Pierre-Olivier Fernagut

Scientific articles

• Recent Advances in Clinical Trials in Multiple System Atrophy
  David Bendetowicz, Margherita Fabbri, Federico Sirna, Pierre-Olivier Fernagut, Alexandra Foubert-Samier, Tiphaine Saulnier, Anne Pavy Le Traon, Cécile Proust-Lima, Olivier Rascol, Wassilios G. Meissner.
  Curr Neurol Neurosci Rep. 2024-02-28. 24(4) : 95-112.
  10.1007/s11910-024-01335-0
• Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration.
  Imad Ghorayeb, Pierre O. Fernagut, Incarnation Aubert, Erwan Bezard, Werner Poewe, Gregor K. Wenning, François Tison.
  Mov. Disord.. 2000-05-01. 15(3) : 531-536.
  10.1002/1531-8257(200005)15:3<531::aid-mds1017>3.0.co;2-c
• Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation
  P.O. Fernagut, E. Diguet, N. Stefanova, M. Biran, G.K. Wenning, P. Canioni, B. Bioulac, F. Tison.
  Neuroscience. 2002-11-01. 114(4) : 1005-1017.
  10.1016/s0306-4522(02)00205-1
• Simultaneous Intrastriatal 6-Hydroxydopamine and Quinolinic Acid Injection: A Model of Early-Stage Striatonigral Degeneration
  Imad Ghorayeb, Zoe Puschban, Pierre O. Fernagut, Christoph Scherfler, Richard Rouland, Gregor K. Wenning, François Tison.
  Experimental Neurology. 2001-01-01. 167(1) : 133-147.
  10.1006/exnr.2000.7535
• Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys
  I Ghorayeb, P.O Fernagut, N Stefanova, G.K Wenning, B Bioulac, F Tison.
  Neuroscience Letters. 2002-12-01. 335(1) : 34-38.
  10.1016/s0304-3940(02)01137-0
• A ‘single toxin–double lesion’ rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis
  I Ghorayeb, P.O Fernagut, L Hervier, B Labattu, B Bioulac, F Tison.
  Neuroscience. 2002-12-01. 115(2) : 533-546.
  10.1016/s0306-4522(02)00401-3
• A simple method to measure stride length as an index of nigrostriatal dysfunction in mice
  Pierre O Fernagut, Elsa Diguet, Bertrand Labattu, François Tison.
  Journal of Neuroscience Methods. 2002-01-01. 113(2) : 123-130.
  10.1016/s0165-0270(01)00485-x
• Dopamine transporter knock‐out mice are hypersensitive to 3‐nitropropionic acid‐induced striatal damage
  Pierre‐O. Fernagut, Elsa Diguet, Mohamed Jaber, Bernard Bioulac, François Tison.
  European Journal of Neuroscience. 2002-06-01. 15(12) : 2053-2056.
  10.1046/j.1460-9568.2002.02047.x
• Motor behaviour deficits and their histopathological and functional correlates in the nigrostriatal system of dopamine transporter knockout mice
  P.-O Fernagut, S Chalon, E Diguet, D Guilloteau, F Tison, M Jaber.
  Neuroscience. 2003-02-01. 116(4) : 1123-1130.
  10.1016/s0306-4522(02)00778-9
• Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
  Zoe Puschban, Pierre-Olivier Fernagut, Emmanuel Brouillet, Fran�ois Tison, Markus Reindl, Kurt A. Jellinger, Werner Poewe, Gregor K. Wenning, Nadia Stefanova.
  Acta Neuropathologica. 2003-08-01. 106(2) : 157-166.
  10.1007/s00401-003-0717-y
• Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington’s disease natural history.
  Elsa Diguet, Pierre-Olivier Fernagut, Elisabeth Normand, Laurie Centelles, Christophe Mulle, François Tison.
  Neurobiology of Disease. 2004-04-01. 15(3) : 667-675.
  10.1016/j.nbd.2003.12.010
• Deleterious effects of minocycline in animal models of Parkinson’s disease and Huntington’s disease.
  Elsa Diguet, Pierre-Olivier Fernagut, Xing Wei, Yansheng Du, Richard Rouland, Christian Gross, Erwan Bezard, François Tison.
  European Journal of Neuroscience. 2004-06-01. 19(12) : 3266-3276.
  10.1111/j.0953-816x.2004.03372.x
• Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome
  Arthur P. Chou, Nigel Maidment, Rebecka Klintenberg, John E. Casida, Sharon Li, Arthur G. Fitzmaurice, Pierre-Olivier Fernagut, Farzad Mortazavi, Marie-Francoise Chesselet, Jeff M. Bronstein.
  Journal of Biological Chemistry. 2008-12-01. 283(50) : 34696-34703.
  10.1074/jbc.m802210200
• The nigrostriatal pathway in Creutzfeldt-Jakob disease.
  Anne Vital, Pierre-Olivier Fernagut, Marie-Hélène Canron, Julien Joux, Erwan Bezard, Marie-Laure Martin-Negrier, Claude Vital, François Tison.
  J Neuropathol Exp Neurol. 2009-07-01. 68(7) : 809-815.
  10.1097/nen.0b013e3181abdae8
• Chronic dopaminergic stimulation in Parkinson’s disease: from dyskinesias to impulse control disorders.
  Valerie Voon, Pierre-Olivier Fernagut, Jeff Wickens, Christelle Baunez, Manuel Rodriguez, Nancy Pavon, Jorge L Juncos, José A Obeso, Erwan Bezard.
  The Lancet Neurology. 2009-12-01. 8(12) : 1140-1149.
  10.1016/s1474-4422(09)70287-x
• Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
  Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard.
  PLoS ONE. 2010-11-22. 5(11) : e14053.
  10.1371/journal.pone.0014053
• Metabolic activity of the subthalamic nucleus in a primate model of L-dopa-unresponsive parkinsonism.
  Pierre-Olivier Fernagut, Quentin Barraud, Erwan Bezard, Imad Ghorayeb, Francois Tison.
  Neurological Research. 2010-12-01. 32(10) : 1050-1053.
  10.1179/016164110x12807570509934
• Protein aggregation in the aging retina.
  François Leger, Pierre-Olivier Fernagut, Marie-Hélène Canron, Sandy Léoni, Claude Vital, François Tison, Erwan Bezard, Anne Vital.
  J Neuropathol Exp Neurol. 2011-01-01. 70(1) : 63-68.
  10.1097/nen.0b013e31820376cc
• NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid
  Martina Fantin, Michele Morari, François Tison, Pierre-Olivier Fernagut.
  Neurological Research. 2011-05-01. 33(4) : 444-447.
  10.1179/1743132810y.0000000002
• Reinforcing properties of Pramipexole in normal and parkinsonian rats.
  Michel Engeln, Serge H. Ahmed, Caroline Vouillac, François Tison, Erwan Bezard, Pierre-Olivier Fernagut.
  Neurobiology of Disease. 2013-01-01. 49 : 79-86.
  10.1016/j.nbd.2012.08.005
• Ambiguous mechanisms of dysphagia in multiple system atrophy
  Pierre-Olivier Fernagut, Anne Vital, Marie-Hélène Canron, François Tison, Wassilios G. Meissner.
  Brain. 2011-08-08. 135(2) : e205-e205.
  10.1093/brain/awr185
• Premotor parkinsonism models.
  Erwan Bezard, Pierre-Olivier Fernagut.
  Parkinsonism & Related Disorders. 2014-01-01. 20 : S17-S19.
  10.1016/s1353-8020(13)70007-5
• Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
  Michel Engeln, Stefania Fasano, Serge H. Ahmed, Martine Cador, Veerle Baekelandt, Erwan Bezard, Pierre-Olivier Fernagut.
  Ann Neurol.. 2013-07-01. 74(1) : 140-144.
  10.1002/ana.23881
• Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
  Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila.
  Ann Neurol.. 2014-02-18. 75(3) : 351-362.
  10.1002/ana.24066
• Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy.
  Olivier Flabeau, Wassilios G. Meissner, Annaig Ozier, Patrick Berger, François Tison, Pierre-Olivier Fernagut.
  Mov Disord.. 2014-01-17. 29(3) : 388-395.
  10.1002/mds.25804
• Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy
  P.O. Fernagut, W.G. Meissner, M. Biran, M. Fantin, F. Bassil, J.M. Franconi, F. Tison.
  Synapse. 2013-11-15. 68(3) : 98-106.
  10.1002/syn.21719
• Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
  Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard.
  Neurobiology of Disease. 2014-02-01. 62 : 179-192.
  10.1016/j.nbd.2013.09.020
• Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia.
  Michel Engeln, Philippe De Deurwaerdère, Qin Li, Erwan Bezard, Pierre-Olivier Fernagut.
  Cereb. Cortex. 2014-04-25. 25(9) : 2783-2792.
  10.1093/cercor/bhu076
• Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
  Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Wassilios G. Meissner.
  Progress in Neurobiology. 2014-07-01. 118 : 1-18.
  10.1016/j.pneurobio.2014.02.005
• Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies.
  Pierre-Olivier Fernagut, Benjamin Dehay, Aline Maillard, Erwan Bezard, Paul Perez, Anne Pavy-Le Traon, Olivier Rascol, Alexandra Foubert-Samier, François Tison, Wassilios G. Meissner.
