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Séminaire – Claire Meissirel

vendredi 29 mars 2019 / 11:30

Deciphering the role of VEGF pathway in synaptic function in physiology and AD pathophysiology

Lieu : Salle de conférence du Centre Broca Nouvelle-Aquitaine


 

Scientific focus

Increasing evidence indicate that the vascular endothelial growth factor (VEGF) and its receptor VEGFR2 mediate key neurobiological processes including among others, adult neurogenesis, hippocampal-dependent synaptic plasticity and cognition. Our recent work demonstrates that the impact of VEGF on adult synaptic plasticity and memory involving the hippocampus requires the neuronal expression of VEGFR2. Moreover, we documented a new crosstalk between VEGFR2 and NMDAR that increases NMDAR synaptic responses in hippocampal neurons and triggers the formation of new synapses.
Our current interest is to determine whether the VEGF/VEGFR2 signaling is impaired in neurological disorders in which glutamatergic transmission mediated by NMDA receptors is altered, such as Alzheimer Disease and Depression.

 

Selected publications

De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C. A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior. Mol Psychiatry. 2016, 21(12):1768-1780.

Meissirel C, Ruiz de Almodovar C, Knevels E, Coulon C, Chounlamountri N, Segura I, de Rossi P, Vinckier S, Anthonis K, Deléglise B, de Mol M, Ali C, Dassonville K, Loyens E, Honnorat J, Michotte Y, Rogemond V, Smolders I, Voets T, Vivien D, Vanden Berghe P, Van den Bosch L, Robberecht W, Chédotal A, Oliviero S, Dewerchin M, Schmucker D, Thomasset N, Salin P, Carmeliet P. VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation. Proc Natl Acad Sci U S A. 2011, 108(33):13782-7.

Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D’Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chédotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010, 30(45):15052-66.

Prochainement

  1. Séminaire – Suzana Herculano-Houzel

    vendredi 26 avril 2019 / 11:30

    Life slows down with more neurons in the cerebral cortex

  2. Ciné-débat : « La peur, cette séduisante sensation… »

    mardi 30 avril 2019 / 18:30

    Projection du film "Le Silence des agneaux" suivie d'un débat.

  3. Séminaire impromptu – Maxime Assous

    vendredi 3 mai 2019 / 10:00 - 11:30

    Extrinsic innervation of striatal interneurons and implications for the local microcircuitry.

  4. Conférence mensuelle – Richard Robitaille

    vendredi 3 mai 2019 / 11:30 - 12:30

    Regulation of synaptic structure ad function by glial cells in health and disease

  5. Séminaire – Stéphanie Trouche

    vendredi 10 mai 2019 / 11:30 - 12:30

    Invitant : Catherine Le Moine

Détails

Date :
vendredi 29 mars 2019
Heure :
11:30
Catégorie d’Évènement:

Lieu

Centre Broca Nouvelle-Aquitaine
38 Rue Albert Marquet
Bordeaux, 33000 France