Loading Events

« All Events

  • This event has passed.

Seminar – Claire Meissirel

Friday 29 March 2019 / 11:30

Deciphering the role of VEGF pathway in synaptic function in physiology and AD pathophysiology

Venue: Centre Broca Nouvelle-Aquitaine / Conference hall


Scientific focus

Increasing evidence indicate that the vascular endothelial growth factor (VEGF) and its receptor VEGFR2 mediate key neurobiological processes including among others, adult neurogenesis, hippocampal-dependent synaptic plasticity and cognition. Our recent work demonstrates that the impact of VEGF on adult synaptic plasticity and memory involving the hippocampus requires the neuronal expression of VEGFR2. Moreover, we documented a new crosstalk between VEGFR2 and NMDAR that increases NMDAR synaptic responses in hippocampal neurons and triggers the formation of new synapses.
Our current interest is to determine whether the VEGF/VEGFR2 signaling is impaired in neurological disorders in which glutamatergic transmission mediated by NMDA receptors is altered, such as Alzheimer Disease and Depression.

Selected publications

De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C. A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior. Mol Psychiatry. 2016, 21(12):1768-1780.

Meissirel C, Ruiz de Almodovar C, Knevels E, Coulon C, Chounlamountri N, Segura I, de Rossi P, Vinckier S, Anthonis K, Deléglise B, de Mol M, Ali C, Dassonville K, Loyens E, Honnorat J, Michotte Y, Rogemond V, Smolders I, Voets T, Vivien D, Vanden Berghe P, Van den Bosch L, Robberecht W, Chédotal A, Oliviero S, Dewerchin M, Schmucker D, Thomasset N, Salin P, Carmeliet P. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A. 2011, 108(33):13782-7.

Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D’Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chédotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010, 30(45):15052-66.

 

Coming soon

  1. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    Tuesday 25 June 2019 - Tuesday 9 July 2019

    Talks are open to everyone

  2. Conference Labex Trail – Goran Angelovski

    Friday 28 June 2019 / 14:30

    Molecular fMRI with Bioresponsive Probes

  3. Atout neurones

    Saturday 29 June 2019 / 14:00 - 20:00

    Tournoi de bridge au profit de la recherche sur le cerveau et conférence d'Olivier Nicole (IMN)

  4. Seminar – Anne Brunet

    Tuesday 2 July 2019 / 11:30

    Understanding and modeling aging

  5. Seminar – Stephanie Borgland

    Friday 5 July 2019 / 11:00 - 12:00

    Diet induced plasticity in the orbitofrontal cortex: implications for overeating

Details

Date:
Friday 29 March 2019
Time:
11:30
Event Category:

Venue

Centre Broca Nouvelle-Aquitaine
38 Rue Albert Marquet
Bordeaux, 33000 France