  Neurobiology of Disease. 2014-07-01. 67 : 133-139.
  10.1016/j.nbd.2014.03.021
• Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia.
  Michel Engeln, Matthieu F. Bastide, Estelle Toulmé, Benjamin Dehay, Mathieu Bourdenx, Evelyne Doudnikoff, Qin Li, Christian E. Gross, Eric Boué-Grabot, Antonio Pisani, Erwan Bezard, Pierre-Olivier Fernagut.
  Biological Psychiatry. 2016-03-01. 79(5) : 354-361.
  10.1016/j.biopsych.2014.07.007
• Current Concepts in the Treatment of Multiple System Atrophy
  Santiago Perez-Lloret, Olivier Flabeau, Pierre-Olivier Fernagut, Anne Pavy-Le Traon, María Verónica Rey, Alexandra Foubert-Samier, Francois Tison, Olivier Rascol, Wassilios G. Meissner.
  Mov Disord Clin Pract. 2015-02-02. 2(1) : 6-16.
  10.1002/mdc3.12145
• Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.
  Matthieu F. Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre-Olivier Fernagut, Christian E. Gross, Nicolas Mallet, Thomas Boraud, Erwan Bézard.
  Biological Psychiatry. 2016-03-01. 79(5) : 345-353.
  10.1016/j.biopsych.2014.08.022
• Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
  Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu F. Bastide, Nathalie Dutheil, Isabel Vollenweider, Laetitia Baud, Camille Piron, Virginie Grouthier, Thomas Boraud, Grégory Porras, Qin Li, Veerle Baekelandt, Dieter Scheller, Anne Michel, Pierre-Olivier Fernagut, François Georges, Grégoire Courtine, Erwan Bezard, Benjamin Dehay.
  acta neuropathol commun. 2015-07-25. 3(1)
  10.1186/s40478-015-0222-2
• Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson’s disease.
  Matthieu F. Bastide, Wassilios G. Meissner, Barbara Picconi, Stefania Fasano, Pierre-Olivier Fernagut, Michael Feyder, Veronica Francardo, Cristina Alcacer, Yunmin Ding, Riccardo Brambilla, Gilberto Fisone, A. Jon Stoessl, Mathieu Bourdenx, Michel Engeln, Sylvia Navailles, Philippe De Deurwaerdère, Wai Kin D. Ko, Nicola Simola, Micaela Morelli, Laurent Groc, Maria-Cruz Rodriguez, Eugenia V. Gurevich, Maryka Quik, Michele Morari, Manuela Mellone, Fabrizio Gardoni, Elisabetta Tronci, Dominique Guehl, François Tison, Alan R. Crossman, Un Jung Kang, Kathy Steece-Collier, Susan Fox, Manolo Carta, M. Angela Cenci, Erwan Bézard.
  Progress in Neurobiology. 2015-09-01. 132 : 96-168.
  10.1016/j.pneurobio.2015.07.002
• Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy
  Fares Bassil, Arnaud Monvoisin, Marie-Helene Canron, Anne Vital, Wassilios G. Meissner, François Tison, Pierre-Olivier Fernagut.
  Mov Disord.. 2015-08-11. 30(13) : 1802-1812.
  10.1002/mds.26329
• Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson’s disease.
  Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre-Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bezard, Michele Morari.
  Neurobiology of Disease. 2016-05-01. 89 : 55-64.
  10.1016/j.nbd.2016.01.016
• Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy.
  Michel Engeln, Solène Ansquer, Emilie Dugast, Erwan Bezard, David Belin, Pierre-Olivier Fernagut.
  Neuropharmacology. 2016-10-01. 109 : 69-77.
  10.1016/j.neuropharm.2016.05.013
• Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.
  Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard, Alain Pruvost, Thierry Leste-Lasserre, Quyen Q. Hoang, Dagmar Ringe, Gregory A. Petsko, Wassilios G. Meissner.
  Proc Natl Acad Sci USA. 2016-08-01. 113(34) : 9593-9598.
  10.1073/pnas.1609291113
• Impulse control disorders in Parkinson’s disease
  Ana Marques, Franck Durif, Pierre-Olivier Fernagut.
  Journal of Neural Transmission. 2018-03-07. 125(8) : 1299-1312.
  10.1007/s00702-018-1870-8
• Dopamine and addiction: what have we learned from 40 years of research
  Marcello Solinas, Pauline Belujon, Pierre Olivier Fernagut, Mohamed Jaber, Nathalie Thiriet.
  Journal of Neural Transmission. 2018-12-19. 126(4) : 481-516.
