Neuroimmunology lab
Our team studies how the immune system and the central nervous system communicate, both under healthy conditions and during disease. We are particularly interested in how this two-way “neuroimmune” dialogue shapes whole-body metabolism, in both males and females.
A major focus of our research is the interaction between microglia—the brain’s resident immune cells—and neurons. We explore how these interactions are influenced by diet, with a special emphasis on the role of lipids in regulating microglial physiology. Beyond microglia, we also investigate how other types of immune cells contribute to systemic metabolic regulation.
To address these questions, we combine a broad range of approaches, from cell and molecular physiology to in vivo models and behavioral studies.
Ultimately, by uncovering the mechanisms of neuroimmune communication, we aim to understand how lifestyle and diet influence whole-body metabolism, and to open new avenues for preventing or treating metabolic and neurological diseases.
Mots clés
Microglie, cellules immunitaires, maladies neurodégénératives, métabolisme énergique, neuroimmunologieSelected publications
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Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar.
Neuropsychopharmacol.. 2020-08-11.
DOI: 10.1038/s41386-020-00793-7 -
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Stéphane Léon, Agnès Nadjar, Carmelo Quarta.
IJMS. 2021-05-15. 22 (10) : 5243.
DOI: 10.3390/ijms22105243 -
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar.
Glia. 2021-09-14.
DOI: 10.1002/glia.24088 -
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar.
Cannabis and Cannabinoid Research. 2021-12-01. 6 (6) : 488-507.
DOI: 10.1089/can.2020.0170 -
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar.
Front. Cell. Neurosci.. 2022-02-10. 16
DOI: 10.3389/fncel.2022.802411 -
Microglia states and nomenclature: A field at its crossroads
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, (...) Agnes Nadjar, (...), Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray.
Neuron. 2022-11-01. 110 (21) : 3458-3483.
DOI: 10.1016/j.neuron.2022.10.020 -
Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, Marie-Ève Tremblay, Agnès Nadjar.
Brain, Behavior, and Immunity. 2023-01-01. 107 : 153-164.
DOI: 10.1016/j.bbi.2022.09.016 -
Rethinking the role of microglia in obesity
G. Cutugno, E. Kyriakidou, A. Nadjar.
Neuropharmacology. 2024-04-01. : 109951.
DOI: 10.1016/j.neuropharm.2024.109951
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC