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Thèse – Laurie Robin

30 novembre 2018 / 13:30

Roles of astroglial type 1 cannabinoid receptor (CB1) in memory and synaptic plasticity

Date de la soutenance: 30/11/2018, 13h30.

Directeur de thèse: Giovanni Marsicano , team leader: « Endocannabinoids and Neuroadaptation » Neurocentre Magendie


The endocannabinoid system is an important modulator of physiological functions. It is composed of cannabinoid receptors,
 their endogenous lipid ligands (the endocannabinoids) and the enzymatic machinery for endocannabinoid synthesis and degradation. The type-1 cannabinoid receptors (CB1) are expressed in different cell types of the brain and are known to be involved in memory processes. Endocannabinoids are mobilized in an activity-dependent manner in brain areas involved in the modulation of memory such as the hippocampus. In this brain region, CB1 receptors are mainly expressed at neuronal pre-synaptic terminals where their stimulation inhibits the release of neurotransmitters, thereby modulating several forms of synaptic activity. 

Publications

Robin, L.M.*, Oliveira da Cruz, J.F.*, Langlais, V.C.*, Martin-Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., Sherwood MW., Belluomo I., Balcells G., Matias I., Bosier B., Drago F., Van Eeckhaut A., Smolders I., Georges F., Araque A., Panatier A., Oliet SHR#, Marsicano G#. (2018). Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory. Neuron 98, 935-944.e5.

Gutiérrez-Rodríguez, A., Bonilla-Del Río, I., Puente, N., Gómez-Urquijo, S.M.,Fontaine, C.J., Egaña-Huguet, J., Elezgarai, I., Ruehle, S., Lutz, B., Robin, L.M., Soria-Gómez E., Bellocchio L., Padwal JD., van der Stelt M., Mendizabal-Zubiaga J., Reguero L., Ramos A., Gerrikagoitia I., Marsicano G., Grandes P. (2018). Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus. Glia 66, 1417–1431

Martin-Fernandez, M., Jamison, S., Robin, L.M, Zhao, Z., Martin, E.D., Aguilar, J., Benneyworth, M.A., Marsicano, G., and Araque, A. (2017). Synapse-specific astrocyte gating of amygdala-related behavior. Nature Neuroscience 20, 1540– 1548.

Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A.C., Delamarre, A., Cannich, A., Vincent, P., Varilh M., Robin LM., Terral G., García-Fernández MD., Colavita M., Mazier W., Drago F, Puente N., Reguero L., Elezgarai I., Dupuy JW., Cota D., Lopez-Rodriguez ML., Barreda-Gómez G., Massa F., Grandes P., Bénard G., Marsicano G. (2016). A cannabinoid link between mitochondria and memory. Nature 539, 555–559

Oliveira da Cruz, J.F.*, Robin, L.M.*, Drago, F., Marsicano, G., and Metna-Laurent, M. (2016). Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.Neuroscience 323, 35–42.

*: equal contribution, #: equal supervision

JURY

DR FERREIRA Guillaume, 
Université de Bordeaux, France, 
Président 
Dr WOTJAK Carsten, 
Max Planck Institute of Psychiatry Munich, Allemagne, 
Rapporteur 
Pr HENNEBERGER Christian,
University of Bonn Medical Center, Bonn, Allemagne, 
Rapporteur 
Dr NADJAR Agnès, 
Université de Bordeaux, France, 
Examinateur
Dr BONVENTO Gilles, 
MirCen, CNRS, UMR 9199, France, 
Examinateur
Dr MARSICANO Giovanni, 
Université de Bordeaux, France, 
Directeur de thèse

 

Prochainement

  1. Séminaire – Suzana Herculano-Houzel

    vendredi 26 avril 2019 / 11:30

    Invitant : Thomas Boraud

  2. Séminaire impromptu – Maxime Assous

    vendredi 3 mai 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  3. Conférence mensuelle – Richard Robitaille

    vendredi 3 mai 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial celles in health and disease

  4. Séminaire – Stéphanie Trouche

    vendredi 10 mai 2019 / 11:30 - 12:30

    Invitant : Catherine Le Moine

  5. Journée Bordeaux Neurocampus

    mercredi 15 mai 2019 / 09:00 - 18:00

    (Haut Carré, Talence)

Détails

Date :
30 novembre 2018
Heure :
13:30
Catégorie d’Évènement: