Benjamin Dehay
Scientific articles
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Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia
eLife. 2025-08-19. 13
10.7554/elife.96076.4 -
Position paper: leveraging non-human primate (NHP) specificities to accelerate Parkinson’s disease and ageing research
npj Parkinsons Dis.. 2025-08-02. 11(1)
10.1038/s41531-025-01088-8 -
Differential Pathological Dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in non-human primates
Sci. Adv.. 2025-06-20. 11(25)
10.1126/sciadv.adu6050 -
Ultrashort Carbon Nanotubes with Luminescent Color Centers Are Bright NIR-II Nanoemitters
ACS Nano. 2025-05-16. 19(21) : 19818-19830.
10.1021/acsnano.5c02171 -
Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques
npj Parkinsons Dis.. 2025-04-13. 11(1)
10.1038/s41531-025-00938-9 -
Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species.
Mol Neurodegeneration. 2025-03-05. 20(1)
10.1186/s13024-025-00816-1 -
Current safety recommendations for handling mouse and human αsynuclein pre-formed fibrils
Neurobiology of Disease. 2025-03-01. 206 : 106820.
10.1016/j.nbd.2025.106820 -
Biological definitions of synucleinopathies should be anchored in clinical trajectories and encompass the complex biology of the disease
Journal of Parkinson’s Disease. 2025-02-04.
10.1177/1877718X241313443 -
Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
npj Parkinsons Dis.. 2024-12-30. 10(1)
10.1038/s41531-024-00850-8 -
Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
npj Parkinsons Dis.. 2024-08-01. 10(1)
10.1038/s41531-024-00757-4 -
Modeling Parkinson’s Disease in Primates
Cold Spring Harb Perspect Med. 2024-06-10. : a041612.
10.1101/cshperspect.a041612 -
Tau seeds from Alzheimer’s disease brains trigger tau spread in macaques while oligomeric‐Aβ mediates pathology maturation
Alzheimer's & Dementia. 2023-12-26.
10.1002/alz.13604 -
Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
npj Parkinsons Dis.. 2023-09-19. 9(1)
10.1038/s41531-023-00579-w -
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Neurobiology of Disease. 2023-03-01. : 106086.
10.1016/j.nbd.2023.106086 -
Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives
Bioconjugate Chem.. 2023-02-28.
10.1021/acs.bioconjchem.3c00041 -
Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease
Cells. 2023-02-15. 12(4) : 621.
10.3390/cells12040621 -
Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
Brain. 2022-11-16.
10.1093/brain/awac428 -
The Zinc Ionophore Clioquinol Reduces Parkinson’s Disease Patient-Derived Brain Extracts-Induced Neurodegeneration
Mol Neurobiol. 2022-08-02.
10.1007/s12035-022-02974-5 -
Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study
Pharmaceutics. 2022-04-13. 14(4) : 857.
10.3390/pharmaceutics14040857 -
Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.
Aging cell. .
10.1111/acel.13584 -
Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Brain. 2022-03-14. 145(3) : 1001-1017.
10.1093/brain/awab374 -
Maladie de Parkinson
Med Sci (Paris). 2022-01-01. 38(1) : 45-51.
10.1051/medsci/2021241 -
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Nat Rev Neurosci. 2021-12-14.
10.1038/s41583-021-00542-9 -
Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Front. Bioeng. Biotechnol.. 2021-11-15. 9
10.3389/fbioe.2021.762209 -
Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
Neurobiology of Aging. 2021-11-01. 107 : 53-56.
10.1016/j.neurobiolaging.2021.07.009 -
Nucleolipid Acid-Based Nanocarriers Restore Neuronal Lysosomal Acidification Defects
Front. Chem.. 2021-08-20. 9
10.3389/fchem.2021.736554 -
PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases
Pharmaceutics. 2021-07-08. 13(7) : 1042.
10.3390/pharmaceutics13071042 -
A New Rise of Non-Human Primate Models of Synucleinopathies
Biomedicines. 2021-03-09. 9(3) : 272.
10.3390/biomedicines9030272 -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy. 2021-02.
10.1080/15548627.2020.1797280 -
Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
Heliyon. 2021-02-01. 7(2) : e06302.
10.1016/j.heliyon.2021.e06302 -
Involvement of Autophagy in Levodopa‐Induced Dyskinesia
Mov Disord. 2021-01-18.
10.1002/mds.28480 -
Evaluation of blood flow as a route for propagation in experimental synucleinopathy
Neurobiology of Disease. 2021-01-01. : 105255.
10.1016/j.nbd.2021.105255 -
L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
Neuropathol Appl Neurobiol. 2020-12-04.
10.1111/nan.12678 -
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
Nat Commun. 2020-09-28. 11(1)
10.1038/s41467-020-18689-x -
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Nat Commun. 2020-07-10. 11(1)
10.1038/s41467-020-17328-9 -
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
Brain. 2020-05-18.
10.1093/brain/awaa110 -
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Brain. 2020-05-01. 143(5) : 1462-1475.
10.1093/brain/awaa096 -
Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates
Neurobiology of Disease. 2020-05-01. : 104951.
10.1016/j.nbd.2020.104951 -
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
Sci. Adv.. 2020-05-01. 6(20) : eaaz9165.
10.1126/sciadv.aaz9165 -
Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates
Neurobiology of Disease. 2020-05-01. : 104941.
10.1016/j.nbd.2020.104941 -
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy
Mov Disord. 2020-04-14.
10.1002/mds.28034 -
Synthesis and Intracellular Uptake of Rhodamine–Nucleolipid Conjugates into a Nanoemulsion Vehicle
ACS Omega. 2020-03-12. 5(11) : 5815-5823.
10.1021/acsomega.9b03992 -
Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
Biomolecules. 2020-03-03. 10(3) : 391.
10.3390/biom10030391 -
Multiple System Atrophy: Recent Developments and Future Perspectives
Mov Disord. 2019-11-06.
10.1002/mds.27894 -
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
. 2019-10-31.
10.1101/825216 -
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
JCI Insight. 2019-08-22. 4(16)
10.1172/jci.insight.129719 -
Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Cells. 2019-06-09. 8(6) : 565.
10.3390/cells8060565 -
Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-related Neurodegenerative Diseases.
Bioconjugate Chem.. 2018-11-13. 29(12) : 4083-4089.
10.1021/acs.bioconjchem.8b00697 -
Are synucleinopathies prion-like disorders?,Les synucléinopathies sont-elles des maladies à prions ?
Pratique Neurologique - FMC. 2018-04-01. 9(2) : 145-151.
10.1016/j.praneu.2018.02.006 -
Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells
J. Neurosci.. 2017-12-07. 38(4) : 814-825.
10.1523/JNEUROSCI.2276-17.2017 -
In vivo models of alpha-synuclein transmission and propagation
Cell Tissue Res. 2017-11-29. 373(1) : 183-193.
10.1007/s00441-017-2730-9 -
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease.
Gene Ther. 2017-11-16. 24(12) : 801-809.
10.1038/gt.2017.84 -
Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
Progress in Neurobiology. 2017-08-01. 155 : 171-193.
10.1016/j.pneurobio.2015.07.003 -
U18666A, an Activator of Sterol Regulatory Element Binding Protein (SREBP) Pathway Modulates Presynaptic Dopaminergic Phenotype of SH-SY5Y Neuroblastoma Cells.
Synapse. 2017-06-20. 71(9) : e21980.
10.1002/syn.21980 -
Autophagy and brain: The case of neurodegenerative diseases,Autophagie et cerveau
Med Sci (Paris). 2017-03-01. 33(3) : 268-274.
10.1051/medsci/20173303013 -
What lysosomes actually tell us about Parkinson’s disease?
Ageing Research Reviews. 2016-12-01. 32 : 140-149.
10.1016/j.arr.2016.02.008 -
Alpha-synuclein-based models of Parkinson’s disease
Revue Neurologique. 2016-06-01. 172(6-7) : 371-378.
10.1016/j.neurol.2016.04.003 -
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Synapse. 2016-01-06. 70(3) : 71-86.
10.1002/syn.21881 -
Alpha-synuclein spreading in Parkinson’s disease
Front. Neuroanat.. 2014-12-18. 8
10.3389/fnana.2014.00159 -
Down-regulating α-synuclein for treating synucleopathies.
Mov Disord.. 2014-09-12. 29(12) : 1463-1465.
10.1002/mds.26028 -
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Autophagy. 2014-03-26. 10(5) : 889-900.
10.4161/auto.28286 -
Evidence piles up for prion-like propagation mechanisms in synucleinopathies
Mov Disord.. 2014-01-02. 29(2) : 187-187.
10.1002/mds.25793 -
Viral vectors in primate research: Examples from Parkinson’s disease research
Neuromethods. 2013-09-19. : 331-341.
10.1007/978-1-62703-610-8_17 -
Single-molecule approach to find out toxic oligomeric alpa-synuclein species formation
Mov. Disord.. 2012-10-01. 27(12) : 1493-1493.
10.1002/mds.25180 -
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex i deficiency
Cell Death Differ. 2012-08-03. 20(1) : 77-85.
10.1038/cdd.2012.95 -
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy. 2012-04-01. 8(4) : 445-544.
10.4161/auto.19496 -
New experimental approach for modeling Parkinson’s disease
Mov. Disord.. 2012-03-01. 27(3) : 344-344.
10.1002/mds.24933 -
Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells
Human Gene Therapy. 2012-01-01. 23(1) : 56-69.
10.1089/hum.2011.054 -
The true nature of α-synuclein unmasked!
Mov. Disord.. 2011-11-01. 26(13) : 2324-2324.
10.1002/mds.24009 -
α-synuclein, a prion-like protein
Mov. Disord.. 2011-04-01. 26(5) : 774-774.
10.1002/mds.23748 -
Lysosomal membrane permeabilization in Parkinson disease
Autophagy. 2011-01-01. 7(1) : 98-100.
10.4161/auto.7.1.13933 -
Pathogenic lysosomal depletion in Parkinson’s disease
Journal of Neuroscience. 2010-09-15. 30(37) : 12535-12544.
10.1523/JNEUROSCI.1920-10.2010 -
Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Ann Neurol.. 2010-04-06. : n/a-n/a.
10.1002/ana.22034 -
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
Proceedings of the National Academy of Sciences. 2007-05-02. 104(19) : 8161-8166.
10.1073/pnas.0609874104 -
Mapping of the epitope of monoclonal antibody 2B4 to the proline-rich region of human Huntingtin, a region critical for aggregation and toxicity
Biotechnol. J.. 2007-05-01. 2(5) : 559-564.
10.1002/biot.200600249 -
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast
J. Biol. Chem.. 2006-09-14. 281(47) : 35608-35615.
10.1074/jbc.M605558200 -
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation
Proceedings of the National Academy of Sciences. 2004-06-21. 101(26) : 9648-9653.
10.1073/pnas.0403015101