Boraud, Christian E Gross.
Journal of Neuroscience Methods. 2000-03-01. 96 (1) : 71-76.
DOI: 10.1016/s0165-0270(99)00184-3 -
Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Th Boraud, E Bezard, J.M Stutzmann, B Bioulac, C.E Gross.
Neuroscience Letters. 2000-03-01. 281 (2-3) : 75-78.
DOI: 10.1016/s0304-3940(00)00780-1 -
Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Christelle Imbert, Erwan Bezard, Stéphane Guitraud, Thomas Boraud, Christian E Gross.
Journal of Neuroscience Methods. 2000-03-01. 96 (1) : 71-76.
DOI: 10.1016/s0165-0270(99)00184-3 -
Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Th Boraud, E Bezard, J.M Stutzmann, B Bioulac, C.E Gross.
Neuroscience Letters. 2000-03-01. 281 (2-3) : 75-78.
DOI: 10.1016/s0304-3940(00)00780-1 -
From experimentation to the surgical treatment of Parkinson’s disease: prelude or suite in basal ganglia research?
C Gross.
Progress in Neurobiology. 1999-12-01. 59 (5) : 509-532.
DOI: 10.1016/s0301-0082(99)00015-5 -
From experimentation to the surgical treatment of Parkinson’s disease: prelude or suite in basal ganglia research?
C Gross.
Progress in Neurobiology. 1999-12-01. 59 (5) : 509-532.
DOI: 10.1016/s0301-0082(99)00015-5 -
Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey.
Erwan Bezard, Christine Brefel, Francois Tison, Helene Peyro-SaintPaul, Philippe Ladure, Olivier Rascol, Christian E. Gross.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999-10-01. 23 (7) : 1237-1246.
DOI: 10.1016/s0278-5846(99)00067-6 -
Effect of the alpha 2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey.
Erwan Bezard, Christine Brefel, Francois Tison, Helene Peyro-SaintPaul, Philippe Ladure, Olivier Rascol, Christian E. Gross.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1999-10-01. 23 (7) : 1237-1246.
DOI: 10.1016/s0278-5846(99)00067-6 -
Reversible leucopenia related to olanzapine
Wassilios Meissner, Tamara Schmidt, Andreas Kupsch, Thomas Trottenberg, Thomas Lempert.
Mov. Disord.. 1999-09-01. 14 (5) : 872-873.
DOI: 10.1002/1531-8257(199909)14:5<872::AID-MDS1026>3.0.CO;2-Y -
Trichloroethylene and parkinsonism: a human and experimental observation.
Dominique Guehl, Erwan Bezard, Sandra Dovero, Thomas Boraud, Bernard Bioulac, Christian Gross.
Eur J Neurol. 1999-09-01. 6 (5) : 609-611.
DOI: 10.1046/j.1468-1331.1999.650609.x -
Cortical stimulation and epileptic seizure: a study of the potential risk in primates.
Erwan Bezard, Thomas Boraud, Jean-Paul Nguyen, Francisco Velasco, Yves Keravel, Christian Gross.
Neurosurgery. 1999-08-01. 45 (2) : 346-350.
DOI: 10.1097/00006123-199908000-00030 -
Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms.
Erwan Bezard, Thomas Boraud, Bernard Bioulac, Christian E. Gross.
European Journal of Neuroscience. 1999-06-01. 11 (6) : 2167-2170.
DOI: 10.1046/j.1460-9568.1999.00627.x -
Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits.
Khanh-Tuoc Lê, Éric Boué-Grabot, Vincent Archambault, Philippe Séguéla.
J. Biol. Chem.. 1999-05-28. 274 (22) : 15415-15419.
DOI: 10.1074/jbc.274.22.15415 -
Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.
Erwan Bezard, Christian E. Gross, Marie-Christine Fournier, Sandra Dovero, Bertrand Bloch, Mohamed Jaber.
Experimental Neurology. 1999-02-01. 155 (2) : 268-273.
DOI: 10.1006/exnr.1998.6995 -
Towards a dynamic approach of experimental parkinsonism
Erwan Bezard, Thomas Boraud, Christelle Imbert, Sandra Dovero Bernard Bioulac, Christian E. Gross.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-11-01. 22 (8) : 1317-1329.
DOI: 10.1016/S0278-5846(98)00072-4 -
Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model.
Erwan Bezard, Jean-Marie Stutzmann, Christelle Imbert, Thomas Boraud, Alain Boireau, Christian E. Gross.
European Journal of Pharmacology. 1998-09-01. 356 (2-3) : 101-104.
DOI: 10.1016/s0014-2999(98)00537-8 -
Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach.
Erwan Bezard, Christian E Gross.
Progress in Neurobiology. 1998-06-01. 55 (2) : 93-116.
DOI: 10.1016/s0301-0082(98)00006-9 -
Glutamatergic compensatory mechanisms in experimental parkinsonism.
Erwan Bezard, Bernard Bioulac, Christian E. Gross.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-05-01. 22 (4) : 609-623.
DOI: 10.1016/s0278-5846(98)00030-x -
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.
Th Boraud, E Bezard, D Guehl, B Bioulac, Ch Gross.
Brain Research. 1998-03-01. 787 (1) : 157-160.
DOI: 10.1016/s0006-8993(97)01563-1 -
Experimental models of Parkinson’s disease: from the static to the dynamic.
Erwan Bezard, Christelle Imbert, Christian E. Gross.
Reviews in the Neurosciences. 1998-01-01. 9 (2)
DOI: 10.1515/revneuro.1998.9.2.71 -
Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice.
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian Gross.
Experimental Neurology. 1997-11-01. 148 (1) : 288-292.
DOI: 10.1006/exnr.1997.6648 -
Regulation of intracellular pH in rat lactotrophs: involvement of anionic exchangers.
L. Garcia.
Endocrinology. 1997-10-01. 138 (10) : 4191-4198.
DOI: 10.1210/en.138.10.4191 -
Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
E Bezard, T Boraud, B Bioulac, C.E Gross.
Neuroscience. 1997-09-01. 81 (2) : 399-404.
DOI: 10.1016/s0306-4522(97)00226-1 -
Kinetics of nigral degeneration in a chronic model of MPTP-treated mice.
Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross.
Neuroscience Letters. 1997-09-01. 234 (1) : 47-50.
DOI: 10.1016/s0304-3940(97)00663-0 -
Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
E Bezard, T Boraud, B Bioulac, C.E Gross.
Neuroscience. 1997-09-01. 81 (2) : 399-404.
DOI: 10.1016/s0306-4522(97)00226-1 -
A chronic MPTP model reproducing the slow evolution of Parkinson’s disease: evolution of motor symptoms in the monkey.
Erwan Bezard, Christelle Imbert, Xavier Deloire, Bernard Bioulac, Christian E Gross.
Brain Research. 1997-08-01. 766 (1-2) : 107-112.
DOI: 10.1016/s0006-8993(97)00531-3 -
Subthalamic stimulation elicits hemiballismus in normal monkey.
Corinne Beurrier, Erwan Bezard, Bernard Bioulac, Christian Gross.
NeuroReport. 1997-05-01. 8 (7) : 1625-1629.
DOI: 10.1097/00001756-199705060-00014 -
Presymptomatic revelation of experimental parkinsonism.
Erwan Bezard, Thomas Boraud, Bernard Bioulac, Christian E. Gross.
NeuroReport. 1997-01-01. 8 (2) : 435-438.
DOI: 10.1097/00001756-199701200-00012 -
High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.
Thomas Boraud, Erwan Bezard, Bernard Bioulac, Christian Gross.
Neuroscience Letters. 1996-08-01. 215 (1) : 17-20.
DOI: 10.1016/s0304-3940(96)12943-8 -
Processed pseudogenes interfere with reverse transcriptase-polymerase chain reaction controls.
Bertrand Garbay, Eric Boue-Grabot, Maurice Garret.
Analytical Biochemistry. 1996-05-01. 237 (1) : 157-159.
DOI: 10.1006/abio.1996.0218 -
Molecular diversity of GABA-gated chloride channels in the rat anterior pituitary.
Eric Boué-Grabot, Bernard Dufy, Maurice Garret.
Brain Research. 1995-12-01. 704 (1) : 125-129.
DOI: 10.1016/0006-8993(95)01192-7
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Benjamin Dehay
Dehay
(Researcher)
Marie-Laure Martin-Négrier Martin-Négrier (University Teacher - Researcher - Hospital practitioner)
Vincent Planche Planche (MCU PH)
Marie-Laure Martin-Négrier Martin-Négrier (University Teacher - Researcher - Hospital practitioner)
Vincent Planche Planche (MCU PH)
Ingénieur(e)s, technicien(ne)s
Evelyne Doudnikoff
Doudnikoff
Marie-Hélène Canron Canron
Marie-Laure Arotcarena Arotcarena
Marie-Laure Thiolat Thiolat
Claire Mazzocco Mazzocco
Marion Piquemal-Lagoueillat Piquemal-Lagoueillat
Melyna Achour Achour
Camille Lancelin Lancelin
Amélie Cordovado Cordovado
Carolina Piva Piva
Marie-Hélène Canron Canron
Marie-Laure Arotcarena Arotcarena
Marie-Laure Thiolat Thiolat
Claire Mazzocco Mazzocco
Marion Piquemal-Lagoueillat Piquemal-Lagoueillat
Melyna Achour Achour
Camille Lancelin Lancelin
Amélie Cordovado Cordovado
Carolina Piva Piva
Post-doctorant(s)
Morgane Darricau
Darricau
Doctorant(s)
Nicolas Prudon
Prudon
Juan Estaun Panzano Estaun Panzano
Rémi Kinet Kinet
Mégane Le Quang Le Quang
Anna Lovisotto Lovisotto
Juan Estaun Panzano Estaun Panzano
Rémi Kinet Kinet
Mégane Le Quang Le Quang
Anna Lovisotto Lovisotto
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC