Physiopathology and therapeutic approaches of stress-related diseases

Neurocentre Magendie

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Our team aims to characterize the neurobiological basis of stress-related diseases, especially traumatic memories, and addiction and cognitive deficits targeting the CB1 receptor. By applying a translational research, our work is dedicated to design and develop innovative therapeutic approaches. The first line of research focuses on the study of the biological system involving glucocorticoid hormones (GC) and more specifically on the identification of the molecular and cellular signaling pathways mediating the memory modulating effects of these hormones. The second line of research focuses on the study of the biological system involving the neurosteroid pregnenolone (PREG) and aims to characterize the cellular and molecular mechanisms involved with regard to the harmful effects of cannabis and cognitive deficits.

Innovative techniques: in vitro and in vivo High Throughout Screening of cell signaling pathways, transgenic mice, mice behavior.

Selected publications

Team leader
Jean-Michel Revest

Team member(s)

Chercheurs, Praticiens hospitaliers...

Guillaume Drutel (University Teacher- Researcher)
Monique Vallée (Researcher)
Umberto Spampinato (Professor - Hospital practitioner)

Ingénieur(e)s, technicien(ne)s



Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC