Nathalie Sans
Team leader
Researcher - PhD (DR) / INSERM/ Contact
+33 5 57 57 37 63
www.orcid.org/0000-0001-7658-2471
/ Address of work
Neurocentre Magendie - INSERM U 1215 - 146, rue Léo Saignat - 33077 Bordeaux
Scientific articles
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The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
Ana Dorrego-Rivas, Jerome Ezan, Maïté M. Moreau, Sonia Poirault-Chassac, Nathalie Aubailly, Julie De Neve, Camille Blanchard, Francis Castets, Amélie Fréal, Arne Battefeld, Nathalie Sans, Mireille Montcouquiol.
Sci. Adv.. 2022-09-09. 8(36)
10.1126/sciadv.abo6333 -
Neuron-Specific Deletion of Scrib in Mice Leads to Neuroanatomical and Locomotor Deficits
Jerome Ezan, Maité M. Moreau, Tamrat M. Mamo, Miki Shimbo, Maureen Decroo, Nathalie Sans, Mireille Montcouquiol.
Front. Genet.. 2022-05-25. 13
10.3389/fgene.2022.872700 -
The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK
Myriam Boëx, Steve Cottin, Marius Halliez, Stéphanie Bauché, Céline Buon, Nathalie Sans, Mireille Montcouquiol, Jordi Molgó, Muriel Amar, Arnaud Ferry, Mégane Lemaitre, Andrée Rouche, Dominique Langui, Asha Baskaran, Bertrand Fontaine, Julien Messéant, Laure Strochlic.
Sci. Signal.. 2022-05-17. 15(734)
10.1126/scisignal.abg4982 -
Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway
Maïté M. Moreau, Susanna Pietropaolo, Jérôme Ezan, Benjamin J. A. Robert, Sylvain Miraux, Marlène Maître, Yoon Cho, Wim E. Crusio, Mireille Montcouquiol, Nathalie Sans.
Cells. 2022-05-10. 11(10) : 1601.
10.3390/cells11101601 -
Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.
Jerome Ezan, Maité M. Moreau, Tamrat M. Mamo, Miki Shimbo, Maureen Decroo, Melanie Richter, Ronan Peyroutou, Rivka Rachel, Fadel Tissir, Froylan Calderon de Anda, Nathalie Sans, Mireille Montcouquiol.
Sci Rep. 2021-04-27. 11(1)
10.1038/s41598-021-88147-1 -
Muscle Van Gogh-like 2 shapes the neuromuscular synapse by regulating MuSK signaling activity
Myriam Boëx, Julien Messéant, Steve Cottin, Marius Halliez, Stéphanie Bauché, Céline Buon, Nathalie Sans, Mireille Montcouquiol, Jordi Molgó, Muriel Amar, Arnaud Ferry, Mégane Lemaitre, Andrée Rouche, Dominique Langui, Asha Baskaran, Bertrand Fontaine, Laure Strochlic.
Preprint bioRxiv. 2020-11-27.
10.1101/2020.11.26.384925 -
Age-related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1.
l Abed AS, Sellami A, Potier M, Ducourneau EG, Gerbeaud-Lassau P, Brayda-Bruno L, Lamothe V, Sans N, Desmedt A, Vanhoutte P, Bennetau-Pelissero C, Trifilieff P, Marighetto A..
Aging Cell. 2020 Oct 3. 19(10) : e13243.
10.1111/acel.13243 -
Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathway
Maïté M. Moreau, Susanna Pietropaolo, Jérôme Ezan, Benjamin J.A. Robert, Sylvain Miraux, Marlène Maître, Yoon Cho, Wim E. Crusio, Mireille Montcouquiol, Nathalie Sans.
. 2020-09-11.
10.1101/2020.09.10.289397 -
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
Benjamin J.A. Robert, Maïté M. Moreau, Steve Dos Santos Carvalho, Gael Barthet, Claudia Racca, Mehdi Bhouri, Anne Quiedeville, Maurice Garret, Bénédicte Atchama, Alice Shaam Al Abed, Christelle Guette, Deborah J. Henderson, Aline Desmedt, Christophe Mulle, Aline Marighetto, Mireille Montcouquiol, Nathalie Sans.
Cell Reports. 2020-06-01. 31(10) : 107743.
10.1016/j.celrep.2020.107743 -
Alpha technology: A powerful tool to detect mouse brain intracellular signaling events
Marion Zanese, Giovanni Tomaselli, Valérie Roullot-Lacarrière, Maïté Moreau, Luigi Bellocchio, Agnès Grel, Giovanni Marsicano, Nathalie Sans, Monique Vallée, Jean-Michel Revest.
Journal of Neuroscience Methods. 2020-02-01. 332 : 108543.
10.1016/j.jneumeth.2019.108543 -
Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth
Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol.
eLife. 2020-01-07. 9
10.7554/eLife.51822 -
Selective neurodevelopmental and behavioral deficits in Scrib conditional knock-out mice recapitulate some phenotypes associated with the Verheij/8q23.4 deletion syndrome
Jerome Ezan, Maité M. Moreau, Tamrat M. Mamo, Miki Shimbo, Maureen Decroo, Melanie Richter, Ronan Peyroutou, Rivka Rachel, Fadel Tissir, Froylan Calderon de Anda, Nathalie Sans, Mireille Montcouquiol.
. 2019-09-23.
10.1101/780130 -
The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.
Marc Chevalier, Laura Cardoit, Maïté Moreau, Nathalie Sans, Mireille Montcouquiol, John Simmers, Muriel Thoby-Brisson.
Neuroscience. 2017-08-01. 357 : 160-171.
10.1016/j.neuroscience.2017.05.046 -
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Stephanie A. Mauriac, Yeri E. Hien, Jonathan E. Bird, Steve Dos-Santos Carvalho, Ronan Peyroutou, Sze Chim Lee, Maite M. Moreau, Jean-Michel Blanc, Aysegul Geyser, Chantal Medina, Olivier Thoumine, Sandra Beer-Hammer, Thomas B. Friedman, Lukas Rüttiger, Andrew Forge, Bernd Nürnberg, Nathalie Sans, Mireille Montcouquiol.
Nat Comms. 2017-04-07. 8 : 14907.
10.1038/ncomms14907 -
Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways
Julien Messéant, Jérôme Ezan, Perrine Delers, Konstantin Glebov, Carmen Marchiol, Franck Lager, Gilles Renault, Fadel Tissir, Mireille Montcouquiol, Nathalie Sans, Claire Legay, Laure Strochlic.
Development. 2017-03-27. 144(9) : 1712-1724.
10.1242/dev.146167 -
Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse.
Muna L Hilal, Maité M Moreau, Claudia Racca, Vera L Pinheiro, Nicolas H Piguel, Marie-Josée Santoni, Steve Dos Santos Carvalho, Jean-Michel Blanc, Yah-Se K Abada, Ronan Peyroutou, Chantal Medina, Hélène Doat, Thomas Papouin, Laurent Vuillard, Jean-Paul Borg, Rivka Rachel, Aude Panatier, Mireille Montcouquiol, Stéphane H R Oliet, Nathalie Sans.
Cerebral Cortex. 2016-11-22. 27(12) : 5635-5651.
10.1093/cercor/bhw333 -
Nutritional Omega-3 deficiency alters glucocorticoid receptor-signaling pathway and neuronal morphology in regionally distinct brain structures associated with emotional deficits
Thomas Larrieu, Muna L. Hilal, Véronique De Smedt-Peyrusse, Nathalie Sans, Sophie Layé.
Neural Plasticity. 2016-01-01. 2016 : 1-9.
10.1155/2016/8574830 -
Planar Cell Polarity Gene Mutations in Autism Spectrum Disorder, Intellectual Disabilities, and Related Deletion/Duplication Syndromes
Nathalie Sans, Jérôme Ezan, Maïté M. Moreau, Mireille Montcouquiol.
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability. 2016-01-01. : 189-219.
10.1016/b978-0-12-800109-7.00013-3 -
Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar.
Journal of Neuroscience. 2015-02-18. 35(7) : 3022-3033.
10.1523/jneurosci.3028-14.2015 -
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice.
Yu Zhang, Audrey Bonnan, Guillaume Bony, Isabelle Ferezou, Susanna Pietropaolo, Melanie Ginger, Nathalie Sans, Jean Rossier, Ben Oostra, Gwen LeMasson, Andreas Frick.
Nat Neurosci. 2014-11-10. 17(12) : 1701-1709.
10.1038/nn.3864 -
Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.
T Larrieu, L M Hilal, C Fourrier, V De Smedt-Peyrusse, Sans N, L Capuron, S Layé.
