Loading Events

« All Events

  • This event has passed.

Thesis defense – Laurie Robin

30 November 2018 / 13:30

30/11/2018, 13h30.

Directeur de thèse: Giovanni Marsicano , team leader: “Endocannabinoids and Neuroadaptation” Neurocentre Magendie

The endocannabinoid system is an important modulator of physiological functions. It is composed of cannabinoid receptors,
 their endogenous lipid ligands (the endocannabinoids) and the enzymatic machinery for endocannabinoid synthesis and degradation. The type-1 cannabinoid receptors (CB1) are expressed in different cell types of the brain and are known to be involved in memory processes. Endocannabinoids are mobilized in an activity-dependent manner in brain areas involved in the modulation of memory such as the hippocampus. In this brain region, CB1 receptors are mainly expressed at neuronal pre-synaptic terminals where their stimulation inhibits the release of neurotransmitters, thereby modulating several forms of synaptic activity. 


Robin, L.M.*, Oliveira da Cruz, J.F.*, Langlais, V.C.*, Martin-Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., Sherwood MW., Belluomo I., Balcells G., Matias I., Bosier B., Drago F., Van Eeckhaut A., Smolders I., Georges F., Araque A., Panatier A., Oliet SHR#, Marsicano G#. (2018). Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory. Neuron 98, 935-944.e5.

Gutiérrez-Rodríguez, A., Bonilla-Del Río, I., Puente, N., Gómez-Urquijo, S.M.,Fontaine, C.J., Egaña-Huguet, J., Elezgarai, I., Ruehle, S., Lutz, B., Robin, L.M., Soria-Gómez E., Bellocchio L., Padwal JD., van der Stelt M., Mendizabal-Zubiaga J., Reguero L., Ramos A., Gerrikagoitia I., Marsicano G., Grandes P. (2018). Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus. Glia 66, 1417–1431

Martin-Fernandez, M., Jamison, S., Robin, L.M, Zhao, Z., Martin, E.D., Aguilar, J., Benneyworth, M.A., Marsicano, G., and Araque, A. (2017). Synapse-specific astrocyte gating of amygdala-related behavior. Nature Neuroscience 20, 1540– 1548.

Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A.C., Delamarre, A., Cannich, A., Vincent, P., Varilh M., Robin LM., Terral G., García-Fernández MD., Colavita M., Mazier W., Drago F, Puente N., Reguero L., Elezgarai I., Dupuy JW., Cota D., Lopez-Rodriguez ML., Barreda-Gómez G., Massa F., Grandes P., Bénard G., Marsicano G. (2016). A cannabinoid link between mitochondria and memory. Nature 539, 555–559

Oliveira da Cruz, J.F.*, Robin, L.M.*, Drago, F., Marsicano, G., and Metna-Laurent, M. (2016). Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.Neuroscience 323, 35–42.

*: equal contribution, #: equal supervision


DR FERREIRA Guillaume, 
Université de Bordeaux, France, 
Dr WOTJAK Carsten, 
Max Planck Institute of Psychiatry Munich, Allemagne, 
University of Bonn Medical Center, Bonn, Allemagne, 
Dr NADJAR Agnès, 
Université de Bordeaux, France, 
Dr BONVENTO Gilles, 
MirCen, CNRS, UMR 9199, France, 
Dr MARSICANO Giovanni, 
Université de Bordeaux, France, 
Directeur de thèse


I subscribe to the newsletter:


30 November 2018
Event Category: