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Seminar – Miriam Melis

Friday 17 May 2019 / 11:30

Maternal THC exposure biases dopamine system towards behavioral metaplasticity, Maternal THC exposure biases dopamine system towards behavioral metaplasticity

Venue: Centre Broca Nouvelle-Aquitaine / conference room / ground floor


Miriam Melis
PhD, Universita di Cagliari

Invited by Francis Chaouloff
DR INSERM/ Neurocentre Magendie / Expertise: endocannabinoïdes, stress, exercice physique

Abstract :

Miriam Melis graduated in Neuroscience at the University of Cagliari where she is currently an associate professor of pharmacology. Her main research interest is to understand neurobiological mechanisms of resilience and susceptibility to neuropsychiatric disorders (e.g., substance use disorder, antisocial behavior, anxiety, depression) that involve adaptations of both mesocorticolimbic dopamine pathway and endocannabinoid system. Vulnerability to neuropsychiatric disorders can be innate (i.e., temperaments, sex) or induced by early life adversities (e.g. drug exposure, adverse social events) and can be examined in rodent models to reveal early and/or endo phenotypes in order to develop novel and age-specific pharmacological strategies for the prevention and treatment of aberrant affective functioning.

Selected publications

Frau R, Fanni S, Serra V, Simola N, Godar SC, Traccis , Devoto P, Bortolato M, Melis M (2019) Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress. Neuropharmacol. doi: 10.1016/j.neuropharm.2019.01.032

Fattore L, Melis M. (2016) Sex differences in impulsive and compulsive behaviors: a focus on drug addiction. Addict Biol. 21(5):1043-51. 

Sagheddu C, Melis M (2015) Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. CNS Neurol Disord Drug Targets. 14 (4): 502-517

Melis M, Sagheddu C, De Felice M, Casti A, Madeddu C, Spiga S, Muntoni AL, Mackie K, Marsicano G, Colombo G, Castelli MP, Pistis M. (2014) Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. Journal of Neuroscience, 34(38):12716-24

Melis M, De Felice M, Lecca S, Fattore L, Pistis M (2013): Sex-specific tonic 2-arachidonoylglycerol signaling at inhibitory inputs onto dopamine neurons of Lister Hooded rats. Frontiers in  Integrative Neuroscience, 7(93):1-13.

Coming soon

  1. Cajal course : Advanced Techniques for Synapse Biology

    Tuesday 15 October 2019 - Wednesday 30 October 2019

    Applications will open in April 2019

  2. Thesis defense – Florelle Domart

    Tuesday 15 October 2019 / 09:30 - 11:30

    Synchrotron X-ray fluorescence and super resolution correlative nanoimaging of metals and proteins in synapses of hippocampal neurons

  3. Honoris Causa ceremony – Monica di Luca

    Tuesday 15 October 2019 / 17:00 - 19:00

    Centre Broca Nouvelle Aquitaine

  4. Seminar – Beat Lutz

    Friday 18 October 2019 / 11:30

    Invited by Giovanni Marsicano

  5. Monthly conference (PhD seminar series) – Deborah Kurrasch

    Thursday 31 October 2019 / 11:30 - 12:30

    The role of microglia in the developing hypothalamus

Details

Date:
Friday 17 May 2019
Time:
11:30
Event Category: