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Seminar – Francesco Papaleo

24 January 2020 / 11:30 - 12:30

Francesco Papaleo

Venue: Centre Broca Nouvelle-Aquitaine

Bottom-Up and Top-Down Control of Emotion Recognition”


Francesco Papaleo
F. Papaleo

Francesco Papaleo
Senior Researcher Tenure Track – Principal Investigator
IIT Central Research Labs Genova
https://www.iit.it/people/francesco-papaleo

Invited by Giovanni Marsicano
Neurocentre Magendie


Summary:

The prefrontal cortex (PFC) has been implicated in processing of the emotional state of others through nonverbal communication. This social cognitive function is altered in psychiatric disorders such as autism and schizophrenia and is hypothesized to rely on an intact cortical neuronal excitatory and inhibitory balance. Here, by combining in vivo electrophysiology with a behavioral task for emotion recognition in mice, we show that neurons in the medial prefrontal cortex (mPFC) are differentially activated during exploration of conspecifics depending on their affective state. Optogenetic manipulations revealed a double dissociation of interneuron roles in emotion recognition; specifically, inhibition of mPFC somatostatin (SOM+) but not of parvalbumin (PV+) interneurons abolishes emotion discrimination. Conversely, activation of mPFC SOM+ interneurons induces social discrimination in this task. Our findings provide new insights into the neurobiological mechanisms of emotion recognition.

Selected publications:

Ferretti V, Papaleo F. Understanding others: emotion recognition abilities in humans and other animals. Genes, Brain Behavior. 2018. Dec13:e12544. doi:10.1111/gbb.12544.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nature Communications. 2018 Jun 11;9(1):2265. doi:10.1038/s41467-018-04711-w.

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Molecular Psychiatry. 2018 Apr;23(4):1040-1050. doi:10.1038/mp.2017.126.

Managò F, Mereu M, Mastwal S, Mastrogiacomo R, Scheggia D, Emanuele M, De Luca MA, Weinberger DR, Wang KH, Papaleo F. Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia. Cell Rep. 2016 Aug 23;16(8):2116-28. doi: 10.1016/j.celrep.2016.07.044.

Huang H, Michetti C, Busnelli M, Managò F, Sannino S, Scheggia D, Giancardo L, Sona D, Murino V, Chini B, Luisa Scattoni M, Papaleo F. Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice. Neuropsychopharmacology. 2014 Apr;39(5):1102-14. doi: 10.1038/npp.2013.310.

Coming soon

  1. Cajal course : Advanced Techniques for Synapse Biology

    Tuesday 15 October 2019 - Wednesday 30 October 2019

    Applications will open in April 2019

  2. Thesis defense – Florelle Domart

    Tuesday 15 October 2019 / 09:30 - 11:30

    Synchrotron X-ray fluorescence and super resolution correlative nanoimaging of metals and proteins in synapses of hippocampal neurons

  3. Honoris Causa ceremony – Monica di Luca

    Tuesday 15 October 2019 / 17:00 - 19:00

    Centre Broca Nouvelle Aquitaine

  4. Seminar – Beat Lutz

    Friday 18 October 2019 / 11:30

    Invited by Giovanni Marsicano

  5. Monthly conference (PhD seminar series) – Deborah Kurrasch

    Thursday 31 October 2019 / 11:30 - 12:30

    The role of microglia in the developing hypothalamus

Details

Date:
24 January 2020
Time:
11:30 - 12:30
Event Category:

Venue

Centre Broca Nouvelle-Aquitaine
38 Rue Albert Marquet
Bordeaux, 33000 France