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Seminar – Miriam Melis

Friday 17 May 2019 / 11:30

Maternal THC exposure biases dopamine system towards behavioral metaplasticity, Maternal THC exposure biases dopamine system towards behavioral metaplasticity

Venue: Centre Broca Nouvelle-Aquitaine / conference room / ground floor


Miriam Melis
PhD, Universita di Cagliari

Invited by Francis Chaouloff
DR INSERM/ Neurocentre Magendie / Expertise: endocannabinoïdes, stress, exercice physique

Abstract :

Miriam Melis graduated in Neuroscience at the University of Cagliari where she is currently an associate professor of pharmacology. Her main research interest is to understand neurobiological mechanisms of resilience and susceptibility to neuropsychiatric disorders (e.g., substance use disorder, antisocial behavior, anxiety, depression) that involve adaptations of both mesocorticolimbic dopamine pathway and endocannabinoid system. Vulnerability to neuropsychiatric disorders can be innate (i.e., temperaments, sex) or induced by early life adversities (e.g. drug exposure, adverse social events) and can be examined in rodent models to reveal early and/or endo phenotypes in order to develop novel and age-specific pharmacological strategies for the prevention and treatment of aberrant affective functioning.

Selected publications

Frau R, Fanni S, Serra V, Simola N, Godar SC, Traccis , Devoto P, Bortolato M, Melis M (2019) Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress. Neuropharmacol. doi: 10.1016/j.neuropharm.2019.01.032

Fattore L, Melis M. (2016) Sex differences in impulsive and compulsive behaviors: a focus on drug addiction. Addict Biol. 21(5):1043-51. 

Sagheddu C, Melis M (2015) Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. CNS Neurol Disord Drug Targets. 14 (4): 502-517

Melis M, Sagheddu C, De Felice M, Casti A, Madeddu C, Spiga S, Muntoni AL, Mackie K, Marsicano G, Colombo G, Castelli MP, Pistis M. (2014) Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. Journal of Neuroscience, 34(38):12716-24

Melis M, De Felice M, Lecca S, Fattore L, Pistis M (2013): Sex-specific tonic 2-arachidonoylglycerol signaling at inhibitory inputs onto dopamine neurons of Lister Hooded rats. Frontiers in  Integrative Neuroscience, 7(93):1-13.

Coming soon

  1. Seminar – Tomonori Takeuchi

    Monday 17 June 2019 / 11:30

    Memory consolidation, dopamine and two distinct novelty systems

  2. Seminar – David Stellwagen

    Thursday 20 June 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  3. Seminar – André Ramos

    Friday 21 June 2019 / 11:30

    Le long (et incertain) chemin entre les comportements liés à l'anxiété et les gènes sous-jacents

  4. Seminar – Manojkumar Saranathan

    Friday 21 June 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  5. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    Sunday 23 June 2019 - Saturday 13 July 2019

    Talks are open to everyone

Details

Date:
Friday 17 May 2019
Time:
11:30
Event Category: