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Seminar – Francesco Papaleo

Friday 13 September 2019 / 11:30

Francesco Papaleo

Venue: Centre Broca Nouvelle-Aquitaine

Bottom-Up and Top-Down Control of Emotion Recognition”


Francesco Papaleo
F. Papaleo

Francesco Papaleo
Senior Researcher Tenure Track – Principal Investigator
IIT Central Research Labs Genova
https://www.iit.it/people/francesco-papaleo

Invited by Giovanni Marsicano
Neurocentre Magendie


Summary:

The prefrontal cortex (PFC) has been implicated in processing of the emotional state of others through nonverbal communication. This social cognitive function is altered in psychiatric disorders such as autism and schizophrenia and is hypothesized to rely on an intact cortical neuronal excitatory and inhibitory balance. Here, by combining in vivo electrophysiology with a behavioral task for emotion recognition in mice, we show that neurons in the medial prefrontal cortex (mPFC) are differentially activated during exploration of conspecifics depending on their affective state. Optogenetic manipulations revealed a double dissociation of interneuron roles in emotion recognition; specifically, inhibition of mPFC somatostatin (SOM+) but not of parvalbumin (PV+) interneurons abolishes emotion discrimination. Conversely, activation of mPFC SOM+ interneurons induces social discrimination in this task. Our findings provide new insights into the neurobiological mechanisms of emotion recognition.

Selected publications:

Ferretti V, Papaleo F. Understanding others: emotion recognition abilities in humans and other animals. Genes, Brain Behavior. 2018. Dec13:e12544. doi:10.1111/gbb.12544.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nature Communications. 2018 Jun 11;9(1):2265. doi:10.1038/s41467-018-04711-w.

Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Molecular Psychiatry. 2018 Apr;23(4):1040-1050. doi:10.1038/mp.2017.126.

Managò F, Mereu M, Mastwal S, Mastrogiacomo R, Scheggia D, Emanuele M, De Luca MA, Weinberger DR, Wang KH, Papaleo F. Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia. Cell Rep. 2016 Aug 23;16(8):2116-28. doi: 10.1016/j.celrep.2016.07.044.

Huang H, Michetti C, Busnelli M, Managò F, Sannino S, Scheggia D, Giancardo L, Sona D, Murino V, Chini B, Luisa Scattoni M, Papaleo F. Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice. Neuropsychopharmacology. 2014 Apr;39(5):1102-14. doi: 10.1038/npp.2013.310.

Coming soon

  1. Monthly conference (PhD seminar series) – Laurent Bourdieu

    Friday 6 September 2019 / 11:30

    Fast 3D imaging of neuronal activity in visual cortex across multiple layers in awake mice

  2. Cajal lectures : Whole brain imaging

    Monday 9 September 2019 - Friday 27 September 2019

    Free entrance lectures / Venue: CGFB

  3. Seminar – Francesco Papaleo

    Friday 13 September 2019 / 11:30

    Bottom-Up and Top-Down Control of Emotion Recognition.

  4. LabEx TRAIL scientific day

    Monday 16 September 2019 / 14:00 - 18:00

    Dedicated to brain connectivity.

  5. Synapse Day

    Tuesday 17 September 2019

    Centre Broca Nouvelle-Aquitaine


Conférence internationale : REWARD

Du 2 au 4 octobre

L’événement en un coup d’oeil :
télécharger le livret (programme,
inscription, soumission d’abstract…)

brainconf.u-bordeaux.fr

Details

Date:
Friday 13 September 2019
Time:
11:30
Event Category:

Venue

Centre Broca Nouvelle-Aquitaine
38 Rue Albert Marquet
Bordeaux, 33000 France