  10.1007/s00702-018-1957-2
• Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy
  Miguel Lopez-Cuina, Pierre-Olivier Fernagut, Marie-Hélène Canron, Anne Vital, Béatrice Lannes, André Maues De Paula, Nathalie Streichenberger, Dominique Guehl, Philippe Damier, Alexandre Eusebio, Jean-Luc Houeto, François Tison, Christine Tranchant, François Viallet, Tatiana Witjas, Stéphane Thobois, Wassilios G. Meissner.
  Neurobiology of Disease. 2018-10-01. 118 : 155-160.
  10.1016/j.nbd.2018.07.016
• Dopamine and eating behavior disorders in Parkinson’s disease: A complex recipe
  Pierre‐Olivier Fernagut.
  Movement Disorders. 2019-06-01. 34(6) : 767-768.
  10.1002/mds.27703
• Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
  Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay.
  JCI Insight. 2019-08-22. 4(16)
  10.1172/jci.insight.129719
• Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
  Miguel Lopez-Cuina, Paul A. Guerin, Marie-Hélène Canron, Anna Delamarre, Benjamin Dehay, Erwan Bezard, Wassilios G. Meissner, Pierre-Olivier Fernagut.
  Mov Disord. 2020-04-14.
  10.1002/mds.28034
• Multiple System Atrophy: Recent Developments and Future Perspectives
  Wassilios G. Meissner, Pierre‐Olivier Fernagut, Benjamin Dehay, Patrice Péran, Anne Pavy‐Le Traon, Alexandra Foubert‐Samier, Miguel Lopez Cuina, Erwan Bezard, François Tison, Olivier Rascol.
  Mov Disord. 2019-11-06.
  10.1002/mds.27894
• Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia
  Elva Fridjonsdottir, Reza Shariatgorji, Anna Nilsson, Theodosia Vallianatou, Luke R. Odell, Luke S. Schembri, Per Svenningsson, Pierre-Olivier Fernagut, Alan R. Crossman, Erwan Bezard, Per E. Andrén.
  Sci. Adv.. 2021-01-01. 7(2) : eabe5948.
  10.1126/sciadv.abe5948
• L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
  Marc Deffains, Marie‐Hélène Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre‐Olivier Fernagut.
  Neuropathol Appl Neurobiol. 2020-12-04.
  10.1111/nan.12678
• Impaired brain insulin signalling in Parkinson’s disease
  Fares Bassil, Anna Delamarre, Marie‐Helene Canron, Nathalie Dutheil, Anne Vital, Marie‐Laure Négrier‐Leibreich, Erwan Bezard, Pierre‐Olivier Fernagut, Wassilios G. Meissner.
  Neuropathol Appl Neurobiol. 2021-08-17.
  10.1111/nan.12760
• A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models
  David Mallet, Thibault Dufourd, Mélina Decourt, Carole Carcenac, Paola Bossù, Laure Verlin, Pierre-Olivier Fernagut, Marianne Benoit-Marand, Gianfranco Spalletta, Emmanuel L. Barbier, Sebastien Carnicella, Véronique Sgambato, Florence Fauvelle, Sabrina Boulet.
  Journal of Clinical Investigation. 2022-02-15. 132(4)
  10.1172/jci146400
• Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural flexibility
  Mélina Decourt, Eric Balado, Maureen Francheteau, Marcello Solinas, Marianne Benoît-Marand, Pierre-Olivier Fernagut.
  npj Parkinson's Disease. 2023-03-01. 9(1)
  10.1038/s41531-023-00475-3
• GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
  Miguel Lopez‐Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard.
  Movement Disorders. 2023-04-24.
  10.1002/mds.29422
• Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
  Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay.
  npj Parkinsons Dis.. 2024-08-01. 10(1)
  10.1038/s41531-024-00757-4
• Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity
  Sarah Chevalier, Mélina Decourt, Maureen Francheteau, François Nicol, Anaïs Balbous, Pierre-Olivier Fernagut, Marianne Benoit-Marand.
  npj Parkinson's Disease. 2024-09-09. 10(1)
  10.1038/s41531-024-00781-4
• Dysfunction of striatal parvalbumin interneurons drives motor stereotypies in Cntnap2−/− mouse model of autism spectrum disorders
  Mathieu Thabault, Cloé Fernandes-Gomes, Anne-Lise Huot, Maureen Francheteau, Anaïs Balbous-Gautier, Pierre-Olivier Fernagut, Laurie Galvan.
  PNAS Nexus. 2024-03-28. 3(4)
  10.1093/pnasnexus/pgae132
• Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism
  Obelia Haida, Tareq Al Sagheer, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Federico Soria, Pierre Olivier Fernagut, Mohamed Jaber.
  Transl Psychiatry. 2019-03-28. 9(1) : 124.
  10.1038/s41398-019-0457-y