Transl Psychiatry. 2014-10-01. 4(10) : e468-e468.
10.1038/tp.2014.108 -
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Nicolas H. Piguel, Sabine Fievre, Jean-Michel Blanc, Mario Carta, Maïté M. Moreau, Enora Moutin, Vera L. Pinheiro, Chantal Medina, Jerome Ezan, Léa Lasvaux, François Loll, Christelle M. Durand, Kai Chang, Ronald S. Petralia, Robert J. Wenthold, F. Anne Stephenson, Laurent Vuillard, Hervé Darbon, Julie Perroy, Christophe Mulle, Mireille Montcouquiol, Claudia Racca, Nathalie Sans.
Cell Reports. 2014-10-01. 9(2) : 712-727.
10.1016/j.celrep.2014.09.017 -
Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.
T Larrieu, L M Hilal, C Fourrier, V De Smedt-Peyrusse, Sans N, L Capuron, S Layé.
Transl Psychiatry. 2014-09-01. 4(9) : e437-e437.
10.1038/tp.2014.77 -
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear
A. P. Giese, J. Ezan, L. Wang, L. Lasvaux, F. Lembo, C. Mazzocco, E. Richard, J. Reboul, J.-P. Borg, M. W. Kelley, N. Sans, J. Brigande, M. Montcouquiol.
Development. 2012-09-18. 139(20) : 3775-3785.
10.1242/dev.074229 -
SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism.
C M Durand, J Perroy, F Loll, D Perrais, L Fagni, T Bourgeron, M Montcouquiol, N Sans.
Mol Psychiatry. 2011-05-24. 17(1) : 71-84.
10.1038/mp.2011.57 -
The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function.
M. M. Moreau, N. Piguel, T. Papouin, M. Koehl, C. M. Durand, M. E. Rubio, F. Loll, E. M. Richard, C. Mazzocco, C. Racca, S. H. R. Oliet, D. Nora Abrous, M. Montcouquiol, N. Sans.
Journal of Neuroscience. 2010-07-21. 30(29) : 9738-9752.
10.1523/jneurosci.6007-09.2010 -
Scrib regulates PAK activity during the cell migration process.
Sébastien Nola, Michael Sebbagh, Sylvie Marchetto, Naël Osmani, Claire Nourry, Stéphane Audebert, Christel Navarro, Rivka Rachel, Mireille Montcouquiol, Nathalie Sans, Sandrine Etienne-Manneville, Jean-Paul Borg, Marie-Josée Santoni.
Human Molecular Genetics. 2008-08-20. 17(22) : 3552-3565.
10.1093/hmg/ddn248 -
Detection of Planar Polarity Proteins in Mammalian Cochlea
Mireille Montcouquiol, Jennifer M. Jones, Nathalie Sans.
Methods in Molecular Biology. 2008-01-01. : 207-219.
10.1007/978-1-59745-249-6_16 -
Asymmetric Localization of Vangl2 and Fz3 Indicate Novel Mechanisms for Planar Cell Polarity in Mammals
Montcouquiol M, Sans N, Huss D, Kach J, Dickman JD, Forge A, Rachel RA, Copeland NG, Jenkins NA, Bogani D, Murdoch J, Warchol ME, Wenthold RJ, Kelley MW..
Journal of Neuroscience. 2006-05-10. 26(19) : 5265-5275.
10.1523/jneurosci.4680-05.2006 -
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.
Nathalie Sans, Philip Y. Wang, Quansheng Du, Ronald S. Petralia, Ya-Xian Wang, Sajan Nakka, Joe B. Blumer, Ian G. Macara, Robert J. Wenthold.
Nat Cell Biol. 2005-11-20. 7(12) : 1179-1190.
10.1038/ncb1325 -
Postnatal developmental changes in AMPA and NMDA receptors in the rat vestibular nuclei.
Nathalie A Sans, Mireille E Montcouquiol, Jacqueline Raymond.
Developmental Brain Research. 2000-09-01. 123(1) : 41-52.
10.1016/s0165-3806(00)00082-1 -
Detection and localization of BDNF in vestibular nuclei during the postnatal development of the rat.
M E. Montcouquiol, N A. Sans, C Travo, A Sans, J Valat.
NeuroReport. 2000-05-01. 11(7) : 1401-1405.
10.1097/00001756-200005150-00010